Details of the Drug

General Information of Drug (ID: DMF0NQR)

Drug Name
Eplerenone
Synonyms
Epoxymexrenone; Inspra; Selara; CGP-30083; Inspra (TN); SC-66110; Eplerenone (JAN/USAN/INN); Inspra, Epoxymexrenone, CGP30083, SC-66110,Eplerenone; 7alpha-methoxycarbonyl-3-oxo-9,11alpha-epoxy-17alpha-pregn-4-ene-21,17-carbolactone
Indication
Disease Entry ICD 11 Status REF
Heart failure BD10-BD13 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [2]
Therapeutic Class
Antihypertensive Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 414.5
Logarithm of the Partition Coefficient (xlogp) 1.4
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 6
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [3]
Bioavailability
69% of drug becomes completely available to its intended biological destination(s) [4]
Elimination
3% of drug is excreted from urine in the unchanged form [3]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 1.723 micromolar/kg/day [5]
Chemical Identifiers
Formula
C24H30O6
IUPAC Name
methyl (1R,2S,9R,10R,11S,14R,15S,17R)-2,15-dimethyl-5,5'-dioxospiro[18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadec-6-ene-14,2'-oxolane]-9-carboxylate
Canonical SMILES
C[C@]12CCC(=O)C=C1C[C@H]([C@@H]3[C@]24[C@H](O4)C[C@]5([C@H]3CC[C@@]56CCC(=O)O6)C)C(=O)OC
InChI
InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1
InChIKey
JUKPWJGBANNWMW-VWBFHTRKSA-N
Cross-matching ID
PubChem CID
443872
ChEBI ID
CHEBI:31547
CAS Number
107724-20-9
DrugBank ID
DB00700
TTD ID
D0Q4SD
INTEDE ID
DR0592
ACDINA ID
D00235
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Mineralocorticoid receptor (MR) TT26PHO MCR_HUMAN Modulator [6]
HUMAN mineralocorticoid receptor (MR) TT9P1CK MCR_HUMAN Antagonist [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [7]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Regulation of Drug Effects [8]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Regulation of Drug Effects [8]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Heart failure
ICD Disease Classification BD10-BD13
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Mineralocorticoid receptor (MR) DTT NR3C2 7.31E-01 -5.31E-04 -1.53E-03
Cytochrome P450 3A5 (CYP3A5) DME CYP3A5 8.58E-01 -3.73E-03 -1.00E-02
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 2.76E-01 -4.64E-01 -9.16E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Eplerenone (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Arn-509 DMT81LZ Minor Increased metabolism of Eplerenone caused by Arn-509 mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [9]
Dronedarone DMA8FS5 Major Decreased metabolism of Eplerenone caused by Dronedarone mediated inhibition of CYP450 enzyme. Angina pectoris [BA40] [10]
Posaconazole DMUL5EW Major Decreased metabolism of Eplerenone caused by Posaconazole mediated inhibition of CYP450 enzyme. Aspergillosis [1F20] [11]
Dalfopristin DM4LTKV Major Decreased metabolism of Eplerenone caused by Dalfopristin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [10]
Clarithromycin DM4M1SG Major Decreased metabolism of Eplerenone caused by Clarithromycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [11]
Troleandomycin DMUZNIG Major Decreased metabolism of Eplerenone caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [11]
Telithromycin DMZ4P3A Major Decreased metabolism of Eplerenone caused by Telithromycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [11]
Cariprazine DMJYDVK Moderate Additive hypotensive effects by the combination of Eplerenone and Cariprazine. Bipolar disorder [6A60] [12]
Phenylbutazone DMAYL0T Moderate Antagonize the effect of Eplerenone when combined with Phenylbutazone. Chronic pain [MG30] [13]
Ketoprofen DMRKXPT Moderate Increased risk of hyperkalemia by the combination of Eplerenone and Ketoprofen. Chronic pain [MG30] [13]
Mifepristone DMGZQEF Major Decreased metabolism of Eplerenone caused by Mifepristone mediated inhibition of CYP450 enzyme. Cushing syndrome [5A70] [14]
Ivacaftor DMZC1HS Moderate Decreased metabolism of Eplerenone caused by Ivacaftor mediated inhibition of CYP450 enzyme. Cystic fibrosis [CA25] [15]
MK-8228 DMOB58Q Major Decreased metabolism of Eplerenone caused by MK-8228 mediated inhibition of CYP450 enzyme. Cytomegaloviral disease [1D82] [10]
Nefazodone DM4ZS8M Major Decreased metabolism of Eplerenone caused by Nefazodone mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [11]
Selegiline DM6034S Moderate Additive hypotensive effects by the combination of Eplerenone and Selegiline. Depression [6A70-6A7Z] [16]
Isocarboxazid DMAF1NB Moderate Additive hypotensive effects by the combination of Eplerenone and Isocarboxazid. Depression [6A70-6A7Z] [16]
Tranylcypromine DMGB5RE Moderate Additive hypotensive effects by the combination of Eplerenone and Tranylcypromine. Depression [6A70-6A7Z] [16]
OPC-34712 DMHG57U Moderate Additive hypotensive effects by the combination of Eplerenone and OPC-34712. Depression [6A70-6A7Z] [12]
Phenelzine DMHIDUE Moderate Additive hypotensive effects by the combination of Eplerenone and Phenelzine. Depression [6A70-6A7Z] [16]
Primidone DM0WX6I Minor Increased metabolism of Eplerenone caused by Primidone mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [9]
Stiripentol DMMSDOY Major Decreased metabolism of Eplerenone caused by Stiripentol mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [10]
Fosphenytoin DMOX3LB Minor Increased metabolism of Eplerenone caused by Fosphenytoin mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [9]
Rufinamide DMWE60C Moderate Increased metabolism of Eplerenone caused by Rufinamide mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [17]
Phenobarbital DMXZOCG Minor Increased metabolism of Eplerenone caused by Phenobarbital mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [9]
Mefenamic acid DMK7HFI Moderate Antagonize the effect of Eplerenone when combined with Mefenamic acid. Female pelvic pain [GA34] [13]
Itraconazole DMCR1MV Major Decreased metabolism of Eplerenone caused by Itraconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [11]
Miconazole DMPMYE8 Moderate Decreased metabolism of Eplerenone caused by Miconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [18]
Ketoconazole DMPZI3Q Major Decreased metabolism of Eplerenone caused by Ketoconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [11]
Boceprevir DMBSHMF Major Decreased metabolism of Eplerenone caused by Boceprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [11]
Telaprevir DMMRV29 Major Decreased metabolism of Eplerenone caused by Telaprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [11]
Rifampin DMA8J1G Minor Increased metabolism of Eplerenone caused by Rifampin mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [11]
Procarbazine DMIK367 Moderate Additive hypotensive effects by the combination of Eplerenone and Procarbazine. Hodgkin lymphoma [2B30] [16]
Delavirdine DM3NF5G Major Decreased metabolism of Eplerenone caused by Delavirdine mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [11]
Fosamprenavir DM4W9B3 Major Decreased metabolism of Eplerenone caused by Fosamprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [11]
Cobicistat DM6L4H2 Major Decreased metabolism of Eplerenone caused by Cobicistat mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [11]
Saquinavir DMG814N Major Decreased metabolism of Eplerenone caused by Saquinavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [11]
Etravirine DMGV8QU Moderate Increased metabolism of Eplerenone caused by Etravirine mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [19]
Amprenavir DMLMXE0 Major Decreased metabolism of Eplerenone caused by Amprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [11]
Darunavir DMN3GCH Major Decreased metabolism of Eplerenone caused by Darunavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [10]
Atazanavir DMSYRBX Major Decreased metabolism of Eplerenone caused by Atazanavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [11]
Eprosartan DM07K2I Moderate Increased risk of hyperkalemia by the combination of Eplerenone and Eprosartan. Hypertension [BA00-BA04] [10]
Captopril DM458UM Moderate Increased risk of hyperkalemia by the combination of Eplerenone and Captopril. Hypertension [BA00-BA04] [10]
TAK-491 DMCF6SX Moderate Increased risk of hyperkalemia by the combination of Eplerenone and TAK-491. Hypertension [BA00-BA04] [10]
Perindopril DMOPZDT Moderate Increased risk of hyperkalemia by the combination of Eplerenone and Perindopril. Hypertension [BA00-BA04] [10]
Quinapril DMR8H31 Moderate Increased risk of hyperkalemia by the combination of Eplerenone and Quinapril. Hypertension [BA00-BA04] [10]
Telmisartan DMS3GX2 Moderate Increased risk of hyperkalemia by the combination of Eplerenone and Telmisartan. Hypertension [BA00-BA04] [10]
Irbesartan DMTP1DC Moderate Increased risk of hyperkalemia by the combination of Eplerenone and Irbesartan. Hypertension [BA00-BA04] [10]
Lisinopril DMUOK4C Moderate Increased risk of hyperkalemia by the combination of Eplerenone and Lisinopril. Hypertension [BA00-BA04] [10]
Potassium chloride DMMTAJC Major Increased risk of hyperkalemia by the combination of Eplerenone and Potassium chloride. Hypo-kalaemia [5C77] [20]
Conivaptan DM1V329 Major Decreased metabolism of Eplerenone caused by Conivaptan mediated inhibition of CYP450 enzyme. Hypo-osmolality/hyponatraemia [5C72] [11]
Tolvaptan DMIWFRL Moderate Increased risk of hyperkalemia by the combination of Eplerenone and Tolvaptan. Hypo-osmolality/hyponatraemia [5C72] [21]
Meclofenamic acid DM05FXR Moderate Antagonize the effect of Eplerenone when combined with Meclofenamic acid. Inflammatory spondyloarthritis [FA92] [22]
Berotralstat DMWA2DZ Major Decreased metabolism of Eplerenone caused by Berotralstat mediated inhibition of CYP450 enzyme. Innate/adaptive immunodeficiency [4A00] [10]
Propiomazine DMKY8V1 Moderate Additive hypotensive effects by the combination of Eplerenone and Propiomazine. Insomnia [7A00-7A0Z] [12]
ITI-007 DMUQ1DO Moderate Additive hypotensive effects by the combination of Eplerenone and ITI-007. Insomnia [7A00-7A0Z] [12]
Crizotinib DM4F29C Major Decreased metabolism of Eplerenone caused by Crizotinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [10]
Brigatinib DM7W94S Moderate Increased metabolism of Eplerenone caused by Brigatinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [23]
Ceritinib DMB920Z Major Decreased metabolism of Eplerenone caused by Ceritinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [11]
PF-06463922 DMKM7EW Moderate Increased metabolism of Eplerenone caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [24]
Selpercatinib DMZR15V Moderate Decreased metabolism of Eplerenone caused by Selpercatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [17]
Idelalisib DM602WT Major Decreased metabolism of Eplerenone caused by Idelalisib mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [11]
IPI-145 DMWA24P Major Decreased metabolism of Eplerenone caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [10]
Dabrafenib DMX6OE3 Moderate Increased metabolism of Eplerenone caused by Dabrafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [17]
Exjade DMHPRWG Moderate Decreased metabolism of Eplerenone caused by Exjade mediated inhibition of CYP450 enzyme. Mineral absorption/transport disorder [5C64] [25]
Ozanimod DMT6AM2 Moderate Additive hypotensive effects by the combination of Eplerenone and Ozanimod. Multiple sclerosis [8A40] [16]
Modafinil DMYILBE Minor Increased metabolism of Eplerenone caused by Modafinil mediated induction of CYP450 enzyme. Narcolepsy [7A20] [26]
Promethazine DM6I5GR Moderate Additive hypotensive effects by the combination of Eplerenone and Promethazine. Nausea/vomiting [MD90] [12]
Netupitant DMEKAYI Major Decreased metabolism of Eplerenone caused by Netupitant mediated inhibition of CYP450 enzyme. Nausea/vomiting [MD90] [10]
Naproxen DMZ5RGV Moderate Antagonize the effect of Eplerenone when combined with Naproxen. Osteoarthritis [FA00-FA05] [13]
Aspirin DM672AH Moderate Antagonize the effect of Eplerenone when combined with Aspirin. Pain [MG30-MG3Z] [22]
Etodolac DM6WJO9 Moderate Antagonize the effect of Eplerenone when combined with Etodolac. Pain [MG30-MG3Z] [13]
Diflunisal DM7EN8I Moderate Antagonize the effect of Eplerenone when combined with Diflunisal. Pain [MG30-MG3Z] [13]
Ibuprofen DM8VCBE Moderate Antagonize the effect of Eplerenone when combined with Ibuprofen. Pain [MG30-MG3Z] [13]
Safinamide DM0YWJC Moderate Additive hypotensive effects by the combination of Eplerenone and Safinamide. Parkinsonism [8A00] [16]
Rasagiline DM3WKQ4 Moderate Additive hypotensive effects by the combination of Eplerenone and Rasagiline. Parkinsonism [8A00] [16]
Abametapir DM2RX0I Moderate Decreased metabolism of Eplerenone caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [27]
Lefamulin DME6G97 Moderate Decreased metabolism of Eplerenone caused by Lefamulin mediated inhibition of CYP450 enzyme. Pneumonia [CA40] [28]
Choline salicylate DM8P137 Moderate Antagonize the effect of Eplerenone when combined with Choline salicylate. Postoperative inflammation [1A00-CA43] [13]
Bromfenac DMKB79O Moderate Antagonize the effect of Eplerenone when combined with Bromfenac. Postoperative inflammation [1A00-CA43] [13]
Lonafarnib DMGM2Z6 Major Decreased metabolism of Eplerenone caused by Lonafarnib mediated inhibition of CYP450 enzyme. Premature ageing appearance [LD2B] [11]
Enzalutamide DMGL19D Minor Increased metabolism of Eplerenone caused by Enzalutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [9]
Levomepromazine DMIKFEL Moderate Additive hypotensive effects by the combination of Eplerenone and Levomepromazine. Psychotic disorder [6A20-6A25] [12]
Temsirolimus DMS104F Moderate Increased plasma concentrations of Eplerenone and Temsirolimus due to competitive inhibition of the same metabolic pathway. Renal cell carcinoma [2C90] [29]
Salsalate DM13P4C Moderate Antagonize the effect of Eplerenone when combined with Salsalate. Rheumatoid arthritis [FA20] [13]
Meloxicam DM2AR7L Moderate Antagonize the effect of Eplerenone when combined with Meloxicam. Rheumatoid arthritis [FA20] [13]
Oxaprozin DM9UB0P Moderate Antagonize the effect of Eplerenone when combined with Oxaprozin. Rheumatoid arthritis [FA20] [13]
Flurbiprofen DMGN4BY Moderate Antagonize the effect of Eplerenone when combined with Flurbiprofen. Rheumatoid arthritis [FA20] [13]
Quetiapine DM1N62C Moderate Additive hypotensive effects by the combination of Eplerenone and Quetiapine. Schizophrenia [6A20] [12]
Mesoridazine DM2ZGAN Moderate Additive hypotensive effects by the combination of Eplerenone and Mesoridazine. Schizophrenia [6A20] [12]
Aripiprazole DM3NUMH Moderate Additive hypotensive effects by the combination of Eplerenone and Aripiprazole. Schizophrenia [6A20] [12]
Iloperidone DM6AUFY Moderate Additive hypotensive effects by the combination of Eplerenone and Iloperidone. Schizophrenia [6A20] [12]
Paliperidone DM7NPJS Moderate Additive hypotensive effects by the combination of Eplerenone and Paliperidone. Schizophrenia [6A20] [12]
Perphenazine DMA4MRX Moderate Additive hypotensive effects by the combination of Eplerenone and Perphenazine. Schizophrenia [6A20] [12]
Molindone DMAH70G Moderate Additive hypotensive effects by the combination of Eplerenone and Molindone. Schizophrenia [6A20] [12]
Thiothixene DMDINC4 Moderate Additive hypotensive effects by the combination of Eplerenone and Thiothixene. Schizophrenia [6A20] [12]
Trifluoperazine DMKBYWI Moderate Additive hypotensive effects by the combination of Eplerenone and Trifluoperazine. Schizophrenia [6A20] [12]
Risperidone DMN6DXL Moderate Additive hypotensive effects by the combination of Eplerenone and Risperidone. Schizophrenia [6A20] [12]
Amisulpride DMSJVAM Moderate Additive hypotensive effects by the combination of Eplerenone and Amisulpride. Schizophrenia [6A20] [12]
Asenapine DMSQZE2 Moderate Additive hypotensive effects by the combination of Eplerenone and Asenapine. Schizophrenia [6A20] [12]
Salicyclic acid DM2F8XZ Moderate Increased risk of hyperkalemia by the combination of Eplerenone and Salicyclic acid. Seborrhoeic dermatitis [EA81] [22]
Voxelotor DMCS6M5 Major Decreased metabolism of Eplerenone caused by Voxelotor mediated inhibition of CYP450 enzyme. Sickle-cell disorder [3A51] [10]
Telotristat ethyl DMDIYFZ Moderate Increased metabolism of Eplerenone caused by Telotristat ethyl mediated induction of CYP450 enzyme. Small intestine developmental anomaly [DA90] [17]
Larotrectinib DM26CQR Moderate Decreased metabolism of Eplerenone caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [11]
Armodafinil DMGB035 Minor Increased metabolism of Eplerenone caused by Armodafinil mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [26]
LEE011 DMMX75K Major Decreased metabolism of Eplerenone caused by LEE011 mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [10]
Pitolisant DM8RFNJ Moderate Increased metabolism of Eplerenone caused by Pitolisant mediated induction of CYP450 enzyme. Somnolence [MG42] [17]
Fostamatinib DM6AUHV Moderate Decreased metabolism of Eplerenone caused by Fostamatinib mediated inhibition of CYP450 enzyme. Thrombocytopenia [3B64] [30]
Sirolimus DMGW1ID Moderate Increased plasma concentrations of Eplerenone and Sirolimus due to competitive inhibition of the same metabolic pathway. Transplant rejection [NE84] [29]
Tacrolimus DMZ7XNQ Moderate Increased plasma concentrations of Eplerenone and Tacrolimus due to competitive inhibition of the same metabolic pathway. Transplant rejection [NE84] [20]
Methdilazine DMAUHQX Moderate Additive hypotensive effects by the combination of Eplerenone and Methdilazine. Vasomotor/allergic rhinitis [CA08] [12]
Trimeprazine DMEMV9D Moderate Additive hypotensive effects by the combination of Eplerenone and Trimeprazine. Vasomotor/allergic rhinitis [CA08] [31]
Amiodarone DMUTEX3 Major Decreased metabolism of Eplerenone caused by Amiodarone mediated inhibition of CYP450 enzyme. Ventricular tachyarrhythmia [BC71] [10]
⏷ Show the Full List of 112 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Hydrazine yellow E00409 164825 Colorant
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Sunset yellow FCF E00255 17730 Colorant
Beta-D-lactose E00099 6134 Diluent; Dry powder inhaler carrier; Lyophilization aid
Carmellose sodium E00625 Not Available Disintegrant
Eisenoxyd E00585 56841934 Colorant
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Polysorbate 80 E00665 Not Available Dispersing agent; Emollient; Emulsifying agent; Plasticizing agent; Solubilizing agent; Surfactant; Suspending agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Triacetin E00080 5541 Humectant; Plasticizing agent; Solvent
Vinylpyrrolidone E00668 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
⏷ Show the Full List of 14 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Eplerenone 25 mg tablet 25 mg Oral Tablet Oral
Eplerenone 50 mg tablet 50 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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