Details of the Drug

General Information of Drug (ID: DMB8CNL)

Drug Name

Lindane

Synonyms

Aalindan; Aficide; Agrocide; Agronexit; Ameisenatod; Ameisentod; Aparasin; Aphtiria; Aphtitria; Aplidal; Arbitex; BBH; Benhexachlor; Benhexol; Benzanex; Benzex; Bexol; Celanex; Chloresene; Codechine; Devoran; Dolmix; Entomoxan; Esoderm; Exagama; Forlin; Gallogama; Gamacarbatox; Gamacid; Gamacide; Gamaphex; Gamene; Gamiso; Gammahexa; Gammahexane; Gammalin; Gammasan; Gammaterr; Gammex; Gammexane; Gammopaz; Gamtox; Geobilan; Gexane; Gyben; HCH; Hcch; Heclotox; Hecoltox; Hexa; Hexablanc; Hexachlor; Hexachloran; Hexachlorane; Hexamul; Hexapoudre; Hexatox; Hexaverm; Hexcidum; Hexicide; Hexit; Hexyclan; Hilbeech; Hortex; Inexit; Isatox; Isotox; Jacutin; Kokotine; Kwell; Lasochron; Lendine; Lentox; Lidenal; Lindafor; Lindagam; Lindagrain; Lindagranox; Lindalo; Lindamul; Lindan; Lindano; Lindanum; Lindapoudre; Lindaterra; Lindatox; Lindex; Lindosep; Lintox; Linvur; Lorexane; Mszycol; Nexit; Nicochloran; Novigam; Novigan; Omnitox; Ovadziak; Owadziak; PLK; Pedraczak; Pflanzol; Quellada; Scabene; Silvanol; Streunex; Submar; Viton; Agrocide III; Agrocide WP; Am eisenatod; Arcotal S; BHCor HCH; Borer Spray; DOL GRANULE; Eso derm; Gamma BHC; HCH [BSI]; HCH [ISO]; Hilbeec h; Isot ox; Lacco HI lin; Lindam ul; Mglawik L; New kotol; Nexen fb; PMS Lindane; Sang gamma; Agrocide 2; Agrocide6G; Agrocide 7; Bentox 10; Detox 25; Gamacide 20; Gammalin 20; Geolin G 3; Hungaria L7; Latka 666; Milbol 49; PS71_SUPELCO; TAP 85; Agrisol G-20; Alpha-BHC; Alpha-HCH; Ben-Hex; Beta-BHC; Beta-HCH; Beta-Lindane; Beta-isomer; D-BHC; Delta-BHC; Delta-HCH; ENT 7,796; ENT 8,601; ENT 9,232; ENT 9,233; ENT 9,234; Epsilon-HCH; Forst-nexen; Gamma-BHC; Gamma-HCH; Gamma-col; HCH (alpha); HCH (beta); KWELL (TN); Kwell-R; Nexen-fb; Nexi t-stark; Nexit-stark; Nexol-E; Sang-gamma; T-HCH; TRI-6; Trives-T

Indication

Disease Entry	ICD 11	Status	REF
Infestations of lice and scabies	1G00.Z	Approved	[1]
Pediculus capitis infestation	1G00.0	Approved	[2]
Pthirus pubis infestation	N.A.	Approved	[2]
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Therapeutic Class

Antiscabies Agent

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

290.8

Logarithm of the Partition Coefficient (xlogp)

3.8

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

ADMET Property

Half-life: The concentration or amount of drug in body reduced by one-half in 18 hours [3]
Metabolism: The drug is metabolized via the hepatic []

Adverse Drug Reaction (ADR)

ADR Term	Variation	Related DOT	DOT ID	REF
Lipid metabolism disorders	Not Available	ACLY	OTRL9ZRP	[4]
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Chemical Identifiers

Formula: C6H6Cl6
IUPAC Name: 1,2,3,4,5,6-hexachlorocyclohexane
Canonical SMILES: C1(C(C(C(C(C1Cl)Cl)Cl)Cl)Cl)Cl
InChI: InChI=1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H
InChIKey: JLYXXMFPNIAWKQ-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 727
ChEBI ID: CHEBI:24536
DrugBank ID: DB00431
TTD ID: D0Q5IN
ACDINA ID: D01211

Repurposed Drugs (RPD)

Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor AMPA (GRIA)	TTAN6JD	NOUNIPROTAC	Antagonist	[5]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)	OTINY3MW	AL8A1_HUMAN	Gene/Protein Processing	[6]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)	OT02MSKN	3BHS2_HUMAN	Gene/Protein Processing	[7]
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1)	OTRI4UR1	CP8B1_HUMAN	Gene/Protein Processing	[8]
Adenylate kinase 4, mitochondrial (AK4)	OTA0T02Q	KAD4_HUMAN	Gene/Protein Processing	[6]
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Drug Response	[9]
Alanine aminotransferase 2 (GPT2)	OTS5VF7N	ALAT2_HUMAN	Gene/Protein Processing	[6]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Gene/Protein Processing	[6]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Gene/Protein Processing	[10]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[11]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[11]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Infestations of lice and scabies

ICD Disease Classification

1G00.Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glutamate receptor AMPA (GRIA)	DTT	NO-GeName	1.79E-04	-0.69	-0.58

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Lindane (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Bethanechol	DMCLHO0	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Bethanechol.	Abnormal micturition [MF50]	[12]
Oliceridine	DM6MDCF	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Oliceridine.	Acute pain [MG31]	[12]
Galantamine	DMEO794	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Galantamine.	Alzheimer disease [8A20]	[12]
Rivastigmine	DMG629M	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Rivastigmine.	Alzheimer disease [8A20]	[12]
Donepezil	DMIYG7Z	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Donepezil.	Alzheimer disease [8A20]	[12]
Marinol	DM70IK5	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Marinol.	Anorexia nervosa [6B80]	[12]
Aminophylline	DML2NIB	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Aminophylline.	Asthma [CA23]	[13]
Ephedrine	DMMV0KW	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Ephedrine.	Asthma [CA23]	[12]
Lisdexamfetamine	DM6W8V5	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Lisdexamfetamine.	Attention deficit hyperactivity disorder [6A05]	[12]
Desipramine	DMT2FDC	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Desipramine.	Attention deficit hyperactivity disorder [6A05]	[12]
Ofloxacin	DM0VQN3	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Ofloxacin.	Bacterial infection [1A00-1C4Z]	[12]
Ciprofloxacin XR	DM2NLS9	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Ciprofloxacin XR.	Bacterial infection [1A00-1C4Z]	[12]
Meropenem	DM62UHC	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Meropenem.	Bacterial infection [1A00-1C4Z]	[12]
Trovafloxacin	DM6AN32	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Trovafloxacin.	Bacterial infection [1A00-1C4Z]	[12]
Sparfloxacin	DMB4HCT	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Sparfloxacin.	Bacterial infection [1A00-1C4Z]	[12]
Gemifloxacin	DMHT34O	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Gemifloxacin.	Bacterial infection [1A00-1C4Z]	[13]
Imipenem	DMI9FBP	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Imipenem.	Bacterial infection [1A00-1C4Z]	[13]
Norfloxacin	DMIZ6W2	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Norfloxacin.	Bacterial infection [1A00-1C4Z]	[12]
ABT-492	DMJFD2I	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and ABT-492.	Bacterial infection [1A00-1C4Z]	[12]
Levofloxacin	DMS60RB	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Levofloxacin.	Bacterial infection [1A00-1C4Z]	[12]
Lomefloxacin	DMVRH9C	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Lomefloxacin.	Bacterial infection [1A00-1C4Z]	[12]
Cariprazine	DMJYDVK	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Cariprazine.	Bipolar disorder [6A60]	[12]
Dihydrocodeine	DMB0FWL	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Dihydrocodeine.	Chronic pain [MG30]	[12]
Levomilnacipran	DMV26S8	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Levomilnacipran.	Chronic pain [MG30]	[12]
Cocaine	DMSOX7I	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Cocaine.	Corneal disease [9A76-9A78]	[12]
Alfentanil	DMVO0UB	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Alfentanil.	Corneal disease [9A76-9A78]	[12]
Remifentanil	DMZTXCH	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Remifentanil.	Corneal disease [9A76-9A78]	[12]
Oxtriphylline	DMLHSE3	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Oxtriphylline.	Cough [MD12]	[12]
Sertraline	DM0FB1J	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Sertraline.	Depression [6A70-6A7Z]	[12]
Trimipramine	DM1SC8M	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Trimipramine.	Depression [6A70-6A7Z]	[12]
Cyclobenzaprine	DM1YBRM	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Cyclobenzaprine.	Depression [6A70-6A7Z]	[12]
Imipramine	DM2NUH3	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Imipramine.	Depression [6A70-6A7Z]	[12]
Fluoxetine	DM3PD2C	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Fluoxetine.	Depression [6A70-6A7Z]	[12]
Nortriptyline	DM4KDYJ	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Nortriptyline.	Depression [6A70-6A7Z]	[12]
Vilazodone	DM4LECQ	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Vilazodone.	Depression [6A70-6A7Z]	[12]
Nefazodone	DM4ZS8M	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Nefazodone.	Depression [6A70-6A7Z]	[12]
Paroxetine	DM5PVQE	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Paroxetine.	Depression [6A70-6A7Z]	[12]
Vortioxetine	DM6F1PU	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Vortioxetine.	Depression [6A70-6A7Z]	[12]
Duloxetine	DM9BI7M	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Duloxetine.	Depression [6A70-6A7Z]	[12]
Isocarboxazid	DMAF1NB	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Isocarboxazid.	Depression [6A70-6A7Z]	[12]
Milnacipran	DMBFE74	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Milnacipran.	Depression [6A70-6A7Z]	[12]
Escitalopram	DMFK9HG	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Escitalopram.	Depression [6A70-6A7Z]	[12]
Tranylcypromine	DMGB5RE	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Tranylcypromine.	Depression [6A70-6A7Z]	[12]
Desvenlafaxine	DMHD4PE	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Desvenlafaxine.	Depression [6A70-6A7Z]	[12]
OPC-34712	DMHG57U	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and OPC-34712.	Depression [6A70-6A7Z]	[12]
Phenelzine	DMHIDUE	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Phenelzine.	Depression [6A70-6A7Z]	[12]
Clomipramine	DMINRKW	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Clomipramine.	Depression [6A70-6A7Z]	[12]
Trazodone	DMK1GBJ	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Trazodone.	Depression [6A70-6A7Z]	[12]
Amoxapine	DMKITQE	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Amoxapine.	Depression [6A70-6A7Z]	[12]
Doxepin	DMPI98T	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Doxepin.	Depression [6A70-6A7Z]	[12]
Maprotiline	DMPWB7T	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Maprotiline.	Depression [6A70-6A7Z]	[12]
Heroin diacetylmorphine	DMDBWHY	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Heroin diacetylmorphine.	Dissociative neurological symptom disorder [6B60]	[12]
Piperazine	DMTY9LU	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Piperazine.	Enterobiasis [1F65]	[12]
Fenfluramine	DM0762O	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Fenfluramine.	Epilepsy/seizure [8A61-8A6Z]	[12]
Rimantadine	DM5DWMU	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Rimantadine.	Influenza [1E30-1E32]	[12]
Amantadine	DMS3YE9	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Amantadine.	Influenza [1E30-1E32]	[13]
Propiomazine	DMKY8V1	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Propiomazine.	Insomnia [7A00-7A0Z]	[12]
ITI-007	DMUQ1DO	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and ITI-007.	Insomnia [7A00-7A0Z]	[12]
Polyethylene glycol	DM4I1JP	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Polyethylene glycol.	Irritable bowel syndrome [DD91]	[14]
Amifampridine	DMK08L3	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Amifampridine.	Lambert-Eaton syndrome [8C62]	[12]
Nelarabine	DMB6VEG	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Nelarabine.	Leukaemia [2A60-2B33]	[12]
Physostigmine	DM2N0TO	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Physostigmine.	Lips/oral mucosa miscellaneous disorder [DA02]	[12]
Chloroquine	DMSI5CB	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Chloroquine.	Malaria [1F40-1F45]	[12]
Blinatumomab	DMGECIJ	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Blinatumomab.	Mature B-cell lymphoma [2A85]	[12]
Dalfampridine	DMM0PDO	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Dalfampridine.	Multiple sclerosis [8A40]	[12]
Neostigmine	DM6T2J3	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Neostigmine.	Myasthenia gravis [8C6Y]	[12]
Dextroamphetamine	DMMIHVP	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Dextroamphetamine.	Narcolepsy [7A20]	[12]
Promethazine	DM6I5GR	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Promethazine.	Nausea/vomiting [MD90]	[12]
Metoclopramide	DMFA5MY	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Metoclopramide.	Nausea/vomiting [MD90]	[12]
Bupropion	DM5PCS7	Major	Increased risk of lowers seizure threshold by the combination of Lindane and Bupropion.	Nicotine use disorder [6C4A]	[15]
Phendimetrazine	DM6TS1N	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Phendimetrazine.	Obesity [5B80-5B81]	[12]
Amfepramone	DM9YSNQ	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Amfepramone.	Obesity [5B80-5B81]	[12]
Sibutramine	DMFJTDI	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Sibutramine.	Obesity [5B80-5B81]	[12]
Benzphetamine	DMIJATC	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Benzphetamine.	Obesity [5B80-5B81]	[12]
Dexfenfluramine	DMJ7YDS	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Dexfenfluramine.	Obesity [5B80-5B81]	[12]
Mazindol	DMZ36RN	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Mazindol.	Obesity [5B80-5B81]	[12]
Levomethadyl Acetate	DM06HG5	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Levomethadyl Acetate.	Opioid use disorder [6C43]	[12]
Pentazocine	DM1XBHS	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Pentazocine.	Pain [MG30-MG3Z]	[12]
Dextropropoxyphene	DM23HCX	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Dextropropoxyphene.	Pain [MG30-MG3Z]	[12]
Butorphanol	DM5KYPJ	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Butorphanol.	Pain [MG30-MG3Z]	[12]
Oxymorphone	DM65AGJ	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Oxymorphone.	Pain [MG30-MG3Z]	[12]
Levorphanol	DMGS80V	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Levorphanol.	Pain [MG30-MG3Z]	[12]
Dezocine	DMJDB0Y	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Dezocine.	Pain [MG30-MG3Z]	[12]
Nalbuphine	DMOSQGU	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Nalbuphine.	Pain [MG30-MG3Z]	[12]
Methamphetamine	DMPM4SK	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Methamphetamine.	Pain [MG30-MG3Z]	[12]
Buprenorphine	DMPRI8G	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Buprenorphine.	Pain [MG30-MG3Z]	[12]
Hydrocodone	DMQ2JO5	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Hydrocodone.	Pain [MG30-MG3Z]	[12]
Meperidine	DMX4GND	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Meperidine.	Pain [MG30-MG3Z]	[13]
Oxycodone	DMXLKHV	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Oxycodone.	Pain [MG30-MG3Z]	[12]
Enzalutamide	DMGL19D	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Enzalutamide.	Prostate cancer [2C82]	[12]
Levomepromazine	DMIKFEL	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Levomepromazine.	Psychotic disorder [6A20-6A25]	[12]
Fluphenazine	DMIT8LX	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Fluphenazine.	Psychotic disorder [6A20-6A25]	[12]
Triflupromazine	DMKFQJP	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Triflupromazine.	Psychotic disorder [6A20-6A25]	[12]
Gatifloxacin	DMSL679	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Gatifloxacin.	Respiratory infection [CA07-CA4Z]	[12]
Doxapram	DMCYANK	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Doxapram.	Respiratory system disease [CB40-CB7Z]	[13]
Oxamniquine	DM2QDX1	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Oxamniquine.	Schistosomiasis [1F86]	[12]
Quetiapine	DM1N62C	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Quetiapine.	Schizophrenia [6A20]	[12]
Mesoridazine	DM2ZGAN	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Mesoridazine.	Schizophrenia [6A20]	[12]
Thioridazine	DM35M8J	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Thioridazine.	Schizophrenia [6A20]	[12]
Aripiprazole	DM3NUMH	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Aripiprazole.	Schizophrenia [6A20]	[12]
Iloperidone	DM6AUFY	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Iloperidone.	Schizophrenia [6A20]	[12]
Paliperidone	DM7NPJS	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Paliperidone.	Schizophrenia [6A20]	[12]
Haloperidol	DM96SE0	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Haloperidol.	Schizophrenia [6A20]	[12]
Perphenazine	DMA4MRX	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Perphenazine.	Schizophrenia [6A20]	[12]
Molindone	DMAH70G	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Molindone.	Schizophrenia [6A20]	[12]
Chlorpromazine	DMBGZI3	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Chlorpromazine.	Schizophrenia [6A20]	[12]
Thiothixene	DMDINC4	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Thiothixene.	Schizophrenia [6A20]	[13]
Trifluoperazine	DMKBYWI	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Trifluoperazine.	Schizophrenia [6A20]	[13]
Risperidone	DMN6DXL	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Risperidone.	Schizophrenia [6A20]	[12]
Asenapine	DMSQZE2	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Asenapine.	Schizophrenia [6A20]	[12]
Pimozide	DMW83TP	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Pimozide.	Schizophrenia [6A20]	[12]
Fentanyl	DM8WAHT	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Fentanyl.	Sensation disturbance [MB40]	[12]
Sufentanil	DMU7YEL	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Sufentanil.	Sensation disturbance [MB40]	[12]
Cinoxacin	DM4EWNS	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Cinoxacin.	Urinary tract infection [GC08]	[12]
Nalidixic acid	DMRM0JV	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Nalidixic acid.	Urinary tract infection [GC08]	[12]
Enoxacin	DMYTE6L	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Enoxacin.	Urinary tract infection [GC08]	[12]
Methdilazine	DMAUHQX	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Methdilazine.	Vasomotor/allergic rhinitis [CA08]	[13]
Trimeprazine	DMEMV9D	Moderate	Increased risk of lowers seizure threshold by the combination of Lindane and Trimeprazine.	Vasomotor/allergic rhinitis [CA08]	[12]
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⏷ Show the Full List of 118 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Hydrochloric acid	E00015	313	Acidulant
Triethanolamine lauryl sulfate	E00188	8777	Complexing agent; Emulsifying agent; Surfactant
Acetone	E00004	180	Solvent
Water	E00035	962	Solvent
Polysorbate 60	E00715	Not Available	Dispersing agent; Emollient; Emulsifying agent; Surfactant; Plasticizing agent; Solubilizing agent; Suspending agent
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Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Lindane 1% shampoo	1%	Shampoo	Topical

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 088190.
2	Lindane FDA Label
3	Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
4	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
5	NMDA-induced seizure intensity is enhanced in COX-2 deficient mice. Neurotoxicology. 2008 Nov;29(6):1114-20.
6	Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
7	Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. J Appl Toxicol. 2006 Nov-Dec;26(6):484-92.
8	Organochloride pesticides modulated gut microbiota and influenced bile acid metabolism in mice. Environ Pollut. 2017 Jul;226:268-276.
9	Interaction between -hexachlorocyclohexane and ADIPOQ genotypes contributes to the risk of type 2 diabetes mellitus in East Chinese adults. Sci Rep. 2016 Nov 24;6:37769. doi: 10.1038/srep37769.
10	-Hexachlorocyclohexane: A Small Molecule with a Big Impact on Human Cellular Biochemistry. Biomedicines. 2020 Nov 16;8(11):505. doi: 10.3390/biomedicines8110505.
11	Low dose induction of micronuclei by lindane. Carcinogenesis. 2004 Apr;25(4):613-22. doi: 10.1093/carcin/bgh048. Epub 2003 Dec 19.
12	Matsuoka LY "Convulsions following application of gamma benzene hexachloride." J Am Acad Dermatol 5 (1981): 98-9. [PMID: 6168673]
13	Cox R, Krupnick J, Bush N, Houpt A "Seizures caused by concomitant use of lindane and dextroamphetamine in a child with attention deficit hyperactivity disorder." J Miss State Med Assoc 41 (2000): 690-2. [PMID: 10974795]
14	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
15	Sheehan DV, Welch JB, Fishman SM "A case of bupropion-induced seizure." J Nerv Ment Dis 174 (1986): 496-8. [PMID: 3090199]