Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBFCTZ)

Drug Name

3h-Indole-5,6-Diol Drug Info

Synonyms

5,6-Dihydroxyindole; 3131-52-0; 1H-Indole-5,6-diol; Dopamine lutine; 3H-INDOLE-5,6-DIOL; dhi; UNII-Z3OC8499KG; 5,6-DihydroxyindoleI; C8H7NO2; CHEMBL92636; Z3OC8499KG; CHEBI:27404; AK-25753; D-3560; 3ID; 5,6-Dihydroxy-1H-indole; indole-5,6-diol; 5,6-dihydroxy indole; AC1L3FSK; EC 412-130-9; SCHEMBL48994; AC1Q7A19; CTK1C3371; DTXSID20185242; SGNZYJXNUURYCH-UHFFFAOYSA-N; MolPort-001-782-232; ZINC895800; BCP02562; ACT06797; EBD26988; ZX-AT011826; KS-00000J9K; CD-595; BDBM50028548; BBL102959; ANW-44822; STL556768; MFCD00798933; FCH834612

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 114683
ChEBI ID: CHEBI:27404
CAS Number: CAS 3131-52-0
TTD Drug ID: DMBFCTZ

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Lactotransferrin (LTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Parecoxib	DMIV8CT	N. A.	N. A.	Phase 4	[3]
Talactoferrin	DMV7T64	Diabetic foot ulcer	BD54	Phase 3	[4]
HLF 1-11	DMDFG1O	Bacteremia	1A73	Phase 1/2	[5]
Nimesulide	DMR1NMD	Metastatic colorectal cancer	2B91	Terminated	[6]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[1]
Fucose	DMAHMSV	N. A.	N. A.	Investigative	[1]
Lauric Acid	DM9C8KQ	Discovery agent	N.A.	Investigative	[1]
Alpha-D-Fucose	DM6VH7A	Discovery agent	N.A.	Investigative	[1]
Nitrilotriacetic Acid	DMIOQFU	Discovery agent	N.A.	Investigative	[1]
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Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[10]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[13]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[14]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[15]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[17]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[18]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[19]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[20]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[21]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[23]
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[25]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[26]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[27]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[28]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[29]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[26]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[34]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lactotransferrin (LTF)	TTSZDQU	TRFL_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)	OT5BZ1J9	P85A_HUMAN	Post-Translational Modifications	[2]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Post-Translational Modifications	[2]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Gene/Protein Processing	[2]

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References

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21	Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
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