Details of the Drug

General Information of Drug (ID: DMB8CNL)

Drug Name
Lindane
Synonyms
Aalindan; Aficide; Agrocide; Agronexit; Ameisenatod; Ameisentod; Aparasin; Aphtiria; Aphtitria; Aplidal; Arbitex; BBH; Benhexachlor; Benhexol; Benzanex; Benzex; Bexol; Celanex; Chloresene; Codechine; Devoran; Dolmix; Entomoxan; Esoderm; Exagama; Forlin; Gallogama; Gamacarbatox; Gamacid; Gamacide; Gamaphex; Gamene; Gamiso; Gammahexa; Gammahexane; Gammalin; Gammasan; Gammaterr; Gammex; Gammexane; Gammopaz; Gamtox; Geobilan; Gexane; Gyben; HCH; Hcch; Heclotox; Hecoltox; Hexa; Hexablanc; Hexachlor; Hexachloran; Hexachlorane; Hexamul; Hexapoudre; Hexatox; Hexaverm; Hexcidum; Hexicide; Hexit; Hexyclan; Hilbeech; Hortex; Inexit; Isatox; Isotox; Jacutin; Kokotine; Kwell; Lasochron; Lendine; Lentox; Lidenal; Lindafor; Lindagam; Lindagrain; Lindagranox; Lindalo; Lindamul; Lindan; Lindano; Lindanum; Lindapoudre; Lindaterra; Lindatox; Lindex; Lindosep; Lintox; Linvur; Lorexane; Mszycol; Nexit; Nicochloran; Novigam; Novigan; Omnitox; Ovadziak; Owadziak; PLK; Pedraczak; Pflanzol; Quellada; Scabene; Silvanol; Streunex; Submar; Viton; Agrocide III; Agrocide WP; Am eisenatod; Arcotal S; BHCor HCH; Borer Spray; DOL GRANULE; Eso derm; Gamma BHC; HCH [BSI]; HCH [ISO]; Hilbeec h; Isot ox; Lacco HI lin; Lindam ul; Mglawik L; New kotol; Nexen fb; PMS Lindane; Sang gamma; Agrocide 2; Agrocide6G; Agrocide 7; Bentox 10; Detox 25; Gamacide 20; Gammalin 20; Geolin G 3; Hungaria L7; Latka 666; Milbol 49; PS71_SUPELCO; TAP 85; Agrisol G-20; Alpha-BHC; Alpha-HCH; Ben-Hex; Beta-BHC; Beta-HCH; Beta-Lindane; Beta-isomer; D-BHC; Delta-BHC; Delta-HCH; ENT 7,796; ENT 8,601; ENT 9,232; ENT 9,233; ENT 9,234; Epsilon-HCH; Forst-nexen; Gamma-BHC; Gamma-HCH; Gamma-col; HCH (alpha); HCH (beta); KWELL (TN); Kwell-R; Nexen-fb; Nexi t-stark; Nexit-stark; Nexol-E; Sang-gamma; T-HCH; TRI-6; Trives-T
Indication
Disease Entry ICD 11 Status REF
Infestations of lice and scabies 1G00.Z Approved [1]
Pediculus capitis infestation 1G00.0 Approved [2]
Pthirus pubis infestation N.A. Approved [2]
Therapeutic Class
Antiscabies Agent
Affected Organisms
Scabies (Sarcoptes scabei) and other insects
ATC Code
P03AB02: Lindane
P03AB: Chlorine containing products
P03A: ECTOPARASITICIDES, INCL. SCABICIDES
P03: ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS
P: ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 290.8
Logarithm of the Partition Coefficient (xlogp) 3.8
Rotatable Bond Count (rotbonds) 0
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 0
ADMET Property
Half-life
The concentration or amount of drug in body reduced by one-half in 18 hours [3]
Metabolism
The drug is metabolized via the hepatic []
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Lipid metabolism disorders Not Available ACLY OTRL9ZRP [4]
Chemical Identifiers
Formula
C6H6Cl6
IUPAC Name
1,2,3,4,5,6-hexachlorocyclohexane
Canonical SMILES
C1(C(C(C(C(C1Cl)Cl)Cl)Cl)Cl)Cl
InChI
InChI=1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H
InChIKey
JLYXXMFPNIAWKQ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
727
ChEBI ID
CHEBI:24536
UNII
59NEE7PCAB
DrugBank ID
DB00431
TTD ID
D0Q5IN
ACDINA ID
D01211
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutamate receptor AMPA (GRIA) TTAN6JD NOUNIPROTAC Antagonist [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1) OTINY3MW AL8A1_HUMAN Gene/Protein Processing [6]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2) OT02MSKN 3BHS2_HUMAN Gene/Protein Processing [7]
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1) OTRI4UR1 CP8B1_HUMAN Gene/Protein Processing [8]
Adenylate kinase 4, mitochondrial (AK4) OTA0T02Q KAD4_HUMAN Gene/Protein Processing [6]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Drug Response [9]
Alanine aminotransferase 2 (GPT2) OTS5VF7N ALAT2_HUMAN Gene/Protein Processing [6]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Gene/Protein Processing [6]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Gene/Protein Processing [10]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [11]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [11]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Infestations of lice and scabies
ICD Disease Classification 1G00.Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glutamate receptor AMPA (GRIA) DTT NO-GeName 1.79E-04 -0.69 -0.58
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Lindane (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Bethanechol DMCLHO0 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Bethanechol. Abnormal micturition [MF50] [12]
Oliceridine DM6MDCF Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Oliceridine. Acute pain [MG31] [12]
Galantamine DMEO794 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Galantamine. Alzheimer disease [8A20] [12]
Rivastigmine DMG629M Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Rivastigmine. Alzheimer disease [8A20] [12]
Donepezil DMIYG7Z Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Donepezil. Alzheimer disease [8A20] [12]
Marinol DM70IK5 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Marinol. Anorexia nervosa [6B80] [12]
Aminophylline DML2NIB Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Aminophylline. Asthma [CA23] [13]
Ephedrine DMMV0KW Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Ephedrine. Asthma [CA23] [12]
Lisdexamfetamine DM6W8V5 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Lisdexamfetamine. Attention deficit hyperactivity disorder [6A05] [12]
Desipramine DMT2FDC Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Desipramine. Attention deficit hyperactivity disorder [6A05] [12]
Ofloxacin DM0VQN3 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Ofloxacin. Bacterial infection [1A00-1C4Z] [12]
Ciprofloxacin XR DM2NLS9 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Ciprofloxacin XR. Bacterial infection [1A00-1C4Z] [12]
Meropenem DM62UHC Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Meropenem. Bacterial infection [1A00-1C4Z] [12]
Trovafloxacin DM6AN32 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Trovafloxacin. Bacterial infection [1A00-1C4Z] [12]
Sparfloxacin DMB4HCT Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Sparfloxacin. Bacterial infection [1A00-1C4Z] [12]
Gemifloxacin DMHT34O Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Gemifloxacin. Bacterial infection [1A00-1C4Z] [13]
Imipenem DMI9FBP Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Imipenem. Bacterial infection [1A00-1C4Z] [13]
Norfloxacin DMIZ6W2 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Norfloxacin. Bacterial infection [1A00-1C4Z] [12]
ABT-492 DMJFD2I Moderate Increased risk of lowers seizure threshold by the combination of Lindane and ABT-492. Bacterial infection [1A00-1C4Z] [12]
Levofloxacin DMS60RB Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Levofloxacin. Bacterial infection [1A00-1C4Z] [12]
Lomefloxacin DMVRH9C Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Lomefloxacin. Bacterial infection [1A00-1C4Z] [12]
Cariprazine DMJYDVK Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Cariprazine. Bipolar disorder [6A60] [12]
Dihydrocodeine DMB0FWL Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Dihydrocodeine. Chronic pain [MG30] [12]
Levomilnacipran DMV26S8 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Levomilnacipran. Chronic pain [MG30] [12]
Cocaine DMSOX7I Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Cocaine. Corneal disease [9A76-9A78] [12]
Alfentanil DMVO0UB Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Alfentanil. Corneal disease [9A76-9A78] [12]
Remifentanil DMZTXCH Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Remifentanil. Corneal disease [9A76-9A78] [12]
Oxtriphylline DMLHSE3 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Oxtriphylline. Cough [MD12] [12]
Sertraline DM0FB1J Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Sertraline. Depression [6A70-6A7Z] [12]
Trimipramine DM1SC8M Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Trimipramine. Depression [6A70-6A7Z] [12]
Cyclobenzaprine DM1YBRM Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Cyclobenzaprine. Depression [6A70-6A7Z] [12]
Imipramine DM2NUH3 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Imipramine. Depression [6A70-6A7Z] [12]
Fluoxetine DM3PD2C Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Fluoxetine. Depression [6A70-6A7Z] [12]
Nortriptyline DM4KDYJ Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Nortriptyline. Depression [6A70-6A7Z] [12]
Vilazodone DM4LECQ Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Vilazodone. Depression [6A70-6A7Z] [12]
Nefazodone DM4ZS8M Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Nefazodone. Depression [6A70-6A7Z] [12]
Paroxetine DM5PVQE Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Paroxetine. Depression [6A70-6A7Z] [12]
Vortioxetine DM6F1PU Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Vortioxetine. Depression [6A70-6A7Z] [12]
Duloxetine DM9BI7M Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Duloxetine. Depression [6A70-6A7Z] [12]
Isocarboxazid DMAF1NB Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Isocarboxazid. Depression [6A70-6A7Z] [12]
Milnacipran DMBFE74 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Milnacipran. Depression [6A70-6A7Z] [12]
Escitalopram DMFK9HG Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Escitalopram. Depression [6A70-6A7Z] [12]
Tranylcypromine DMGB5RE Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Tranylcypromine. Depression [6A70-6A7Z] [12]
Desvenlafaxine DMHD4PE Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Desvenlafaxine. Depression [6A70-6A7Z] [12]
OPC-34712 DMHG57U Moderate Increased risk of lowers seizure threshold by the combination of Lindane and OPC-34712. Depression [6A70-6A7Z] [12]
Phenelzine DMHIDUE Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Phenelzine. Depression [6A70-6A7Z] [12]
Clomipramine DMINRKW Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Clomipramine. Depression [6A70-6A7Z] [12]
Trazodone DMK1GBJ Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Trazodone. Depression [6A70-6A7Z] [12]
Amoxapine DMKITQE Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Amoxapine. Depression [6A70-6A7Z] [12]
Doxepin DMPI98T Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Doxepin. Depression [6A70-6A7Z] [12]
Maprotiline DMPWB7T Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Maprotiline. Depression [6A70-6A7Z] [12]
Heroin diacetylmorphine DMDBWHY Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Heroin diacetylmorphine. Dissociative neurological symptom disorder [6B60] [12]
Piperazine DMTY9LU Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Piperazine. Enterobiasis [1F65] [12]
Fenfluramine DM0762O Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Fenfluramine. Epilepsy/seizure [8A61-8A6Z] [12]
Rimantadine DM5DWMU Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Rimantadine. Influenza [1E30-1E32] [12]
Amantadine DMS3YE9 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Amantadine. Influenza [1E30-1E32] [13]
Propiomazine DMKY8V1 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Propiomazine. Insomnia [7A00-7A0Z] [12]
ITI-007 DMUQ1DO Moderate Increased risk of lowers seizure threshold by the combination of Lindane and ITI-007. Insomnia [7A00-7A0Z] [12]
Polyethylene glycol DM4I1JP Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Polyethylene glycol. Irritable bowel syndrome [DD91] [14]
Amifampridine DMK08L3 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Amifampridine. Lambert-Eaton syndrome [8C62] [12]
Nelarabine DMB6VEG Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Nelarabine. Leukaemia [2A60-2B33] [12]
Physostigmine DM2N0TO Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Physostigmine. Lips/oral mucosa miscellaneous disorder [DA02] [12]
Chloroquine DMSI5CB Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Chloroquine. Malaria [1F40-1F45] [12]
Blinatumomab DMGECIJ Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Blinatumomab. Mature B-cell lymphoma [2A85] [12]
Dalfampridine DMM0PDO Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Dalfampridine. Multiple sclerosis [8A40] [12]
Neostigmine DM6T2J3 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Neostigmine. Myasthenia gravis [8C6Y] [12]
Dextroamphetamine DMMIHVP Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Dextroamphetamine. Narcolepsy [7A20] [12]
Promethazine DM6I5GR Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Promethazine. Nausea/vomiting [MD90] [12]
Metoclopramide DMFA5MY Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Metoclopramide. Nausea/vomiting [MD90] [12]
Bupropion DM5PCS7 Major Increased risk of lowers seizure threshold by the combination of Lindane and Bupropion. Nicotine use disorder [6C4A] [15]
Phendimetrazine DM6TS1N Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Phendimetrazine. Obesity [5B80-5B81] [12]
Amfepramone DM9YSNQ Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Amfepramone. Obesity [5B80-5B81] [12]
Sibutramine DMFJTDI Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Sibutramine. Obesity [5B80-5B81] [12]
Benzphetamine DMIJATC Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Benzphetamine. Obesity [5B80-5B81] [12]
Dexfenfluramine DMJ7YDS Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Dexfenfluramine. Obesity [5B80-5B81] [12]
Mazindol DMZ36RN Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Mazindol. Obesity [5B80-5B81] [12]
Levomethadyl Acetate DM06HG5 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Levomethadyl Acetate. Opioid use disorder [6C43] [12]
Pentazocine DM1XBHS Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Pentazocine. Pain [MG30-MG3Z] [12]
Dextropropoxyphene DM23HCX Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Dextropropoxyphene. Pain [MG30-MG3Z] [12]
Butorphanol DM5KYPJ Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Butorphanol. Pain [MG30-MG3Z] [12]
Oxymorphone DM65AGJ Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Oxymorphone. Pain [MG30-MG3Z] [12]
Levorphanol DMGS80V Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Levorphanol. Pain [MG30-MG3Z] [12]
Dezocine DMJDB0Y Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Dezocine. Pain [MG30-MG3Z] [12]
Nalbuphine DMOSQGU Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Nalbuphine. Pain [MG30-MG3Z] [12]
Methamphetamine DMPM4SK Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Methamphetamine. Pain [MG30-MG3Z] [12]
Buprenorphine DMPRI8G Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Buprenorphine. Pain [MG30-MG3Z] [12]
Hydrocodone DMQ2JO5 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Hydrocodone. Pain [MG30-MG3Z] [12]
Meperidine DMX4GND Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Meperidine. Pain [MG30-MG3Z] [13]
Oxycodone DMXLKHV Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Oxycodone. Pain [MG30-MG3Z] [12]
Enzalutamide DMGL19D Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Enzalutamide. Prostate cancer [2C82] [12]
Levomepromazine DMIKFEL Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Levomepromazine. Psychotic disorder [6A20-6A25] [12]
Fluphenazine DMIT8LX Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Fluphenazine. Psychotic disorder [6A20-6A25] [12]
Triflupromazine DMKFQJP Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Triflupromazine. Psychotic disorder [6A20-6A25] [12]
Gatifloxacin DMSL679 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Gatifloxacin. Respiratory infection [CA07-CA4Z] [12]
Doxapram DMCYANK Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Doxapram. Respiratory system disease [CB40-CB7Z] [13]
Oxamniquine DM2QDX1 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Oxamniquine. Schistosomiasis [1F86] [12]
Quetiapine DM1N62C Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Quetiapine. Schizophrenia [6A20] [12]
Mesoridazine DM2ZGAN Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Mesoridazine. Schizophrenia [6A20] [12]
Thioridazine DM35M8J Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Thioridazine. Schizophrenia [6A20] [12]
Aripiprazole DM3NUMH Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Aripiprazole. Schizophrenia [6A20] [12]
Iloperidone DM6AUFY Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Iloperidone. Schizophrenia [6A20] [12]
Paliperidone DM7NPJS Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Paliperidone. Schizophrenia [6A20] [12]
Haloperidol DM96SE0 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Haloperidol. Schizophrenia [6A20] [12]
Perphenazine DMA4MRX Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Perphenazine. Schizophrenia [6A20] [12]
Molindone DMAH70G Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Molindone. Schizophrenia [6A20] [12]
Chlorpromazine DMBGZI3 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Chlorpromazine. Schizophrenia [6A20] [12]
Thiothixene DMDINC4 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Thiothixene. Schizophrenia [6A20] [13]
Trifluoperazine DMKBYWI Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Trifluoperazine. Schizophrenia [6A20] [13]
Risperidone DMN6DXL Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Risperidone. Schizophrenia [6A20] [12]
Asenapine DMSQZE2 Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Asenapine. Schizophrenia [6A20] [12]
Pimozide DMW83TP Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Pimozide. Schizophrenia [6A20] [12]
Fentanyl DM8WAHT Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Fentanyl. Sensation disturbance [MB40] [12]
Sufentanil DMU7YEL Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Sufentanil. Sensation disturbance [MB40] [12]
Cinoxacin DM4EWNS Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Cinoxacin. Urinary tract infection [GC08] [12]
Nalidixic acid DMRM0JV Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Nalidixic acid. Urinary tract infection [GC08] [12]
Enoxacin DMYTE6L Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Enoxacin. Urinary tract infection [GC08] [12]
Methdilazine DMAUHQX Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Methdilazine. Vasomotor/allergic rhinitis [CA08] [13]
Trimeprazine DMEMV9D Moderate Increased risk of lowers seizure threshold by the combination of Lindane and Trimeprazine. Vasomotor/allergic rhinitis [CA08] [12]
⏷ Show the Full List of 118 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Hydrochloric acid E00015 313 Acidulant
Triethanolamine lauryl sulfate E00188 8777 Complexing agent; Emulsifying agent; Surfactant
Acetone E00004 180 Solvent
Water E00035 962 Solvent
Polysorbate 60 E00715 Not Available Dispersing agent; Emollient; Emulsifying agent; Surfactant; Plasticizing agent; Solubilizing agent; Suspending agent
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Lindane 1% shampoo 1% Shampoo Topical
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 088190.
2 Lindane FDA Label
3 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
4 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
5 NMDA-induced seizure intensity is enhanced in COX-2 deficient mice. Neurotoxicology. 2008 Nov;29(6):1114-20.
6 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
7 Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. J Appl Toxicol. 2006 Nov-Dec;26(6):484-92.
8 Organochloride pesticides modulated gut microbiota and influenced bile acid metabolism in mice. Environ Pollut. 2017 Jul;226:268-276.
9 Interaction between -hexachlorocyclohexane and ADIPOQ genotypes contributes to the risk of type 2 diabetes mellitus in East Chinese adults. Sci Rep. 2016 Nov 24;6:37769. doi: 10.1038/srep37769.
10 -Hexachlorocyclohexane: A Small Molecule with a Big Impact on Human Cellular Biochemistry. Biomedicines. 2020 Nov 16;8(11):505. doi: 10.3390/biomedicines8110505.
11 Low dose induction of micronuclei by lindane. Carcinogenesis. 2004 Apr;25(4):613-22. doi: 10.1093/carcin/bgh048. Epub 2003 Dec 19.
12 Matsuoka LY "Convulsions following application of gamma benzene hexachloride." J Am Acad Dermatol 5 (1981): 98-9. [PMID: 6168673]
13 Cox R, Krupnick J, Bush N, Houpt A "Seizures caused by concomitant use of lindane and dextroamphetamine in a child with attention deficit hyperactivity disorder." J Miss State Med Assoc 41 (2000): 690-2. [PMID: 10974795]
14 Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
15 Sheehan DV, Welch JB, Fishman SM "A case of bupropion-induced seizure." J Nerv Ment Dis 174 (1986): 496-8. [PMID: 3090199]