Details of Disease

General Information of Disease (ID: DISIY60C)

Disease Name Coeliac disease
Synonyms non tropical sprue; celiac sprue; coeliac sprue; celiac disease; gluten intolerance; idiopathic steatorrhea; gluten-induced enteropathy
Disease Class DA95: Coeliac disease
Definition
An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet.
Disease Hierarchy
DISF979Y: Small intestine disorder
DISYKSRF: Genetic disease
DISGMUVS: Malabsorption syndrome
DISLAIH9: Autoimmune disorder of gastrointestinal tract
DISIY60C: Coeliac disease
ICD Code
ICD-11
ICD-11: DA95
ICD-10
ICD-10: K90.0
ICD-9
ICD-9: 579
Expand ICD-11
'DA95
Expand ICD-10
'K90.0
Expand ICD-9
579
Disease Identifiers
MONDO ID
MONDO_0005130
MESH ID
D002446
UMLS CUI
C0007570
MedGen ID
3291
HPO ID
HP:0002608
Orphanet ID
555
SNOMED CT ID
396331005

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 11 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
ALV-003 DMXSFA0 Phase 2 NA [1]
AMG-714 DM1T3KQ Phase 2 Antibody [2]
IMGX003 DMCK3TJ Phase 2 NA [2]
INN-202 DMNEO4Q Phase 2 NA [2]
RG7625 DMDGPKS Phase 2 NA [2]
TAK-062 DMJLFAK Phase 2 Enzyme replacement [3]
TAK-101 DMCUS0X Phase 2 NA [4]
ZED1227 DMDXEN5 Phase 2 Small molecule [5]
BL-7010 DMGSW16 Phase 1/2 NA [6]
HLA-DQ2 peptide vaccine DMK6SL9 Phase 1 NA [7]
NexVax2 DMUAL7N Phase 1 NA [8]
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⏷ Show the Full List of 11 Drug(s)
This Disease is Treated as An Indication in 1 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
AG-014 DM97269 Investigative NA [9]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 81 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
APOB TTN1IE2 Limited Biomarker [10]
APOC3 TTXOZQ1 Limited Biomarker [10]
CCR4 TT7HQD0 Limited Biomarker [11]
CCR9 TTIPS8B Limited Biomarker [12]
CD36 TTPJMCU Limited Biomarker [10]
CD80 TT89Z17 Limited Biomarker [11]
CXCL11 TTWG0RE Limited Biomarker [13]
CXCL9 TTWE5PB Limited Biomarker [10]
ETS1 TTTGPSD Limited Genetic Variation [14]
FCGR3A TTIFOC0 Limited Biomarker [10]
GEM TTAZF9M Limited Genetic Variation [15]
ICOSLG TTB9Z8R Limited Biomarker [11]
IL15RA TTGN89I Limited Biomarker [16]
IRF1 TT4TU3L Limited Biomarker [17]
KLRK1 TTLRN4A Limited Altered Expression [18]
LCN2 TTKTLAI Limited Biomarker [10]
LPL TTOF3WZ Limited Biomarker [10]
MBL2 TTMQDZ5 Limited Altered Expression [19]
MMP12 TTXZ0KQ Limited Biomarker [10]
RUNX3 TTKCVO7 Limited Biomarker [11]
S100A9 TT0TMQG Limited Biomarker [10]
SLC11A2 TT2IS7P Limited Genetic Variation [20]
SLC30A8 TTXIGT7 Limited Biomarker [21]
SLC6A14 TTB6H2S Limited Biomarker [10]
SOAT2 TTAK0IN Limited Biomarker [10]
TFF1 TTNOJIZ Limited Biomarker [10]
TMPRSS6 TTL9KE7 Limited Genetic Variation [22]
TNFRSF14 TTWGTC1 Limited Biomarker [11]
TNFRSF9 TTPW9LJ Limited Biomarker [10]
CFTR TTRLZHP moderate Biomarker [23]
CXCL10 TTQOVYA moderate Altered Expression [24]
DAG1 TT4X7PG moderate Genetic Variation [25]
ERAP2 TTVGS1C moderate Genetic Variation [25]
GPR35 TT254XD moderate Genetic Variation [25]
ICOS TTE5VP6 moderate Genetic Variation [11]
IL18RAP TTZUJVE moderate Genetic Variation [26]
IL2 TTF89GD moderate Biomarker [16]
LRRK2 TTK0FEA moderate Genetic Variation [25]
MMP3 TTUZ2L5 moderate Biomarker [10]
SH2B3 TT36N7Z moderate Genetic Variation [27]
TNFSF15 TTEST6I moderate Genetic Variation [25]
ATP4A TTF1QVM Strong Biomarker [28]
BTNL3 TTBGWN3 Strong Biomarker [29]
CCR3 TTD3XFU Strong Genetic Variation [30]
CD14 TT6I7DC Strong Genetic Variation [31]
CD3E TTZAT79 Strong Biomarker [32]
CD3G TTV3XPL Strong Altered Expression [33]
CD4 TTN2JFW Strong Altered Expression [34]
CNR2 TTMSFAW Strong Genetic Variation [35]
CR2 TT0HUN7 Strong Altered Expression [36]
DMD TTWLFXU Strong Biomarker [37]
DUSP10 TTF3RJ0 Strong Biomarker [38]
FCGR2A TTXT21W Strong Genetic Variation [39]
HP TTLC8E1 Strong Altered Expression [40]
IL12B TTGW72V Strong Genetic Variation [41]
IL21 TT9QEJ6 Strong Biomarker [16]
IL22 TTLDX4N Strong Altered Expression [42]
IL2RA TT10Y9E Strong Genetic Variation [43]
IL5RA TTXH9AD Strong Biomarker [44]
KCNJ11 TT329V4 Strong Genetic Variation [45]
KIR2DS1 TTVWAGF Strong Genetic Variation [46]
KIR3DL2 TTQH3N0 Strong Genetic Variation [46]
LCT TTA0OSE Strong Genetic Variation [47]
LMO2 TTFX379 Strong Biomarker [48]
LTBR TTFO0PM Strong Altered Expression [49]
NAPEPLD TTFMCB6 Strong Altered Expression [50]
NCR1 TTQNRJM Strong Biomarker [18]
PNPLA3 TTEUAEH Strong Genetic Variation [51]
PRKCQ TT1MS7X Strong Biomarker [52]
PTPN2 TTY8PUS Strong Genetic Variation [30]
QPCT TTJ7YTV Strong Genetic Variation [53]
RUNX1 TTWIN3H Strong Genetic Variation [30]
SMAD3 TTHQZV7 Strong Altered Expression [54]
TGM1 TT7A949 Strong Biomarker [55]
TICAM1 TT2GQT6 Strong Biomarker [56]
TNFAIP3 TT5W0IO Strong Genetic Variation [57]
TOR1A TTF85KW Strong Biomarker [58]
TPO TT52XDZ Strong Biomarker [59]
ULK3 TTYENHQ Strong Biomarker [60]
ZFP36L1 TT8QVJO Strong Genetic Variation [61]
FCGRT TTKLPHO Definitive Genetic Variation [62]
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⏷ Show the Full List of 81 DTT(s)
This Disease Is Related to 4 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC30A10 DTYBI73 Limited Biomarker [21]
ATP12A DT5NLZA Strong Biomarker [28]
SLC22A4 DT2EG60 Strong Genetic Variation [63]
SLC9A4 DTU8PXI Strong Genetic Variation [14]
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This Disease Is Related to 6 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
PCK1 DEPLH5Z Limited Biomarker [10]
TGM6 DEUWCVD Limited Biomarker [64]
UGT1A4 DELOY3P Limited Biomarker [10]
PON3 DETXQZ1 Disputed Biomarker [65]
MMEL1 DEYCUQ2 Strong Genetic Variation [30]
TPMT DEFQ8VO Strong Biomarker [66]
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⏷ Show the Full List of 6 DME(s)
This Disease Is Related to 133 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ACE OTDF1964 Limited Biomarker [10]
ASAH2 OT47TIF3 Limited Biomarker [10]
CAPN8 OTXTW2I4 Limited Biomarker [10]
CSN2 OT22C0PD Limited Biomarker [67]
GBP5 OTS4AO4A Limited Biomarker [10]
GOT2 OT6XBWN0 Limited Altered Expression [40]
IFI27 OTI2XGIT Limited Biomarker [10]
ISYNA1 OT49ONSE Limited Altered Expression [68]
LRAT OTB7CJKY Limited Biomarker [10]
MTG1 OTC9U1LI Limited Biomarker [69]
PIWIL2 OT1PXQIF Limited Biomarker [10]
RGS1 OTGXJYMG Limited Genetic Variation [70]
TAP2 OTWSYFI7 Limited Genetic Variation [71]
ACAD8 OT3JI5GB moderate Genetic Variation [72]
ADCY7 OTAWMGP3 moderate Genetic Variation [25]
ADGRL2 OTCXD2YR moderate Genetic Variation [25]
ANKRD30A OTJXYAE5 moderate Genetic Variation [25]
ANKRD55 OT62KZII moderate Genetic Variation [25]
ATXN2L OTP5M3R9 moderate Genetic Variation [25]
BACH2 OT17GS18 moderate Biomarker [73]
C1orf141 OTASPHL0 moderate Genetic Variation [25]
CARD9 OTJ81AWD moderate Genetic Variation [25]
CRB1 OTXYUNG0 moderate Genetic Variation [25]
FNBP1 OTSJ5KKA moderate Genetic Variation [25]
INS-IGF2 OTZR74BO moderate Genetic Variation [25]
LURAP1L OTSJ29M5 moderate Genetic Variation [25]
NKD1 OTY3MO97 moderate Genetic Variation [25]
SUOX OTEJQ9FC moderate Genetic Variation [25]
TAGAP OTHJNNO2 moderate Biomarker [73]
ACACA OT5CQPZY Strong Genetic Variation [74]
ACSL5 OT3L9XO3 Strong Biomarker [75]
ADAD1 OTXRDF3Z Strong Genetic Variation [76]
AFF3 OTR0705Z Strong Genetic Variation [30]
AMELX OTIN26MM Strong Biomarker [77]
ARHGAP31 OTUYTF4I Strong Genetic Variation [61]
ATAD1 OTJ02XFL Strong Genetic Variation [78]
ATG16L1 OTEOYC5D Strong Genetic Variation [25]
BCKDHB OT8OSVYU Strong Biomarker [79]
BEST1 OTWHE1ZC Strong Biomarker [37]
BTNL8 OTRQT8CK Strong Biomarker [29]
C6orf47 OTMKBNDD Strong Genetic Variation [80]
CCDC33 OTOIFZ4R Strong Biomarker [81]
CD247 OT45FGUX Strong Altered Expression [82]
CD48 OT83ZNPP Strong Genetic Variation [83]
CD8A OTDWQJXK Strong Altered Expression [82]
CHMP2B OTZA7RJB Strong Genetic Variation [20]
CIITA OTRJNZFO Strong Genetic Variation [84]
CLC OTYMYR85 Strong Biomarker [85]
CLDN2 OTRF3D6Y Strong Altered Expression [86]
CLDN3 OT71MN9S Strong Altered Expression [87]
CLDN5 OTUX60YO Strong Genetic Variation [88]
CLEC10A OTD8HQT6 Strong Altered Expression [89]
CLEC16A OTLGV5SV Strong Genetic Variation [90]
DEFA5 OT95CBQ9 Strong Altered Expression [91]
DEFB103B OT8RWY64 Strong Biomarker [92]
DMRT1 OT5PU9U1 Strong Genetic Variation [20]
ELMO1 OTY2ORXK Strong Genetic Variation [30]
FLNB OTPCOYL6 Strong Genetic Variation [93]
FRMD4B OTVI6YFP Strong Genetic Variation [74]
FUT2 OTLXM6WI Strong Genetic Variation [25]
GABBR1 OTU5A52J Strong Biomarker [94]
GINS2 OT974IYI Strong Biomarker [95]
GNA13 OTVDL515 Strong Biomarker [96]
GRINA OTMC1O66 Strong Biomarker [97]
GTF2A1 OTWW4PN0 Strong Genetic Variation [98]
HFE OTDD93KB Strong Biomarker [66]
HLA-C OTV38BUJ Strong Biomarker [99]
HLA-DMB OT17HGXJ Strong Biomarker [100]
HLA-DPA1 OT7OG7Y2 Strong Biomarker [101]
HLA-DQA2 OT1DH0N9 Strong Genetic Variation [102]
HLA-DRB3 OT5PM9N7 Strong Genetic Variation [103]
HNRNPD OT5UO1FA Strong Genetic Variation [104]
IFT122 OTSK3OAD Strong Altered Expression [105]
IL17RE OTMFTNLS Strong Altered Expression [82]
IL18R1 OT83XMPQ Strong Biomarker [106]
INAVA OTGXNB86 Strong Genetic Variation [14]
IRF2 OTAZRUW3 Strong Altered Expression [107]
IRF4 OT1DHQ1P Strong Genetic Variation [61]
IRGM OTKD3O5Z Strong Genetic Variation [108]
ISCU OTSW6DQP Strong Altered Expression [89]
KIR2DL5A OT09FZE1 Strong Genetic Variation [109]
KIR2DL5B OTSV0JL9 Strong Genetic Variation [109]
KIR3DL1 OTPOSXFX Strong Genetic Variation [15]
KLRC2 OTT4N86S Strong Altered Expression [18]
LAMP3 OTN0XL3W Strong Biomarker [110]
LMO1 OTB59SKB Strong Biomarker [111]
MAGI2 OTXDDKZS Strong Biomarker [112]
MICB OTS2DVDW Strong Genetic Variation [113]
MLN OTBZ5SE5 Strong Altered Expression [114]
MSH5 OTDARQT3 Strong Genetic Variation [115]
MYNN OT61R1HP Strong Genetic Variation [11]
NCALD OTJZ8UEL Strong Biomarker [116]
NCF2 OTAUW7L2 Strong Genetic Variation [30]
NDUFA2 OTNSTATK Strong Genetic Variation [31]
NELFCD OTOLTZPU Strong Altered Expression [117]
NFIA OTDHQ9CG Strong Genetic Variation [14]
NFKBIB OTY1ZJXH Strong Biomarker [118]
NKAIN2 OTI4H30Z Strong Genetic Variation [74]
NKX2-3 OTF4IL5J Strong Genetic Variation [108]
NTS OTPGDNQS Strong Biomarker [119]
NXF1 OTEFHXG6 Strong Genetic Variation [93]
ODR4 OTGC56W3 Strong Biomarker [111]
OLIG3 OTU8XLAF Strong Genetic Variation [120]
OPTN OT2UXWH9 Strong Genetic Variation [121]
OR10A4 OTYYB8SY Strong Biomarker [122]
PARD3 OTH5BPLO Strong Biomarker [123]
PBX3 OT8WMVM4 Strong Biomarker [124]
PHLDB1 OTIRCB6I Strong Genetic Variation [14]
PLEK OTB73XXA Strong Genetic Variation [11]
PPP1R12B OTONIS87 Strong Altered Expression [116]
PPP6C OTR1STMJ Strong Genetic Variation [124]
PTPRK OTAP5AT3 Strong Genetic Variation [61]
PUS10 OTFFJWZX Strong Genetic Variation [125]
RMI2 OTA0HP4S Strong Genetic Variation [11]
SCG2 OTXWUQQL Strong Altered Expression [96]
SEC14L2 OTJST64D Strong Genetic Variation [93]
SERPINE2 OTYF5340 Strong Genetic Variation [124]
SMG7 OTZDB0JX Strong Genetic Variation [30]
SPINK4 OTHTCW94 Strong Genetic Variation [126]
STAT4 OTAK3VFR Strong Genetic Variation [30]
STPG4 OT5K4UFL Strong Genetic Variation [127]
TBC1D7 OT1ALJ63 Strong Genetic Variation [128]
TCN2 OT41D0L3 Strong Genetic Variation [129]
TG OT3ELHIJ Strong Biomarker [130]
THEMIS OTXODBXJ Strong Genetic Variation [14]
TIA1 OTGPN3P8 Strong Altered Expression [131]
TJP1 OTBDCUPK Strong Altered Expression [132]
TMEM187 OTOE4G8T Strong Genetic Variation [125]
TOLLIP OTYEO4NR Strong Altered Expression [133]
TRABD OTCFGFJH Strong Biomarker [48]
TRIM69 OTTEGTRD Strong Biomarker [56]
DNAH8 OTGES2OU Definitive Biomarker [59]
PI3 OT47MTC3 Definitive Biomarker [134]
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⏷ Show the Full List of 133 DOT(s)

References

1 ClinicalTrials.gov (NCT00959114) Safety and Efficacy of ALV003 for the Treatment of Celiac Disease. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 ClinicalTrials.gov (NCT05353985) A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of TAK-062 for the Treatment of Active Celiac Disease in Subjects Attempting a Gluten-Free Diet. U.S.National Institutes of Health.
4 ClinicalTrials.gov (NCT04530123) A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Dose-Ranging Study to Evaluate the Efficacy and Safety of TAK-101 for the Prevention of Gluten-Specific T Cell Activation in Subjects With Celiac Disease on a Gluten-Free Diet. U.S.National Institutes of Health.
5 Features of ZED1227: The First-In-Class Tissue Transglutaminase Inhibitor Undergoing Clinical Evaluation for the Treatment of Celiac Disease. Cells. 2022 May 17;11(10):1667.
6 ClinicalTrials.gov (NCT01990885) Safety and Systemic Exposure Study of BL-7010 in Well-Controlled Celiac Patients.. U.S. National Institutes of Health.
7 Clinical pipeline report, company report or official report of Immusant.
8 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
10 Celiac disease biomarkers identified by transcriptome analysis of small intestinal biopsies.Cell Mol Life Sci. 2018 Dec;75(23):4385-4401. doi: 10.1007/s00018-018-2898-5. Epub 2018 Aug 10.
11 Multiple common variants for celiac disease influencing immune gene expression.Nat Genet. 2010 Apr;42(4):295-302. doi: 10.1038/ng.543. Epub 2010 Feb 28.
12 Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort.PLoS One. 2016 Mar 25;11(3):e0152476. doi: 10.1371/journal.pone.0152476. eCollection 2016.
13 The role of CXCR3 and its ligands CXCL10 and CXCL11 in the pathogenesis of celiac disease.Medicine (Baltimore). 2019 Jun;98(25):e15949. doi: 10.1097/MD.0000000000015949.
14 Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci.Eur J Hum Genet. 2016 Feb;24(2):291-7. doi: 10.1038/ejhg.2015.87. Epub 2015 Apr 29.
15 Contribution of KIR genes, HLA class I ligands, and KIR/HLA class I ligand combinations on the genetic predisposition to celiac disease and coexisting celiac disease and type 1 diabetes mellitus.Rev Esp Enferm Dig. 2015 Sep;107(9):547-53. doi: 10.17235/reed.2015.3817/2015.
16 Identification of a c Receptor Antagonist That Prevents Reprogramming of Human Tissue-resident Cytotoxic T Cells by IL15 and IL21.Gastroenterology. 2020 Feb;158(3):625-637.e13. doi: 10.1053/j.gastro.2019.10.006. Epub 2019 Oct 14.
17 Immunopathology of childhood celiac disease-Key role of intestinal epithelial cells.PLoS One. 2017 Sep 21;12(9):e0185025. doi: 10.1371/journal.pone.0185025. eCollection 2017.
18 NKp46 is a diagnostic biomarker and may be a therapeutic target in gastrointestinal T-cell lymphoproliferative diseases: a CELAC study.Gut. 2019 Aug;68(8):1396-1405. doi: 10.1136/gutjnl-2018-317371. Epub 2018 Nov 17.
19 Mannan-binding lectin levels related to spontaneous abortion in Brazilian patients with celiac disease.Dig Dis Sci. 2008 Dec;53(12):3152-7. doi: 10.1007/s10620-008-0268-0. Epub 2008 May 14.
20 The DMT1 IVS4+44C>A polymorphism and the risk of iron deficiency anemia in children with celiac disease.PLoS One. 2017 Oct 12;12(10):e0185822. doi: 10.1371/journal.pone.0185822. eCollection 2017.
21 Anti-Zinc Transporter Protein 8 Antibody Testing Is Not Informative in Routine Prediabetes Screening in Young Patients with Autoimmune Thyroiditis and Celiac Disease.Horm Res Paediatr. 2016;86(2):100-105. doi: 10.1159/000448003. Epub 2016 Aug 3.
22 The role of TMPRSS6 and HFE variants in iron deficiency anemia in celiac disease.Am J Hematol. 2018 Mar;93(3):383-393. doi: 10.1002/ajh.24991. Epub 2017 Dec 18.
23 Defective proteostasis in celiac disease as a new therapeutic target.Cell Death Dis. 2019 Feb 8;10(2):114. doi: 10.1038/s41419-019-1392-9.
24 Transcriptional profiling of human intestinal plasma cells reveals effector functions beyond antibody production.United European Gastroenterol J. 2019 Dec;7(10):1399-1407. doi: 10.1177/2050640619862461. Epub 2019 Jul 3.
25 Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.Nat Med. 2015 Sep;21(9):1018-27. doi: 10.1038/nm.3933. Epub 2015 Aug 24.
26 Systematic review and meta-analysis of the association between IL18RAP rs917997 and CCR3 rs6441961 polymorphisms with celiac disease risks.Expert Rev Gastroenterol Hepatol. 2015;9(10):1327-38. doi: 10.1586/17474124.2015.1075880. Epub 2015 Aug 8.
27 Association between IL2/IL21 and SH2B3 polymorphisms and risk of celiac disease: a meta-analysis.Genet Mol Res. 2015 Oct 27;14(4):13221-35. doi: 10.4238/2015.October.26.19.
28 Genome-Wide Association Study of Microscopic Colitis in the UK Biobank Confirms Immune-Related Pathogenesis.J Crohns Colitis. 2019 Dec 10;13(12):1578-1582. doi: 10.1093/ecco-jcc/jjz104.
29 Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease.Cell. 2019 Feb 21;176(5):967-981.e19. doi: 10.1016/j.cell.2018.12.039. Epub 2019 Feb 7.
30 Functional implications of disease-specific variants in loci jointly associated with coeliac disease and rheumatoid arthritis.Hum Mol Genet. 2016 Jan 1;25(1):180-90. doi: 10.1093/hmg/ddv455. Epub 2015 Nov 5.
31 Celiac disease and Down syndrome mortality: a nationwide cohort study.BMC Pediatr. 2017 Jan 31;17(1):41. doi: 10.1186/s12887-017-0801-4.
32 Recurrent partial trisomy 1q22-q44 in clonal intraepithelial lymphocytes in refractory celiac sprue.Gastroenterology. 2003 Jul;125(1):40-6. doi: 10.1016/s0016-5085(03)00692-9.
33 Defective synthesis or association of T-cell receptor chains underlies loss of surface T-cell receptor-CD3 expression in enteropathy-associated T-cell lymphoma.Blood. 2008 Dec 15;112(13):5103-10. doi: 10.1182/blood-2008-04-150748. Epub 2008 Sep 24.
34 Increased FOXP3 expression in small-bowel mucosa of children with coeliac disease and type I diabetes mellitus.Scand J Gastroenterol. 2009;44(4):422-30. doi: 10.1080/00365520802624177.
35 Genetic Variant Q63R of Cannabinoid Receptor 2 Causes Differential ERK Phosphorylation in Human Immune Cells.Genet Test Mol Biomarkers. 2018 May;22(5):320-326. doi: 10.1089/gtmb.2018.0005. Epub 2018 Apr 25.
36 The role of HLA DQ2 and DQ8 in dissecting celiac-like disease in common variable immunodeficiency.J Clin Immunol. 2013 Jul;33(5):909-16. doi: 10.1007/s10875-013-9892-3. Epub 2013 Apr 23.
37 Coeliac disease.Paediatr Int Child Health. 2019 Feb;39(1):23-31. doi: 10.1080/20469047.2018.1504431. Epub 2018 Aug 13.
38 A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.PLoS One. 2013 Aug 2;8(8):e70174. doi: 10.1371/journal.pone.0070174. Print 2013.
39 Association of FcgR2a, but not FcgR3a, with inflammatory bowel diseases across three Caucasian populations.Inflamm Bowel Dis. 2010 Dec;16(12):2080-9. doi: 10.1002/ibd.21342.
40 Serum zonulin is elevated in IBS and correlates with stool frequency in IBS-D.United European Gastroenterol J. 2019 Jun;7(5):709-715. doi: 10.1177/2050640619826419. Epub 2019 Jan 19.
41 IL12B and IRF1 gene polymorphisms and susceptibility to celiac disease.Eur J Immunogenet. 2003 Dec;30(6):421-5. doi: 10.1111/j.1365-2370.2003.00428.x.
42 Altered transcription of inflammation-related genes in dental pulp of coeliac children.Int J Paediatr Dent. 2016 Sep;26(5):351-6. doi: 10.1111/ipd.12207. Epub 2015 Oct 6.
43 Contrasting the Genetic Background of Type 1 Diabetes and Celiac Disease Autoimmunity.Diabetes Care. 2015 Oct;38 Suppl 2(Suppl 2):S37-44. doi: 10.2337/dcs15-2007.
44 Gliadin-mediated proliferation and innate immune activation in celiac disease are due to alterations in vesicular trafficking.PLoS One. 2011 Feb 25;6(2):e17039. doi: 10.1371/journal.pone.0017039.
45 Sulfonylurea treatment in a girl with neonatal diabetes (KCNJ11 R201H) and celiac disease: impact of low compliance to the gluten free diet.Diabetes Res Clin Pract. 2009 Jun;84(3):332-4. doi: 10.1016/j.diabres.2009.02.024. Epub 2009 Apr 3.
46 KIR/HLA combination associated with the risk of complications in celiac disease.Int J Biol Markers. 2011 Oct-Dec;26(4):221-8. doi: 10.5301/JBM.2011.8903.
47 Lactase genetic polymorphisms and coeliac disease in children: a cohort study.Ann Hum Biol. 2015 Jan;42(1):101-4. doi: 10.3109/03014460.2014.944216. Epub 2014 Aug 13.
48 Case-finding in primary care for coeliac disease: Accuracy and cost-effectiveness of a rapid point-of-care test.United European Gastroenterol J. 2018 Jul;6(6):855-865. doi: 10.1177/2050640618761700. Epub 2018 Feb 20.
49 Immunochip meta-analysis in European and Argentinian populations identifies two novel genetic loci associated with celiac disease.Eur J Hum Genet. 2020 Mar;28(3):313-323. doi: 10.1038/s41431-019-0520-4. Epub 2019 Oct 7.
50 Abnormal anandamide metabolism in celiac disease.J Nutr Biochem. 2012 Oct;23(10):1245-8. doi: 10.1016/j.jnutbio.2011.06.017. Epub 2011 Dec 29.
51 PNPLA3 rs738409 Polymorphism Predicts Development and Severity of Hepatic Steatosis but Not Metabolic Syndrome in Celiac Disease.Nutrients. 2018 Sep 5;10(9):1239. doi: 10.3390/nu10091239.
52 Common and different genetic background for rheumatoid arthritis and coeliac disease.Hum Mol Genet. 2009 Nov 1;18(21):4195-203. doi: 10.1093/hmg/ddp365. Epub 2009 Jul 31.
53 A new allele within the transmembrane region of the human MICA gene with seven GCT repeats.Tissue Antigens. 2002 Dec;60(6):526-8. doi: 10.1034/j.1399-0039.2002.600608.x.
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