Details of the Drug Combination

General Information of Drug Combination (ID: DCI669K)

• Drug Combination Name: Staurosporine + Marizomib
• Indication: Diffuse intrinsic pontine glioma; Status: Investigative [1]
• Component Drugs:
  Staurosporine (DM0E9BR): Small molecular drug
  Marizomib (DME9QGW): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: DIPG25
  Zero Interaction Potency (ZIP) Score: 1.67
  Bliss Independence Score: 1.29
  Loewe Additivity Score: 4.72
  LHighest Single Agent (HSA) Score: 7.78

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Staurosporine

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[2]

Staurosporine Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Inhibitor of nuclear factor kappa-B kinase beta (IKKB)	TTJ3E9X	IKKB_HUMAN	Inhibitor	[8]
Protein kinase C (PRKC)	TTYVX59	NOUNIPROTAC	Inhibitor	[9]

Staurosporine Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[10]

Staurosporine Interacts with 38 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Muscarinic acetylcholine receptor M1 (CHRM1)	OTKW3E6B	ACM1_HUMAN	Affects Binding	[11]
Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)	OT8DXMS3	E2AK2_HUMAN	Decreases Activity	[12]
Caspase-1 (CASP1)	OTZ3YQFU	CASP1_HUMAN	Increases Activity	[13]
Acetylcholinesterase (ACHE)	OT2H8HG6	ACES_HUMAN	Increases Activity	[14]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Activity	[15]
Telomerase reverse transcriptase (TERT)	OT085VVA	TERT_HUMAN	Decreases Activity	[16]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[17]
BAG family molecular chaperone regulator 4 (BAG4)	OTUPX3M2	BAG4_HUMAN	Decreases Expression	[18]
Interleukin-33 (IL33)	OTT5YWK3	IL33_HUMAN	Increases Expression	[19]
Prelamin-A/C (LMNA)	OT3SG7ZR	LMNA_HUMAN	Increases Cleavage	[20]
Interleukin-5 (IL5)	OTAFPSCO	IL5_HUMAN	Decreases Activity	[21]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[22]
Neurotensin/neuromedin N (NTS)	OTPGDNQS	NEUT_HUMAN	Increases Activity	[23]
Pro-adrenomedullin (ADM)	OT7T0TA4	ADML_HUMAN	Decreases Expression	[24]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Increases Expression	[25]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[26]
Caspase-2 (CASP2)	OTUDYSPP	CASP2_HUMAN	Increases Cleavage	[26]
Large proline-rich protein BAG6 (BAG6)	OT4Z0S2U	BAG6_HUMAN	Decreases Expression	[18]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Activity	[27]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Activity	[18]
Caspase-6 (CASP6)	OTXLD3EC	CASP6_HUMAN	Increases Cleavage	[20]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Increases Expression	[28]
Sodium-dependent dopamine transporter (SLC6A3)	OT39XG28	SC6A3_HUMAN	Increases Activity	[29]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Increases Cleavage	[30]
Protein phosphatase 3 catalytic subunit alpha (PPP3CA)	OT58PUEN	PP2BA_HUMAN	Increases Cleavage	[31]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1)	OT6VY3A3	SPTN1_HUMAN	Increases Cleavage	[20]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Activity	[18]
Prostaglandin E synthase 3 (PTGES3)	OTPPQWI0	TEBP_HUMAN	Increases Cleavage	[20]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Decreases Expression	[32]
Caspase-10 (CASP10)	OTE6J88E	CASPA_HUMAN	Increases Activity	[18]
Solute carrier family 12 member 5 (SLC12A5)	OTBA2M8Y	S12A5_HUMAN	Increases Activity	[33]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Decreases Response To Substance	[34]
Beclin-1 (BECN1)	OT4X293M	BECN1_HUMAN	Decreases Response To Substance	[35]
Ubiquitin-like protein ATG12 (ATG12)	OTJRO09Y	ATG12_HUMAN	Affects Response To Substance	[35]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Response To Substance	[36]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Response To Substance	[37]
Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)	OTVT4YA1	ATG7_HUMAN	Affects Response To Substance	[35]
BAG family molecular chaperone regulator 3 (BAG3)	OTVXYUDQ	BAG3_HUMAN	Decreases Response To Substance	[18]

Indication(s) of Marizomib

Disease Entry	ICD 11	Status	REF
Glioblastoma of brain	2A00.00	Phase 3	[3]
Malignant glioma	2A00.0	Phase 1	[4]
Multiple myeloma	2A83	Phase 1	[4]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]

Marizomib Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Proteasome (PS)	TTU7ZMG	NOUNIPROTAC	Inhibitor	[38]

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