Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCY9PO)

Drug Name
Itarnafloxin Drug Info
Synonyms Quarfloxin; CX-3385; CX-3543; Quadruplex DNA oncogene inhibitor (cancer), Cylene; C-Myc/VEGF oncogene inhibitor (cancer), Cylene
Indication
Disease Entry ICD 11 Status REF
leukaemia 2A60-2B33 Phase 2 [1]
Cross-matching ID
PubChem CID
11635763
CAS Number
CAS 865311-47-3
TTD Drug ID
DMCY9PO

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Nucleolin (NCL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ACT-GRO-777 DMMG61B Solid tumour/cancer 2A00-2F9Z Phase 2 [4]
IPP-204106 DM8E3N6 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [5]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [6]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [7]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [8]
Methotrexate DM2TEOL Anterior urethra cancer Approved [9]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [10]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [11]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [12]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [13]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [14]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [15]
⏷ Show the Full List of 12 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [16]
Gefitinib DM15F0X Colon adenocarcinoma Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [19]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [20]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [21]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [20]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [23]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Selenium DM25CGV N. A. N. A. Approved [27]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [28]
Etretinate DM2CZFA Keratosis ED56 Approved [29]
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [31]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [32]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [37]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [38]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [39]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [41]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [42]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [43]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [44]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [46]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [48]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
Quizartinib DM8Y4JS Acute myeloid leukaemia 2A60 Approved [52]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TP53-binding protein 1 (TP53BP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [12]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [57]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [58]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [59]
Arsenic DMTL2Y1 N. A. N. A. Approved [60]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [61]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [62]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Nucleolin (NCL) TTCSZH7 NUCL_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [2]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Gene/Protein Processing [3]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Gene/Protein Processing [3]
Nucleolin (NCL) OTBXPKMP NUCL_HUMAN Protein Interaction/Cellular Processes [2]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [2]
TP53-binding protein 1 (TP53BP1) OTL8879S TP53B_HUMAN Gene/Protein Processing [3]

References

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5 Company report (ImmuPharma)
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28 Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
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