Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5NM6E)

Drug Name
NADH Drug Info
Synonyms
DPNH; Dihydrodiphosphopyridine nucleotide; Dihydronicotinamide adenine dinucleotide; Diphosphopyridine nucleotide reduced; NADH dianion; Nicotinamide adenine dinucleotide reduced; Reduced Nicotinamide Adenine Dinucleotide; NADH2; Beta-DPNH; Beta-NADH; Coenzyme I, reduced; Cozymase I, reduced; Diphosphopyridine nucleotide,reduced form; NAD-reduced; Nicotinamide adenine dinucleotide, reduced form; Reduced nicotinamide-adenine dinucleotide; Beta-Nicotinamide adenine dinucleotide, reduced dipotassium salt; NADH+H+; Nicotinaminde-Adenine-Dinucleotide; Adenosine pyrophosphate, 5'->5'-ester with 1,4-dihydro-1-beta-D-ribofuranosylnicotinamide (7CI); Adenosine 5'-(trihydrogen pyrophosphate), 5'->5'-ester with 1,4-dihydro-1-beta-D-ribofuranosylnicotinamide (8CI); Adenosine 5'-(trihydrogen diphosphate), P'->5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide (9CI); Adenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate}; Adenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] diphosphate}; [5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate; [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate; [(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-[[(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-phosphinic acid
Indication
Disease Entry ICD 11 Status REF
Parkinson disease 8A00.0 Approved [1]
Therapeutic Class
Dietary supplement
Cross-matching ID
PubChem CID
439153
ChEBI ID
CHEBI:16908
CAS Number
CAS 58-68-4
TTD Drug ID
DM5NM6E
INTEDE Drug ID
DR1123

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting NADH dehydrogenase (MT-ND3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
N-Formylmethionine DM7GBDX Discovery agent N.A. Investigative [8]
6-Thiophen-3-yl-imidazo[2,1-b]thiazole DM90VJ6 Discovery agent N.A. Investigative [9]
6-Thiophen-2-yl-imidazo[2,1-b]thiazole DMC013U Discovery agent N.A. Investigative [9]
Drug(s) Metabolized By Alcohol dehydrogenase class-V (ADH6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [10]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [11]
Drug(s) Metabolized By Aldo-keto reductase 1A1 (AKR1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [12]
Ethanol DMDRQZU Chronic pain MG30 Approved [10]
2,3-dihydroxypropanal DMOWNB4 Discovery agent N.A. Investigative [13]
Nitrobenzaldehyde DM4UHB5 N. A. N. A. Investigative [13]
D-glucuronate DM1YBTC N. A. N. A. Investigative [13]
BRN-0471734 DMZMWVX N. A. N. A. Investigative [13]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Metabolized By Alcohol dehydrogenase class-I alpha (ADH1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [14]
SILODOSIN DMJSBT6 Benign prostatic hyperplasia GA90 Approved [15]
Drug(s) Metabolized By Alcohol dehydrogenase class-I beta (ADH1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [14]
Drug(s) Metabolized By Gastric alcohol dehydrogenase (ADH7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [10]
Drug(s) Metabolized By Alcohol dehydrogenase class-III (ADH5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [10]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [16]
Drug(s) Metabolized By Diaphorase-1 (CYB5R3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ferricyanide DM1TH08 N. A. N. A. Investigative [4]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
NADH dehydrogenase (MT-ND3) TTTJF7V NU3M_HUMAN Binder [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Aldo-keto reductase 1A1 (AKR1A1) DED2FW3 AK1A1_HUMAN Substrate [3]
Alcohol dehydrogenase class-I alpha (ADH1A) DEE5M8O ADH1A_HUMAN Substrate [3]
Alcohol dehydrogenase class-V (ADH6) DE017IC ADH6_HUMAN Substrate [3]
Gastric alcohol dehydrogenase (ADH7) DEZMAHX ADH7_HUMAN Substrate [3]
Alcohol dehydrogenase class-III (ADH5) DEIOH6A ADHX_HUMAN Substrate [3]
Alcohol dehydrogenase class-I beta (ADH1B) DEEN9RD ADH1B_HUMAN Substrate [3]
Diaphorase-1 (CYB5R3) DE4A3BL NB5R3_HUMAN Substrate [4]
Hydroxyacyl-CoA dehydrogenase 2 (HSD17B10) DEGSPC9 HCD2_HUMAN Substrate [5]
Retinol dehydrogenase 13 (RDH13) DESICUZ RDH13_HUMAN Substrate [6]
Retinol dehydrogenase 14 (RDH14) DEWDJU4 RDH14_HUMAN Substrate [7]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4487).
2 Mechanism of cadmium-decreased glucuronidation in the rat. Biochem Pharmacol. 1992 Dec 1;44(11):2139-47.
3 Conformational changes and catalysis by alcohol dehydrogenase. Arch Biochem Biophys. 2010 Jan 1;493(1):3-12.
4 Expression of a novel P275L variant of NADH:cytochrome b5 reductase gives functional insight into the conserved motif important for pyridine nucleotide binding. Arch Biochem Biophys. 2006 Mar 1;447(1):59-67.
5 A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease. J Biol Chem. 1998 Apr 24;273(17):10741-6.
6 Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity. FEBS J. 2008 Jan;275(1):138-47.
7 Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues. FEBS Lett. 2002 Nov 20;531(3):489-93.
8 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
9 Thienylimidazo[2,1-b]thiazoles as inhibitors of mitochondrial NADH dehydrogenase. J Med Chem. 1995 Mar 31;38(7):1090-7.
10 Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism. Alcohol Clin Exp Res. 2006 Jul;30(7):1132-42.
11 A review of the pharmacokinetics of abacavir. Clin Pharmacokinet. 2008;47(6):351-71.
12 Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver. Drug Metab Dispos. 2008 Oct;36(10):2113-20.
13 The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity. Biochemistry. 1996 Nov 12;35(45):14276-80.
14 Natural alcohol exposure: is ethanol the main substrate for alcohol dehydrogenases in animals? Chem Biol Interact. 2011 May 30;191(1-3):14-25.
15 Pharmacokinetics and disposition of silodosin (KMD-3213). Yakugaku Zasshi. 2006 Mar;126 Spec no.:237-45.
16 PEGylated proteins: evaluation of their safety in the absence of definitive metabolism studies. Drug Metab Dispos. 2007 Jan;35(1):9-16.