Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAWEQH)

• Drug Name: 3-MeSO2-DDE Drug Info
• Synonyms: 1-Chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene; Meso2-dde; 62938-14-1; 3-Methylsulfonyl-dde; 3-Meso(2)-dde; AC1Q3QDJ; AC1L3O8E; CTK2F6395; DTXSID20212143; 5-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)vinyl]phenyl methyl sulfone; 2-(2-methylsulphonyl-4-chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethene; Benzene, 4-chloro-1-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-2-(methylsulfonyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 119115
  CAS Number: CAS 62938-14-1
  TTD Drug ID: DMAWEQH

Molecule-Related Drug Atlas

Drug(s) Targeting Steroid 11-beta-hydroxylase (CYP11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[3]
Osilodrostat	DMIJC9X	Cushing disease	5A70	Approved	[4]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[1]
4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diol	DM6Z5EK	Discovery agent	N.A.	Investigative	[5]
4-Indan-(1Z)-ylidenemethyl-pyridine	DM25DR7	Discovery agent	N.A.	Investigative	[6]
4-[(4'-Hydroxybiphenyl-4-yl)methyl]pyridine	DMIEMWA	Discovery agent	N.A.	Investigative	[5]
4-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine	DMY08FE	Discovery agent	N.A.	Investigative	[6]
5-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyrimidine	DM2RIHT	Discovery agent	N.A.	Investigative	[6]
4-((1H-imidazol-1-yl)methyl)benzonitrile	DMFUBRC	Discovery agent	N.A.	Investigative	[3]
4-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine	DMHDZUO	Discovery agent	N.A.	Investigative	[6]

Drug(s) Affected By Steroid 21-hydroxylase (CYP21A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[11]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[12]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[13]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[14]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[15]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[16]

Drug(s) Affected By Cytochrome P450 11B1, mitochondrial (CYP11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[17]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[18]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[21]
Potassium Chloride	DMMTAJC	Hypokalemia	5C77	Approved	[22]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[2]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[23]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[24]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[24]

Drug(s) Affected By Cytochrome P450 11B2, mitochondrial (CYP11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[25]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[18]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Potassium Chloride	DMMTAJC	Hypokalemia	5C77	Approved	[22]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[27]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[28]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[26]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[9]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[29]

Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[36]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[37]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[38]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Steroid 11-beta-hydroxylase (CYP11B1)	TTIQUX7	C11B1_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cytochrome P450 11B1, mitochondrial (CYP11B1)	OTKKL894	C11B1_HUMAN	Gene/Protein Processing	[2]
Cytochrome P450 11B2, mitochondrial (CYP11B2)	OTIOLWYN	C11B2_HUMAN	Gene/Protein Processing	[2]
Steroid 21-hydroxylase (CYP21A2)	OTN0UDVP	CP21A_HUMAN	Gene/Protein Processing	[2]
Steroidogenic acute regulatory protein, mitochondrial (STAR)	OTFEZ5AI	STAR_HUMAN	Gene/Protein Processing	[2]

References

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