DDI Drug Name |
DDI Drug ID |
Severity |
Mechanism |
Comorbidity |
REF |
Ivosidenib |
DM8S6T7
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and Ivosidenib. |
Acute myeloid leukaemia [2A60]
|
[7] |
Arn-509 |
DMT81LZ
|
Moderate |
Increased risk of lowers seizure threshold by the combination of Polyethylene glycol and Arn-509. |
Acute myeloid leukaemia [2A60]
|
[8] |
Gilteritinib |
DMWQ4MZ
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and Gilteritinib. |
Acute myeloid leukaemia [2A60]
|
[7] |
Oliceridine |
DM6MDCF
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and Oliceridine. |
Acute pain [MG31]
|
[8] |
ABT-492 |
DMJFD2I
|
Moderate |
Increased risk of lowers seizure threshold by the combination of Polyethylene glycol and ABT-492. |
Bacterial infection [1A00-1C4Z]
|
[9] |
PF-04449913 |
DMSB068
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and PF-04449913. |
Chronic myelomonocytic leukaemia [2A40]
|
[7] |
Osilodrostat |
DMIJC9X
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and Osilodrostat. |
Cushing syndrome [5A70]
|
[7] |
Deutetrabenazine |
DMUPFLI
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and Deutetrabenazine. |
Dystonic disorder [8A02]
|
[7] |
Ingrezza |
DMVPLNC
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and Ingrezza. |
Dystonic disorder [8A02]
|
[7] |
Fostemsavir |
DM50ILT
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and Fostemsavir. |
Human immunodeficiency virus disease [1C60-1C62]
|
[10] |
Amifampridine |
DMK08L3
|
Moderate |
Increased risk of lowers seizure threshold by the combination of Polyethylene glycol and Amifampridine. |
Lambert-Eaton syndrome [8C62]
|
[9] |
Osimertinib |
DMRJLAT
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and Osimertinib. |
Lung cancer [2C25]
|
[7] |
Selpercatinib |
DMZR15V
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and Selpercatinib. |
Lung cancer [2C25]
|
[7] |
LGX818 |
DMNQXV8
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and LGX818. |
Melanoma [2C30]
|
[7] |
Siponimod |
DM2R86O
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and Siponimod. |
Multiple sclerosis [8A40]
|
[7] |
Ozanimod |
DMT6AM2
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and Ozanimod. |
Multiple sclerosis [8A40]
|
[7] |
Entrectinib |
DMMPTLH
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and Entrectinib. |
Non-small cell lung cancer [2C25]
|
[7] |
Rucaparib |
DM9PVX8
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and Rucaparib. |
Ovarian cancer [2C73]
|
[7] |
Triclabendazole |
DMPWGBR
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and Triclabendazole. |
Parasitic worm infestation [1F90]
|
[7] |
Macimorelin |
DMQYJIR
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and Macimorelin. |
Pituitary gland disorder [5A60-5A61]
|
[7] |
Lefamulin |
DME6G97
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and Lefamulin. |
Pneumonia [CA40]
|
[7] |
Relugolix |
DMK7IWL
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and Relugolix. |
Prostate cancer [2C82]
|
[7] |
LEE011 |
DMMX75K
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and LEE011. |
Solid tumour/cancer [2A00-2F9Z]
|
[7] |
Pitolisant |
DM8RFNJ
|
Moderate |
Increased risk of ventricular arrhythmias by the combination of Polyethylene glycol and Pitolisant. |
Somnolence [MG42]
|
[7] |
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