General Information of Drug Off-Target (DOT) (ID: OTJRMUAG)

DOT Name Carbonic anhydrase 2 (CA2)
Synonyms EC 4.2.1.1; Carbonate dehydratase II; Carbonic anhydrase C; CAC; Carbonic anhydrase II; CA-II; Cyanamide hydratase CA2; EC 4.2.1.69
Gene Name CA2
Related Disease
Autosomal recessive osteopetrosis 3 ( )
UniProt ID
CAH2_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
12CA ; 1A42 ; 1AM6 ; 1AVN ; 1BCD ; 1BIC ; 1BN1 ; 1BN3 ; 1BN4 ; 1BNM ; 1BNN ; 1BNQ ; 1BNT ; 1BNU ; 1BNV ; 1BNW ; 1BV3 ; 1CA2 ; 1CA3 ; 1CAH ; 1CAI ; 1CAJ ; 1CAK ; 1CAL ; 1CAM ; 1CAN ; 1CAO ; 1CAY ; 1CAZ ; 1CCS ; 1CCT ; 1CCU ; 1CIL ; 1CIM ; 1CIN ; 1CNB ; 1CNC ; 1CNG ; 1CNH ; 1CNI ; 1CNJ ; 1CNK ; 1CNW ; 1CNX ; 1CNY ; 1CRA ; 1CVA ; 1CVB ; 1CVC ; 1CVD ; 1CVE ; 1CVF ; 1CVH ; 1DCA ; 1DCB ; 1EOU ; 1F2W ; 1FQL ; 1FQM ; 1FQN ; 1FQR ; 1FR4 ; 1FR7 ; 1FSN ; 1FSQ ; 1FSR ; 1G0E ; 1G0F ; 1G1D ; 1G3Z ; 1G45 ; 1G46 ; 1G48 ; 1G4J ; 1G4O ; 1G52 ; 1G53 ; 1G54 ; 1H4N ; 1H9N ; 1H9Q ; 1HCA ; 1HEA ; 1HEB ; 1HEC ; 1HED ; 1HVA ; 1I8Z ; 1I90 ; 1I91 ; 1I9L ; 1I9M ; 1I9N ; 1I9O ; 1I9P ; 1I9Q ; 1IF4 ; 1IF5 ; 1IF6 ; 1IF7 ; 1IF8 ; 1IF9 ; 1KWQ ; 1KWR ; 1LG5 ; 1LG6 ; 1LGD ; 1LUG ; 1LZV ; 1MOO ; 1MUA ; 1OKL ; 1OKM ; 1OKN ; 1OQ5 ; 1RAY ; 1RAZ ; 1RZA ; 1RZB ; 1RZC ; 1RZD ; 1RZE ; 1T9N ; 1TB0 ; 1TBT ; 1TE3 ; 1TEQ ; 1TEU ; 1TG3 ; 1TG9 ; 1TH9 ; 1THK ; 1TTM ; 1UGA ; 1UGB ; 1UGC ; 1UGD ; 1UGE ; 1UGF ; 1UGG ; 1XEG ; 1XEV ; 1XPZ ; 1XQ0 ; 1YDA ; 1YDB ; 1YDC ; 1YDD ; 1YO0 ; 1YO1 ; 1YO2 ; 1Z9Y ; 1ZE8 ; 1ZFK ; 1ZFQ ; 1ZGE ; 1ZGF ; 1ZH9 ; 1ZSA ; 1ZSB ; 1ZSC ; 2ABE ; 2AW1 ; 2AX2 ; 2CA2 ; 2CBA ; 2CBB ; 2CBC ; 2CBD ; 2CBE ; 2EU2 ; 2EU3 ; 2EZ7 ; 2F14 ; 2FMG ; 2FMZ ; 2FNK ; 2FNM ; 2FNN ; 2FOQ ; 2FOS ; 2FOU ; 2FOV ; 2GD8 ; 2GEH ; 2H15 ; 2H4N ; 2HD6 ; 2HKK ; 2HL4 ; 2HNC ; 2HOC ; 2ILI ; 2NNG ; 2NNO ; 2NNS ; 2NNV ; 2NWO ; 2NWP ; 2NWY ; 2NWZ ; 2NXR ; 2NXS ; 2NXT ; 2O4Z ; 2OSF ; 2OSM ; 2POU ; 2POV ; 2POW ; 2Q1B ; 2Q1Q ; 2Q38 ; 2QO8 ; 2QOA ; 2QP6 ; 2VVA ; 2VVB ; 2WD2 ; 2WD3 ; 2WEG ; 2WEH ; 2WEJ ; 2WEO ; 2X7S ; 2X7T ; 2X7U ; 3B4F ; 3BET ; 3BL0 ; 3BL1 ; 3C7P ; 3CA2 ; 3CAJ ; 3CYU ; 3D8W ; 3D92 ; 3D93 ; 3D9Z ; 3DAZ ; 3DBU ; 3DC3 ; 3DC9 ; 3DCC ; 3DCS ; 3DCW ; 3DD0 ; 3DD8 ; 3DV7 ; 3DVB ; 3DVC ; 3DVD ; 3EFI ; 3EFT ; 3F4X ; 3F8E ; 3FFP ; 3GZ0 ; 3HFP ; 3HKN ; 3HKQ ; 3HKT ; 3HKU ; 3HLJ ; 3HS4 ; 3IBI ; 3IBL ; 3IBN ; 3IBU ; 3IEO ; 3IGP ; 3K2F ; 3K34 ; 3K7K ; 3KIG ; 3KKX ; 3KNE ; 3KOI ; 3KOK ; 3KON ; 3KS3 ; 3KWA ; 3L14 ; 3M04 ; 3M14 ; 3M1J ; 3M1K ; 3M1Q ; 3M1W ; 3M2N ; 3M2X ; 3M2Y ; 3M2Z ; 3M3X ; 3M40 ; 3M5E ; 3M5S ; 3M5T ; 3M67 ; 3M96 ; 3M98 ; 3MHC ; 3MHI ; 3MHL ; 3MHM ; 3MHO ; 3ML2 ; 3MMF ; 3MNA ; 3MNH ; 3MNI ; 3MNJ ; 3MNK ; 3MNU ; 3MWO ; 3MYQ ; 3MZC ; 3N0N ; 3N2P ; 3N3J ; 3N4B ; 3NB5 ; 3NI5 ; 3NJ9 ; 3OIK ; 3OIL ; 3OIM ; 3OKU ; 3OKV ; 3OY0 ; 3OYQ ; 3OYS ; 3P3H ; 3P3J ; 3P44 ; 3P4V ; 3P55 ; 3P58 ; 3P5A ; 3P5L ; 3PJJ ; 3PO6 ; 3PYK ; 3QYK ; 3R16 ; 3R17 ; 3RG3 ; 3RG4 ; 3RGE ; 3RJ7 ; 3RLD ; 3RYJ ; 3RYV ; 3RYX ; 3RYY ; 3RYZ ; 3RZ0 ; 3RZ1 ; 3RZ5 ; 3RZ7 ; 3RZ8 ; 3S71 ; 3S72 ; 3S73 ; 3S74 ; 3S75 ; 3S76 ; 3S77 ; 3S78 ; 3S8X ; 3S9T ; 3SAP ; 3SAX ; 3SBH ; 3SBI ; 3T5U ; 3T5Z ; 3T82 ; 3T83 ; 3T84 ; 3T85 ; 3TMJ ; 3TVN ; 3TVO ; 3U3A ; 3U45 ; 3U47 ; 3U7C ; 3V2J ; 3V2M ; 3V3F ; 3V3G ; 3V3H ; 3V3I ; 3V3J ; 3V5G ; 3V7X ; 3VBD ; 3ZP9 ; 4BCW ; 4BF1 ; 4BF6 ; 4CA2 ; 4CAC ; 4CQ0 ; 4DZ7 ; 4DZ9 ; 4E3D ; 4E3F ; 4E3G ; 4E3H ; 4E49 ; 4E4A ; 4E5Q ; 4FIK ; 4FL7 ; 4FPT ; 4FRC ; 4FU5 ; 4FVN ; 4FVO ; 4G0C ; 4GL1 ; 4HBA ; 4HEW ; 4HEY ; 4HEZ ; 4HF3 ; 4HT0 ; 4IDR ; 4ILX ; 4ITO ; 4ITP ; 4IWZ ; 4JS6 ; 4JSA ; 4JSS ; 4JSW ; 4JSZ ; 4K0S ; 4K0T ; 4K0Z ; 4K13 ; 4K1Q ; 4KAP ; 4KNI ; 4KNJ ; 4KUV ; 4KUW ; 4KUY ; 4KV0 ; 4L5U ; 4L5V ; 4L5W ; 4LHI ; 4LP6 ; 4M2R ; 4M2U ; 4M2V ; 4M2W ; 4MDG ; 4MDL ; 4MDM ; 4MLT ; 4MLX ; 4MO8 ; 4MTY ; 4N0X ; 4N16 ; 4PQ7 ; 4PXX ; 4PYX ; 4PYY ; 4PZH ; 4Q06 ; 4Q07 ; 4Q08 ; 4Q09 ; 4Q49 ; 4Q6D ; 4Q6E ; 4Q78 ; 4Q7P ; 4Q7S ; 4Q7V ; 4Q7W ; 4Q81 ; 4Q83 ; 4Q87 ; 4Q8X ; 4Q8Y ; 4Q8Z ; 4Q90 ; 4Q99 ; 4Q9Y ; 4QEF ; 4QIY ; 4QJM ; 4QK1 ; 4QK2 ; 4QK3 ; 4QSA ; 4QSB ; 4QSI ; 4QTL ; 4QY3 ; 4R59 ; 4R5A ; 4R5B ; 4RFC ; 4RFD ; 4RH2 ; 4RIU ; 4RIV ; 4RN4 ; 4RUX ; 4RUY ; 4RUZ ; 4WL4 ; 4WW6 ; 4XE1 ; 4Y0J ; 4YGJ ; 4YGK ; 4YGL ; 4YGN ; 4YVY ; 4YWP ; 4YX4 ; 4YXI ; 4YXO ; 4YXU ; 4YYT ; 4Z0Q ; 4Z1E ; 4Z1J ; 4Z1K ; 4Z1N ; 4ZAO ; 4ZWI ; 4ZWX ; 4ZWY ; 4ZWZ ; 4ZX0 ; 4ZX1 ; 5A6H ; 5AMD ; 5AMG ; 5AML ; 5BNL ; 5BRU ; 5BRV ; 5BRW ; 5BYI ; 5C8I ; 5CA2 ; 5CAC ; 5CLU ; 5DOG ; 5DOH ; 5DRS ; 5DSK ; 5DSL ; 5DSM ; 5DSO ; 5DSP ; 5DSQ ; 5DSR ; 5E28 ; 5E2K ; 5E2R ; 5E2S ; 5EH5 ; 5EH7 ; 5EH8 ; 5EHE ; 5EHV ; 5EHW ; 5EIJ ; 5EKH ; 5EKJ ; 5EKM ; 5EOI ; 5FDC ; 5FDI ; 5FLO ; 5FLP ; 5FLQ ; 5FLR ; 5FLS ; 5FLT ; 5FNG ; 5FNH ; 5FNI ; 5FNJ ; 5FNK ; 5FNL ; 5FNM ; 5G01 ; 5G03 ; 5G0B ; 5G0C ; 5GMN ; 5J8Z ; 5JDV ; 5JE7 ; 5JEG ; 5JEH ; 5JEP ; 5JES ; 5JG3 ; 5JG5 ; 5JGS ; 5JGT ; 5JMZ ; 5JN3 ; 5JN7 ; 5JQ0 ; 5JQT ; 5L3O ; 5L6K ; 5L6T ; 5L70 ; 5L9E ; 5LJQ ; 5LJT ; 5LL4 ; 5LL8 ; 5LLC ; 5LLE ; 5LLG ; 5LLH ; 5LMD ; 5LVS ; 5M78 ; 5MJN ; 5N0D ; 5N0E ; 5N1R ; 5N1S ; 5N24 ; 5N25 ; 5NEA ; 5NEE ; 5NXG ; 5NXI ; 5NXM ; 5NXO ; 5NXP ; 5NXV ; 5NXW ; 5NY1 ; 5NY3 ; 5NY6 ; 5NYA ; 5O07 ; 5OGN ; 5OGO ; 5OGP ; 5SZ0 ; 5SZ1 ; 5SZ2 ; 5SZ3 ; 5SZ4 ; 5SZ5 ; 5SZ6 ; 5SZ7 ; 5T71 ; 5T72 ; 5T74 ; 5T75 ; 5TFX ; 5TH4 ; 5THI ; 5THJ ; 5THN ; 5TI0 ; 5TXY ; 5TY1 ; 5TY8 ; 5TY9 ; 5TYA ; 5U0D ; 5U0E ; 5U0F ; 5U0G ; 5ULN ; 5UMC ; 5VGY ; 5W8B ; 5WEX ; 5WG7 ; 5WGP ; 5WLR ; 5WLT ; 5WLU ; 5WLV ; 5Y2R ; 5Y2S ; 5YUI ; 5YUJ ; 5YUK ; 5ZXW ; 6B4D ; 6B59 ; 6B5A ; 6BBS ; 6BC9 ; 6BCC ; 6C7W ; 6C7X ; 6CA2 ; 6CEH ; 6CJV ; 6D1L ; 6D1M ; 6E8P ; 6E8X ; 6E91 ; 6E92 ; 6EBE ; 6ECZ ; 6EDA ; 6EEA ; 6EEH ; 6EEO ; 6EQU ; 6FJI ; 6FJJ ; 6G3Q ; 6G6T ; 6GCY ; 6GDC ; 6GM9 ; 6GOT ; 6GXB ; 6GXE ; 6H29 ; 6H2Z ; 6H33 ; 6H34 ; 6H3Q ; 6H6S ; 6HD2 ; 6HQX ; 6HR3 ; 6HX5 ; 6HXD ; 6HZX ; 6I0W ; 6I1U ; 6I2F ; 6I3E ; 6IC2 ; 6KLZ ; 6KM0 ; 6KM1 ; 6KM2 ; 6KM3 ; 6KM4 ; 6KM5 ; 6KM6 ; 6LUU ; 6LUV ; 6LUW ; 6LUX ; 6LUY ; 6LUZ ; 6LV1 ; 6LV2 ; 6LV3 ; 6LV4 ; 6LV5 ; 6LV6 ; 6LV7 ; 6LV8 ; 6LV9 ; 6LVA ; 6MBV ; 6MBY ; 6NLV ; 6NM0 ; 6ODZ ; 6OE0 ; 6OE1 ; 6OTI ; 6OTK ; 6OTM ; 6OTO ; 6OTP ; 6OTQ ; 6OUB ; 6OUD ; 6OUE ; 6OUF ; 6OUH ; 6OUI ; 6OUJ ; 6OUK ; 6OUM ; 6PDV ; 6PEA ; 6PGX ; 6Q3O ; 6Q9T ; 6QEB ; 6QL1 ; 6QL2 ; 6QL3 ; 6R6F ; 6R6J ; 6RFH ; 6RG3 ; 6RG4 ; 6RG5 ; 6RH4 ; 6RHJ ; 6RHK ; 6RIG ; 6RIT ; 6RJJ ; 6RKN ; 6RL9 ; 6RM1 ; 6RMP ; 6RMX ; 6RMY ; 6RNP ; 6ROB ; 6ROE ; 6ROF ; 6RQI ; 6RRG ; 6RRI ; 6RS5 ; 6RSZ ; 6RVF ; 6RVK ; 6RVL ; 6RW1 ; 6RZX ; 6S03 ; 6S9G ; 6S9Z ; 6SAC ; 6SAS ; 6SAY ; 6SB7 ; 6SBH ; 6SBL ; 6SBM ; 6SD7 ; 6SDH ; 6SDI ; 6SDJ ; 6SDL ; 6SDS ; 6SEY ; 6SFQ ; 6SFU ; 6SG0 ; 6SG6 ; 6SX9 ; 6SYB ; 6SYS ; 6T4N ; 6T4O ; 6T4P ; 6T5C ; 6T7U ; 6T81 ; 6T9Z ; 6U4Q ; 6U4T ; 6UFB ; 6UFC ; 6UFD ; 6UGN ; 6UGO ; 6UGP ; 6UGQ ; 6UGR ; 6UGZ ; 6UH0 ; 6UX1 ; 6UZU ; 6VJ3 ; 6VKG ; 6WKA ; 6WQ4 ; 6WQ5 ; 6WQ7 ; 6WQ8 ; 6WQ9 ; 6XVH ; 6XWZ ; 6XXT ; 6YH4 ; 6YH5 ; 6YH6 ; 6YH7 ; 6YH8 ; 6YH9 ; 6YHA ; 6YHB ; 6YHC ; 6YJ3 ; 6YKC ; 6YKH ; 6YMA ; 6YMB ; 6YO2 ; 6YO4 ; 6YO7 ; 6YOI ; 6YOK ; 6YOL ; 6YPW ; 6YQT ; 6YQU ; 6YRI ; 6YZJ ; 6YZK ; 6YZL ; 6YZM ; 6YZN ; 6YZO ; 6YZP ; 6YZQ ; 6YZR ; 6YZS ; 6YZT ; 6YZU ; 6YZV ; 6YZW ; 6YZX ; 6Z04 ; 6ZR8 ; 7A6V ; 7AEQ ; 7AES ; 7AGN ; 7ASJ ; 7BFA ; 7BG5 ; 7BHH ; 7BI5 ; 7CA2 ; 7JNR ; 7JNV ; 7JNW ; 7JNX ; 7JNZ ; 7JO0 ; 7JO1 ; 7JO2 ; 7JO3 ; 7JOB ; 7JOC ; 7K6I ; 7K6J ; 7K6K ; 7K6L ; 7K6T ; 7K6U ; 7K6X ; 7K6Z ; 7M23 ; 7M24 ; 7M26 ; 7MU3 ; 7NH6 ; 7NH8 ; 7NTB ; 7NZR ; 7NZS ; 7NZT ; 7NZU ; 7NZW ; 7NZX ; 7OK8 ; 7ONV ; 7ORP ; 7ORQ ; 7OYM ; 7OYN ; 7OYO ; 7OYP ; 7OYQ ; 7OYR ; 7Q0C ; 7Q0E ; 7QBH ; 7QGX ; 7QGY ; 7QGZ ; 7QNV ; 7QRK ; 7QSE ; 7QSI ; 7QZX ; 7R1X ; 7RNY ; 7RNZ ; 7RRE ; 7RRF ; 7SUW ; 7SUY ; 7SV1 ; 7SV8 ; 7U5W ; 7U5X ; 7YWT ; 7ZL6 ; 7ZWB ; 8AA6 ; 8AAE ; 8B29 ; 8BJX ; 8BOE ; 8C0Q ; 8C0R ; 8CA2 ; 8CR0 ; 8DJ9 ; 8EM3 ; 8EMU ; 8EXC ; 8EXG ; 8EYL ; 8FAL ; 8FAU ; 8FQX ; 8FQY ; 8FQZ ; 8FR1 ; 8FR2 ; 8FR4 ; 8R1I ; 9CA2
EC Number
4.2.1.1; 4.2.1.69
Pfam ID
PF00194
Sequence
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
Function
Catalyzes the reversible hydration of carbon dioxide. Can also hydrate cyanamide to urea. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Essential for bone resorption and osteoclast differentiation. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption.
KEGG Pathway
Nitrogen metabolism (hsa00910 )
Metabolic pathways (hsa01100 )
Proximal tubule bicarbo.te reclamation (hsa04964 )
Collecting duct acid secretion (hsa04966 )
Gastric acid secretion (hsa04971 )
Pancreatic secretion (hsa04972 )
Bile secretion (hsa04976 )
Reactome Pathway
Erythrocytes take up oxygen and release carbon dioxide (R-HSA-1247673 )
Reversible hydration of carbon dioxide (R-HSA-1475029 )
Erythrocytes take up carbon dioxide and release oxygen (R-HSA-1237044 )

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Autosomal recessive osteopetrosis 3 DISWBB4P Definitive Autosomal recessive [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
This DOT Affected the Drug Response of 2 Drug(s)
Drug Name Drug ID Highest Status Interaction REF
Cisplatin DMRHGI9 Approved Carbonic anhydrase 2 (CA2) affects the response to substance of Cisplatin. [41]
4-hydroxy-2-nonenal DM2LJFZ Investigative Carbonic anhydrase 2 (CA2) affects the binding of 4-hydroxy-2-nonenal. [42]
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This DOT Affected the Biotransformations of 1 Drug(s)
Drug Name Drug ID Highest Status Interaction REF
Bicarbonate DMT5E36 Investigative Carbonic anhydrase 2 (CA2) increases the chemical synthesis of Bicarbonate. [43]
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2 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the methylation of Carbonic anhydrase 2 (CA2). [2]
Bisphenol A DM2ZLD7 Investigative Bisphenol A decreases the methylation of Carbonic anhydrase 2 (CA2). [32]
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47 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Ciclosporin DMAZJFX Approved Ciclosporin decreases the expression of Carbonic anhydrase 2 (CA2). [3]
Tretinoin DM49DUI Approved Tretinoin increases the expression of Carbonic anhydrase 2 (CA2). [4]
Cupric Sulfate DMP0NFQ Approved Cupric Sulfate increases the expression of Carbonic anhydrase 2 (CA2). [5]
Estradiol DMUNTE3 Approved Estradiol increases the expression of Carbonic anhydrase 2 (CA2). [6]
Ivermectin DMDBX5F Approved Ivermectin decreases the expression of Carbonic anhydrase 2 (CA2). [7]
Quercetin DM3NC4M Approved Quercetin increases the expression of Carbonic anhydrase 2 (CA2). [8]
Temozolomide DMKECZD Approved Temozolomide decreases the expression of Carbonic anhydrase 2 (CA2). [9]
Calcitriol DM8ZVJ7 Approved Calcitriol increases the expression of Carbonic anhydrase 2 (CA2). [10]
Progesterone DMUY35B Approved Progesterone decreases the expression of Carbonic anhydrase 2 (CA2). [11]
Dexamethasone DMMWZET Approved Dexamethasone increases the expression of Carbonic anhydrase 2 (CA2). [12]
Diethylstilbestrol DMN3UXQ Approved Diethylstilbestrol increases the expression of Carbonic anhydrase 2 (CA2). [13]
Rosiglitazone DMILWZR Approved Rosiglitazone affects the expression of Carbonic anhydrase 2 (CA2). [14]
Sodium lauryl sulfate DMLJ634 Approved Sodium lauryl sulfate decreases the expression of Carbonic anhydrase 2 (CA2). [15]
Indomethacin DMSC4A7 Approved Indomethacin increases the activity of Carbonic anhydrase 2 (CA2). [16]
Ethinyl estradiol DMODJ40 Approved Ethinyl estradiol increases the expression of Carbonic anhydrase 2 (CA2). [17]
Cyclophosphamide DM4O2Z7 Approved Cyclophosphamide decreases the expression of Carbonic anhydrase 2 (CA2). [18]
Alitretinoin DMME8LH Approved Alitretinoin increases the expression of Carbonic anhydrase 2 (CA2). [19]
Propofol DMB4OLE Approved Propofol decreases the activity of Carbonic anhydrase 2 (CA2). [20]
Phenylephrine DMZHUO5 Approved Phenylephrine decreases the activity of Carbonic anhydrase 2 (CA2). [21]
Epinephrine DM3KJBC Approved Epinephrine increases the expression of Carbonic anhydrase 2 (CA2). [22]
Furosemide DMMQ8ZG Approved Furosemide decreases the activity of Carbonic anhydrase 2 (CA2). [23]
Topiramate DM82Z30 Approved Topiramate decreases the activity of Carbonic anhydrase 2 (CA2). [24]
Enalapril DMNFUZR Approved Enalapril decreases the activity of Carbonic anhydrase 2 (CA2). [25]
Acetazolamide DM1AF5U Approved Acetazolamide decreases the activity of Carbonic anhydrase 2 (CA2). [16]
Voriconazole DMAOL2S Approved Voriconazole decreases the activity of Carbonic anhydrase 2 (CA2). [26]
Methazolamide DM7J2TA Approved Methazolamide decreases the activity of Carbonic anhydrase 2 (CA2). [23]
Seocalcitol DMKL9QO Phase 3 Seocalcitol increases the expression of Carbonic anhydrase 2 (CA2). [27]
Guaiacol DMN4E7T Phase 3 Guaiacol decreases the activity of Carbonic anhydrase 2 (CA2). [20]
Genistein DM0JETC Phase 2/3 Genistein increases the expression of Carbonic anhydrase 2 (CA2). [13]
DNCB DMDTVYC Phase 2 DNCB decreases the expression of Carbonic anhydrase 2 (CA2). [28]
Afimoxifene DMFORDT Phase 2 Afimoxifene increases the expression of Carbonic anhydrase 2 (CA2). [29]
STX-140 DMJK5CT Phase 2 STX-140 decreases the activity of Carbonic anhydrase 2 (CA2). [30]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the expression of Carbonic anhydrase 2 (CA2). [3]
BUTYLATEDHYDROXYTOLUENE DMJ56MS Phase 1 BUTYLATEDHYDROXYTOLUENE decreases the activity of Carbonic anhydrase 2 (CA2). [20]
PMID28460551-Compound-2 DM4DOUB Patented PMID28460551-Compound-2 decreases the expression of Carbonic anhydrase 2 (CA2). [31]
PMID26394986-Compound-22 DM43Z1G Patented PMID26394986-Compound-22 decreases the activity of Carbonic anhydrase 2 (CA2). [23]
T83193 DMHO29Y Patented T83193 decreases the activity of Carbonic anhydrase 2 (CA2). [20]
Milchsaure DM462BT Investigative Milchsaure increases the expression of Carbonic anhydrase 2 (CA2). [33]
Coumarin DM0N8ZM Investigative Coumarin decreases the activity of Carbonic anhydrase 2 (CA2). [34]
Rutin DMEHRAJ Investigative Rutin decreases the activity of Carbonic anhydrase 2 (CA2). [35]
Sulfate DMW0ZBF Investigative Sulfate decreases the activity of Carbonic anhydrase 2 (CA2). [36]
CHALCONE DM16QTM Investigative CHALCONE decreases the activity of Carbonic anhydrase 2 (CA2). [37]
PHENYLTHIOUREA DMM1IAU Investigative PHENYLTHIOUREA decreases the activity of Carbonic anhydrase 2 (CA2). [38]
Thiourea DMUELHN Investigative Thiourea decreases the activity of Carbonic anhydrase 2 (CA2). [39]
1,2,4-Triazole DM73F5A Investigative 1,2,4-Triazole decreases the activity of Carbonic anhydrase 2 (CA2). [40]
2,6-di-t-butylphenol DMY8LDT Investigative 2,6-di-t-butylphenol decreases the activity of Carbonic anhydrase 2 (CA2). [20]
6-hydroxybenzo[d][1,3]oxathiol-2-one DMDRSNH Investigative 6-hydroxybenzo[d][1,3]oxathiol-2-one decreases the activity of Carbonic anhydrase 2 (CA2). [23]
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⏷ Show the Full List of 47 Drug(s)

References

1 A phenocopy of CAII deficiency: a novel genetic explanation for inherited infantile osteopetrosis with distal renal tubular acidosis. J Med Genet. 2003 Feb;40(2):115-21. doi: 10.1136/jmg.40.2.115.
2 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
3 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
4 Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
5 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
6 Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
7 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
8 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
9 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
10 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
11 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
12 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
13 Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
14 Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
15 CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
16 Indomethacin activates carbonic anhydrase and antagonizes the effect of the specific carbonic anhydrase inhibitor acetazolamide, by a direct mechanism of action. Int J Clin Pharmacol Ther. 2001 Jun;39(6):265-70.
17 The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
18 Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
19 Investigation of the mechanisms by which EB1089 abrogates apoptosis induced by 9-cis retinoic acid in pancreatic cancer cells. Pancreas. 2006 Jan;32(1):93-100.
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21 Synephrine and phenylephrine act as -amylase, -glycosidase, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase enzymes inhibitors. J Biochem Mol Toxicol. 2017 Nov;31(11). doi: 10.1002/jbt.21973. Epub 2017 Aug 11.
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