Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMARWG5)

• Drug Name: HYDRAZINECARBOXAMIDE Drug Info
• Synonyms: Aminourea; 57-56-7; Carbamylhydrazine; Carbazamide; Semikarbazid; Urea, amino-; Aminoharnstoff; Aminomocovina; Hydrazine, carbamoyl-; Carbamoylhydrazine; Carbamic acid, hydrazide; Carbamidsaeurehydrazid; Semikarbazid [Czech]; Aminomocovina [Czech]; UNII-37QUC23K2X; EINECS 200-339-6; CHEMBL903; BRN 0506319; 37QUC23K2X; CHEBI:28306; DUIOPKIIICUYRZ-UHFFFAOYSA-N; 4426-72-6; Hydrazinecarboxamide, hydrochloride (1:1); isosemicarbazide; amino-urea; 1-azanylurea; carbamic acid hydrazide; Lopac-S-2201

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5196
  ChEBI ID: CHEBI:28306
  CAS Number: CAS 57-56-7
  TTD Drug ID: DMARWG5

Molecule-Related Drug Atlas

Drug(s) Targeting Monoamine oxidase type B (MAO-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selegiline Hydrochloride	DM3VR1L	Parkinson disease	8A00.0	Approved	[4]
Phenelzine	DMHIDUE	Depression	6A70-6A7Z	Approved	[5]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[6]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[7]
Safinamide mesylate	DM0J2ZT	Parkinson disease	8A00.0	Approved	[8]
Rasagiline	DM3WKQ4	Parkinson disease	8A00.0	Approved	[9]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[10]
Pargyline	DMM0HR1	Hypertension	BA00-BA04	Approved	[11]
Indeloxazine	DMWO3N6	Dementia	6D80-6D86	Approved	[12]
Budipine	DMODHQI	Migraine	8A80	Approved	[13]

Drug(s) Targeting Monoamine oxidase type A (MAO-A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Moclobemide	DMNZWL7	Depression	6A70-6A7Z	Approved	[14]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[15]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[16]
Isocarboxazid	DMAF1NB	Depression	6A70-6A7Z	Approved	[17]
TRYPTAMINE	DMAFPHB	N. A.	N. A.	Phase 3	[18]
Psoralen	DMIZJ8M	N. A.	N. A.	Phase 3	[19]
CHF-3381	DMQ2O8V	Neuropathic pain	8E43.0	Phase 2	[20]
Ladostigil	DMJSY3Q	Alzheimer disease	8A20	Phase 2	[21]
CX157	DMS2WB5	Mood disorder	6A60-6E23	Phase 2	[22]
PIPERINE	DMYEAB1	Vitiligo	ED63.0	Phase 1/2	[23]

Drug(s) Affected By Amine oxidase 3 (AOC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[25]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[28]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[29]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Ammonia	DMOEVK6	Coronary artery disease	BA80	Approved	[31]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[32]

Drug(s) Affected By Glutamate receptor ionotropic, NMDA 1 (GRIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[33]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[33]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[33]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[37]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[38]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[33]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Amine oxidase 3 (AOC3)	OT30YKV0	AOC3_HUMAN	Gene/Protein Processing	[2]
Glutamate receptor ionotropic, NMDA 1 (GRIN1)	OTZ5YBO8	NMDZ1_HUMAN	Gene/Protein Processing	[3]

References

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