Details of the Drug Combinations

General Information of This Drug (ID: DME9QGW)

Drug Name

Marizomib DME9QGW

Synonyms

MARIZOMIB; salinosporamide A; 437742-34-2; (-)-Salinosporamide A; UNII-703P9YDP7F; NPI-0052; NPI 0052; ML 858; 703P9YDP7F; CHEBI:48045; (1R,4R,5S)-4-(2-chloroethyl)-1-[(S)-(1S)-cyclohex-2-en-1-yl(hydroxy)methyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione; Marizomib [USAN:INN]; marizomibum; Marizomib (USAN/INN); Salinosporamide A (NPI-0052, Marizomib); SCHEMBL151667; CHEMBL371405; NGWSFRIPKNWYAO-SHTIJGAHSA-N; ZINC3990364; BDBM50398608; 2531AH; AKOS027323566; DB11762; Z-3093; D09640; 855517-10-1

Indication

Disease Entry	ICD 11	Status	REF
Glioblastoma of brain	2A00.00	Phase 3	[1]
Malignant glioma	2A00.0	Phase 1	[2]
Multiple myeloma	2A83	Phase 1	[2]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

152 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
(R)-PFI-2 + Marizomib	DCPGSJ9	(R)-PFI-2	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole + Marizomib	DC3YWC5	1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
6-hydroxybenzo[d][1,3]oxathiol-2-one + Marizomib	DC76W5X	6-hydroxybenzo[d][1,3]oxathiol-2-one	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
A-674563 + Marizomib	DC7JVKO	A-674563	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
ABT-737 + Marizomib	DC7XQF1	ABT-737	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Acalabrutinib + Marizomib	DC1QMDY	Acalabrutinib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
AEW-541 + Marizomib	DCZYRNR	AEW-541	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Akt inhibitor VIII + Marizomib	DCJEO7M	Akt inhibitor VIII	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Alpelisib + Marizomib	DCBHUGV	Alpelisib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Alprostadil + Marizomib	DCE2PDD	Alprostadil	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Alvespimycin hydrochloride + Marizomib	DCL0F5H	Alvespimycin hydrochloride	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Amg-1 + Marizomib	DCQKQK4	Amg-1	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
AR-42 + Marizomib	DCMAYTP	AR-42	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Arfolitixorin + Marizomib	DCABOGD	Arfolitixorin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Aspirin + Marizomib	DCX3E16	Aspirin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
AST-1306 + Marizomib	DCGEPJO	AST-1306	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Auranofin + Marizomib	DCOCGYW	Auranofin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
AZD8186 + Marizomib	DCOXJG3	AZD8186	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Bafilomycin A1 + Marizomib	DC1JU7S	Bafilomycin A1	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
BAY1143572 + Marizomib	DCXDCKP	BAY1143572	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Belnacasan + Marizomib	DCSKXRX	Belnacasan	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Bepridil + Marizomib	DCX8MJ1	Bepridil	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
BGT226 + Marizomib	DCAOI2K	BGT226	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
BIX-01294 + Marizomib	DCEHEQV	BIX-01294	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
BLU-554 + Marizomib	DCSGH51	BLU-554	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
BMS-509744 + Marizomib	DCP5O8U	BMS-509744	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
BMS-754807 + Marizomib	DCGXVLA	BMS-754807	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
BMS-754807 + Marizomib	DCRKX7Y	BMS-754807	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[4]
BVD-523 + Marizomib	DCF7EI4	BVD-523	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
CC-115 + Marizomib	DCJVJL6	CC-115	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
CC-25430 + Marizomib	DCX4MYF	CC-25430	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
CF102 + Marizomib	DCNS6P4	CF102	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
CI-966 + Marizomib	DCL7H7N	CI-966	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Cidofovir + Marizomib	DCW2MNF	Cidofovir	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Citarinostat + Marizomib	DC3HMV3	Citarinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Cladribine + Marizomib	DCBVOWG	Cladribine	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
CPI-203 + Marizomib	DCZLH0O	CPI-203	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Crizotinib + Marizomib	DCQQ424	Crizotinib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
CUDC-101 + Marizomib	DCX77LV	CUDC-101	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Cyclosporin A + Marizomib	DCVFZJP	Cyclosporin A	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Debio 0932 + Marizomib	DC038T7	Debio 0932	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Dexanabinol + Marizomib	DCO6F9B	Dexanabinol	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Diltiazem + Marizomib	DC7UBDN	Diltiazem	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Diosmin + Marizomib	DCRJ5JE	Diosmin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Disulfide compound 1 + Marizomib	DCHMLK9	Disulfide compound 1	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Doxorubicin + Marizomib	DC9ZTS9	Doxorubicin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Eltanexor oral + Marizomib	DCCDAP6	Eltanexor oral	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Elvitegravir + Marizomib	DCFXKDM	Elvitegravir	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Emetine + Marizomib	DCMAW42	Emetine	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
ER819762 + Marizomib	DCLOHFE	ER819762	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Evacetrapib + Marizomib	DCQ5G4P	Evacetrapib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Everolimus + Marizomib	DCQXCKA	Everolimus	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Ezetimibe + Marizomib	DCRM99S	Ezetimibe	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
FG-2216 + Marizomib	DC96OA0	FG-2216	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Flavopiridol + Marizomib	DCC0PHV	Flavopiridol	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Fostamatinib + Marizomib	DCCBSZN	Fostamatinib	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[4]
Ganetespib + Marizomib	DCMRAFC	Ganetespib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
GDC-0032 + Marizomib	DC6E335	GDC-0032	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Gliclazide + Marizomib	DCIAMVJ	Gliclazide	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
HM-78136B + Marizomib	DCXOR3P	HM-78136B	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Irinotecan + Marizomib	DC2O7W2	Irinotecan	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
IRX4204 + Marizomib	DCH7RY8	IRX4204	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Isoniazid + Marizomib	DCWWX9X	Isoniazid	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Ivosidenib + Marizomib	DCBA06T	Ivosidenib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Ixabepilone + Marizomib	DC4IW81	Ixabepilone	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
KU-60019 + Marizomib	DC2K552	KU-60019	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
LAROPIPRANT + Marizomib	DCM3A5C	LAROPIPRANT	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Larotrectinib + Marizomib	DCT1TR6	Larotrectinib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
LGK974 + Marizomib	DCLZOEK	LGK974	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Lumefantrine + Marizomib	DCOJ2AM	Lumefantrine	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
LY2801653 + Marizomib	DCPTFTN	LY2801653	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
M2698 + Marizomib	DC137QB	M2698	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Marizomib + PMID28460551-Compound-2	DCUCY34	PMID28460551-Compound-2	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Marizomib + Panobinostat	DC79IRS	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Marizomib + AS602868	DC7YFKB	AS602868	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[4]
Marizomib + Ruxolitinib	DCZSCS1	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[5]
MCI-186 + Marizomib	DCV1CNF	MCI-186	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
MG-132 + Marizomib	DCNBEHN	MG-132	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Mivebresib + Marizomib	DCVNTGI	Mivebresib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
MK-3207 + Marizomib	DCAXCO8	MK-3207	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
MK-4827 + Marizomib	DC8BGNB	MK-4827	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
MLN8237 + Marizomib	DC4UR9R	MLN8237	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[4]
Napabucasin + Marizomib	DC1BFKW	Napabucasin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Netarsudil + Marizomib	DCCR6B2	Netarsudil	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Oltipraz + Marizomib	DCIKUAD	Oltipraz	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Oprozomib + Marizomib	DC5Z4TZ	Oprozomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Panobinostat + Marizomib	DCF23UH	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Pazopanib + Marizomib	DCUX937	Pazopanib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
PD-0325901 + Marizomib	DC8E6S6	PD-0325901	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Pentostatin + Marizomib	DCW1IE8	Pentostatin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Pexidartinib + Marizomib	DC9PMG6	Pexidartinib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
PF-03772304 + Marizomib	DCPL9YV	PF-03772304	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
PF-04457845 + Marizomib	DCA97KH	PF-04457845	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
PF-3758309 + Marizomib	DCAWL16	PF-3758309	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
PF-4418948 + Marizomib	DCIFTW7	PF-4418948	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
PF-4989216 + Marizomib	DC6Z8L0	PF-4989216	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
PF-562271 + Marizomib	DCEWIV5	PF-562271	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
PI-103 + Marizomib	DCWYKA5	PI-103	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
PIK-75 + Marizomib	DC71HZJ	PIK-75	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Piperazinyl methyl quinazolinone derivative 2 + Marizomib	DCIOT0N	Piperazinyl methyl quinazolinone derivative 2	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
PMID28460551-Compound-2 + Marizomib	DC2XHTR	PMID28460551-Compound-2	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
PNU-282987 + Marizomib	DCFD4GE	PNU-282987	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
PRALNACASAN + Marizomib	DCHKLG7	PRALNACASAN	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Pravastatin + Marizomib	DCUA7QQ	Pravastatin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Pretomanid + Marizomib	DCDTF3X	Pretomanid	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
PTX-008 + Marizomib	DC0HDNK	PTX-008	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Pyrazinamide + Marizomib	DC3V94C	Pyrazinamide	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Pyroxamide + Marizomib	DCMHHPG	Pyroxamide	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
RAF265 + Marizomib	DC0HJF3	RAF265	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[4]
Rebamipide + Marizomib	DCIWGK8	Rebamipide	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Resminostat + Marizomib	DCLEHQH	Resminostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Ridaforolimus + Marizomib	DC7IK4Q	Ridaforolimus	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Rifaximin + Marizomib	DCNCNFT	Rifaximin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Rilmenidine + Marizomib	DCSLXA5	Rilmenidine	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Risedronate + Marizomib	DCZMW6Z	Risedronate	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
RKI-1447 + Marizomib	DCCBF6F	RKI-1447	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Rofecoxib + Marizomib	DCMF9SU	Rofecoxib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Romidepsin + Marizomib	DCDMRDQ	Romidepsin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
RS-130830 + Marizomib	DCXM47J	RS-130830	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
RX-5902 + Marizomib	DC236TD	RX-5902	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
SAR245409 + Marizomib	DC9FXK9	SAR245409	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Sgx523 + Marizomib	DCLANPP	Sgx523	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Sibutramine + Marizomib	DC1O0TR	Sibutramine	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Staurosporine + Marizomib	DCI669K	Staurosporine	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Sulfanilamide + Marizomib	DC2UHFC	Sulfanilamide	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Sunitinib malate + Marizomib	DC603T4	Sunitinib malate	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
SY-1425 + Marizomib	DCJY3UW	SY-1425	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
TG100-115 + Marizomib	DCZXFJ9	TG100-115	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
TH-302 + Marizomib	DCMR1KO	TH-302	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
THAPSIGARGIN + Marizomib	DCHNST4	THAPSIGARGIN	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
THZ1 + Marizomib	DCBHCKW	THZ1	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
THZ531 + Marizomib	DCBGWXS	THZ531	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
TPX-0005 + Marizomib	DCE15O3	TPX-0005	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Tretinoin + Marizomib	DC0RHS6	Tretinoin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Triciribine + Marizomib	DC0NGMU	Triciribine	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Trifluridine + Marizomib	DCG6NWS	Trifluridine	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Trimetrexate + Marizomib	DCP46OV	Trimetrexate	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
UCN-01 + Marizomib	DCX22K8	UCN-01	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Venglustat + Marizomib	DCEZZ29	Venglustat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Verdinexor + Marizomib	DC1585R	Verdinexor	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
VESNARINONE + Marizomib	DCF55UT	VESNARINONE	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Voriconazole + Marizomib	DCJ3PKI	Voriconazole	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
VX-702 + Marizomib	DCGTMUB	VX-702	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
VX-745 + Marizomib	DCNSVSG	VX-745	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
WAY-100635 + Marizomib	DC54XLK	WAY-100635	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Withaferin A + Marizomib	DCWRQJF	Withaferin A	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Wortmannin + Marizomib	DC88JPN	Wortmannin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
XCT790 + Marizomib	DC2FDGL	XCT790	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
XL-888 + Marizomib	DC5HTTC	XL-888	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
XMD8-92 + Marizomib	DCS5YG7	XMD8-92	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Z 360 + Marizomib	DC1HZYA	Z 360	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Zanubrutinib + Marizomib	DCZ4HDN	Zanubrutinib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
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⏷ Show the Full List of 152 DrugCom(s)

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Marizomib + Temozolomide	DC2K52M	Temozolomide	Glioblastoma	[6]
Panobinostat + Marizomib	DCYTX8Z	Panobinostat	Diffuse Intrinsic Pontine Glioma	[7]
Dexamethasone + Marizomib	DC9U386	Dexamethasone	Multiple Myeloma	[8]
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References

1	ClinicalTrials.gov (NCT03345095) A Phase III Trial of With Marizomib in Patients With Newly Diagnosed Glioblastoma (MIRAGE). U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Clinical pipeline report, company report or official report of Triphase Accelerator .
4	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
6	ClinicalTrials.gov (NCT02903069) Study of Marizomib With Temozolomide and Radiotherapy in Patients With Newly Diagnosed Brain Cancer
7	ClinicalTrials.gov (NCT04341311) Phase I Study of Marizomib + Panobinostat for Children With DIPG
8	ClinicalTrials.gov (NCT05050305) Marizomib Central Nervous System (CNS)