Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME81U3)

• Drug Name: 3-Methyl-7-pyrrolidin-1-yl-hept-5-yn-2-one Drug Info
• Synonyms: CHEMBL353023; 3-Methyl-7-pyrrolidin-1-yl-hept-5-yn-2-one

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 15685977
  TTD Drug ID: DME81U3

Molecule-Related Drug Atlas

Drug(s) Targeting Muscarinic acetylcholine receptor M4 (CHRM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[2]
Methacholine Chloride	DMGS4QH	Asthma	CA23	Approved	[3]
Tropicamide	DM1D90W	Mydriasis	LA11.62	Approved	[4]
Diphenidol	DMHPWOM	Nausea	MD90	Approved	[5]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one	DMM9X0G	Discovery agent	N.A.	Investigative	[6]
A-987306	DMU34BK	Discovery agent	N.A.	Investigative	[7]
ISOCLOZAPINE	DM52CPU	Discovery agent	N.A.	Investigative	[8]
FLUMEZAPINE	DMW0HOG	Discovery agent	N.A.	Investigative	[9]
ISOLOXAPINE	DMH1BN4	Discovery agent	N.A.	Investigative	[10]
Acetic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester	DMVEH40	Discovery agent	N.A.	Investigative	[3]

Drug(s) Targeting Muscarinic acetylcholine receptor M1 (CHRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[2]
Fesoterodine fumarate	DM13495	Overactive bladder	GC50.0	Approved	[11]
SMT-D002	DM1I93C	Seborrhea	ED91.2	Approved	[12]
Clidinium	DMUMQZ0	Abdominal stomach pain	DD91.4	Approved	[13]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[14]
Oxyphenonium	DMMQHOZ	Visceral spasms	MD81.4	Approved	[15]
Benztropine	DMGZOVN	Parkinson disease	8A00.0	Approved	[16]
Glycopyrrolate	DM2M3ZA	Anaesthesia	9A78.6	Approved	[17]
Pirenzepine	DMP6M1N	Peptic ulcer	DA61	Approved	[18]
Cycrimine	DM8C43Q	Parkinson disease	8A00.0	Approved	[19]

Drug(s) Targeting Muscarinic acetylcholine receptor M2 (CHRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[2]
Methacholine Chloride	DMGS4QH	Asthma	CA23	Approved	[3]
SMT-D002	DM1I93C	Seborrhea	ED91.2	Approved	[12]
Methylscopolamine	DM5VWOB	Peptic ulcer	DA61	Approved	[20]
Gallamine Triethiodide	DMPO0MS	Stabilize muscle contraction	FB3Z	Approved	[21]
FP-1097	DMC1F2T	Urinary incontinence	MF50.2	Phase 2	[22]
PSD-506	DMT0KB1	Overactive bladder	GC50.0	Discontinued in Phase 2	[23]
Otenzepad	DMRXHAC	Heart failure	BD10-BD13	Discontinued in Phase 2	[24]
SCH-211803	DM92E0W	Parkinson disease	8A00.0	Discontinued in Phase 1	[25]
Alvameline	DMLN0Y5	Alzheimer disease	8A20	Terminated	[26]

Drug(s) Targeting Muscarinic acetylcholine receptor M3 (CHRM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolterodine	DMSHPW8	Overactive bladder	GC50.0	Approved	[27]
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[2]
Tiotropium	DMFDC0Q	Chronic obstructive pulmonary disease	CA22	Approved	[28]
Ipratropium	DMFQ320	Obstructive lung disease	CA22.Z	Approved	[29]
Darifenacin	DMWXLYZ	Overactive bladder	GC50.0	Approved	[30]
Methacholine Chloride	DMGS4QH	Asthma	CA23	Approved	[31]
SMT-D002	DM1I93C	Seborrhea	ED91.2	Approved	[12]
Solifenacin	DMG592Q	Overactive bladder	GC50.0	Approved	[32]
Methylscopolamine	DM5VWOB	Peptic ulcer	DA61	Approved	[33]
Cevimeline	DMWSMND	Sjogren syndrome	4A43.20	Approved	[34]

Drug(s) Targeting Muscarinic acetylcholine receptor M5 (CHRM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Promazine	DMZAL7W	Acute intermittent hepatic porphyria	5C58.11	Approved	[35]
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[2]
Pilocarpine	DMV9ADG	Glaucoma/ocular hypertension	9C61	Approved	[36]
Anisodine	DMNOSWU	Central and peripheral nervous disease	8A04-8E7Z	Approved	[37]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[38]
Propiverine	DMUWBIJ	Urinary incontinence	MF50.2	Approved	[39]
Umeclidinium	DM4E8O9	Chronic obstructive pulmonary disease	CA22	Approved	[40]
Cimetropium bromide	DMZHPNE	Gastric motility disorder	DA21	Approved	[41]
Butylscopolamine	DMZKXB7	Dysmenorrhea	GA34.3	Approved	[42]
Trospium	DMX6RTG	Overactive bladder	GC50.0	Approved	[43]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M1 (CHRM1)	TTZ9SOR	ACM1_HUMAN	Inhibitor	[1]
Muscarinic acetylcholine receptor M2 (CHRM2)	TTYEG6Q	ACM2_HUMAN	Inhibitor	[1]
Muscarinic acetylcholine receptor M3 (CHRM3)	TTQ13Z5	ACM3_HUMAN	Inhibitor	[1]
Muscarinic acetylcholine receptor M4 (CHRM4)	TTQ3JTF	ACM4_HUMAN	Inhibitor	[1]
Muscarinic acetylcholine receptor M5 (CHRM5)	TTH18TF	ACM5_HUMAN	Inhibitor	[1]

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