Details of the Drug Combination

General Information of Drug Combination (ID: DCVNTGI)

Drug Combination Name
Mivebresib Marizomib
Indication
Disease Entry Status REF
Diffuse intrinsic pontine glioma Investigative [1]
Component Drugs Mivebresib   DMCPF90 Marizomib   DME9QGW
N.A. Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: DIPG25
Zero Interaction Potency (ZIP) Score: 6.97
Bliss Independence Score: 6.88
Loewe Additivity Score: 10.65
LHighest Single Agent (HSA) Score: 16.51

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Mivebresib
Disease Entry ICD 11 Status REF
Acute myeloid leukaemia 2A60 Phase 1 [2]
Multiple myeloma 2A83 Phase 1 [2]
Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
Mivebresib Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Bromodomain and extraterminal domain protein (BET) TTE4BSY NOUNIPROTAC Inhibitor [2]
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Mivebresib Interacts with 164 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Coiled-coil domain-containing protein 154 (CCDC154) OTFGNMNP CC154_HUMAN Decreases Expression [6]
Nuclear pore complex-interacting protein family member A5 (NPIPA5) OTGIKZ9V NPIA5_HUMAN Increases Expression [6]
Sodium-dependent phosphate transport protein 3 (SLC17A2) OT5U4CFD NPT3_HUMAN Decreases Expression [6]
AT-rich interactive domain-containing protein 1A (ARID1A) OTRWDV3P ARI1A_HUMAN Decreases Expression [7]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Decreases Expression [7]
FYN-binding protein 1 (FYB1) OT6345CH FYB1_HUMAN Decreases Expression [6]
Forkhead box protein P2 (FOXP2) OTVX6A59 FOXP2_HUMAN Decreases Expression [6]
Calpain-5 (CAPN5) OTQ8QM7K CAN5_HUMAN Increases Expression [6]
RNA-binding protein Musashi homolog 1 (MSI1) OTAN4FSC MSI1H_HUMAN Decreases Expression [6]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [7]
Uncharacterized protein KIAA0513 (KIAA0513) OT7AVTFB K0513_HUMAN Increases Expression [6]
Tetraspanin-1 (TSPAN1) OTZQPIYK TSN1_HUMAN Decreases Expression [6]
Bromodomain-containing protein 4 (BRD4) OT2Y2TCW BRD4_HUMAN Increases Expression [7]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (PLCH2) OTYERO80 PLCH2_HUMAN Decreases Expression [6]
Breast carcinoma-amplified sequence 1 (BCAS1) OTQKJR81 BCAS1_HUMAN Decreases Expression [6]
Integrin alpha-10 (ITGA10) OTM0V5AO ITA10_HUMAN Decreases Expression [6]
Cytochrome P450 7B1 (CYP7B1) OTIKFYP6 CP7B1_HUMAN Increases Expression [6]
Slit homolog 2 protein (SLIT2) OTLS2RJ4 SLIT2_HUMAN Increases Expression [6]
Protein HEXIM1 (HEXIM1) OTBK7278 HEXI1_HUMAN Increases Expression [7]
Apolipoprotein L3 (APOL3) OT95SQHR APOL3_HUMAN Decreases Expression [6]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Increases Phosphorylation [7]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Increases Expression [7]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [6]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [7]
Erythropoietin (EPO) OTZ90CN4 EPO_HUMAN Decreases Expression [6]
N-myc proto-oncogene protein (MYCN) OTWD33K1 MYCN_HUMAN Decreases Expression [8]
Heat shock protein beta-1 (HSPB1) OTHFZ8ED HSPB1_HUMAN Decreases Phosphorylation [7]
Inhibin alpha chain (INHA) OT7HWCO3 INHA_HUMAN Decreases Expression [6]
Galectin-2 (LGALS2) OTY08TMQ LEG2_HUMAN Decreases Expression [6]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [7]
Eukaryotic translation initiation factor 4E (EIF4E) OTDAWNLA IF4E_HUMAN Decreases Phosphorylation [7]
Complement component C8 alpha chain (C8A) OTIJ65J4 CO8A_HUMAN Decreases Expression [6]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [7]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [7]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Increases Expression [6]
Plastin-2 (LCP1) OTK61F2A PLSL_HUMAN Decreases Expression [6]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [7]
Leukemia inhibitory factor (LIF) OTO46S5S LIF_HUMAN Decreases Expression [6]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [7]
Tyrosine aminotransferase (TAT) OT2CJ91O ATTY_HUMAN Decreases Expression [6]
Endoglin (ENG) OTL2LSMI EGLN_HUMAN Decreases Expression [6]
Interleukin-1 receptor antagonist protein (IL1RN) OT308CBE IL1RA_HUMAN Decreases Expression [6]
Glutathione hydrolase 1 proenzyme (GGT1) OTYDA1Z7 GGT1_HUMAN Decreases Expression [6]
Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) OTSXJGQF ITIH1_HUMAN Decreases Expression [6]
Alanine--glyoxylate aminotransferase (AGXT) OTIPTH3Q AGT1_HUMAN Decreases Expression [6]
Glycerol-3-phosphate dehydrogenase , cytoplasmic (GPD1) OTQW7TMB GPDA_HUMAN Decreases Expression [6]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Decreases Phosphorylation [7]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [7]
Protein kinase C eta type (PRKCH) OTC498N5 KPCL_HUMAN Decreases Expression [6]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [7]
Proteasome subunit beta type-8 (PSMB8) OTW5XGMF PSB8_HUMAN Decreases Expression [6]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [7]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Decreases Expression [7]
cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B) OTZEXEFH KAP3_HUMAN Increases Expression [6]
Alpha-L-iduronidase (IDUA) OTTQQ7FN IDUA_HUMAN Increases Expression [6]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [7]
Proteasome subunit beta type-10 (PSMB10) OTURUR9B PSB10_HUMAN Decreases Expression [6]
Signal transducer and activator of transcription 5A (STAT5A) OTBSJGN3 STA5A_HUMAN Decreases Expression [7]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Increases Phosphorylation [7]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Decreases Phosphorylation [7]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Cleavage [7]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Increases Expression [7]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [7]
Sodium- and chloride-dependent glycine transporter 1 (SLC6A9) OTHRUON2 SC6A9_HUMAN Decreases Expression [6]
Aldo-keto reductase family 1 member D1 (AKR1D1) OTBDJ6RL AK1D1_HUMAN Decreases Expression [6]
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 (FUT6) OTBZUQ7F FUT6_HUMAN Decreases Expression [6]
Ephrin-B2 (EFNB2) OT0DCUOM EFNB2_HUMAN Increases Expression [6]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [7]
Huntingtin-associated protein 1 (HAP1) OT6SG0JQ HAP1_HUMAN Increases Expression [6]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Cleavage [7]
Protein ripply3 (RIPPLY3) OT1HK35I DSCR6_HUMAN Decreases Expression [6]
T-box transcription factor TBX4 (TBX4) OTW58FG4 TBX4_HUMAN Decreases Expression [6]
Transmembrane protease serine 3 (TMPRSS3) OT0GTO1Z TMPS3_HUMAN Decreases Expression [6]
Claudin-2 (CLDN2) OTRF3D6Y CLD2_HUMAN Decreases Expression [6]
Sestrin-3 (SESN3) OTJRY1Y5 SESN3_HUMAN Increases Expression [6]
Inhibin beta E chain (INHBE) OTOI2NYG INHBE_HUMAN Decreases Expression [6]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Decreases Expression [7]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [7]
Microtubule-associated protein 1A (MAP1A) OTHO8K43 MAP1A_HUMAN Increases Expression [6]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Decreases Expression [7]
Perilipin-5 (PLIN5) OTV8G50L PLIN5_HUMAN Increases Expression [6]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Affects Folding [7]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [7]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [7]
Forkhead box protein M1 (FOXM1) OT5887KR FOXM1_HUMAN Decreases Expression [7]
Schlafen family member 5 (SLFN5) OTT1AESL SLFN5_HUMAN Increases Expression [6]
Putative sodium-coupled neutral amino acid transporter 11 (SLC38A11) OTFXRU35 S38AB_HUMAN Decreases Expression [6]
Protein mab-21-like 4 (MAB21L4) OT4FRKXR MB214_HUMAN Decreases Expression [6]
Serine/threonine-protein kinase PAK 1 (PAK1) OT17LZNZ PAK1_HUMAN Decreases Expression [6]
Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2) OTFHWIY8 DHRS2_HUMAN Increases Expression [6]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Decreases Phosphorylation [7]
GRB2-related adapter protein (GRAP) OTO1P7YX GRAP_HUMAN Decreases Expression [6]
Potassium voltage-gated channel subfamily C member 3 (KCNC3) OT811KOM KCNC3_HUMAN Increases Expression [6]
Dihydropyrimidinase-related protein 3 (DPYSL3) OTINJV20 DPYL3_HUMAN Increases Expression [6]
Lymphocyte antigen 6D (LY6D) OTXCR0SB LY6D_HUMAN Decreases Expression [6]
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A) OTKUW1WT PDE3A_HUMAN Decreases Expression [6]
Alpha-internexin (INA) OT1D33T4 AINX_HUMAN Increases Expression [6]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Affects Folding [7]
Transcription factor NF-E2 45 kDa subunit (NFE2) OTLM94BI NFE2_HUMAN Decreases Expression [6]
POU domain class 2-associating factor 1 (POU2AF1) OTOO6WHL OBF1_HUMAN Decreases Expression [6]
Protein Aster-B (GRAMD1B) OTCG1GX2 ASTRB_HUMAN Decreases Expression [6]
Protein phosphatase 1J (PPM1J) OTM6GDJJ PPM1J_HUMAN Increases Expression [6]
Uncharacterized protein C9orf152 (C9ORF152) OTOGLK0I CI152_HUMAN Decreases Expression [6]
Solute carrier family 35 member F1 (SLC35F1) OTRXHR2P S35F1_HUMAN Increases Expression [6]
Tau-tubulin kinase 1 (TTBK1) OTYW316L TTBK1_HUMAN Decreases Expression [6]
Terminal nucleotidyltransferase 5C (TENT5C) OTOWVQ4O TET5C_HUMAN Increases Expression [6]
FERM and PDZ domain-containing protein 2 (FRMPD2) OT8OM5MA FRPD2_HUMAN Decreases Expression [6]
Actin-binding LIM protein 2 (ABLIM2) OT62KOXF ABLM2_HUMAN Increases Expression [6]
Protein FAM171B (FAM171B) OT4DJHCM F171B_HUMAN Increases Expression [6]
Lysophospholipase D GDPD3 (GDPD3) OTOHM9QM GDPD3_HUMAN Decreases Expression [6]
Regulator of DNA class I crossover intermediates 1 (REDIC1) OT9KXL4O RDIC1_HUMAN Decreases Expression [6]
E3 ubiquitin-protein ligase TRIM50 (TRIM50) OTXA2IXF TRI50_HUMAN Decreases Expression [6]
Inactive serine/threonine-protein kinase TEX14 (TEX14) OTBL9LPZ TEX14_HUMAN Increases Expression [6]
Dynein regulatory complex subunit 7 (DRC7) OTGURR1R DRC7_HUMAN Decreases Expression [6]
E3 ubiquitin-protein ligase TRIM22 (TRIM22) OTJBLG5R TRI22_HUMAN Decreases Expression [6]
Dermatan-sulfate epimerase-like protein (DSEL) OTVNQD3I DSEL_HUMAN Increases Expression [6]
N-acetylglutamate synthase, mitochondrial (NAGS) OTITB7DO NAGS_HUMAN Decreases Expression [6]
Protein mab-21-like 3 (MAB21L3) OTX0I0V0 MB213_HUMAN Decreases Expression [6]
Dynein axonemal assembly factor 3 (DNAAF3) OT3OHO0O DAAF3_HUMAN Increases Expression [6]
Protein FAM181A (FAM181A) OTBQCMNL F181A_HUMAN Decreases Expression [6]
Mixed lineage kinase domain-like protein (MLKL) OTDSLC81 MLKL_HUMAN Decreases Expression [6]
Transmembrane protein 229B (TMEM229B) OT50LI46 T229B_HUMAN Decreases Expression [6]
Arrestin domain-containing protein 4 (ARRDC4) OTINJ0FX ARRD4_HUMAN Increases Expression [6]
Transcription factor MafA (MAFA) OTBCA105 MAFA_HUMAN Increases Expression [6]
Phosphoethanolamine/phosphocholine phosphatase (PHOSPHO1) OT43A0JA PHOP1_HUMAN Increases Expression [6]
Secreted and transmembrane protein 1 (SECTM1) OT5500CF SCTM1_HUMAN Decreases Expression [6]
Cholesterol transporter ABCA5 (ABCA5) OT4B9D92 ABCA5_HUMAN Increases Expression [6]
Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1) OTS8G0EN BAP1_HUMAN Decreases Expression [7]
Liver-expressed antimicrobial peptide 2 (LEAP2) OTUOPIS5 LEAP2_HUMAN Decreases Expression [6]
Terminal nucleotidyltransferase 5B (TENT5B) OTO2P28B TET5B_HUMAN Increases Expression [6]
Dapper homolog 3 (DACT3) OTSNQ55G DACT3_HUMAN Increases Expression [6]
Proline-rich AKT1 substrate 1 (AKT1S1) OT4JHN4Y AKTS1_HUMAN Decreases Phosphorylation [7]
Hepatitis A virus cellular receptor 1 (HAVCR1) OT184CRZ HAVR1_HUMAN Decreases Expression [6]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Decreases Expression [7]
Carboxypeptidase B2 (CPB2) OTPIL8IE CBPB2_HUMAN Decreases Expression [6]
Apoptosis-inducing factor 3 (AIFM3) OTSWKCAO AIFM3_HUMAN Decreases Expression [6]
CUB and sushi domain-containing protein 1 (CSMD1) OTIVDSC4 CSMD1_HUMAN Decreases Expression [6]
Tetraspanin-32 (TSPAN32) OTSXW7EW TSN32_HUMAN Decreases Expression [6]
Bile acid receptor (NR1H4) OTWZLPTB NR1H4_HUMAN Decreases Expression [6]
TSC22 domain family protein 3 (TSC22D3) OT03UM03 T22D3_HUMAN Decreases Expression [6]
Endosomal/lysosomal proton channel TMEM175 (TMEM175) OT6DUIYC TM175_HUMAN Increases Expression [6]
Mitochondrial ornithine transporter 2 (SLC25A2) OTD98O80 ORNT2_HUMAN Increases Expression [6]
Keratin-associated protein 3-1 (KRTAP3-1) OTRWUHTE KRA31_HUMAN Decreases Expression [6]
Linker for activation of T-cells family member 2 (LAT2) OTWJDKIH NTAL_HUMAN Decreases Expression [6]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) OTVSFHTL CRLD2_HUMAN Increases Expression [6]
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1) OTINY3MW AL8A1_HUMAN Decreases Expression [6]
Regulating synaptic membrane exocytosis protein 4 (RIMS4) OTHZMO8Y RIMS4_HUMAN Increases Expression [6]
Rho-related GTP-binding protein RhoJ (RHOJ) OTWI65OA RHOJ_HUMAN Decreases Expression [6]
Protein TANC2 (TANC2) OTDXY7PX TANC2_HUMAN Increases Expression [6]
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) OTR1XD9B GPAT1_HUMAN Decreases Expression [6]
Ras-related protein Rab-6B (RAB6B) OT5N57RK RAB6B_HUMAN Increases Expression [6]
Solute carrier family 22 member 11 (SLC22A11) OTAJLNJZ S22AB_HUMAN Decreases Expression [6]
Transmembrane protein 74B (TMEM74B) OTM7QFEC TM74B_HUMAN Decreases Expression [6]
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) OTFOJUIQ PHAG1_HUMAN Increases Expression [6]
Rhomboid-related protein 2 (RHBDL2) OTJPJ8N6 RHBL2_HUMAN Decreases Expression [6]
Sphingomyelin phosphodiesterase 3 (SMPD3) OTHQBETH NSMA2_HUMAN Increases Expression [6]
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) OT9G360P IF2B1_HUMAN Decreases Expression [8]
Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2) OT8NJE5D SI1L2_HUMAN Increases Expression [6]
Dynein axonemal heavy chain 17 (DNAH17) OT4G6E70 DYH17_HUMAN Decreases Expression [6]
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1) OTRI4UR1 CP8B1_HUMAN Decreases Expression [6]
Protein EFR3 homolog B (EFR3B) OTVKWU2L EFR3B_HUMAN Increases Expression [6]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C) OTXK0SDM 2ABG_HUMAN Decreases Expression [6]
Choline-phosphate cytidylyltransferase B (PCYT1B) OTMGVT01 PCY1B_HUMAN Decreases Expression [6]
Tolloid-like protein 2 (TLL2) OTHZ4TBL TLL2_HUMAN Increases Expression [6]
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⏷ Show the Full List of 164 DOT(s)
Indication(s) of Marizomib
Disease Entry ICD 11 Status REF
Glioblastoma of brain 2A00.00 Phase 3 [3]
Malignant glioma 2A00.0 Phase 1 [4]
Multiple myeloma 2A83 Phase 1 [4]
Solid tumour/cancer 2A00-2F9Z Phase 1 [5]
Marizomib Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Proteasome (PS) TTU7ZMG NOUNIPROTAC Inhibitor [9]
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References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 ClinicalTrials.gov (NCT03345095) A Phase III Trial of With Marizomib in Patients With Newly Diagnosed Glioblastoma (MIRAGE). U.S. National Institutes of Health.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Clinical pipeline report, company report or official report of Triphase Accelerator .
6 Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells. PLoS One. 2022 Apr 29;17(4):e0266966. doi: 10.1371/journal.pone.0266966. eCollection 2022.
7 Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells. Blood Cancer J. 2019 Jan 15;9(2):4. doi: 10.1038/s41408-018-0165-5.
8 IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression. Mol Cancer. 2023 May 29;22(1):88. doi: 10.1186/s12943-023-01792-0.
9 Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials. Curr Cancer Drug Targets. 2011 Mar;11(3):254-84.