Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBV19T)

• Drug Name: diphenylamine-2-carboxylic acid Drug Info
• Synonyms: N-phenylanthranilic acid; fenamic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 4386
  ChEBI ID: CHEBI:34756
  CAS Number: CAS 91-40-7
  TTD Drug ID: DMBV19T

Molecule-Related Drug Atlas

Drug(s) Targeting Chloride channel protein 7 (ClC-7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[6]
DIDS	DMKSQUB	Discovery agent	N.A.	Investigative	[6]
SITS	DMCMIUG	Discovery agent	N.A.	Investigative	[3]
GTPgammaS	DMJUXKY	Discovery agent	N.A.	Investigative	[3]
NS5818	DM629TD	Discovery agent	N.A.	Investigative	[6]

Drug(s) Targeting Chloride channel protein 2 (CLC-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lubiprostone	DMJTEMW	Chronic idiopathic constipation	DC32	Approved	[7]
RK-023	DM2VO97	Alopecia	ED70	Phase 2	[8]
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[2]
Acid-activated omeprazole	DMTOEJX	Discovery agent	N.A.	Investigative	[9]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[10]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[4]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[11]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[12]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[12]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[4]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[4]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[13]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[4]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[11]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[19]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[4]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[21]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[22]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[4]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[11]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[4]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[4]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[24]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[25]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[23]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[4]

Drug(s) Affected By Cystic fibrosis transmembrane conductance regulator (CFTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivacaftor	DMZC1HS	Cystic fibrosis	CA25	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Miglustat	DM5J64S	Niemann-Pick disease type C		Approved	[30]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[5]
Milrinone	DM8TUPF	Congestive heart failure	BD10	Approved	[28]
Oxidized glutathione	DM9EQC0	Breast cancer	2C60-2C65	Approved	[31]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Chloride channel protein 2 (CLC-2)	TT30NW6	CLCN2_HUMAN	Blocker (channel blocker)	[2]
Chloride channel protein 7 (ClC-7)	TTST1AJ	CLCN7_HUMAN	Blocker (channel blocker)	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[4]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[4]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[4]
Cystic fibrosis transmembrane conductance regulator (CFTR)	OT6B22QH	CFTR_HUMAN	Gene/Protein Processing	[5]

References

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• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 699).
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 709).
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