Details of the Drug Combination

General Information of Drug Combination (ID: DC2O7W2)

Drug Combination Name
Irinotecan Marizomib
Indication
Disease Entry Status REF
Diffuse intrinsic pontine glioma Investigative [1]
Component Drugs Irinotecan   DMP6SC2 Marizomib   DME9QGW
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: DIPG25
Zero Interaction Potency (ZIP) Score: 4.63
Bliss Independence Score: 3.53
Loewe Additivity Score: 8.78
LHighest Single Agent (HSA) Score: 11.27

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Irinotecan
Disease Entry ICD 11 Status REF
Adenocarcinoma 2D40 Approved [2]
Advanced cancer 2A00-2F9Z Approved [2]
Appendiceal neoplasm N.A. Approved [2]
Astrocytoma 2A00.0Y Approved [2]
Brain glioma N.A. Approved [2]
Colon adenocarcinoma N.A. Approved [2]
Colorectal cancer 2B91.Z Approved [3]
Endocrine gland neoplasm N.A. Approved [2]
Kidney neoplasm N.A. Approved [2]
Metastasis from malignant tumor of colon N.A. Approved [2]
Peritoneal neoplasm N.A. Approved [2]
Rectal adenocarcinoma 2B92 Approved [2]
Rectal neoplasm N.A. Approved [2]
Rectum mucinous adenocarcinoma N.A. Approved [2]
Adult glioblastoma N.A. Investigative [2]
Colon cancer 2B90.Z Investigative [2]
Colon mucinous adenocarcinoma N.A. Investigative [2]
Diarrhea ME05.1 Investigative [2]
Gastric cancer 2B72 Investigative [2]
Neuroblastoma 2D11.2 Investigative [2]
Irinotecan Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
DNA topoisomerase I (TOP1) TTGTQHC TOP1_HUMAN Modulator [15]
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Irinotecan Interacts with 6 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [16]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [17]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [17]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [18]
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [19]
Multidrug resistance-associated protein 5 (ABCC5) DTYVM24 MRP5_HUMAN Substrate [20]
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⏷ Show the Full List of 6 DTP(s)
Irinotecan Interacts with 8 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [21]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [22]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Metabolism [23]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Metabolism [24]
Carboxylesterase 1 (CES1) DEB30C5 EST1_HUMAN Metabolism [21]
Carboxylesterase 3 (CES3) DEMI4VE EST3_HUMAN Metabolism [25]
Carboxylesterase 2 (CES2) DETHCPD EST2_HUMAN Metabolism [25]
Beta-glucuronidase (uidA) DE9RA0I BGLR_ECOLI Metabolism [26]
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⏷ Show the Full List of 8 DME(s)
Irinotecan Interacts with 469 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Increases Expression [27]
Carboxylesterase 3 (CES3) OT00OP43 EST3_HUMAN Increases Hydrolysis [25]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Response To Substance [28]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Increases Response To Substance [28]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Expression [10]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Decreases Response To Substance [29]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Increases Response To Substance [28]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Response To Substance [29]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Increases ADR [30]
Thiopurine S-methyltransferase (TPMT) OTFOX70W TPMT_HUMAN Increases Expression [10]
Cytochrome P450 2A6 (CYP2A6) OT52TWG3 CP2A6_HUMAN Decreases Activity [31]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Decreases Activity [31]
Annexin A2 (ANXA2) OTFNS0CC ANXA2_HUMAN Increases Expression [32]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [32]
FXYD domain-containing ion transport regulator 3 (FXYD3) OT9PPRHE FXYD3_HUMAN Increases Expression [32]
B-cell CLL/lymphoma 9 protein (BCL9) OTRBIPR4 BCL9_HUMAN Increases Expression [9]
Chromodomain-helicase-DNA-binding protein 1 (CHD1) OT9R9G0H CHD1_HUMAN Decreases Expression [9]
Prostaglandin E synthase (PTGES) OTB7YQFU PTGES_HUMAN Increases Expression [9]
tRNA (TRDMT1) OTAYQ8ZF TRDMT_HUMAN Decreases Expression [9]
Guanine nucleotide exchange factor DBS (MCF2L) OTEURA8N MCF2L_HUMAN Decreases Expression [9]
Fanconi anemia group G protein (FANCG) OT7MC8TZ FANCG_HUMAN Increases Expression [9]
Monocarboxylate transporter 5 (SLC16A4) OT1YXBKC MOT5_HUMAN Decreases Expression [9]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [9]
Prominin-1 (PROM1) OTBHV8NX PROM1_HUMAN Decreases Expression [9]
A-kinase anchor protein 10, mitochondrial (AKAP10) OTPNFTOU AKA10_HUMAN Decreases Expression [9]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Decreases Expression [9]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Decreases Expression [9]
G2/mitotic-specific cyclin-B2 (CCNB2) OTIEXTDK CCNB2_HUMAN Decreases Expression [9]
Heat shock 70 kDa protein 4L (HSPA4L) OT181WZB HS74L_HUMAN Decreases Expression [9]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Decreases Expression [9]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [9]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [9]
Lactotransferrin (LTF) OT8JWCZ0 TRFL_HUMAN Decreases Expression [9]
Histidine-rich glycoprotein (HRG) OTPLUFOG HRG_HUMAN Increases Expression [9]
Thy-1 membrane glycoprotein (THY1) OTVONVTB THY1_HUMAN Increases Expression [9]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Increases Expression [9]
Myeloperoxidase (MPO) OTOOXLIN PERM_HUMAN Decreases Expression [9]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [9]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [9]
Integrin alpha-V (ITGAV) OTAM7JTR ITAV_HUMAN Decreases Expression [9]
Annexin A6 (ANXA6) OT9KIQ0Y ANXA6_HUMAN Increases Expression [9]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Increases Expression [9]
Sulfotransferase 1A3 (SULT1A4) OTHJ8WWV ST1A3_HUMAN Increases Expression [9]
Serine/threonine-protein kinase A-Raf (ARAF) OTZJ0FNO ARAF_HUMAN Increases Expression [9]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Decreases Expression [9]
Collagen alpha-1(VI) chain (COL6A1) OTYKSCOB CO6A1_HUMAN Increases Expression [9]
Keratin, type II cytoskeletal 5 (KRT5) OTVGI9HT K2C5_HUMAN Decreases Expression [9]
Nidogen-1 (NID1) OTKLBLS6 NID1_HUMAN Increases Expression [9]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Increases Expression [9]
Protein C-ets-2 (ETS2) OTPVHOZ7 ETS2_HUMAN Increases Expression [9]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [9]
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PPP3CB) OTEGNEHW PP2BB_HUMAN Decreases Expression [9]
SH2/SH3 adapter protein NCK1 (NCK1) OTKYZ4OP NCK1_HUMAN Decreases Expression [9]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [9]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [9]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [9]
Interferon-induced GTP-binding protein Mx2 (MX2) OT05NF37 MX2_HUMAN Decreases Expression [9]
Integrin alpha-X (ITGAX) OTOGIMHE ITAX_HUMAN Increases Expression [9]
Myelin and lymphocyte protein (MAL) OTBM30SW MAL_HUMAN Increases Expression [9]
Glutathione peroxidase 3 (GPX3) OT6PK94R GPX3_HUMAN Increases Expression [9]
5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2) OTJXOUCL HEM0_HUMAN Increases Expression [9]
Receptor-type tyrosine-protein phosphatase delta (PTPRD) OTZPJ3GX PTPRD_HUMAN Increases Expression [9]
Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) OTGP7D5Y GATA3_HUMAN Decreases Expression [9]
Adenomatous polyposis coli protein (APC) OTKV0TIK APC_HUMAN Decreases Expression [9]
Retinoblastoma-like protein 1 (RBL1) OTDEBFYC RBL1_HUMAN Decreases Expression [9]
AT-rich interactive domain-containing protein 4A (ARID4A) OT1XKBZ0 ARI4A_HUMAN Decreases Expression [9]
M-phase inducer phosphatase 2 (CDC25B) OT12MSRY MPIP2_HUMAN Decreases Expression [9]
Syndecan-4 (SDC4) OTKUVUGZ SDC4_HUMAN Increases Expression [9]
C-C chemokine receptor type 1 (CCR1) OT4FC783 CCR1_HUMAN Increases Expression [9]
G-protein coupled receptor 183 (GPR183) OTRILX7G GP183_HUMAN Increases Expression [9]
CD70 antigen (CD70) OTHB2AL1 CD70_HUMAN Increases Expression [9]
T-lymphocyte activation antigen CD80 (CD80) OTJBLUQE CD80_HUMAN Increases Expression [9]
Dual specificity protein kinase TTK (TTK) OTBY1Z5H TTK_HUMAN Decreases Expression [9]
DNA replication licensing factor MCM4 (MCM4) OT19PNNG MCM4_HUMAN Decreases Expression [9]
Replication factor C subunit 3 (RFC3) OT1MS7AO RFC3_HUMAN Decreases Expression [9]
Cyclin-F (CCNF) OTJFVU43 CCNF_HUMAN Decreases Expression [9]
Transcription factor ETV6 (ETV6) OTCZMG61 ETV6_HUMAN Decreases Expression [9]
DNA mismatch repair protein Msh2 (MSH2) OT10H1AB MSH2_HUMAN Decreases Expression [9]
Hydroxycarboxylic acid receptor 3 (HCAR3) OTJBHLX0 HCAR3_HUMAN Increases Expression [9]
Centromere protein F (CENPF) OT7AG0SW CENPF_HUMAN Decreases Expression [9]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Decreases Expression [9]
5-formyltetrahydrofolate cyclo-ligase (MTHFS) OTZ39JNR MTHFS_HUMAN Decreases Expression [9]
Protein Tob1 (TOB1) OTNW949D TOB1_HUMAN Increases Expression [9]
C-C chemokine receptor type 6 (CCR6) OT61JMYX CCR6_HUMAN Decreases Expression [9]
Serine/threonine-protein kinase Nek2 (NEK2) OT1H27HO NEK2_HUMAN Decreases Expression [9]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [9]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Increases Expression [9]
UV excision repair protein RAD23 homolog B (RAD23B) OT0PGOG3 RD23B_HUMAN Decreases Expression [9]
Sestrin-2 (SESN2) OT889IXY SESN2_HUMAN Increases Expression [9]
Neutrophil defensin 1 (DEFA1) OT5N1B9B DEF1_HUMAN Decreases Expression [9]
Ras-related C3 botulinum toxin substrate 3 (RAC3) OT2RE7A7 RAC3_HUMAN Increases Expression [9]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6) OT1SLUZH TSG6_HUMAN Decreases Expression [9]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [9]
Runt-related transcription factor 1 (RUNX1) OTU7J84H RUNX1_HUMAN Decreases Expression [9]
Transcription factor Spi-B (SPIB) OTO4YKYI SPIB_HUMAN Increases Expression [9]
Myocyte-specific enhancer factor 2B (MEF2B) OT880SE6 MEF2B_HUMAN Increases Expression [9]
DNA-binding protein inhibitor ID-2 (ID2) OT0U1D53 ID2_HUMAN Decreases Expression [9]
Dual specificity protein phosphatase 2 (DUSP2) OTH54FMR DUS2_HUMAN Increases Expression [9]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) OTOA8WU2 PDE4B_HUMAN Decreases Expression [9]
Regulator of G-protein signaling 1 (RGS1) OTGXJYMG RGS1_HUMAN Increases Expression [9]
Dystrophia myotonica WD repeat-containing protein (DMWD) OT0CBZ6F DMWD_HUMAN Increases Expression [9]
Histone acetyltransferase p300 (EP300) OTL8QJDX EP300_HUMAN Decreases Expression [9]
Dihydropyrimidine dehydrogenase (DPYD) OTWRF2NR DPYD_HUMAN Decreases Expression [9]
Tyrosine-protein phosphatase non-receptor type 13 (PTPN13) OTESFZSO PTN13_HUMAN Decreases Expression [9]
Rho GTPase-activating protein 5 (ARHGAP5) OTOQELUN RHG05_HUMAN Decreases Expression [9]
MAL-like protein (MALL) OTKGZ89D MALL_HUMAN Increases Expression [9]
TNF receptor-associated factor 1 (TRAF1) OTTLM5RU TRAF1_HUMAN Decreases Expression [9]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [9]
Cyclin-dependent kinase 5 activator 2 (CDK5R2) OTNUTLPU CD5R2_HUMAN Increases Expression [9]
Centromere protein R (ITGB3BP) OT6Q7GR3 CENPR_HUMAN Decreases Expression [9]
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) OTPLXCDN DYR1A_HUMAN Decreases Expression [9]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [9]
Krueppel-like factor 9 (KLF9) OTBFEJRQ KLF9_HUMAN Increases Expression [9]
Cyclin-dependent kinase 13 (CDK13) OT3P7JF1 CDK13_HUMAN Decreases Expression [9]
Protein Tob2 (TOB2) OTEEHL60 TOB2_HUMAN Increases Expression [9]
Serine/threonine-protein kinase 38 (STK38) OTKMYCYR STK38_HUMAN Increases Expression [9]
Retinoblastoma-binding protein 5 (RBBP5) OT12W2MK RBBP5_HUMAN Decreases Expression [9]
Receptor tyrosine-protein kinase erbB-4 (ERBB4) OT9L6C41 ERBB4_HUMAN Increases Expression [9]
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2) OTRHB9SR NHRF2_HUMAN Increases Expression [9]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) OTBOSJHO TRADD_HUMAN Increases Expression [9]
Nuclear receptor coactivator 1 (NCOA1) OTLIUJQD NCOA1_HUMAN Increases Expression [9]
Tubulin-specific chaperone C (TBCC) OTBF0X8R TBCC_HUMAN Increases Expression [9]
Cyclin-dependent kinase inhibitor 3 (CDKN3) OTBE3H07 CDKN3_HUMAN Decreases Expression [9]
Receptor-type tyrosine-protein phosphatase-like N (PTPRN) OTAP7NOL PTPRN_HUMAN Increases Expression [9]
B-cell CLL/lymphoma 7 protein family member A (BCL7A) OTYFUJTP BCL7A_HUMAN Increases Expression [9]
Transmembrane protein 41B (TMEM41B) OTW0B0KS TM41B_HUMAN Decreases Expression [9]
Transcription initiation factor TFIID subunit 2 (TAF2) OTTIGJ9M TAF2_HUMAN Decreases Expression [9]
DNA cross-link repair 1A protein (DCLRE1A) OT68PVSD DCR1A_HUMAN Decreases Expression [9]
C-myc promoter-binding protein (DENND4A) OT8FFZ29 MYCPP_HUMAN Decreases Expression [9]
COMM domain-containing protein 6 (COMMD6) OTRZQJFW COMD6_HUMAN Increases Expression [9]
Bone morphogenetic protein 8A (BMP8A) OT1997IN BMP8A_HUMAN Increases Expression [9]
Pleckstrin homology domain-containing family H member 3 (PLEKHH3) OTREOQBO PKHH3_HUMAN Increases Expression [9]
DNA damage-binding protein 2 (DDB2) OTO8HVVB DDB2_HUMAN Increases Expression [9]
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) OTMDVWPS DYRK2_HUMAN Decreases Expression [9]
Histone H2A type 1-C (H2AC6) OTF3YK7V H2A1C_HUMAN Decreases Expression [9]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Decreases Expression [9]
Sorting nexin-18 (SNX18) OT68KT3X SNX18_HUMAN Decreases Expression [9]
Oncostatin-M-specific receptor subunit beta (OSMR) OTORWHPL OSMR_HUMAN Increases Expression [9]
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) OTQR6ENW M3K5_HUMAN Decreases Expression [9]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [9]
Ubiquitin-like-conjugating enzyme ATG10 (ATG10) OTVRPC5X ATG10_HUMAN Decreases Expression [9]
Serine/threonine-protein kinase PLK3 (PLK3) OT19CT2Z PLK3_HUMAN Increases Expression [9]
E3 ubiquitin-protein ligase Topors (TOPORS) OT1ERFFQ TOPRS_HUMAN Decreases Expression [9]
Serine/threonine-protein kinase PLK2 (PLK2) OTKMJXJ8 PLK2_HUMAN Increases Expression [9]
Gamma-adducin (ADD3) OTDRSHAZ ADDG_HUMAN Decreases Expression [9]
Targeting protein for Xklp2 (TPX2) OTWLJYH0 TPX2_HUMAN Decreases Expression [9]
Protocadherin gamma-C3 (PCDHGC3) OTDXTUMI PCDGK_HUMAN Increases Expression [9]
Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) OTDCNTC3 PTN22_HUMAN Increases Expression [9]
Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1) OTBV52DR SMHD1_HUMAN Decreases Expression [10]
Serine/threonine-protein kinase Sgk1 (SGK1) OT301T1U SGK1_HUMAN Increases Expression [10]
Matrilin-2 (MATN2) OTVDR68G MATN2_HUMAN Increases Expression [10]
Krev interaction trapped protein 1 (KRIT1) OT58AP1I KRIT1_HUMAN Decreases Expression [10]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Decreases Expression [10]
Calmegin (CLGN) OTEWVFQV CLGN_HUMAN Increases Expression [10]
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) OTB3BFCV HNRDL_HUMAN Decreases Expression [10]
Centrosomal protein of 290 kDa (CEP290) OTVN52VH CE290_HUMAN Decreases Expression [10]
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28) OTRBREQ9 ANR28_HUMAN Decreases Expression [10]
FYN-binding protein 1 (FYB1) OT6345CH FYB1_HUMAN Decreases Expression [10]
Protein phosphatase 1D (PPM1D) OT8NLZ9D PPM1D_HUMAN Increases Expression [10]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Decreases Expression [10]
Krueppel-like factor 4 (KLF4) OT4O9RQW KLF4_HUMAN Increases Expression [10]
Density-regulated protein (DENR) OTXP9HOY DENR_HUMAN Decreases Expression [10]
E3 ubiquitin-protein ligase MARCHF6 (MARCHF6) OTBTA03N MARH6_HUMAN Increases Expression [10]
Oligophrenin-1 (OPHN1) OTDURZAV OPHN1_HUMAN Increases Expression [10]
NEDD4-binding protein 1 (N4BP1) OTN2TL6N N4BP1_HUMAN Decreases Expression [10]
Ankyrin repeat domain-containing protein 17 (ANKRD17) OTQ3DYEP ANR17_HUMAN Decreases Expression [10]
Nuclear receptor corepressor 1 (NCOR1) OT04XNOU NCOR1_HUMAN Decreases Expression [10]
Death effector domain-containing protein (DEDD) OTIL349E DEDD_HUMAN Decreases Expression [10]
Glutaredoxin-3 (GLRX3) OTUPAU1N GLRX3_HUMAN Affects Expression [10]
Tubulin polymerization-promoting protein (TPPP) OTCFMSUF TPPP_HUMAN Increases Expression [10]
Protein transport protein Sec31A (SEC31A) OT2U42AC SC31A_HUMAN Decreases Expression [10]
SR-related and CTD-associated factor 4 (SCAF4) OTFGHB1E SCAF4_HUMAN Decreases Expression [10]
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) OT9QIHEQ RECK_HUMAN Increases Expression [10]
Tissue-type plasminogen activator (PLAT) OTQPDNAB TPA_HUMAN Decreases Expression [10]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Decreases Expression [10]
HLA class I histocompatibility antigen, B alpha chain (HLA-B) OTNXFWY2 HLAB_HUMAN Decreases Expression [10]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1) OTRGGIFP DRB1_HUMAN Increases Expression [10]
Myelin basic protein (MBP) OTFZCEDB MBP_HUMAN Decreases Expression [10]
Fibronectin (FN1) OTB5ZN4Q FINC_HUMAN Increases Expression [10]
Albumin (ALB) OTVMM513 ALBU_HUMAN Decreases Expression [10]
Transferrin receptor protein 1 (TFRC) OT8ZPBDL TFR1_HUMAN Increases Expression [10]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Decreases Expression [10]
Transcription factor Sp1 (SP1) OTISPT4X SP1_HUMAN Decreases Expression [10]
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) OTIRPN6B ROA1_HUMAN Decreases Expression [10]
U2 small nuclear ribonucleoprotein A' (SNRPA1) OTWJZFAP RU2A_HUMAN Decreases Expression [10]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Increases Expression [10]
Chorionic somatomammotropin hormone 2 (CSH2) OTW8JVAN CSH2_HUMAN Decreases Expression [10]
Tissue factor pathway inhibitor (TFPI) OTA0FX16 TFPI1_HUMAN Decreases Expression [10]
Breakpoint cluster region protein (BCR) OTCN76C1 BCR_HUMAN Decreases Expression [10]
Interferon-induced transmembrane protein 1 (IFITM1) OTECO1G8 IFM1_HUMAN Increases Expression [10]
HLA class II histocompatibility antigen, DR beta 4 chain (HLA-DRB4) OTNXIHQU DRB4_HUMAN Increases Expression [10]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Decreases Expression [10]
Arylsulfatase B (ARSB) OTTYDDNU ARSB_HUMAN Decreases Expression [10]
Carboxypeptidase E (CPE) OTXNTV79 CBPE_HUMAN Increases Expression [10]
Integrin alpha-2 (ITGA2) OTPFL017 ITA2_HUMAN Increases Expression [10]
Gap junction alpha-1 protein (GJA1) OTT94MKL CXA1_HUMAN Affects Expression [10]
Peptidyl-glycine alpha-amidating monooxygenase (PAM) OTX8HV5B AMD_HUMAN Decreases Expression [10]
Glutathione hydrolase 1 proenzyme (GGT1) OTYDA1Z7 GGT1_HUMAN Decreases Expression [10]
Ras GTPase-activating protein 1 (RASA1) OTZJ3LP4 RASA1_HUMAN Decreases Expression [10]
Synaptotagmin-1 (SYT1) OTVTPOI6 SYT1_HUMAN Decreases Expression [10]
Receptor-type tyrosine-protein phosphatase gamma (PTPRG) OT9N2WOF PTPRG_HUMAN Decreases Expression [10]
Paired box protein Pax-7 (PAX7) OTDMQRPO PAX7_HUMAN Decreases Expression [10]
Annexin A13 (ANXA13) OTM33P73 ANX13_HUMAN Decreases Expression [10]
Lens fiber major intrinsic protein (MIP) OTEBLU3E MIP_HUMAN Decreases Expression [10]
Fibroblast growth factor 9 (FGF9) OT2SKDGM FGF9_HUMAN Decreases Expression [10]
Glycerol kinase (GK) OTK2YRA0 GLPK_HUMAN Decreases Expression [10]
Cystathionine gamma-lyase (CTH) OTC90LA0 CGL_HUMAN Increases Expression [10]
Myosin-10 (MYH10) OTXN2WXS MYH10_HUMAN Decreases Expression [10]
Large ribosomal subunit protein uL4 (RPL4) OTTYJB0X RL4_HUMAN Decreases Expression [10]
T-complex protein 1 subunit zeta (CCT6A) OTCYWL5F TCPZ_HUMAN Decreases Expression [10]
Reduced folate transporter (SLC19A1) OTWB0BTO S19A1_HUMAN Decreases Expression [10]
Matrin-3 (MATR3) OTESJ5S7 MATR3_HUMAN Decreases Expression [10]
Transcriptional regulator ATRX (ATRX) OT77RSQW ATRX_HUMAN Decreases Expression [10]
Vesicle-fusing ATPase (NSF) OTKRJ2ZT NSF_HUMAN Decreases Expression [10]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Decreases Expression [10]
Nuclear pore complex protein Nup153 (NUP153) OTCAS0AR NU153_HUMAN Decreases Expression [10]
Gastrotropin (FABP6) OTIRQWLW FABP6_HUMAN Increases Expression [10]
Host cell factor 1 (HCFC1) OT0UCK62 HCFC1_HUMAN Decreases Expression [10]
Collagen alpha-4(IV) chain (COL4A4) OT9G0MCT CO4A4_HUMAN Decreases Expression [10]
Coatomer subunit alpha (COPA) OTZ1DTXU COPA_HUMAN Increases Expression [10]
Cadherin-4 (CDH4) OT8LH3HN CADH4_HUMAN Decreases Expression [10]
C-terminal-binding protein 2 (CTBP2) OTGZGT87 CTBP2_HUMAN Decreases Expression [10]
ADP-ribosylation factor-like protein 4C (ARL4C) OTQ3QNNU ARL4C_HUMAN Increases Expression [10]
Epiplakin (EPPK1) OT7BAU8C EPIPL_HUMAN Increases Expression [10]
Lysyl oxidase homolog 3 (LOXL3) OTLLY1QI LOXL3_HUMAN Decreases Expression [10]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Decreases Expression [10]
AP-2 complex subunit beta (AP2B1) OTL6LZJ4 AP2B1_HUMAN Decreases Expression [10]
Hemoglobin subunit gamma-1 (HBG1) OTVL4NSU HBG1_HUMAN Decreases Expression [10]
Mothers against decapentaplegic homolog 3 (SMAD3) OTNA96MR SMAD3_HUMAN Decreases Expression [10]
ADP-ribosylation factor 1 (ARF1) OT5C4C3L ARF1_HUMAN Decreases Expression [10]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Affects Expression [10]
Clathrin heavy chain 1 (CLTC) OTBFASMA CLH1_HUMAN Decreases Expression [10]
Centromere-associated protein E (CENPE) OTQ7AP04 CENPE_HUMAN Decreases Expression [10]
Paired box protein Pax-5 (PAX5) OTYBJJWX PAX5_HUMAN Decreases Expression [10]
Dystonin (DST) OTHZBM4X DYST_HUMAN Decreases Expression [10]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Decreases Expression [10]
Recombining binding protein suppressor of hairless (RBPJ) OTD7CUG0 SUH_HUMAN Decreases Expression [10]
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) OT5GO2PL KHDR1_HUMAN Decreases Expression [10]
Protein phosphatase 3 catalytic subunit alpha (PPP3CA) OT58PUEN PP2BA_HUMAN Decreases Expression [10]
Leukocyte surface antigen CD47 (CD47) OTLDZ0KZ CD47_HUMAN Increases Expression [10]
Transmembrane protein 267 (TMEM267) OTEAAVK7 TM267_HUMAN Decreases Expression [10]
Proline-rich nuclear receptor coactivator 1 (PNRC1) OTQMLEE1 PNRC1_HUMAN Increases Expression [10]
Alpha-globin transcription factor CP2 (TFCP2) OTA246TE TFCP2_HUMAN Decreases Expression [10]
Disks large homolog 1 (DLG1) OTCRZYWT DLG1_HUMAN Decreases Expression [10]
Serine/threonine-protein kinase 4 (STK4) OTBRYNNH STK4_HUMAN Decreases Expression [10]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Decreases Expression [10]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Decreases Expression [10]
BMP and activin membrane-bound inhibitor homolog (BAMBI) OTCEJ8W5 BAMBI_HUMAN Increases Expression [10]
Dynactin subunit 2 (DCTN2) OTMB4IXD DCTN2_HUMAN Increases Expression [10]
Cullin-4A (CUL4A) OTTBV70J CUL4A_HUMAN Decreases Expression [10]
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) OT5UO1FA HNRPD_HUMAN Decreases Expression [10]
Guanine nucleotide-binding protein subunit alpha-13 (GNA13) OTVDL515 GNA13_HUMAN Increases Expression [10]
Disco-interacting protein 2 homolog A (DIP2A) OTXPTR8R DIP2A_HUMAN Decreases Expression [10]
Uncharacterized protein KIAA0040 (KIAA0040) OT27EBY3 K0040_HUMAN Increases Expression [10]
Kinesin-like protein KIF14 (KIF14) OTXHT4JM KIF14_HUMAN Decreases Expression [10]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI) OTR443C5 BGH3_HUMAN Decreases Expression [10]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Increases Expression [10]
MICOS complex subunit MIC60 (IMMT) OTBDSLE7 MIC60_HUMAN Affects Expression [10]
WD40 repeat-containing protein SMU1 (SMU1) OTLCSLGL SMU1_HUMAN Decreases Expression [10]
Neuroblastoma breakpoint family member 1 (NBPF1) OTAZ55UQ NBPF1_HUMAN Decreases Expression [10]
Cell adhesion molecule-related/down-regulated by oncogenes (CDON) OT81X593 CDON_HUMAN Decreases Expression [10]
Protein LBH (LBH) OT87AT1X LBH_HUMAN Decreases Expression [10]
Shugoshin 2 (SGO2) OTNGJDS8 SGO2_HUMAN Decreases Expression [10]
PAN2-PAN3 deadenylation complex subunit PAN3 (PAN3) OTYBA69S PAN3_HUMAN Decreases Expression [10]
Sterile alpha motif domain-containing protein 9 (SAMD9) OTDG48P0 SAMD9_HUMAN Increases Expression [10]
Serine/threonine-protein phosphatase 4 regulatory subunit 3B (PPP4R3B) OT1VTUL9 P4R3B_HUMAN Decreases Expression [10]
Acyl-coenzyme A thioesterase THEM4 (THEM4) OTSIZU8Y THEM4_HUMAN Decreases Expression [10]
MAGUK p55 subfamily member 7 (MPP7) OT3G3HTZ MPP7_HUMAN Increases Expression [10]
DDB1- and CUL4-associated factor 8 (DCAF8) OT3VFSLG DCAF8_HUMAN Decreases Expression [10]
Collagen alpha-1(XIII) chain (COL13A1) OTM9IM6J CODA1_HUMAN Increases Expression [10]
Probable E3 ubiquitin-protein ligase HECTD2 (HECTD2) OTDIBGQV HECD2_HUMAN Decreases Expression [10]
Serine/threonine-protein kinase MRCK alpha (CDC42BPA) OTCPFOSA MRCKA_HUMAN Decreases Expression [10]
Rho GTPase-activating protein SYDE2 (SYDE2) OTOEIXSM SYDE2_HUMAN Increases Expression [10]
Deubiquitinase MYSM1 (MYSM1) OTO73N00 MYSM1_HUMAN Decreases Expression [10]
AT-rich interactive domain-containing protein 2 (ARID2) OTIRJXWM ARID2_HUMAN Decreases Expression [10]
Glucose 1,6-bisphosphate synthase (PGM2L1) OTSBNRT5 PGM2L_HUMAN Increases Expression [10]
UPF0547 protein C16orf87 (C16ORF87) OT658H5A CP087_HUMAN Decreases Expression [10]
Kelch-like protein 24 (KLHL24) OTWZSX5C KLH24_HUMAN Increases Expression [10]
Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) OTV01EFP C1TM_HUMAN Decreases Expression [10]
Rho-related GTP-binding protein RhoU (RHOU) OTERIAD4 RHOU_HUMAN Increases Expression [10]
Protein ABHD13 (ABHD13) OTF2E8M6 ABHDD_HUMAN Decreases Expression [10]
G2/M phase-specific E3 ubiquitin-protein ligase (G2E3) OT06BFRQ G2E3_HUMAN Decreases Expression [10]
Diphthine--ammonia ligase (DPH6) OTOJ7BXR DPH6_HUMAN Decreases Expression [10]
Pogo transposable element with ZNF domain (POGZ) OT4CYWC1 POGZ_HUMAN Decreases Expression [10]
FERM domain-containing protein 5 (FRMD5) OTC73XJK FRMD5_HUMAN Decreases Expression [10]
Phosphatidylinositol-glycan biosynthesis class W protein (PIGW) OTT9SMTF PIGW_HUMAN Decreases Expression [10]
Amphoterin-induced protein 2 (AMIGO2) OTPAIT1O AMGO2_HUMAN Increases Expression [10]
Dihydrofolate reductase 2, mitochondrial (DHFR2) OTPHUWEY DYR2_HUMAN Decreases Expression [10]
ELKS/Rab6-interacting/CAST family member 1 (ERC1) OTYBGGNO RB6I2_HUMAN Decreases Expression [10]
Armadillo repeat-containing protein 8 (ARMC8) OTNAXGM7 ARMC8_HUMAN Decreases Expression [10]
Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) OTNJX38T M4K3_HUMAN Decreases Expression [10]
Protein FAM219A (FAM219A) OTAFZHY9 F219A_HUMAN Decreases Expression [10]
Homeobox protein Mohawk (MKX) OT7H7Z50 MKX_HUMAN Decreases Expression [10]
Threonine synthase-like 1 (THNSL1) OTQNFH3E THNS1_HUMAN Decreases Expression [10]
Porimin (TMEM123) OTDMVZD6 PORIM_HUMAN Decreases Expression [10]
Rho guanine nucleotide exchange factor 39 (ARHGEF39) OT9UKTQ5 ARG39_HUMAN Decreases Expression [10]
Type 2 DNA topoisomerase 6 subunit B-like (TOP6BL) OTCYPUNK TO6BL_HUMAN Increases Expression [10]
Protein SCAI (SCAI) OTAK3TMO SCAI_HUMAN Decreases Expression [10]
Diacylglycerol lipase-beta (DAGLB) OT1S9869 DGLB_HUMAN Decreases Expression [10]
Regulator of G-protein signaling 22 (RGS22) OTCTFGW6 RGS22_HUMAN Decreases Expression [10]
Phospholipase DDHD1 (DDHD1) OTWTHOWK DDHD1_HUMAN Decreases Expression [10]
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) OTCV7AGV PCAT1_HUMAN Decreases Expression [10]
Biorientation of chromosomes in cell division protein 1-like 1 (BOD1L1) OTTD5FJ8 BD1L1_HUMAN Decreases Expression [10]
Atlastin-2 (ATL2) OT93AUOO ATLA2_HUMAN Increases Expression [10]
Centrosomal protein of 192 kDa (CEP192) OTBLFV7T CE192_HUMAN Decreases Expression [10]
DEP domain-containing protein 1B (DEPDC1B) OTMVFOT1 DEP1B_HUMAN Decreases Expression [10]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Decreases Expression [10]
Microprocessor complex subunit DGCR8 (DGCR8) OT62LXE4 DGCR8_HUMAN Decreases Expression [10]
Tribbles homolog 2 (TRIB2) OTHSX3MX TRIB2_HUMAN Affects Expression [10]
Protein FAM3C (FAM3C) OTBR6U9G FAM3C_HUMAN Decreases Expression [10]
CREB-binding protein (CREBBP) OTPA4QGM CBP_HUMAN Decreases Expression [10]
Histone acetyltransferase KAT2B (KAT2B) OTWQITWK KAT2B_HUMAN Increases Expression [10]
Homeobox protein DLX-4 (DLX4) OTLWVCN4 DLX4_HUMAN Increases Expression [10]
Protein tyrosine phosphatase type IVA 1 (PTP4A1) OTK0NFXJ TP4A1_HUMAN Decreases Expression [10]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Increases Expression [10]
Exocyst complex component 4 (EXOC4) OT5EWXAN EXOC4_HUMAN Decreases Expression [10]
RalBP1-associated Eps domain-containing protein 1 (REPS1) OTX4ERRK REPS1_HUMAN Decreases Expression [10]
Protein LTV1 homolog (LTV1) OTZILJDI LTV1_HUMAN Decreases Expression [10]
PDZ and LIM domain protein 5 (PDLIM5) OTLQVV22 PDLI5_HUMAN Decreases Expression [10]
DISP complex protein LRCH3 (LRCH3) OTDLBLMU LRCH3_HUMAN Decreases Expression [10]
Rho GTPase-activating protein 7 (DLC1) OTP8LMCR RHG07_HUMAN Decreases Expression [10]
Tribbles homolog 1 (TRIB1) OTPEO17G TRIB1_HUMAN Increases Expression [10]
Mitochondrial inner membrane protease subunit 2 (IMMP2L) OT9WGAFD IMP2L_HUMAN Decreases Expression [10]
Transcription factor 12 (TCF12) OTZVONNU HTF4_HUMAN Decreases Expression [10]
ATP synthase subunit s, mitochondrial (DMAC2L) OT2OQ1UD ATP5S_HUMAN Decreases Expression [10]
Semaphorin-3C (SEMA3C) OTEGUY7F SEM3C_HUMAN Increases Expression [10]
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (DPH2) OT9P91XR DPH2_HUMAN Decreases Expression [10]
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) OTB78IF4 ODC_HUMAN Decreases Expression [10]
Deubiquitinase DESI2 (DESI2) OTHUOKOC DESI2_HUMAN Decreases Expression [10]
Acireductone dioxygenase (ADI1) OT8IOD03 MTND_HUMAN Decreases Expression [10]
Protein C1orf43 (C1ORF43) OTT9CVZR CA043_HUMAN Decreases Expression [10]
RNA-binding protein 24 (RBM24) OTQI1AR1 RBM24_HUMAN Increases Expression [10]
Nucleolar and spindle-associated protein 1 (NUSAP1) OT85HIJ5 NUSAP_HUMAN Decreases Expression [10]
E3 ubiquitin-protein ligase TRIM9 (TRIM9) OTKYG33W TRIM9_HUMAN Increases Expression [10]
E3 ubiquitin-protein ligase TRIM4 (TRIM4) OTLKQNKQ TRIM4_HUMAN Increases Expression [10]
Histone-lysine N-methyltransferase SETD5 (SETD5) OTRPAVEO SETD5_HUMAN Decreases Expression [10]
Alpha-ketoglutarate-dependent dioxygenase FTO (FTO) OTXML85Y FTO_HUMAN Decreases Expression [10]
Centrosomal protein of 295 kDa (CEP295) OTVTTXRO CE295_HUMAN Decreases Expression [10]
Sentrin-specific protease 6 (SENP6) OT05LLF4 SENP6_HUMAN Decreases Expression [10]
Cytochrome c oxidase assembly factor 1 homolog (COA1) OTHSX40F COA1_HUMAN Decreases Expression [10]
Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19) OTH88TXU ADA19_HUMAN Increases Expression [10]
Pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2) OTXV0ZD0 PHS2_HUMAN Decreases Expression [10]
Metal transporter CNNM2 (CNNM2) OTZHO8WU CNNM2_HUMAN Increases Expression [10]
Pleckstrin homology domain-containing family A member 5 (PLEKHA5) OT2MNW8T PKHA5_HUMAN Decreases Expression [10]
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) OTQDHSMI MCCB_HUMAN Decreases Expression [10]
E3 ubiquitin-protein ligase SMURF1 (SMURF1) OT5UIZR8 SMUF1_HUMAN Affects Expression [10]
Large ribosomal subunit protein mL65 (MRPS30) OTDXIAGG RT30_HUMAN Decreases Expression [10]
Transcription factor 7-like 2 (TCF7L2) OTVWPZ8B TF7L2_HUMAN Decreases Expression [10]
Muscleblind-like protein 1 (MBNL1) OTOV7J85 MBNL1_HUMAN Decreases Expression [10]
Lymphoid-specific helicase (HELLS) OTVVV668 HELLS_HUMAN Decreases Expression [10]
Phenylalanine--tRNA ligase beta subunit (FARSB) OT8N9TT5 SYFB_HUMAN Decreases Expression [10]
Midasin (MDN1) OTNBSPTW MDN1_HUMAN Affects Expression [10]
tRNA:m(4)X modification enzyme TRM13 homolog (TRMT13) OT2H0MCE TRM13_HUMAN Decreases Expression [10]
E3 ubiquitin-protein ligase RLIM (RLIM) OTEBRNHJ RNF12_HUMAN Decreases Expression [10]
G patch domain-containing protein 2-like (GPATCH2L) OTETUZ64 GPT2L_HUMAN Decreases Expression [10]
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) OTFOJUIQ PHAG1_HUMAN Increases Expression [10]
Huntingtin-interacting protein K (HYPK) OTRWRVWN HYPK_HUMAN Affects Expression [10]
Inhibitor of growth protein 3 (ING3) OTDIJXFP ING3_HUMAN Decreases Expression [10]
Rho guanine nucleotide exchange factor 12 (ARHGEF12) OTM2D3LT ARHGC_HUMAN Decreases Expression [10]
Cysteine-rich motor neuron 1 protein (CRIM1) OTTZNV6Y CRIM1_HUMAN Decreases Expression [10]
Voltage-dependent T-type calcium channel subunit alpha-1I (CACNA1I) OTRH8X8A CAC1I_HUMAN Decreases Expression [10]
eIF-2-alpha kinase GCN2 (EIF2AK4) OTLE1JY8 E2AK4_HUMAN Affects Expression [10]
DNA polymerase kappa (POLK) OTKZ38JH POLK_HUMAN Decreases Expression [10]
Mediator of RNA polymerase II transcription subunit 13 (MED13) OTP5LEJE MED13_HUMAN Decreases Expression [10]
Jupiter microtubule associated homolog 1 (JPT1) OT6CRZEU JUPI1_HUMAN Decreases Expression [10]
BTB/POZ domain-containing protein 3 (BTBD3) OTZ607YT BTBD3_HUMAN Decreases Expression [10]
Thyroid hormone receptor-associated protein 3 (THRAP3) OTG25JOG TR150_HUMAN Decreases Expression [10]
rRNA-processing protein FCF1 homolog (FCF1) OTTI9M2D FCF1_HUMAN Affects Expression [10]
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1) OTBCIBC7 SAMH1_HUMAN Affects Expression [10]
Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (HS3ST3B1) OTK53GUD HS3SB_HUMAN Increases Expression [10]
Calcineurin-binding protein cabin-1 (CABIN1) OT4G5CIK CABIN_HUMAN Decreases Expression [10]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1) OTY8J0S4 ZNT1_HUMAN Decreases Expression [10]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Increases Phosphorylation [33]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [34]
Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9) OTM2T1FI COQ9_HUMAN Decreases Expression [12]
Interleukin-33 (IL33) OTT5YWK3 IL33_HUMAN Increases Expression [35]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Increases Phosphorylation [36]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Increases Expression [35]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Decreases Secretion [37]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Increases Secretion [38]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Expression [39]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [36]
Protein kinase C beta type (PRKCB) OTYQ0656 KPCB_HUMAN Increases Phosphorylation [38]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Affects Expression [40]
DNA excision repair protein ERCC-1 (ERCC1) OTNPYQHI ERCC1_HUMAN Decreases Expression [11]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [35]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Expression [41]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [38]
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Increases Expression [38]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Decreases Expression [42]
Protein kinase C alpha type (PRKCA) OT5UWNRD KPCA_HUMAN Increases Phosphorylation [38]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Increases Activity [39]
3-mercaptopyruvate sulfurtransferase (MPST) OTCDPH5D THTM_HUMAN Decreases Expression [12]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [43]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Increases Expression [12]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Increases Expression [35]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Decreases Expression [35]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [44]
Protein kinase C iota type (PRKCI) OTKBAVT3 KPCI_HUMAN Increases Phosphorylation [38]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Increases Phosphorylation [43]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [45]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Decreases Expression [46]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Increases Expression [12]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Activity [34]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [36]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Decreases Expression [47]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Increases Expression [12]
DNA-dependent protein kinase catalytic subunit (PRKDC) OTJVS4EG PRKDC_HUMAN Increases Phosphorylation [48]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Activity [39]
Protein kinase C delta type (PRKCD) OTSEH90E KPCD_HUMAN Increases Phosphorylation [38]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Increases Expression [49]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [46]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Phosphorylation [36]
Transcription factor HES-1 (HES1) OT8P19W2 HES1_HUMAN Increases Activity [50]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [46]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Expression [35]
Extracellular tyrosine-protein kinase PKDCC (PKDCC) OTVXJR26 PKDCC_HUMAN Decreases Expression [12]
Pleckstrin homology-like domain family A member 2 (PHLDA2) OTMV9DPP PHLA2_HUMAN Increases Expression [12]
Docking protein 6 (DOK6) OTX55OIF DOK6_HUMAN Decreases Expression [12]
tRNA-splicing endonuclease subunit Sen2 (TSEN2) OT1UWYRI SEN2_HUMAN Decreases Expression [12]
Protein FAN (NSMAF) OTYNVZ23 FAN_HUMAN Decreases Expression [12]
Probable ATP-dependent RNA helicase DDX17 (DDX17) OTXRMMBP DDX17_HUMAN Decreases Expression [12]
F-box/WD repeat-containing protein 5 (FBXW5) OT5TQK3H FBXW5_HUMAN Increases Expression [12]
PRKC apoptosis WT1 regulator protein (PAWR) OTKY7W52 PAWR_HUMAN Decreases Expression [12]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Increases Expression [38]
Homeobox protein HMX1 (HMX1) OT65ZGE0 HMX1_HUMAN Increases Expression [12]
Abl interactor 2 (ABI2) OT8GIIS5 ABI2_HUMAN Decreases Expression [12]
Inhibitor of Bruton tyrosine kinase (IBTK) OTB2GM4G IBTK_HUMAN Decreases Expression [12]
SERTA domain-containing protein 1 (SERTAD1) OTBHKZQP SRTD1_HUMAN Increases Expression [12]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Decreases Response To Substance [51]
Phospholipid phosphatase 1 (PLPP1) OT0IIMI5 PLPP1_HUMAN Decreases Response To Substance [51]
DNA polymerase alpha catalytic subunit (POLA1) OT1WXFVY DPOLA_HUMAN Increases Response To Substance [51]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Response To Substance [52]
Collagen alpha-1(VII) chain (COL7A1) OT3MIRZJ CO7A1_HUMAN Decreases Response To Substance [51]
Integrin alpha-E (ITGAE) OT41KCRX ITAE_HUMAN Increases Response To Substance [51]
Nicastrin (NCSTN) OT5QBTA4 NICA_HUMAN Affects Response To Substance [50]
V-type proton ATPase 21 kDa proteolipid subunit c'' (ATP6V0B) OT8GTI1V VATO_HUMAN Increases Response To Substance [51]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Affects Response To Substance [53]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1) OT9HYT7A PLCB1_HUMAN Increases ADR [54]
DNA polymerase epsilon subunit 2 (POLE2) OTAC9V6L DPOE2_HUMAN Increases Response To Substance [51]
Protein DBF4 homolog A (DBF4) OTBL7JHQ DBF4A_HUMAN Increases Response To Substance [51]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Decreases Response To Substance [51]
Cell division cycle protein 20 homolog (CDC20) OTCOEZRV CDC20_HUMAN Increases Response To Substance [51]
RNA-binding motif, single-stranded-interacting protein 1 (RBMS1) OTD13PJN RBMS1_HUMAN Decreases Response To Substance [51]
S-phase kinase-associated protein 2 (SKP2) OTD5B41X SKP2_HUMAN Increases Response To Substance [51]
Pre-B-cell leukemia transcription factor-interacting protein 1 (PBXIP1) OTEAAUBY PBIP1_HUMAN Decreases Response To Substance [51]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Response To Substance [55]
DNA mismatch repair protein Mlh1 (MLH1) OTG5XDD8 MLH1_HUMAN Affects Response To Substance [53]
Origin recognition complex subunit 1 (ORC1) OTHWU8IJ ORC1_HUMAN Increases Response To Substance [51]
U6 snRNA-associated Sm-like protein LSm7 (LSM7) OTHZ2XPX LSM7_HUMAN Increases Response To Substance [51]
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) OTJC60Q7 THIL_HUMAN Increases Response To Substance [51]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Increases Response To Substance [51]
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Decreases Response To Substance [51]
Ras-related protein Rab-31 (RAB31) OTMLXQZ0 RAB31_HUMAN Decreases Response To Substance [51]
Copper-transporting ATPase 1 (ATP7A) OTMR3GXP ATP7A_HUMAN Decreases Response To Substance [56]
Plasma membrane calcium-transporting ATPase 4 (ATP2B4) OTMWFDAC AT2B4_HUMAN Decreases Response To Substance [51]
E3 ubiquitin-protein ligase CCNB1IP1 (CCNB1IP1) OTOTVMC8 CIP1_HUMAN Increases Response To Substance [51]
Protein FAM50B (FAM50B) OTP3H38A FA50B_HUMAN Increases ADR [57]
DNA fragmentation factor subunit beta (DFFB) OTPBW5N5 DFFB_HUMAN Increases Response To Substance [51]
ATP-binding cassette sub-family B member 6 (ABCB6) OTPGZFES ABCB6_HUMAN Decreases Response To Substance [58]
E3 ubiquitin-protein ligase RNF34 (RNF34) OTQY58LU RNF34_HUMAN Decreases Response To Substance [45]
DNA-directed RNA polymerase III subunit RPC7 (POLR3G) OTU3TGQ9 RPC7_HUMAN Increases Response To Substance [51]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Response To Substance [59]
NADPH--cytochrome P450 reductase (POR) OTVIDOCH NCPR_HUMAN Increases Response To Substance [28]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Decreases Response To Substance [60]
Phosphoserine aminotransferase (PSAT1) OTVV1YV9 SERC_HUMAN Increases Response To Substance [51]
Uncharacterized protein C8orf34 (C8ORF34) OTXCTHDG CH034_HUMAN Increases ADR [54]
Small nuclear ribonucleoprotein F (SNRPF) OTZE5W6G RUXF_HUMAN Increases Response To Substance [51]
Adenylate kinase 2, mitochondrial (AK2) OTZG3X2H KAD2_HUMAN Increases Response To Substance [51]
------------------------------------------------------------------------------------
⏷ Show the Full List of 469 DOT(s)
Indication(s) of Marizomib
Disease Entry ICD 11 Status REF
Glioblastoma of brain 2A00.00 Phase 3 [4]
Malignant glioma 2A00.0 Phase 1 [5]
Multiple myeloma 2A83 Phase 1 [5]
Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
Marizomib Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Proteasome (PS) TTU7ZMG NOUNIPROTAC Inhibitor [61]
------------------------------------------------------------------------------------

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