Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTASPHL0)

DOT Name Uncharacterized protein C1orf141 (C1ORF141)
Gene Name C1ORF141
Related Disease
Leprosy ( )
Multiple sclerosis ( )
Sarcoidosis ( )
Uveitis ( )
Autoimmune disease ( )
Autoimmune disease, susceptibility to, 6 ( )
Autoimmune thyroid disease ( )
Coeliac disease ( )
Common variable immunodeficiency ( )
Juvenile idiopathic arthritis ( )
STAT3-related early-onset multisystem autoimmune disease ( )
Systemic lupus erythematosus ( )
Type-1 diabetes ( )
Inflammatory bowel disease ( )
Ankylosing spondylitis ( )
Crohn disease ( )
Psoriasis ( )
Psoriatic arthritis ( )
Sclerosing cholangitis ( )
Ulcerative colitis ( )
UniProt ID
CA141_HUMAN
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Pfam ID
PF15078
Sequence
MAEKILEKLDVLDKQAEIILARRTKINRLQSEGRKTTMAIPLTFDFQLEFEEALATSASK
AISKIKEDKSCSITKSKMHVSFKCEPEPRKSNFEKSNLRPFFIQTNVKNKESESTAQIEK
KPRKPLDSVGLLEGDRNKRKKSPQMNDFNIKENKSVRNYQLSKYRSVRKKSLLPLCFEDE
LKNPHAKIVNVSPTKTVTSHMEQKDTNPIIFHDTEYVRMLLLTKNRFSSHPLENENIYPH
KRTNFILERNCEILKSIIGNQSISLFKPQKTMPTVQRKDIQIPMSFKAGHTTVDDKLKKK
TNKQTLENRSWNTLYNFSQNFSSLTKQFVGYLDKAVIHEMSAQTGKFERMFSAGKPTSIP
TSSALPVKCYSKPFKYIYELNNVTPLDNLLNLSNEILNAS

Molecular Interaction Atlas (MIA) of This DOT

20 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Leprosy DISAA4UI Strong Genetic Variation [1]
Multiple sclerosis DISB2WZI Strong Genetic Variation [2]
Sarcoidosis DISE5B8Z Strong Genetic Variation [3]
Uveitis DISV0RYS Strong Genetic Variation [4]
Autoimmune disease DISORMTM moderate Genetic Variation [5]
Autoimmune disease, susceptibility to, 6 DISHNUXI moderate Genetic Variation [5]
Autoimmune thyroid disease DISIHC6A moderate Genetic Variation [5]
Coeliac disease DISIY60C moderate Genetic Variation [5]
Common variable immunodeficiency DISHE7JQ moderate Genetic Variation [5]
Juvenile idiopathic arthritis DISQZGBV moderate Genetic Variation [5]
STAT3-related early-onset multisystem autoimmune disease DISAXTN7 moderate Genetic Variation [5]
Systemic lupus erythematosus DISI1SZ7 moderate Genetic Variation [5]
Type-1 diabetes DIS7HLUB moderate Genetic Variation [5]
Inflammatory bowel disease DISGN23E Disputed Genetic Variation [6]
Ankylosing spondylitis DISRC6IR Limited Genetic Variation [7]
Crohn disease DIS2C5Q8 Limited Genetic Variation [8]
Psoriasis DIS59VMN Limited Genetic Variation [7]
Psoriatic arthritis DISLWTG2 Limited Genetic Variation [9]
Sclerosing cholangitis DIS7GZNB Limited Genetic Variation [7]
Ulcerative colitis DIS8K27O Limited Genetic Variation [7]
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⏷ Show the Full List of 20 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Permethrin DMZ0Q1G Approved Permethrin decreases the expression of Uncharacterized protein C1orf141 (C1ORF141). [10]
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1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene affects the methylation of Uncharacterized protein C1orf141 (C1ORF141). [11]
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References

1 Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.Nat Genet. 2015 Mar;47(3):267-71. doi: 10.1038/ng.3212. Epub 2015 Feb 2.
2 Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.Ann Neurol. 2011 Dec;70(6):897-912. doi: 10.1002/ana.22609.
3 Identification of Immune-Relevant Factors Conferring Sarcoidosis Genetic Risk.Am J Respir Crit Care Med. 2015 Sep 15;192(6):727-36. doi: 10.1164/rccm.201503-0418OC.
4 Uveitis genetics.Exp Eye Res. 2020 Jan;190:107853. doi: 10.1016/j.exer.2019.107853. Epub 2019 Oct 25.
5 Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.Nat Med. 2015 Sep;21(9):1018-27. doi: 10.1038/nm.3933. Epub 2015 Aug 24.
6 A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.Science. 2006 Dec 1;314(5804):1461-3. doi: 10.1126/science.1135245. Epub 2006 Oct 26.
7 Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.Nat Genet. 2016 May;48(5):510-8. doi: 10.1038/ng.3528. Epub 2016 Mar 14.
8 A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn's Disease in Japanese Individuals.J Crohns Colitis. 2019 Apr 26;13(5):648-658. doi: 10.1093/ecco-jcc/jjy197.
9 Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis.Ann Rheum Dis. 2019 Mar;78(3):e214158. doi: 10.1136/annrheumdis-2018-214158. Epub 2018 Dec 14.
10 Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
11 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.