Details of the Drug Combination

General Information of Drug Combination (ID: DCNBEHN)

Drug Combination Name

MG-132 Marizomib

Indication

Disease Entry	Status	REF
Diffuse intrinsic pontine glioma	Investigative	[1]

Component Drugs

MG-132 DMKA2YS

Marizomib DME9QGW

N.A.

Small molecular drug

2D MOL

3D MOL

High-throughput Screening Result

Testing Cell Line: DIPG25

Zero Interaction Potency (ZIP) Score: 27.49

Bliss Independence Score: 21.07

Loewe Additivity Score: 6.28

LHighest Single Agent (HSA) Score: 26.31

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

MG-132 Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[13]
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MG-132 Interacts with 183 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Carbonyl reductase 3 (CBR3)	OT9G6SF0	CBR3_HUMAN	Increases Expression	[14]
Glutathione S-transferase A2 (GSTA2)	OTW7UB1H	GSTA2_HUMAN	Increases Expression	[15]
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Decreases Expression	[16]
Peptidyl-prolyl cis-trans isomerase A (PPIA)	OTHJMWQQ	PPIA_HUMAN	Decreases Expression	[16]
Glutathione S-transferase P (GSTP1)	OTLP0A0Y	GSTP1_HUMAN	Increases Expression	[17]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Increases Expression	[5]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Increases Expression	[5]
Nitric oxide synthase 3 (NOS3)	OTLDT7NR	NOS3_HUMAN	Decreases Degradation	[18]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Increases Expression	[19]
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Increases Expression	[19]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Increases Expression	[19]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Increases Expression	[19]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)	OTM0GDTP	IF2A_HUMAN	Increases Expression	[20]
Nuclear receptor subfamily 1 group I member 3 (NR1I3)	OTS3SGH7	NR1I3_HUMAN	Decreases Activity	[21]
Transcription factor Sp3 (SP3)	OTYDQZ1T	SP3_HUMAN	Increases Expression	[22]
HCLS1-associated protein X-1 (HAX1)	OTOJWV3F	HAX1_HUMAN	Affects Expression	[23]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)	OTBPCU2O	TR10A_HUMAN	Increases Expression	[10]
26S proteasome non-ATPase regulatory subunit 11 (PSMD11)	OT8KO67V	PSD11_HUMAN	Increases Expression	[24]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12)	OTWICA51	PSD12_HUMAN	Increases Expression	[24]
26S proteasome non-ATPase regulatory subunit 14 (PSMD14)	OTJWHMZ5	PSDE_HUMAN	Increases Expression	[24]
Suppressor of cytokine signaling 3 (SOCS3)	OTY183WJ	SOCS3_HUMAN	Decreases Degradation	[25]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[10]
Proteasome subunit alpha type-7 (PSMA7)	OTPHI6ST	PSA7_HUMAN	Increases Expression	[24]
Transcription regulator protein BACH1 (BACH1)	OTY8004K	BACH1_HUMAN	Increases Expression	[26]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)	OTLF4ZB1	IKKA_HUMAN	Increases Activity	[27]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Increases Expression	[28]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Affects Expression	[29]
Cytochrome P450 26A1 (CYP26A1)	OTL1DFWV	CP26A_HUMAN	Decreases Expression	[24]
26S proteasome non-ATPase regulatory subunit 3 (PSMD3)	OT585WY8	PSMD3_HUMAN	Increases Expression	[24]
Serine protease HTRA2, mitochondrial (HTRA2)	OTC7616F	HTRA2_HUMAN	Increases Expression	[23]
E3 ubiquitin-protein ligase parkin (PRKN)	OTJBN41W	PRKN_HUMAN	Decreases Expression	[30]
E3 ubiquitin-protein ligase MARCHF6 (MARCHF6)	OTBTA03N	MARH6_HUMAN	Increases Stability	[31]
Nuclear protein 1 (NUPR1)	OT4FU8C0	NUPR1_HUMAN	Increases Expression	[24]
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3)	OTT00T7Q	PLOD3_HUMAN	Decreases Expression	[32]
Microphthalmia-associated transcription factor (MITF)	OT6XJCZH	MITF_HUMAN	Decreases Expression	[24]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)	OTY9R6FZ	ERN1_HUMAN	Increases Expression	[33]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Increases Expression	[34]
Pre-mRNA-splicing factor SPF27 (BCAS2)	OTRMF2WY	SPF27_HUMAN	Decreases Expression	[24]
Glutathione reductase, mitochondrial (GSR)	OTM2TUYM	GSHR_HUMAN	Increases Expression	[26]
Superoxide dismutase (SOD1)	OT39TA1L	SODC_HUMAN	Decreases Expression	[35]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Decreases Expression	[36]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Increases Expression	[37]
GTPase KRas (KRAS)	OT78QCN8	RASK_HUMAN	Increases Expression	[24]
Pro-epidermal growth factor (EGF)	OTANRJ0L	EGF_HUMAN	Increases Expression	[24]
Insulin-like growth factor II (IGF2)	OTJ4O6MW	IGF2_HUMAN	Decreases Response To Substance	[38]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Decreases Expression	[24]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Decreases Response To Substance	[39]
Fibronectin (FN1)	OTB5ZN4Q	FINC_HUMAN	Decreases Secretion	[40]
Estrogen receptor (ESR1)	OTKLU61J	ESR1_HUMAN	Decreases Expression	[24]
Glucocorticoid receptor (NR3C1)	OTCI2YDI	GCR_HUMAN	Increases Expression	[24]
Receptor tyrosine-protein kinase erbB-2 (ERBB2)	OTOAUNCK	ERBB2_HUMAN	Decreases Expression	[24]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Expression	[24]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[41]
Progesterone receptor (PGR)	OT0FZ3QE	PRGR_HUMAN	Increases Expression	[42]
Glutathione peroxidase 1 (GPX1)	OTE2O72Q	GPX1_HUMAN	Increases Expression	[35]
Cathepsin D (CTSD)	OTQZ36F3	CATD_HUMAN	Increases Cleavage	[8]
Annexin A2 (ANXA2)	OTFNS0CC	ANXA2_HUMAN	Decreases Expression	[24]
Steryl-sulfatase (STS)	OTXTJQPC	STS_HUMAN	Decreases Expression	[38]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Increases Expression	[7]
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)	OTIRPN6B	ROA1_HUMAN	Increases Expression	[43]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[44]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[45]
Retinoic acid receptor alpha (RARA)	OT192V9V	RARA_HUMAN	Increases Ubiquitination	[46]
Retinol-binding protein 3 (RBP3)	OTIWM4GT	RET3_HUMAN	Decreases Degradation	[47]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Increases Expression	[33]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)	OTA675TJ	GTR1_HUMAN	Increases Expression	[48]
Steroid hormone receptor ERR1 (ESRRA)	OTTDTUSP	ERR1_HUMAN	Increases Expression	[49]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Increases Expression	[26]
26S proteasome regulatory subunit 6A (PSMC3)	OTSKT0JI	PRS6A_HUMAN	Increases Expression	[24]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Increases Expression	[24]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)	OTAFHAVI	ATF6A_HUMAN	Increases Expression	[8]
Retinoic acid receptor RXR-alpha (RXRA)	OTP1TBDM	RXRA_HUMAN	Increases Expression	[50]
Receptor tyrosine-protein kinase erbB-3 (ERBB3)	OTRSST0A	ERBB3_HUMAN	Decreases Expression	[36]
Ribosomal protein S6 kinase beta-1 (RPS6KB1)	OTAELNGX	KS6B1_HUMAN	Decreases Phosphorylation	[51]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Increases Expression	[52]
Proteasome subunit alpha type-1 (PSMA1)	OTNBVM2U	PSA1_HUMAN	Increases Expression	[24]
Proteasome subunit alpha type-2 (PSMA2)	OTJRT2ZL	PSA2_HUMAN	Increases Expression	[24]
Proteasome subunit alpha type-3 (PSMA3)	OT52M10V	PSA3_HUMAN	Increases Expression	[24]
Proteasome subunit alpha type-4 (PSMA4)	OTAD2XXI	PSA4_HUMAN	Increases Expression	[24]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Increases Expression	[53]
Aryl hydrocarbon receptor nuclear translocator (ARNT)	OTMSIEZY	ARNT_HUMAN	Decreases Expression	[54]
Calnexin (CANX)	OTYP1F6J	CALX_HUMAN	Affects Localization	[55]
Proteasome subunit beta type-9 (PSMB9)	OTFV57T8	PSB9_HUMAN	Increases Expression	[24]
Proteasome subunit alpha type-5 (PSMA5)	OT38E6Y1	PSA5_HUMAN	Increases Expression	[24]
Proteasome subunit beta type-4 (PSMB4)	OTOJ9OHA	PSB4_HUMAN	Increases Expression	[24]
Proteasome subunit beta type-6 (PSMB6)	OT9VXPNW	PSB6_HUMAN	Increases Expression	[24]
Proteasome subunit beta type-5 (PSMB5)	OTOZXAS6	PSB5_HUMAN	Decreases Expression	[35]
Cystatin-D (CST5)	OTHJXNJG	CYTD_HUMAN	Decreases Expression	[24]
Retinoblastoma-like protein 1 (RBL1)	OTDEBFYC	RBL1_HUMAN	Increases Expression	[56]
Protein PML (PML)	OT6SM2GD	PML_HUMAN	Decreases Degradation	[57]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Increases Phosphorylation	[27]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Decreases Degradation	[58]
Polycomb complex protein BMI-1 (BMI1)	OTROVLJ0	BMI1_HUMAN	Increases Expression	[59]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Increases Expression	[34]
Copper-transporting ATPase 2 (ATP7B)	OTPWLNCO	ATP7B_HUMAN	Decreases Degradation	[60]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Decreases Expression	[54]
26S proteasome regulatory subunit 7 (PSMC2)	OTJ4V337	PRS7_HUMAN	Increases Expression	[24]
Peroxisome proliferator-activated receptor gamma (PPARG)	OTHMARHO	PPARG_HUMAN	Increases Activity	[61]
Alpha-synuclein (SNCA)	OTPWC1MR	SYUA_HUMAN	Increases Phosphorylation	[59]
Proteasome subunit beta type-10 (PSMB10)	OTURUR9B	PSB10_HUMAN	Decreases Expression	[24]
Signal transducer and activator of transcription 6 (STAT6)	OTCKMP49	STAT6_HUMAN	Affects Phosphorylation	[62]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Increases Expression	[37]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Cleavage	[63]
26S proteasome regulatory subunit 6B (PSMC4)	OTS3XN41	PRS6B_HUMAN	Increases Expression	[24]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Decreases Degradation	[64]
Neurogenic locus notch homolog protein 1 (NOTCH1)	OTI1WADQ	NOTC1_HUMAN	Increases Expression	[65]
Glutamate--cysteine ligase catalytic subunit (GCLC)	OTESDI4D	GSH1_HUMAN	Increases Expression	[7]
Glutamate--cysteine ligase regulatory subunit (GCLM)	OT6CP234	GSH0_HUMAN	Increases Expression	[26]
26S proteasome non-ATPase regulatory subunit 8 (PSMD8)	OTY6X27P	PSMD8_HUMAN	Increases Expression	[24]
CCAAT/enhancer-binding protein alpha (CEBPA)	OTOM9OE4	CEBPA_HUMAN	Increases Ubiquitination	[66]
Proteasome subunit beta type-3 (PSMB3)	OTVBON40	PSB3_HUMAN	Increases Expression	[24]
Proteasome subunit beta type-2 (PSMB2)	OTX0UG5W	PSB2_HUMAN	Increases Expression	[24]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Decreases Expression	[52]
Microsomal triglyceride transfer protein large subunit (MTTP)	OTNUVSDT	MTP_HUMAN	Increases Expression	[67]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Activity	[33]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Increases Expression	[68]
Proteasome subunit alpha type-6 (PSMA6)	OTJ6RPX5	PSA6_HUMAN	Increases Expression	[24]
26S proteasome regulatory subunit 4 (PSMC1)	OTLHD56E	PRS4_HUMAN	Increases Expression	[24]
26S proteasome regulatory subunit 8 (PSMC5)	OTJOORMR	PRS8_HUMAN	Increases Expression	[24]
26S proteasome regulatory subunit 10B (PSMC6)	OTG8997V	PRS10_HUMAN	Increases Expression	[24]
Glutathione S-transferase omega-1 (GSTO1)	OTUJ93MN	GSTO1_HUMAN	Increases Expression	[26]
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)	OTTM6KRB	ADA17_HUMAN	Increases Expression	[8]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Increases Activity	[41]
Protein SET (SET)	OTGYYQJO	SET_HUMAN	Decreases Expression	[32]
POU domain, class 5, transcription factor 1 (POU5F1)	OTDHHN7O	PO5F1_HUMAN	Increases Expression	[65]
Caveolin-1 (CAV1)	OTEZUR1L	CAV1_HUMAN	Decreases Expression	[69]
Heat shock factor protein 2 (HSF2)	OTXNJIJ9	HSF2_HUMAN	Increases Activity	[41]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Decreases Activity	[44]
Sex-determining region Y protein (SRY)	OT516T6D	SRY_HUMAN	Decreases Degradation	[70]
Protein kinase C delta type (PRKCD)	OTSEH90E	KPCD_HUMAN	Increases Phosphorylation	[61]
Proteasome activator complex subunit 1 (PSME1)	OTDHLJWH	PSME1_HUMAN	Decreases Expression	[24]
Recombining binding protein suppressor of hairless (RBPJ)	OTD7CUG0	SUH_HUMAN	Increases Expression	[71]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[72]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Degradation	[73]
Forkhead box protein M1 (FOXM1)	OT5887KR	FOXM1_HUMAN	Decreases Expression	[24]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Increases Expression	[74]
TAR DNA-binding protein 43 (TARDBP)	OTVOSFWW	TADBP_HUMAN	Increases Ubiquitination	[75]
26S proteasome non-ATPase regulatory subunit 2 (PSMD2)	OT6HZHN7	PSMD2_HUMAN	Increases Expression	[24]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Increases Expression	[27]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)	OTXEE550	APR_HUMAN	Increases Expression	[24]
Transcription factor E2F2 (E2F2)	OTO75RM7	E2F2_HUMAN	Decreases Expression	[24]
Reticulocalbin-2 (RCN2)	OTIU8JWD	RCN2_HUMAN	Increases Expression	[32]
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)	OT1QHOS2	NF2L1_HUMAN	Increases Expression	[76]
Phosphatidate phosphatase LPIN1 (LPIN1)	OTQ75KF2	LPIN1_HUMAN	Increases Expression	[77]
Proteasome activator complex subunit 4 (PSME4)	OTDGF53O	PSME4_HUMAN	Increases Expression	[24]
26S proteasome non-ATPase regulatory subunit 6 (PSMD6)	OTX59EGK	PSMD6_HUMAN	Increases Expression	[24]
Prostaglandin E synthase 3 (PTGES3)	OTPPQWI0	TEBP_HUMAN	Decreases Degradation	[78]
ELAV-like protein 1 (ELAVL1)	OTY55PLY	ELAV1_HUMAN	Increases Expression	[79]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Increases Expression	[7]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Increases Ubiquitination	[80]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Decreases Degradation	[81]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Increases Stability	[82]
Rab-like protein 6 (RABL6)	OTJLVIQ1	RABL6_HUMAN	Decreases Expression	[24]
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)	OTLS7C99	LRRK2_HUMAN	Increases Ubiquitination	[83]
E3 ubiquitin-protein ligase RNF144B (RNF144B)	OTN7FCDE	R144B_HUMAN	Decreases Degradation	[84]
FUN14 domain-containing protein 1 (FUNDC1)	OTA6IVKQ	FUND1_HUMAN	Increases Expression	[85]
Regulatory-associated protein of mTOR (RPTOR)	OT4TQZ9F	RPTOR_HUMAN	Increases Expression	[37]
COMM domain-containing protein 1 (COMMD1)	OT7WUD5R	COMD1_HUMAN	Increases Expression	[86]
Programmed cell death 6-interacting protein (PDCD6IP)	OTS8T6A7	PDC6I_HUMAN	Increases Expression	[32]
Estrogen receptor beta (ESR2)	OTXNR2WQ	ESR2_HUMAN	Increases Expression	[87]
Histone deacetylase 2 (HDAC2)	OTUYVFKN	HDAC2_HUMAN	Increases Ubiquitination	[88]
Type II iodothyronine deiodinase (DIO2)	OTGPNSLH	IOD2_HUMAN	Increases Expression	[89]
Histone acetyltransferase KAT5 (KAT5)	OTL7257A	KAT5_HUMAN	Increases Expression	[90]
Tribbles homolog 3 (TRIB3)	OTG5OS7X	TRIB3_HUMAN	Decreases Expression	[24]
Proteasome subunit beta type-7 (PSMB7)	OT2NKD2K	PSB7_HUMAN	Increases Expression	[24]
26S proteasome non-ATPase regulatory subunit 1 (PSMD1)	OTW258OV	PSMD1_HUMAN	Increases Expression	[24]
Krueppel-like factor 6 (KLF6)	OTQY9S7F	KLF6_HUMAN	Increases Expression	[24]
Equilibrative nucleoside transporter 1 (SLC29A1)	OTLOOZZS	S29A1_HUMAN	Increases Expression	[24]
Endothelial PAS domain-containing protein 1 (EPAS1)	OTRE3O8U	EPAS1_HUMAN	Increases Expression	[91]
Angiotensin-converting enzyme 2 (ACE2)	OTTRZGU7	ACE2_HUMAN	Decreases Expression	[8]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)	OTUYHB84	MLP3B_HUMAN	Increases Expression	[92]
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)	OT4U7SBG	GBRL1_HUMAN	Increases Expression	[24]
Glutathione S-transferase omega-2 (GSTO2)	OTVDSNLH	GSTO2_HUMAN	Increases Expression	[26]
Thiol S-methyltransferase TMT1A (TMT1A)	OT4IAAZP	TMT1A_HUMAN	Decreases Expression	[24]
Anillin (ANLN)	OTXJY54C	ANLN_HUMAN	Decreases Expression	[24]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)	OT0DZGY4	E2AK3_HUMAN	Increases Phosphorylation	[8]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)	OTHCDQ22	PRGC1_HUMAN	Decreases Degradation	[93]
Proteasome activator complex subunit 2 (PSME2)	OTYPP33T	PSME2_HUMAN	Decreases Expression	[24]
26S proteasome non-ATPase regulatory subunit 13 (PSMD13)	OTNQ351N	PSD13_HUMAN	Increases Expression	[24]
E3 ubiquitin-protein ligase ARIH1 (ARIH1)	OTO3XDR2	ARI1_HUMAN	Increases Expression	[94]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1)	OTNEN8QK	SO1B1_HUMAN	Decreases Degradation	[95]
Parkinson disease protein 7 (PARK7)	OT0SKNTG	PARK7_HUMAN	Decreases Response To Substance	[96]
Polyamine-transporting ATPase 13A2 (ATP13A2)	OTKWBUGK	AT132_HUMAN	Decreases Response To Substance	[97]
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⏷ Show the Full List of 183 DOT(s)

Indication(s) of Marizomib

Disease Entry	ICD 11	Status	REF
Glioblastoma of brain	2A00.00	Phase 3	[2]
Malignant glioma	2A00.0	Phase 1	[3]
Multiple myeloma	2A83	Phase 1	[3]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]

Marizomib Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Proteasome (PS)	TTU7ZMG	NOUNIPROTAC	Inhibitor	[98]
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References

1	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2	ClinicalTrials.gov (NCT03345095) A Phase III Trial of With Marizomib in Patients With Newly Diagnosed Glioblastoma (MIRAGE). U.S. National Institutes of Health.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Clinical pipeline report, company report or official report of Triphase Accelerator .
5	A p38-p65 transcription complex induced by endothelin-1 mediates signal transduction in cancer cells. Biochim Biophys Acta. 2008 Sep;1783(9):1613-22.
6	BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite. J Biol Chem. 2008 Aug 15;283(33):22363-70.
7	Induction of ubiquitin C (UBC) gene transcription is mediated by HSF1: role of proteotoxic and oxidative stress. FEBS Open Bio. 2018 Jul 24;8(9):1471-1485. doi: 10.1002/2211-5463.12484. eCollection 2018 Sep.
8	The unfolded protein response controls ER stress-induced apoptosis of lung epithelial cells through angiotensin generation. Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L846-L854. doi: 10.1152/ajplung.00449.2015. Epub 2016 Sep 16.
9	A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. Biochem J. 2004 Dec 1;384(Pt 2):391-400. doi: 10.1042/BJ20041498.
10	Proteasome inhibitor MG132 sensitizes HPV-positive human cervical cancer cells to rhTRAIL-induced apoptosis. Int J Cancer. 2006 Apr 15;118(8):1892-900. doi: 10.1002/ijc.21580.
11	The proteasome inhibitor bortezomib is a potent inducer of zinc finger AN1-type domain 2a gene expression: role of heat shock factor 1 (HSF1)-heat shock factor 2 (HSF2) heterocomplexes. J Biol Chem. 2014 May 2;289(18):12705-15. doi: 10.1074/jbc.M113.513242. Epub 2014 Mar 11.
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