Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3786U)

Drug Name

F-12509A Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Arteriosclerosis	BD40	Terminated	[1]

Cross-matching ID

PubChem CID: 9862964
TTD Drug ID: DM3786U

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Approved Drug(s)

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Drug(s) Targeting Sphingosine kinase 1 (SPHK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenoxodiol	DMBUJVX	Ovarian cancer	2C73	Phase 1/2	[3]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[4]
PMID27539678-Compound-6	DMBKNDE	N. A.	N. A.	Patented	[5]
Methylbenzenesulfonamide derivative 1	DMUNME2	N. A.	N. A.	Patented	[5]
PMID27539678-Compound-12	DMNIKTA	N. A.	N. A.	Patented	[5]
PMID27539678-Compound-10	DM61SR0	N. A.	N. A.	Patented	[5]
PMID27539678-Compound-16	DMMDJH8	N. A.	N. A.	Patented	[5]
PMID27539678-Compound-14	DMZ02LA	N. A.	N. A.	Patented	[5]
PMID27539678-Compound-13	DM1J2V8	N. A.	N. A.	Patented	[5]
PMID27539678-Compound-11	DMIKAJC	N. A.	N. A.	Patented	[5]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[37]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[33]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[43]
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Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[6]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[7]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[8]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[9]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[10]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[12]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[13]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[14]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[15]
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Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[18]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[19]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[24]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[25]
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Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[28]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[29]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[32]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sphingosine kinase 1 (SPHK1)	TTOHFIY	SPHK1_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[2]
Cytochrome c (CYCS)	OTBFALJD	CYC_HUMAN	Protein Interaction/Cellular Processes	[2]
Diablo IAP-binding mitochondrial protein (DIABLO)	OTHJ9MCZ	DBLOH_HUMAN	Protein Interaction/Cellular Processes	[2]
E3 ubiquitin-protein ligase XIAP	OT24GP9B	XIAP_HUMAN	Gene/Protein Processing	[2]
Sphingosine kinase 1 (SPHK1)	OTWYPBVD	SPHK1_HUMAN	Gene/Protein Processing	[2]

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References

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