Details of the Drug Combination

General Information of Drug Combination (ID: DCW2MNF)

Drug Combination Name
Cidofovir Marizomib
Indication
Disease Entry Status REF
Diffuse intrinsic pontine glioma Investigative [1]
Component Drugs Cidofovir   DMA13GD Marizomib   DME9QGW
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: DIPG25
Zero Interaction Potency (ZIP) Score: 7.63
Bliss Independence Score: 7.38
Loewe Additivity Score: 0.99
LHighest Single Agent (HSA) Score: 1.88

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Cidofovir
Disease Entry ICD 11 Status REF
Cytomegalovirus infection 1D82 Approved [2]
Cytomegalovirus retinitis 9B72.00 Approved [3]
Cidofovir Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Herpes simplex virus DNA polymerase UL30 (HSV UL30) TTIU7X1 DPOL_HHV11 Modulator [8]
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Cidofovir Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [9]
Organic anion transporter 1 (SLC22A6) DTQ23VB S22A6_HUMAN Substrate [10]
Organic anion transporter 3 (SLC22A8) DTVP67E S22A8_HUMAN Substrate [10]
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Cidofovir Interacts with 256 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Organic anion transporter 3 (SLC22A8) OT8BY933 S22A8_HUMAN Increases Response To Substance [11]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [12]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Decreases Activity [12]
Interleukin-19 (IL19) OT9VGDIP IL19_HUMAN Increases Secretion [13]
Solute carrier family 12 member 8 (SLC12A8) OTHJP5FU S12A8_HUMAN Affects Expression [7]
PDZ and LIM domain protein 1 (PDLIM1) OT4EGCPG PDLI1_HUMAN Increases Expression [7]
Golgi integral membrane protein 4 (GOLIM4) OTB5NV8A GOLI4_HUMAN Decreases Expression [7]
Agrin (AGRN) OTWJENAZ AGRIN_HUMAN Increases Expression [7]
Podocalyxin (PODXL) OTPNQXF3 PODXL_HUMAN Decreases Expression [7]
Pirin (PIR) OT8ALXHU PIR_HUMAN Increases Expression [7]
TRAF-type zinc finger domain-containing protein 1 (TRAFD1) OT7AU2R3 TRAD1_HUMAN Increases Expression [7]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Affects Expression [7]
Long-chain fatty acid transport protein 2 (SLC27A2) OT7JEG5F S27A2_HUMAN Decreases Expression [7]
Rho guanine nucleotide exchange factor 10 (ARHGEF10) OTHJ1Y4I ARHGA_HUMAN Decreases Expression [7]
Apoptosis regulatory protein Siva (SIVA1) OTDT0XZK SIVA_HUMAN Increases Expression [7]
Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) OT8L6EGI BCAT2_HUMAN Increases Expression [7]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [7]
D-3-phosphoglycerate dehydrogenase (PHGDH) OT1LMRTG SERA_HUMAN Affects Expression [7]
E3 ubiquitin-protein ligase SIAH2 (SIAH2) OTKED2XN SIAH2_HUMAN Affects Expression [7]
Cochlin (COCH) OTBEHD89 COCH_HUMAN Increases Expression [7]
Protein sprouty homolog 1 (SPRY1) OT764FXI SPY1_HUMAN Affects Expression [7]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Increases Expression [7]
TP53-regulated inhibitor of apoptosis 1 (TRIAP1) OTEAUJXN TRIA1_HUMAN Increases Expression [7]
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) OTLVN68B AAKB2_HUMAN Decreases Expression [7]
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) OT6CLFXB MCAT_HUMAN Increases Expression [7]
Asparagine--tRNA ligase, cytoplasmic (NARS1) OTFS4J1W SYNC_HUMAN Decreases Expression [7]
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2) OTITCN3Q MA1A2_HUMAN Decreases Expression [7]
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A) OT4RF9Z4 PDE8A_HUMAN Decreases Expression [7]
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) OTSQGLSB TI17B_HUMAN Affects Expression [7]
PR domain zinc finger protein 1 (PRDM1) OTQLSVBS PRDM1_HUMAN Decreases Expression [7]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [7]
Ribosomal L1 domain-containing protein 1 (RSL1D1) OT3CL4R3 RL1D1_HUMAN Affects Expression [7]
E3 ubiquitin-protein ligase listerin (LTN1) OTIW2HTX LTN1_HUMAN Decreases Expression [7]
Solute carrier organic anion transporter family member 2B1 (SLCO2B1) OTERJ4VQ SO2B1_HUMAN Increases Expression [7]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3) OTQ9ALTR GCNT3_HUMAN Increases Expression [7]
Tetraspanin-12 (TSPAN12) OTF9I3CX TSN12_HUMAN Decreases Expression [7]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Increases Expression [7]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Increases Expression [7]
Ceruloplasmin (CP) OTM8JE4Y CERU_HUMAN Increases Expression [7]
Collagen alpha-1(IV) chain (COL4A1) OTL6D1YE CO4A1_HUMAN Affects Expression [7]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Increases Expression [7]
Fructose-bisphosphate aldolase A (ALDOA) OTWRFTIB ALDOA_HUMAN Increases Expression [7]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Decreases Expression [7]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Expression [7]
Transcription factor AP-2-alpha (TFAP2A) OTMYT3NK AP2A_HUMAN Decreases Expression [7]
Integrin beta-1 (ITGB1) OT6G1IAR ITB1_HUMAN Affects Expression [7]
Bifunctional glutamate/proline--tRNA ligase (EPRS1) OTXK0FLB SYEP_HUMAN Decreases Expression [7]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [7]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Increases Expression [7]
Keratin, type I cytoskeletal 19 (KRT19) OTDGDQ75 K1C19_HUMAN Increases Expression [7]
Gamma-enolase (ENO2) OTRODL0T ENOG_HUMAN Increases Expression [7]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [7]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Decreases Expression [7]
RNA-binding protein RO60 (RO60) OTLGM5A8 RO60_HUMAN Decreases Expression [7]
Retinoic acid receptor alpha (RARA) OT192V9V RARA_HUMAN Increases Expression [7]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Decreases Expression [7]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Increases Expression [7]
DNA topoisomerase 1 (TOP1) OT51O0CF TOP1_HUMAN Affects Expression [7]
Cation-independent mannose-6-phosphate receptor (IGF2R) OTDXPQVX MPRI_HUMAN Affects Expression [7]
Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) OTV04QE5 P4HA1_HUMAN Decreases Expression [7]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Increases Expression [7]
Fos-related antigen 2 (FOSL2) OT3MT9HJ FOSL2_HUMAN Decreases Expression [7]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Decreases Expression [7]
Histone H1.2 (H1-2) OT0AVI4M H12_HUMAN Increases Expression [7]
Aspartate aminotransferase, cytoplasmic (GOT1) OTZLM5UB AATC_HUMAN Increases Expression [7]
Protein SON (SON) OT9VWV18 SON_HUMAN Decreases Expression [7]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [7]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Affects Activity [7]
Keratin, type I cytoskeletal 15 (KRT15) OTS6WLF7 K1C15_HUMAN Increases Expression [7]
Ephrin-A1 (EFNA1) OTU2NUA2 EFNA1_HUMAN Decreases Expression [7]
Iduronate 2-sulfatase (IDS) OTZO94EO IDS_HUMAN Decreases Expression [7]
Ferrochelatase, mitochondrial (FECH) OTDWEI6C HEMH_HUMAN Decreases Expression [7]
Diacylglycerol kinase alpha (DGKA) OTTBVNEZ DGKA_HUMAN Increases Expression [7]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Affects Expression [7]
Thromboxane-A synthase (TBXAS1) OTAXZJJ4 THAS_HUMAN Increases Expression [7]
Bromodomain-containing protein 2 (BRD2) OTQP2MVJ BRD2_HUMAN Decreases Expression [7]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Affects Expression [7]
Threonine--tRNA ligase 1, cytoplasmic (TARS1) OT0PWST5 SYTC_HUMAN Decreases Expression [7]
Adenylate kinase 4, mitochondrial (AK4) OTA0T02Q KAD4_HUMAN Increases Expression [7]
ETS domain-containing protein Elk-4 (ELK4) OTVSSEOE ELK4_HUMAN Decreases Expression [7]
Tyrosine-protein kinase receptor UFO (AXL) OTKA2SUX UFO_HUMAN Increases Expression [7]
High affinity cationic amino acid transporter 1 (SLC7A1) OTR2ZVA8 CTR1_HUMAN Increases Expression [7]
Sodium- and chloride-dependent taurine transporter (SLC6A6) OT67U7G3 SC6A6_HUMAN Affects Expression [7]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [7]
Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1) OTQHB52T P5CR1_HUMAN Increases Expression [7]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1) OTB06ESI ACSL1_HUMAN Decreases Expression [7]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Decreases Expression [7]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Affects Activity [7]
Serpin B5 (SERPINB5) OTSMXQRJ SPB5_HUMAN Increases Expression [7]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Affects Activity [7]
Transaldolase (TALDO1) OTDKV2S2 TALDO_HUMAN Increases Expression [7]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [7]
Glycine--tRNA ligase (GARS1) OT5B6R9Y GARS_HUMAN Increases Expression [7]
Isoleucine--tRNA ligase, cytoplasmic (IARS1) OT9WXH5N SYIC_HUMAN Increases Expression [7]
Tumor necrosis factor ligand superfamily member 9 (TNFSF9) OTV9L89D TNFL9_HUMAN Increases Expression [7]
Neutral amino acid transporter A (SLC1A4) OTVODHAE SATT_HUMAN Increases Expression [7]
Nicotinamide phosphoribosyltransferase (NAMPT) OTVJR3GL NAMPT_HUMAN Increases Expression [7]
ATP-binding cassette sub-family G member 1 (ABCG1) OT5BG6MK ABCG1_HUMAN Decreases Expression [7]
Retinaldehyde dehydrogenase 3 (ALDH1A3) OT1C9NKQ AL1A3_HUMAN Increases Expression [7]
Sodium- and chloride-dependent glycine transporter 1 (SLC6A9) OTHRUON2 SC6A9_HUMAN Decreases Expression [7]
Glutamate--cysteine ligase catalytic subunit (GCLC) OTESDI4D GSH1_HUMAN Decreases Expression [7]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Increases Expression [7]
Alanine--tRNA ligase, cytoplasmic (AARS1) OTW8D813 SYAC_HUMAN Decreases Expression [7]
Cysteine--tRNA ligase, cytoplasmic (CARS1) OTOUZF6O SYCC_HUMAN Decreases Expression [7]
Serine--tRNA ligase, cytoplasmic (SARS1) OTFKXQ1O SYSC_HUMAN Increases Expression [7]
Max-interacting protein 1 (MXI1) OTUQ9E0D MXI1_HUMAN Decreases Expression [7]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Affects Expression [7]
Dipeptidyl peptidase 1 (CTSC) OT79WJZZ CATC_HUMAN Increases Expression [7]
Ataxin-1 (ATXN1) OTQF0HNR ATX1_HUMAN Decreases Expression [7]
Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) OT6W40XU P5CS_HUMAN Affects Expression [7]
Serine/threonine-protein kinase SIK1 (SIK1) OT6FCHME SIK1_HUMAN Affects Expression [7]
Ribose-phosphate pyrophosphokinase 1 (PRPS1) OTN3A6CN PRPS1_HUMAN Increases Expression [7]
Rho-related GTP-binding protein RhoE (RND3) OTXMXPIH RND3_HUMAN Affects Expression [7]
Protein BTG2 (BTG2) OTZF6K1H BTG2_HUMAN Increases Expression [7]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Affects Expression [7]
Runt-related transcription factor 1 (RUNX1) OTU7J84H RUNX1_HUMAN Increases Expression [7]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Increases Expression [7]
1,4-alpha-glucan-branching enzyme (GBE1) OTK2N05B GLGB_HUMAN Increases Expression [7]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [7]
Transmembrane protein 94 (TMEM94) OTT4ZSUA TMM94_HUMAN Decreases Expression [7]
Zinc finger protein Rlf (RLF) OTCSPZVK RLF_HUMAN Decreases Expression [7]
Peptidyl-prolyl cis-trans isomerase G (PPIG) OTZ8BTTM PPIG_HUMAN Decreases Expression [7]
Ras-related protein Rab-31 (RAB31) OTMLXQZ0 RAB31_HUMAN Increases Expression [7]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Affects Expression [7]
Runt-related transcription factor 2 (RUNX2) OT97RQQM RUNX2_HUMAN Increases Expression [7]
Kelch-like ECH-associated protein 1 (KEAP1) OTFHOD0C KEAP1_HUMAN Increases Expression [7]
Dihydropyrimidinase-related protein 3 (DPYSL3) OTINJV20 DPYL3_HUMAN Increases Expression [7]
Src substrate cortactin (CTTN) OTJRG4ES SRC8_HUMAN Increases Expression [7]
Enhancer of filamentation 1 (NEDD9) OTGCFN4M CASL_HUMAN Decreases Expression [7]
Protein disulfide-isomerase A5 (PDIA5) OT76ZSX5 PDIA5_HUMAN Increases Expression [7]
Transmembrane glycoprotein NMB (GPNMB) OTB7KQKV GPNMB_HUMAN Decreases Expression [7]
Condensin complex subunit 1 (NCAPD2) OT8VGE2O CND1_HUMAN Affects Expression [7]
Probable E3 ubiquitin-protein ligase HERC3 (HERC3) OTWMKYD9 HERC3_HUMAN Decreases Expression [7]
Plectin (PLEC) OTU4XDEG PLEC_HUMAN Decreases Expression [7]
Disks large-associated protein 5 (DLGAP5) OTWCN39U DLGP5_HUMAN Increases Expression [7]
Microtubule-associated protein RP/EB family member 2 (MAPRE2) OTAE3MX4 MARE2_HUMAN Increases Expression [7]
Neutral amino acid transporter B(0) (SLC1A5) OTE2H26Q AAAT_HUMAN Increases Expression [7]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Affects Expression [7]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Decreases Expression [7]
Neuronal regeneration-related protein (NREP) OT2AZPKK NREP_HUMAN Increases Expression [7]
kinase isozyme 4, mitochondrial (PDK4) OTCMHMBZ PDK4_HUMAN Increases Expression [7]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Affects Activity [7]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Increases Expression [7]
Dual specificity protein phosphatase 5 (DUSP5) OTH96RA7 DUS5_HUMAN Increases Expression [7]
Laminin subunit alpha-3 (LAMA3) OTFME7HT LAMA3_HUMAN Affects Expression [7]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) OTQYEXL2 F264_HUMAN Affects Expression [7]
Tumor protein D53 (TPD52L1) OTSA6U0I TPD53_HUMAN Affects Expression [7]
Atos homolog protein A (ATOSA) OTWFM5G0 ATOSA_HUMAN Decreases Expression [7]
Glycerol-3-phosphate acyltransferase 3 (GPAT3) OTJUGPK0 GPAT3_HUMAN Increases Expression [7]
Quinone oxidoreductase PIG3 (TP53I3) OTSCM68G QORX_HUMAN Increases Expression [7]
FRAS1-related extracellular matrix protein 2 (FREM2) OTEK6BZR FREM2_HUMAN Decreases Expression [7]
ALS2 C-terminal-like protein (ALS2CL) OT8RY7TZ AL2CL_HUMAN Affects Expression [7]
Endogenous Bornavirus-like nucleoprotein 2 (EBLN2) OTSZ86MP EBLN2_HUMAN Decreases Expression [7]
ATPase family AAA domain-containing protein 2 (ATAD2) OT8MCRNY ATAD2_HUMAN Increases Expression [7]
Ribosomal protein eS27-like (RPS27L) OTZWHU0N RS27L_HUMAN Increases Expression [7]
Arginine/serine-rich coiled-coil protein 2 (RSRC2) OTLE0KQM RSRC2_HUMAN Decreases Expression [7]
BEN domain-containing protein 5 (BEND5) OT6J6LY3 BEND5_HUMAN Affects Expression [7]
Mitochondrial enolase superfamily member 1 (ENOSF1) OT65D3ZK ENOF1_HUMAN Decreases Expression [7]
Serine/threonine-protein kinase TAO1 (TAOK1) OTFFLV6Q TAOK1_HUMAN Decreases Expression [7]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) OTE8GBUR RIR2B_HUMAN Decreases Expression [7]
Probable helicase senataxin (SETX) OTG3JNOQ SETX_HUMAN Decreases Expression [7]
Protein mono-ADP-ribosyltransferase TIPARP (TIPARP) OTZ4BG4B PARPT_HUMAN Increases Expression [7]
Protein LYRIC (MTDH) OTGH7N4C LYRIC_HUMAN Decreases Expression [7]
Liprin-beta-1 (PPFIBP1) OTRA2S7B LIPB1_HUMAN Increases Expression [7]
Extracellular sulfatase Sulf-2 (SULF2) OTIXMUVL SULF2_HUMAN Decreases Expression [7]
Patatin-like phospholipase domain-containing protein 6 (PNPLA6) OTT5T45Q PLPL6_HUMAN Increases Expression [7]
Probable ATP-dependent RNA helicase DHX37 (DHX37) OTM1A5KP DHX37_HUMAN Decreases Expression [7]
Stromal membrane-associated protein 1 (SMAP1) OTQN3BVL SMAP1_HUMAN Decreases Expression [7]
Protein O-mannosyl-transferase TMTC2 (TMTC2) OTY1QWYU TMTC2_HUMAN Decreases Expression [7]
CAP-Gly domain-containing linker protein 4 (CLIP4) OT75KVQK CLIP4_HUMAN Decreases Expression [7]
Ninein (NIN) OTVH3M4Z NIN_HUMAN Decreases Expression [7]
Ceramide synthase 5 (CERS5) OT5A2DNI CERS5_HUMAN Increases Expression [7]
F-box only protein 22 (FBXO22) OTEJ5MO0 FBX22_HUMAN Increases Expression [7]
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4) OTQK3M9X ABHD4_HUMAN Increases Expression [7]
F-box only protein 30 (FBXO30) OTD1P6LA FBX30_HUMAN Decreases Expression [7]
Pantothenate kinase 1 (PANK1) OT2CZVRT PANK1_HUMAN Decreases Expression [7]
SH3 domain and tetratricopeptide repeat-containing protein 1 (SH3TC1) OT0HYZIU S3TC1_HUMAN Decreases Expression [7]
Uncharacterized protein C4orf3 (C4ORF3) OT6TFN1O CD003_HUMAN Decreases Expression [7]
Paraspeckle component 1 (PSPC1) OTYS6WQ8 PSPC1_HUMAN Decreases Expression [7]
Histone acetyltransferase KAT6B (KAT6B) OTMUDTAH KAT6B_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase rififylin (RFFL) OT85MGDH RFFL_HUMAN Increases Expression [7]
DNA damage-binding protein 2 (DDB2) OTO8HVVB DDB2_HUMAN Increases Expression [7]
Sortilin-related receptor (SORL1) OTQ8FFNS SORL_HUMAN Decreases Expression [7]
Rho-related GTP-binding protein Rho6 (RND1) OTOC223Z RND1_HUMAN Increases Expression [7]
Probable ATP-dependent RNA helicase DDX17 (DDX17) OTXRMMBP DDX17_HUMAN Decreases Expression [7]
GTP-binding protein Rit1 (RIT1) OTVNOGOH RIT1_HUMAN Increases Expression [7]
Ninjurin-1 (NINJ1) OTLRZ1EU NINJ1_HUMAN Increases Expression [7]
KICSTOR complex protein ITFG2 (ITFG2) OT0NLZ8I ITFG2_HUMAN Affects Expression [7]
Protein TMEPAI (PMEPA1) OTY8Z9UF PMEPA_HUMAN Increases Expression [7]
Protein FAM162A (FAM162A) OT882DND F162A_HUMAN Decreases Expression [7]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Affects Expression [7]
Transmembrane protein 45B (TMEM45B) OTVQCO8N TM45B_HUMAN Decreases Expression [7]
Carboxymethylenebutenolidase homolog (CMBL) OT8H3S3G CMBL_HUMAN Increases Expression [7]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Increases Expression [7]
Protein FAM89A (FAM89A) OTNASAXT FA89A_HUMAN Increases Expression [7]
ERO1-like protein alpha (ERO1A) OTVKOQWM ERO1A_HUMAN Increases Expression [7]
Protein LRATD2 (LRATD2) OTEZBUUL LRAT2_HUMAN Increases Expression [7]
Protein FAM210B, mitochondrial (FAM210B) OT2QHEQ6 F210B_HUMAN Increases Expression [7]
E1A-binding protein p400 (EP400) OTVQ75NX EP400_HUMAN Decreases Expression [7]
Bcl-2-modifying factor (BMF) OT90NSLI BMF_HUMAN Increases Expression [7]
Protein FAM210A (FAM210A) OT3ZFJFJ F210A_HUMAN Increases Expression [7]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [7]
Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) OT9C3KFI KKCC2_HUMAN Increases Expression [7]
Spermatid perinuclear RNA-binding protein (STRBP) OTU7XLZL STRBP_HUMAN Decreases Expression [7]
Eukaryotic translation initiation factor 3 subunit C (EIF3C) OTR8RF9X EIF3C_HUMAN Decreases Expression [7]
Cell surface A33 antigen (GPA33) OT5JP00S GPA33_HUMAN Increases Expression [7]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [7]
Cancer-related nucleoside-triphosphatase (NTPCR) OTTRT6Z9 NTPCR_HUMAN Increases Expression [7]
Oxidoreductase HTATIP2 (HTATIP2) OT9MZ4QO HTAI2_HUMAN Affects Expression [7]
G-protein coupled receptor 87 (GPR87) OTQX45UM GPR87_HUMAN Decreases Expression [7]
Angiopoietin-related protein 4 (ANGPTL4) OTQL5SPX ANGL4_HUMAN Increases Expression [7]
Sulfiredoxin-1 (SRXN1) OTYDBO4L SRXN1_HUMAN Increases Expression [7]
Solute carrier family 2, facilitated glucose transporter member 11 (SLC2A11) OTNC55HX GTR11_HUMAN Affects Expression [7]
Coiled-coil domain-containing protein 90B, mitochondrial (CCDC90B) OTFFWB0C CC90B_HUMAN Decreases Expression [7]
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) OT4U7SBG GBRL1_HUMAN Decreases Expression [7]
DNA-directed RNA polymerase III subunit RPC6 (POLR3F) OTYC0I4I RPC6_HUMAN Decreases Expression [7]
Iron-sulfur cluster assembly enzyme ISCU (ISCU) OTSW6DQP ISCU_HUMAN Increases Expression [7]
Serine/threonine-protein kinase PLK3 (PLK3) OT19CT2Z PLK3_HUMAN Increases Expression [7]
Polyprenol reductase (SRD5A3) OT9IJLX7 PORED_HUMAN Decreases Expression [7]
E3 ubiquitin ligase RNF121 (RNF121) OTA0YMLW RN121_HUMAN Decreases Expression [7]
Ankyrin repeat family A protein 2 (ANKRA2) OTLSLV5A ANRA2_HUMAN Decreases Expression [7]
p53-induced death domain-containing protein 1 (PIDD1) OTWFM930 PIDD1_HUMAN Affects Expression [7]
Stromal cell-derived factor 2-like protein 1 (SDF2L1) OTE7JIO2 SDF2L_HUMAN Increases Expression [7]
ATP-binding cassette sub-family B member 6 (ABCB6) OTPGZFES ABCB6_HUMAN Increases Expression [7]
ABC-type oligopeptide transporter ABCB9 (ABCB9) OTSOBOL5 ABCB9_HUMAN Increases Expression [7]
Suppressor of SWI4 1 homolog (PPAN) OT0UFQBZ SSF1_HUMAN Decreases Expression [7]
Fructose-2,6-bisphosphatase TIGAR (TIGAR) OTR7NMRJ TIGAR_HUMAN Increases Expression [7]
Ectonucleoside triphosphate diphosphohydrolase 7 (ENTPD7) OT3QER33 ENTP7_HUMAN Increases Expression [7]
Dual specificity protein phosphatase 22 (DUSP22) OTEZ3U85 DUS22_HUMAN Increases Expression [7]
PAK4-inhibitor INKA2 (INKA2) OT9RA64U INKA2_HUMAN Increases Expression [7]
3-oxoacyl- synthase, mitochondrial (OXSM) OTMDWHOM OXSM_HUMAN Increases Expression [7]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Affects Expression [7]
Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2) OT7FCZRM PP4R2_HUMAN Decreases Expression [7]
LIM and cysteine-rich domains protein 1 (LMCD1) OT3AWE8O LMCD1_HUMAN Increases Expression [7]
Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2) OT8NJE5D SI1L2_HUMAN Decreases Expression [7]
Leucine--tRNA ligase, cytoplasmic (LARS1) OT4557NF SYLC_HUMAN Decreases Expression [7]
Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) OTSB4XO0 DPM3_HUMAN Increases Expression [7]
DnaJ homolog subfamily B member 9 (DNAJB9) OT38EQT6 DNJB9_HUMAN Increases Expression [7]
Mitochondrial fission process protein 1 (MTFP1) OT3L6F7U MTFP1_HUMAN Increases Expression [7]
SERTA domain-containing protein 1 (SERTAD1) OTBHKZQP SRTD1_HUMAN Increases Expression [7]
GTP:AMP phosphotransferase AK3, mitochondrial (AK3) OTM59ZGG KAD3_HUMAN Increases Expression [7]
Tubulointerstitial nephritis antigen (TINAG) OTY7BSD7 TINAG_HUMAN Decreases Expression [7]
Oxidative stress-induced growth inhibitor 1 (OSGIN1) OT9KIVZW OSGI1_HUMAN Affects Expression [7]
Two pore channel protein 1 (TPCN1) OTT4C4DI TPC1_HUMAN Increases Expression [7]
Ras-related protein Rab-26 (RAB26) OTHMPRJK RAB26_HUMAN Increases Expression [7]
Heme transporter FLVCR2 (FLVCR2) OTAM94ID FLVC2_HUMAN Affects Expression [7]
Lysine-specific demethylase 3A (KDM3A) OTZYJ8VN KDM3A_HUMAN Decreases Expression [7]
RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) OTHHFW17 CTDP1_HUMAN Decreases Expression [7]
Pleckstrin homology-like domain family A member 3 (PHLDA3) OTXFUDO2 PHLA3_HUMAN Increases Expression [7]
Phosphoserine aminotransferase (PSAT1) OTVV1YV9 SERC_HUMAN Increases Expression [7]
Sestrin-1 (SESN1) OTSFDZWL SESN1_HUMAN Increases Expression [7]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [14]
Hepatitis A virus cellular receptor 1 (HAVCR1) OT184CRZ HAVR1_HUMAN Increases Secretion [15]
Putative cyclin-dependent kinase inhibitor 1A (cdkn1a) OT0BQQU9 Q683K8_CANLF Increases ADR [16]
UMP-CMP kinase (CMPK1) OT6DUAF3 KCY_HUMAN Increases Phosphorylation [17]
Pre-mRNA-processing factor 19 (PRPF19) OTQ1STV3 PRP19_HUMAN Increases ADR [16]
------------------------------------------------------------------------------------
⏷ Show the Full List of 256 DOT(s)
Indication(s) of Marizomib
Disease Entry ICD 11 Status REF
Glioblastoma of brain 2A00.00 Phase 3 [4]
Malignant glioma 2A00.0 Phase 1 [5]
Multiple myeloma 2A83 Phase 1 [5]
Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
Marizomib Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Proteasome (PS) TTU7ZMG NOUNIPROTAC Inhibitor [18]
------------------------------------------------------------------------------------

References

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3 Cidofovir FDA Label
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5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 Clinical pipeline report, company report or official report of Triphase Accelerator .
7 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
8 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
9 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
10 Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2). Pharm Res. 2007 Apr;24(4):811-5.
11 Intracellular concentrations determine the cytotoxicity of adefovir, cidofovir and tenofovir. Toxicol In Vitro. 2015 Feb;29(1):251-8. doi: 10.1016/j.tiv.2014.10.019.
12 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
13 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
14 Antiviral agent cidofovir decreases Epstein-Barr virus (EBV) oncoproteins and enhances the radiosensitivity in EBV-related malignancies. Oncogene. 2003 Apr 17;22(15):2260-71. doi: 10.1038/sj.onc.1206402.
15 Transporter-dependent cytotoxicity of antiviral drugs in primary cultures of human proximal tubular cells. Toxicology. 2018 Jul 1;404-405:10-24. doi: 10.1016/j.tox.2018.05.002. Epub 2018 May 5.
16 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
17 Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates. J Med Chem. 2011 Jan 13;54(1):222-32. doi: 10.1021/jm1011462. Epub 2010 Dec 3.
18 Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials. Curr Cancer Drug Targets. 2011 Mar;11(3):254-84.