Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5LUED)

• Drug Name: 3-keto-lithocholic acid Drug Info
• Synonyms: dehydrolithocholic acid; 3-keto-LCA

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5283906
  ChEBI ID: CHEBI:17639
  CAS Number: CAS 1553-56-6
  TTD Drug ID: DM5LUED

Molecule-Related Drug Atlas

Drug(s) Targeting Vitamin D3 receptor (VDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[6]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[7]
Calcidiol	DMN4CV5	Hypophosphatemia		Approved	[6]
Doxercalciferol	DM6FG1P	Chronic kidney disease	GB61	Approved	[8]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[9]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[10]
Dihydrotachysterol	DMFB97P	Hypocalcemia	5B5K.1	Approved	[11]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[12]
Paricalcitol	DMYBV3G	Hyperparathyroidism	5A51	Approved	[13]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[14]

Drug(s) Targeting Pregnane X receptor (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
WAY-214950	DM8ODI7	Discovery agent	N.A.	Investigative	[15]
Hyperforin	DM2L3PE	Discovery agent	N.A.	Investigative	[16]
pregnenolone-16alpha-carbonitrile	DM0LW7G	Discovery agent	N.A.	Investigative	[17]
trihydroxycholestane	DMSP56N	Discovery agent	N.A.	Investigative	[18]
schisandrin A	DMWQ480	Discovery agent	N.A.	Investigative	[19]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[20]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[21]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[22]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[23]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[25]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[26]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[27]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[28]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 11 (DHRS11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[5]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[5]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[5]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[35]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Pregnane X receptor (NR1I2)	TT7LCTF	NR1I2_HUMAN	Agonist	[2]
Vitamin D3 receptor (VDR)	TTK59TV	VDR_HUMAN	Agonist	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Gene/Protein Processing	[4]
Dehydrogenase/reductase SDR family member 11 (DHRS11)	OTU3J0ZL	DHR11_HUMAN	Biotransformations	[5]

References

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