Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFZ1YW)

• Drug Name: RO-320432 Drug Info
• Synonyms: ro 32-0432; Ro-32-0432; CHEMBL26501; (S)-3-(8-(Dimethylaminomethyl)-6,7,8,9-tetrahydropyrido(1,2-a)indol-10-yl)-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione hydrochloride; (S)-3-(8-((Dimethylamino)methyl)-6,7,8,9-tetrahydropyrido(1,2-a)indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrol-2,5-dione; (S)-3-(8-((Dimethylamino)methyl)-6,7,8,9-tetrahydropyrido(1,2-a)indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione; 151342-35-7; 1H-Pyrrole-2,5-dione, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido(1,2-a)in
• Cross-matching ID:
  PubChem CID: 127757
  CAS Number: CAS 151342-35-7
  TTD Drug ID: DMFZ1YW

Molecule-Related Drug Atlas

Drug(s) Targeting Protein kinase C epsilon (PRKCE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meprobamate	DMHM93Y	Anxiety		Approved	[3]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[4]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[5]
CDE-6960	DMA0DKI	Inflammation	1A00-CA43.1	Terminated	[6]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[7]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione	DMDO175	Discovery agent	N.A.	Investigative	[8]
3,4-diphenyl-1H-pyrrole-2,5-dione	DMPK6YT	Discovery agent	N.A.	Investigative	[8]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione	DMGC7RY	Discovery agent	N.A.	Investigative	[8]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione	DM3EV9N	Discovery agent	N.A.	Investigative	[8]
LY-326449	DMN53M4	Discovery agent	N.A.	Investigative	[9]

Drug(s) Targeting Protein kinase C alpha (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[10]
Sotrastaurin acetate	DME53YS	Renal transplantation	NE84	Phase 2	[11]
PMID28460551-Compound-3	DMA1FRM	N. A.	N. A.	Patented	[12]
ISIS 3521	DMZFS69	N. A.	N. A.	Discontinued in Phase 2	[13]
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[14]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[5]
Acteoside	DM0YHKB	Nephritis	GB40	Terminated	[15]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[7]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[16]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[17]

Drug(s) Targeting Protein kinase C theta (PRKCQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sotrastaurin acetate	DME53YS	Renal transplantation	NE84	Phase 2	[11]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[5]
CDE-6960	DMA0DKI	Inflammation	1A00-CA43.1	Terminated	[6]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[7]
LY-326449	DMN53M4	Discovery agent	N.A.	Investigative	[9]
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[18]
[2,2':5',2'']Terthiophen-4-yl-methanol	DMRQC1F	Discovery agent	N.A.	Investigative	[19]
4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol	DM8IYG1	Discovery agent	N.A.	Investigative	[20]
2-(4-Hydroxy-phenyl)-3,3-diphenyl-acrylonitrile	DMNGW1A	Discovery agent	N.A.	Investigative	[20]
[2,2':5',2'']Terthiophene-4,5''-dicarbaldehyde	DMWDNLI	Discovery agent	N.A.	Investigative	[19]

Drug(s) Targeting Protein kinase C beta (PRKCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enzastaurin	DM5H0R9	Diffuse large B-cell lymphoma	2A81	Phase 3	[21]
RUBOXISTAURIN HYDROCHLORIDE	DMQOCD8	Lymphoma	2A80-2A86	Phase 3	[22]
Sotrastaurin acetate	DME53YS	Renal transplantation	NE84	Phase 2	[11]
LY333531	DMGMC8H	Solid tumour/cancer	2A00-2F9Z	Phase 2	[23]
MS-553	DM7ER9J	Chronic lymphocytic leukaemia	2A82.0	Phase 1	[24]
Linetastine	DMF8B62	Rhinitis	FA20	Discontinued in Phase 2	[25]
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[14]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[5]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[7]
LY-326449	DMN53M4	Discovery agent	N.A.	Investigative	[9]

Drug(s) Targeting Protein kinase C delta (PRKCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KAI-9803	DMELJDI	Acute myocardial infarction	BA41	Phase 1/2	[26]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[5]
AD 198	DMJFY2I	N. A.	N. A.	Terminated	[27]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[7]
LY-326449	DMN53M4	Discovery agent	N.A.	Investigative	[9]
PROSTRATIN	DM1HMJ5	Human immunodeficiency virus infection	1C62	Investigative	[28]
[2,2':5',2'']Terthiophen-4-yl-methanol	DMRQC1F	Discovery agent	N.A.	Investigative	[19]
4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol	DM8IYG1	Discovery agent	N.A.	Investigative	[20]
2-(4-Hydroxy-phenyl)-3,3-diphenyl-acrylonitrile	DMNGW1A	Discovery agent	N.A.	Investigative	[20]
[2,2':5',2'']Terthiophene-4,5''-dicarbaldehyde	DMWDNLI	Discovery agent	N.A.	Investigative	[19]

Drug(s) Targeting Protein kinase C gamma (PRKCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[29]
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[14]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[5]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[7]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[30]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione	DMDO175	Discovery agent	N.A.	Investigative	[8]
3,4-diphenyl-1H-pyrrole-2,5-dione	DMPK6YT	Discovery agent	N.A.	Investigative	[8]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione	DMGC7RY	Discovery agent	N.A.	Investigative	[8]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione	DM3EV9N	Discovery agent	N.A.	Investigative	[8]
LY-326449	DMN53M4	Discovery agent	N.A.	Investigative	[9]

Drug(s) Targeting Protein kinase C zeta (PRKCZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methyl 2-amino-4-phenylthiophene-3-carboxylate	DM9BYJ0	N. A.	N. A.	Patented	[31]
Y-9680	DMHAVYS	N. A.	N. A.	Patented	[31]
US8889696, 39	DMKXRJ4	N. A.	N. A.	Patented	[32]
US8889672, 252-036-001	DM8B1Q4	N. A.	N. A.	Patented	[31]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[5]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[7]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[33]
LY-326449	DMN53M4	Discovery agent	N.A.	Investigative	[9]
[2,2':5',2'']Terthiophen-4-yl-methanol	DMRQC1F	Discovery agent	N.A.	Investigative	[19]
4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol	DM8IYG1	Discovery agent	N.A.	Investigative	[20]

Drug(s) Targeting Glycogen synthase kinase-3 beta (GSK-3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMO-02	DMJRU3A	Myotonic dystrophy	8C71.0	Phase 2/3	[34]
LY2090314	DMTBFE4	Acute myeloid leukaemia	2A60	Phase 2	[35]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[36]
Tideglusib	DME4LA1	Alzheimer disease	8A20	Phase 2	[37]
9-ING-41	DM57TY3	Myelofibrosis	2A20.2	Phase 2	[38]
Neu-120	DMXKOUC	Parkinson disease	8A00.0	Phase 1/2	[39]
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[40]
CHIR-99021	DMB8MNU	Allergic inflammation	4A80-4A85	Patented	[41]
TDZD-8	DMG6Q45	Malignant glioma	2A00.0	Patented	[42]
AR-A014418	DMUPN01	Ovarian cancer	2C73	Patented	[43]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycogen synthase kinase-3 beta (GSK-3B)	TTRSMW9	GSK3B_HUMAN	Inhibitor	[1]
Protein kinase C alpha (PRKCA)	TTFJ8Q1	KPCA_HUMAN	Inhibitor	[2]
Protein kinase C beta (PRKCB)	TTYPXQF	KPCB_HUMAN	Inhibitor	[2]
Protein kinase C delta (PRKCD)	TT9WJ8U	KPCD_HUMAN	Inhibitor	[2]
Protein kinase C epsilon (PRKCE)	TTBZ7OD	KPCE_HUMAN	Inhibitor	[2]
Protein kinase C gamma (PRKCG)	TTRFOXJ	KPCG_HUMAN	Inhibitor	[2]
Protein kinase C theta (PRKCQ)	TT8QL1J	KPCT_HUMAN	Inhibitor	[2]
Protein kinase C zeta (PRKCZ)	TTUWGRA	KPCZ_HUMAN	Inhibitor	[2]

References

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