Details of Disease

General Information of Disease (ID: DISRC6IR)

Disease Name	Ankylosing spondylitis
Synonyms	Bekhterev syndrome; Bekhterev's disease; ankylosing spondylarthritis; Marie-Strumpell disease
Disease Class	FA92: Inflammatory spondyloarthritis
Definition	An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.
Disease Hierarchy	DISTSB4J: Rheumatoid arthritis DIS3HV6E: Spondylitis DISBPYCZ: Spondyloarthropathy DIS1WLVR: Vertebral joint disorder DISRC6IR: Ankylosing spondylitis
ICD Code	ICD-11 ICD-11: FA92.0 ICD-10 ICD-10: M45 ICD-9 ICD-9: 720 Expand ICD-11 'FA92.0 Expand ICD-10 'M45 Expand ICD-9 720
Disease Identifiers	MONDO ID MONDO_0005306 MESH ID D013167 UMLS CUI C0038013 MedGen ID 11561 Orphanet ID 825 SNOMED CT ID 9631008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Dexibuprofen	DMFYBD0	Approved	Small molecular drug	[1]
Meclofenamic acid	DM05FXR	Approved	Small molecular drug	[2]
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This Disease is Treated as An Indication in 5 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
BI 655066	DMBH4FL	Phase 3	Antibody	[3]
SAR153191	DMXAO4J	Phase 3	NA	[4]
SB2	DMS1PFA	Phase 3	NA	[5]
LT-NS001	DM6F20L	Phase 2/3	Small molecular drug	[6]
AdV-tK	DMCEXTL	Phase 2	NA	[7]
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This Disease is Treated as An Indication in 1 Preclinical Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
GP2015	DMVYFTQ	Application submitted	NA	[5]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 104 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
AHR	TT037IE	Limited	Altered Expression	[8]
ATXN2	TTPQJ7P	Limited	Genetic Variation	[9]
BTLA	TTER58P	Limited	Genetic Variation	[10]
CCR9	TTIPS8B	Limited	Biomarker	[11]
CD40	TT1ERKL	Limited	Altered Expression	[12]
CYP26A1	TTD7Q0R	Limited	Genetic Variation	[13]
DNMT3A	TTJUALD	Limited	Genetic Variation	[9]
DPEP1	TTYUENF	Limited	Biomarker	[14]
ERN1	TTKIAT3	Limited	Genetic Variation	[9]
GPR35	TT254XD	Limited	Genetic Variation	[9]
HDAC7	TTMUEK1	Limited	Genetic Variation	[9]
HLA-DQB2	TTL7VOU	Limited	Genetic Variation	[15]
HRH4	TTXJ178	Limited	Genetic Variation	[16]
IFNGR2	TT13TL0	Limited	Genetic Variation	[9]
IL15RA	TTGN89I	Limited	Genetic Variation	[17]
IL19	TT87RWS	Limited	Genetic Variation	[9]
IL1R2	TT51DEV	Limited	Genetic Variation	[18]
IL32	TTD4G7L	Limited	Biomarker	[19]
ITGA1	TTPERWV	Limited	Biomarker	[20]
ITGAE	TTH0Z37	Limited	Biomarker	[20]
ITGAL	TT48WR6	Limited	Genetic Variation	[9]
KEAP1	TT3Z6Y9	Limited	Genetic Variation	[9]
KIR2DL1	TT4UXPE	Limited	Altered Expression	[21]
KSR1	TTHL1TV	Limited	Genetic Variation	[9]
LRRK2	TTK0FEA	Limited	Genetic Variation	[9]
LSS	TT7O8ZA	Limited	Altered Expression	[22]
LTBR	TTFO0PM	Limited	Genetic Variation	[23]
NPEPPS	TT371QC	Limited	Biomarker	[24]
OSMR	TTAH0KM	Limited	Genetic Variation	[9]
PPM1A	TTLA7IX	Limited	Altered Expression	[25]
PRKCB	TTYPXQF	Limited	Genetic Variation	[9]
PRKCQ	TT1MS7X	Limited	Genetic Variation	[9]
PTPN2	TTY8PUS	Limited	Genetic Variation	[9]
RIC8B	TT26BHC	Limited	Genetic Variation	[9]
RPS6KB1	TTG0U4H	Limited	Genetic Variation	[9]
SGSH	TTPJ2SH	Limited	Biomarker	[26]
SRR	TTZFUY6	Limited	Genetic Variation	[27]
SSRP1	TTETDKQ	Limited	Biomarker	[28]
ST8SIA4	TTDP8YM	Limited	Genetic Variation	[29]
TNFRSF14	TTWGTC1	Limited	Genetic Variation	[9]
TRPM3	TTO3TD8	Limited	Biomarker	[30]
TYK2	TTBYWP2	Limited	Biomarker	[31]
VIPR1	TTCL30I	Limited	Genetic Variation	[32]
DAG1	TT4X7PG	moderate	Genetic Variation	[33]
HLA-A	TTHONFT	moderate	Biomarker	[34]
HTR1E	TTCPG9S	moderate	Biomarker	[35]
IL12B	TTGW72V	moderate	Altered Expression	[36]
LANCL1	TTZW8NS	moderate	Biomarker	[37]
NR5A2	TTAU3SY	moderate	Genetic Variation	[9]
SH2B3	TT36N7Z	moderate	Genetic Variation	[9]
SHCBP1	TTZ9WGL	moderate	Biomarker	[38]
TNFRSF1A	TTG043C	moderate	Genetic Variation	[39]
TRB	TT84HCW	moderate	Genetic Variation	[40]
TRBC1	TT1DHW2	moderate	Genetic Variation	[40]
ANK1	TTKFPMH	Strong	Genetic Variation	[41]
ASPA	TT6TLZP	Strong	Genetic Variation	[42]
ASRGL1	TT4WT91	Strong	Altered Expression	[43]
BMP2	TTP3IGX	Strong	Altered Expression	[44]
CD28	TTQ13FT	Strong	Genetic Variation	[45]
CD6	TTMF6KC	Strong	Biomarker	[46]
CDC37	TT5SOEU	Strong	Genetic Variation	[23]
CYP2D6	TTVG215	Strong	Genetic Variation	[47]
DEPTOR	TTLYP6D	Strong	Biomarker	[48]
DKK1	TTE3RAC	Strong	Genetic Variation	[49]
DMD	TTWLFXU	Strong	Biomarker	[50]
E2F2	TT5FYX0	Strong	Altered Expression	[51]
EBI3	TTJF68X	Strong	Biomarker	[52]
ETS1	TTTGPSD	Strong	Genetic Variation	[9]
FCGR2A	TTXT21W	Strong	Genetic Variation	[23]
FCGR2B	TT5RWKQ	Strong	Altered Expression	[53]
FCGR3A	TTIFOC0	Strong	Biomarker	[54]
HHAT	TT1VNCG	Strong	Genetic Variation	[23]
IFNL1	TTM624L	Strong	Biomarker	[55]
IL12RB2	TT4SWR8	Strong	Genetic Variation	[56]
IL17A	TTG0MT6	Strong	Genetic Variation	[57]
IL1R1	TTWOTEA	Strong	Genetic Variation	[9]
IL22	TTLDX4N	Strong	Biomarker	[58]
IL2RA	TT10Y9E	Strong	Genetic Variation	[39]
IL2RB	TT9721Y	Strong	Genetic Variation	[15]
IL37	TTQTX98	Strong	Altered Expression	[59]
IL7R	TTAWI51	Strong	Biomarker	[60]
KDM5A	TTIG67W	Strong	Genetic Variation	[61]
KIR2DS1	TTVWAGF	Strong	Biomarker	[62]
KIR3DL2	TTQH3N0	Strong	Biomarker	[63]
LRP5	TT7VMG4	Strong	Genetic Variation	[49]
MBL2	TTMQDZ5	Strong	Biomarker	[64]
MMP3	TTUZ2L5	Strong	Genetic Variation	[65]
NFKB1	TTUIZKC	Strong	Altered Expression	[66]
PADI4	TTQHAXM	Strong	Altered Expression	[67]
PPARGC1B	TTKSQ3W	Strong	Genetic Variation	[68]
PSIP1	TTH9LDP	Strong	Biomarker	[69]
PTGER4	TT79WV3	Strong	Genetic Variation	[70]
PTGIS	TTLXKZR	Strong	Genetic Variation	[71]
SAA1	TTY0DN9	Strong	Genetic Variation	[72]
SEMA3A	TTVKD3S	Strong	Biomarker	[73]
SLC38A1	TT1YE9Z	Strong	Altered Expression	[74]
SOCS1	TT8COJM	Strong	Biomarker	[75]
TAP1	TT7JZI8	Strong	Genetic Variation	[76]
TBX21	TTNF9PH	Strong	Biomarker	[77]
TNFRSF11B	TT2CJ75	Strong	Biomarker	[78]
TNFRSF1B	TT63WSF	Strong	Genetic Variation	[79]
TNFSF11	TT9E8HR	Strong	Biomarker	[78]
USP8	TT1J07C	Strong	Genetic Variation	[80]
CA1	TTHQPL7	Definitive	Biomarker	[81]
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⏷ Show the Full List of 104 DTT(s)

This Disease Is Related to 3 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC39A11	DTEOAND	Limited	Genetic Variation	[9]
SLC9A8	DTNY0C2	Limited	Genetic Variation	[9]
SLC17A2	DTRF4L3	Strong	Genetic Variation	[82]
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This Disease Is Related to 6 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
GGCT	DEKW6PB	Limited	Genetic Variation	[83]
UBASH3B	DE10BJ5	Limited	Genetic Variation	[84]
NAT1	DE7OAB3	moderate	Genetic Variation	[85]
PARK7	DEPOVCH	moderate	Genetic Variation	[9]
NAT10	DEZV4AP	Strong	Altered Expression	[43]
UGT2B17	DEAZDL8	Strong	Genetic Variation	[86]
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⏷ Show the Full List of 6 DME(s)

This Disease Is Related to 196 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACTA2	OTEDLG8E	Limited	Genetic Variation	[9]
ANKDD1B	OTRBPTMU	Limited	Autosomal dominant	[87]
ANKRD55	OT62KZII	Limited	Genetic Variation	[9]
ASAP2	OTGEXULW	Limited	Genetic Variation	[9]
ATG16L1	OTEOYC5D	Limited	Genetic Variation	[88]
ATG5	OT4T5SMS	Limited	Genetic Variation	[42]
BACH2	OT17GS18	Limited	Genetic Variation	[9]
BANK1	OTXAAA11	Limited	Genetic Variation	[9]
BCL11B	OT8KKCVJ	Limited	Genetic Variation	[89]
BMP8A	OT1997IN	Limited	Altered Expression	[90]
BRWD1	OTOSRVDC	Limited	Genetic Variation	[91]
BSN	OTZ72VIB	Limited	Genetic Variation	[9]
C17orf67	OTCL5EE8	Limited	Genetic Variation	[9]
C1orf141	OTASPHL0	Limited	Genetic Variation	[9]
CARD11	OTRCTLYC	Limited	Biomarker	[92]
CARD9	OTJ81AWD	Limited	Genetic Variation	[9]
CCL3L1	OTQXCYB1	Limited	Genetic Variation	[93]
CDKN2D	OT2TTZPZ	Limited	Biomarker	[94]
CFDP1	OTXY7J96	Limited	Genetic Variation	[95]
CFHR2	OTACE5Y1	Limited	Genetic Variation	[96]
CLEC16A	OTLGV5SV	Limited	Genetic Variation	[9]
CMC1	OTCWYKPI	Limited	Genetic Variation	[9]
CNOT3	OT4D5Z9L	Limited	Genetic Variation	[97]
CPEB4	OTW1SCZW	Limited	Genetic Variation	[9]
CREB3L1	OT2JHIHM	Limited	Biomarker	[98]
CREM	OTJIJ5AL	Limited	Genetic Variation	[9]
DAP	OT5YLL7E	Limited	Genetic Variation	[9]
DBP	OTE0W7LN	Limited	Genetic Variation	[99]
DEFB104A	OTLQZR6K	Limited	Biomarker	[100]
DENND1B	OT3VCNPE	Limited	Genetic Variation	[9]
DLAT	OT9LBJVN	Limited	Altered Expression	[101]
DMP1	OTBWBWW7	Limited	Genetic Variation	[102]
DSPP	OT1TYNDN	Limited	Biomarker	[103]
DUSP4	OT6WAO12	Limited	Altered Expression	[104]
DVL2	OTMNYNCM	Limited	Altered Expression	[105]
EDIL3	OTDVVNS0	Limited	Genetic Variation	[106]
EEF1E1	OTRA6XOB	Limited	Biomarker	[107]
EIF4G2	OTEO98CR	Limited	Genetic Variation	[95]
FAM118A	OT6EM97E	Limited	Genetic Variation	[9]
FAM177A1	OTXTA14N	Limited	Genetic Variation	[9]
FCRL5	OTA7VHNE	Limited	Genetic Variation	[108]
FGD1	OTV3T64P	Limited	Genetic Variation	[109]
FIBP	OTI7131S	Limited	Genetic Variation	[9]
FNDC3A	OTUX3S2I	Limited	Genetic Variation	[9]
FUT2	OTLXM6WI	Limited	Genetic Variation	[9]
GAL3ST2	OTZT1PLE	Limited	Genetic Variation	[9]
GCKR	OTSIWXGG	Limited	Genetic Variation	[9]
GEMIN4	OTX7402E	Limited	Genetic Variation	[95]
GFER	OTVK43OK	Limited	Biomarker	[26]
GNA12	OT3IRZH3	Limited	Genetic Variation	[9]
GPR65	OTCF5O4G	Limited	Genetic Variation	[110]
HAPLN1	OTXWR9TJ	Limited	Genetic Variation	[106]
HCLS1	OTX7WGYN	Limited	Genetic Variation	[84]
HIPK1	OTSEA8RS	Limited	Genetic Variation	[9]
HLA-DOB	OTKADDUB	Limited	Genetic Variation	[15]
IFIH1	OTZA2AHA	Limited	Genetic Variation	[9]
IFIT3	OTPGHZB9	Limited	Biomarker	[111]
IL10RA	OTOX3D1D	Limited	Genetic Variation	[112]
IL6R	OTCQL07Z	Limited	Genetic Variation	[9]
INAVA	OTGXNB86	Limited	Genetic Variation	[9]
JAZF1	OTXTYSYD	Limited	Genetic Variation	[9]
KIR2DS4	OT00N6UJ	Limited	Genetic Variation	[113]
LAIR2	OTKCADXC	Limited	Biomarker	[97]
LRIT1	OTNEQPMZ	Limited	Biomarker	[38]
MARCHF2	OTADQ0OA	Limited	Biomarker	[114]
MST1	OTOC4UNG	Limited	Genetic Variation	[9]
MSX2	OT1WDKE1	Limited	Genetic Variation	[115]
MYOM2	OTD2UOXW	Limited	Genetic Variation	[116]
MYRF	OTKF6AEB	Limited	Genetic Variation	[9]
NCR2	OT2H13BX	Limited	Altered Expression	[117]
NDFIP1	OTIORSWF	Limited	Genetic Variation	[9]
NDUFS4	OTJKUYEE	Limited	Biomarker	[118]
OR2AG1	OTEITRP4	Limited	Genetic Variation	[119]
OTULIN	OTEE02J4	Limited	Biomarker	[30]
PANK2	OTFBW889	Limited	Biomarker	[26]
PAPPA	OTTTG9PG	Limited	Biomarker	[120]
PFDN5	OTTKPTUP	Limited	Biomarker	[121]
POLM	OT0SRIP4	Limited	Altered Expression	[122]
PPP2R3C	OT7E6V9B	Limited	Genetic Variation	[9]
PRDM1	OTQLSVBS	Limited	Genetic Variation	[9]
PRPF31	OTSJ0Z1Y	Limited	Genetic Variation	[123]
PSMD2	OT6HZHN7	Limited	Genetic Variation	[95]
PSMG1	OTZ5I6UM	Limited	Genetic Variation	[91]
PUS10	OTFFJWZX	Limited	Genetic Variation	[9]
RAVER1	OTMHBTLE	Limited	Genetic Variation	[9]
RDX	OTNSYUN6	Limited	Genetic Variation	[9]
RELN	OTLKMW1O	Limited	Autosomal dominant	[87]
REM1	OTUXL0HC	Limited	Biomarker	[124]
RHEB	OTFLTSEC	Limited	Biomarker	[125]
RMI2	OTA0HP4S	Limited	Genetic Variation	[9]
RRBP1	OT4ZTPTM	Limited	Altered Expression	[126]
SAGE1	OT4H6FFA	Limited	Genetic Variation	[127]
SBNO2	OT1C6J3K	Limited	Genetic Variation	[9]
SCNN1A	OTE2KVZV	Limited	Genetic Variation	[128]
SETD1A	OTVVWRIC	Limited	Genetic Variation	[9]
SIGLEC7	OTNDLURR	Limited	Genetic Variation	[84]
SKAP2	OTSF44KP	Limited	Genetic Variation	[9]
SP140	OTQZHFMT	Limited	Genetic Variation	[9]
SPAG9	OT45AHMB	Limited	Biomarker	[26]
SPOCK2	OTXSVTSA	Limited	Biomarker	[129]
STK11	OT1YZSP3	Limited	Genetic Variation	[9]
TESPA1	OTEGT4GI	Limited	Genetic Variation	[130]
THADA	OTYZQX0F	Limited	Genetic Variation	[9]
TMEM258	OTXSDU14	Limited	Genetic Variation	[9]
TNFAIP8L2	OTII0RM0	Limited	Biomarker	[131]
TNFRSF6B	OTKAN9G7	Limited	Genetic Variation	[9]
TRAF4	OTJLRVMC	Limited	Altered Expression	[132]
TRAF5	OTSBTLO0	Limited	Genetic Variation	[133]
TREML2	OTKQGKVJ	Limited	Biomarker	[134]
TSKU	OT1XMRIM	Limited	Biomarker	[135]
TSPAN14	OT29167O	Limited	Genetic Variation	[9]
PTX3	OTPXHRKU	Disputed	Altered Expression	[136]
ADCY3	OTGOQM6B	moderate	Genetic Variation	[9]
ADCY7	OTAWMGP3	moderate	Genetic Variation	[33]
ADGRL2	OTCXD2YR	moderate	Genetic Variation	[33]
ANKRD30A	OTJXYAE5	moderate	Genetic Variation	[33]
ARMH1	OTTJC0D6	moderate	Biomarker	[37]
ATXN2L	OTP5M3R9	moderate	Genetic Variation	[33]
CD226	OT4UG0KB	moderate	Genetic Variation	[9]
CRB1	OTXYUNG0	moderate	Genetic Variation	[33]
CREG1	OTRHJ8HK	moderate	Biomarker	[137]
CSN3	OTR61MI8	moderate	Biomarker	[138]
DNASE1L3	OTEUIMC2	moderate	Altered Expression	[139]
EBNA1BP2	OTBRVMZH	moderate	Biomarker	[37]
FNBP1	OTSJ5KKA	moderate	Genetic Variation	[33]
GLYAT	OT3WWYXD	moderate	Genetic Variation	[9]
IL27	OTIS3OF8	moderate	Genetic Variation	[9]
INS-IGF2	OTZR74BO	moderate	Genetic Variation	[33]
LURAP1L	OTSJ29M5	moderate	Genetic Variation	[33]
NKD1	OTY3MO97	moderate	Genetic Variation	[33]
PKIG	OTOIWE5G	moderate	Genetic Variation	[9]
PSMD7	OT7PZZ4K	moderate	Biomarker	[37]
RABEPK	OTCZSREH	moderate	Biomarker	[37]
RGS11	OTIAZ36F	moderate	Biomarker	[140]
SUOX	OTEJQ9FC	moderate	Genetic Variation	[33]
TBKBP1	OTXTU37H	moderate	Biomarker	[24]
A1CF	OTJBKFA1	Strong	Genetic Variation	[42]
ALPP	OTZU4G9W	Strong	Altered Expression	[43]
ANKH	OTCN25R5	Strong	Genetic Variation	[141]
ANO6	OTTA5KQJ	Strong	Genetic Variation	[106]
ATRNL1	OTY5JUX2	Strong	Altered Expression	[43]
BEST1	OTWHE1ZC	Strong	Biomarker	[50]
CAST	OTBXZZGF	Strong	Genetic Variation	[82]
CCL27	OTUZYC61	Strong	Altered Expression	[43]
CDAN1	OTCVZRG6	Strong	Altered Expression	[142]
CDKAL1	OTA0SGNE	Strong	Genetic Variation	[143]
CPQ	OTTNZNLD	Strong	Genetic Variation	[144]
FCGR3B	OTSLSPZG	Strong	Biomarker	[54]
FCRL4	OT3DVTRV	Strong	Biomarker	[145]
FLNB	OTPCOYL6	Strong	Genetic Variation	[76]
GC	OTWS63BY	Strong	Genetic Variation	[146]
GINS1	OTVQZMMQ	Strong	Biomarker	[147]
GINS2	OT974IYI	Strong	Biomarker	[147]
GPSM1	OTA0SJBG	Strong	Genetic Variation	[23]
HLA-DPA1	OT7OG7Y2	Strong	Genetic Variation	[148]
HLA-DPB1	OTW8JHU2	Strong	Genetic Variation	[149]
HLA-E	OTX1CTFB	Strong	Genetic Variation	[150]
HSPA14	OTZCA5LK	Strong	Biomarker	[151]
HSPA1L	OTC2V1K6	Strong	Genetic Variation	[152]
IL18R1	OT83XMPQ	Strong	Biomarker	[52]
IL1F10	OTJAASGC	Strong	Biomarker	[153]
IL2RG	OTRZ3OMY	Strong	Biomarker	[51]
JMY	OTH5FFVK	Strong	Genetic Variation	[61]
KIF21B	OTFXFIU3	Strong	Genetic Variation	[154]
KIR2DL5A	OT09FZE1	Strong	Genetic Variation	[113]
KIR2DL5B	OTSV0JL9	Strong	Genetic Variation	[113]
KIR2DS5	OTXLEN11	Strong	Biomarker	[155]
MEFV	OTRJ6S6K	Strong	Genetic Variation	[80]
MPP1	OTA2ENZQ	Strong	Genetic Variation	[39]
NFATC1	OT4TMERS	Strong	Biomarker	[156]
NINL	OTWIK6HT	Strong	Biomarker	[157]
NOG	OTGRHHPG	Strong	Biomarker	[44]
NXF1	OTEFHXG6	Strong	Genetic Variation	[76]
ORMDL3	OTAB7MZF	Strong	Genetic Variation	[158]
PDLIM3	OTVXQC81	Strong	Altered Expression	[43]
PDLIM7	OTAZVODU	Strong	Genetic Variation	[159]
PLD6	OTER78DB	Strong	Biomarker	[160]
POLG2	OTDBMZJB	Strong	Genetic Variation	[39]
PSMD12	OTWICA51	Strong	Genetic Variation	[39]
PTPN22	OTDCNTC3	Strong	Genetic Variation	[161]
ROPN1L	OTRWZJ68	Strong	Genetic Variation	[42]
RPF1	OT4J1CRC	Strong	Biomarker	[162]
RPL17	OTTYMPS6	Strong	Genetic Variation	[163]
SCD5	OTSSUQ3Z	Strong	Genetic Variation	[164]
SEC14L2	OTJST64D	Strong	Genetic Variation	[76]
SFTPA2	OT6SFOMU	Strong	Biomarker	[165]
SIX6	OTD1RD9D	Strong	Biomarker	[86]
SNAPC4	OTKB9WL6	Strong	Genetic Variation	[18]
STAT4	OTAK3VFR	Strong	Genetic Variation	[166]
TAP2	OTWSYFI7	Strong	Genetic Variation	[76]
TAPBP	OTL81AVZ	Strong	Biomarker	[167]
TBCA	OTCCWMGK	Strong	Biomarker	[160]
TRIM31	OT7VW6RP	Strong	Genetic Variation	[168]
KREMEN1	OTGJFSAC	Definitive	Biomarker	[169]
MUC19	OTM06UGV	Definitive	Genetic Variation	[143]
RIOX1	OTN41QXP	Definitive	Biomarker	[170]
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⏷ Show the Full List of 196 DOT(s)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7219).
3	ClinicalTrials.gov (NCT02443298) Efficacy and Safety of BI 655066 in Patients With Severe Persistent Asthma.. U.S. National Institutes of Health.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7999).
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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