General Information of Drug Combination (ID: DCIIXKY)

Drug Combination Name
Vancomycin Daptomycin
Indication
Disease Entry Status REF
Bacteremia Phase 3 [1]
Component Drugs Vancomycin   DM3JFIH Daptomycin   DMFDQ3I
N.A. N.A.
2D MOL 2D MOL
3D MOL is unavailable 3D MOL is unavailable

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Vancomycin
Disease Entry ICD 11 Status REF
Bacteremia 1A73 Approved [2]
Bacterial endocarditis N.A. Approved [2]
Clostridioides difficile infection 1A04 Approved [2]
Methicillin-resistant staphylococci infection 1A00-1A09 Approved [3]
Neonatal sepsis N.A. Approved [2]
Staphylococcal pneumonia N.A. Approved [2]
Staphylococcus aureus infection N.A. Approved [2]
MRSA infection 1D01.0Y Investigative [4]
Skin infection 1F28-1G0Z Investigative [2]
Vancomycin Interacts with 14 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
VanA ligase (vanA) DEOFMQ7 Q0WYK7_ENTFL Metabolism [7]
VanA ligase (vanA) DEO97D6 VANA_ENTFC Metabolism [7]
VanB ligase (vanB) DE27YVU Q58F99_ENTFC Metabolism [7]
VanC2 ligase (vanC) DEIF4P9 VANC_ENTGA Metabolism [8]
VanG ligase (vanG) DEPH3S7 A0A076ZC24_STRAP Metabolism [9]
VanA ligase (vanA) DEO8E75 A0A437UFE2_ENTAV Metabolism [7]
VanB ligase (vanB) DER7KFQ VANB_ENTFA Metabolism [7]
VanC2 ligase (vanC) DEH73ZC Q47720_ENTCA Metabolism [10]
D-alanylalanine synthetase (ddl) DE035GU A0A1Q6S944_9FIRM Metabolism [9]
VanG ligase (vanG) DEPN8F9 A0A076YRI6_STRAG Metabolism [9]
VanB ligase (vanB) DEMDEJ8 Q58F99_ENTFC Metabolism [11]
VanB ligase (vanB) DE2GMEK Q58F99_ENTFC Metabolism [11]
VanA ligase (vanA) DEN6VO0 A0A376GZ73_ENTGA Metabolism [12]
VanA ligase (vanA) DESOXHP A0A4U9YK96_ENTCA Metabolism [13], [12]
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⏷ Show the Full List of 14 DME(s)
Vancomycin Interacts with 4 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
HLA class I histocompatibility antigen, B alpha chain (HLA-B) OTNXFWY2 HLAB_HUMAN Affects Expression [14]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Decreases Expression [15]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB) OT17HGXJ DMB_HUMAN Affects Expression [14]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Affects Expression [14]
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Indication(s) of Daptomycin
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Approved [5]
Skin infection 1F28-1G0Z Investigative [6]
Daptomycin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Bacterial Dihydropteroate synthetase (Bact folP) TT4ILYC DHPS_ECOLI Binder [16]
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Daptomycin Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
CDP-alcohol phosphatidyltransferase (pgsA) DE49HWX A0A081Q830_STRMT Metabolism [17]
CDP-alcohol phosphatidyltransferase (pgsA) DETMA7Z A0A081R409_STROR Metabolism [17]
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References

1 ClinicalTrials.gov (NCT02208063) A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial
2 Vancomycin FDA Label
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
5 How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73.
6 Daptomycin FDA Label
7 Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother. 1993 Aug;37(8):1563-71.
8 Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance. Gene. 1992 Mar 1;112(1):53-8.
9 vanG element insertions within a conserved chromosomal site conferring vancomycin resistance to Streptococcus agalactiae and Streptococcus anginosus. mBio. 2014 Jul 22;5(4):e01386-14.
10 Bacterial resistance to vancomycin: overproduction, purification, and characterization of VanC2 from Enterococcus casseliflavus as a D-Ala-D-Ser ligase. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10040-4.
11 vanI: a novel D-Ala-D-Lac vancomycin resistance gene cluster found in Desulfitobacterium hafniense. Microb Biotechnol. 2014 Sep;7(5):456-66.
12 Emergence of high-level resistance to glycopeptides in Enterococcus gallinarum and Enterococcus casseliflavus. Antimicrob Agents Chemother. 1994 Jul;38(7):1675-7.
13 vanA in Enterococcus faecium, Enterococcus faecalis, and Enterococcus casseliflavus detected in French cattle. Foodborne Pathog Dis. 2009 Nov;6(9):1107-11.
14 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
15 [Successful treatment of MRSA-associated glomerulonephritis with antibiotic therapy]. Nihon Jinzo Gakkai Shi. 2003;45(1):37-41.
16 Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin. Chem Biol. 2004 Jul;11(7):949-57.
17 Mutations in cdsA and pgsA correlate with daptomycin resistance in Streptococcus mitis and S. oralis. Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01531-18.