Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG0PXI)

• Drug Name: Dihydrolanosterol Drug Info
• Synonyms: Dihydrolanosterin; Dihydrolanosterol; Lanost-8-en-3-ol; Lanost-8-en-3-ol #; Lanost-8-en-3-ol, (3.beta.)-; Lanost-8-en-3.beta.-ol; Lanost-8-en-3beta-ol; Lanostenol; Lanosterol, dihydro-; MBZYKEVPFYHDOH-BQNIITSRSA-N; SCHEMBL288306; (3beta)-Lanost-8-en-3-ol; 24,25-Dihydrolanosterol; 24-dihydrolanosterol; 3beta-Hydroxylanost-8-ene; 5alpha-Lanost-8-en-3 beta-ol; 5alpha-Lanost-8-en-3beta-ol; 79-62-9; 9H273A8B2X; CHEBI:28113; CHEMBL4213010; DTXSID101000181; UNII-9H273A8B2X
• Cross-matching ID:
  PubChem CID: 440560
  ChEBI ID: CHEBI:28113
  CAS Number: CAS 79-62-9
  TTD Drug ID: DMG0PXI
  INTEDE Drug ID: DR2224

Molecule-Related Drug Atlas

Drug(s) Metabolized By Cytochrome P450 51B1 (cyp51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lanosterol	DMHN74V	Discovery agent	N.A.	Investigative	[3]

Drug(s) Metabolized By Cytochrome P450 monooxygenase 51A (cyp51A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lanosterol	DMHN74V	Discovery agent	N.A.	Investigative	[1]
Obtusifoldienol	DMA63FQ	N. A.	N. A.	Investigative	[1] , [2]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[6]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[7]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[8]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[9]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[10]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[11]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[13]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[14]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[15]

Drug(s) Affected By Lanosterol 14-alpha demethylase (CYP51A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[17]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[19]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[21]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[22]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 monooxygenase 51A (cyp51A)	DEVSF75	CP51A_ASPFU	Substrate	[1] , [2]
Cytochrome P450 51B1 (cyp51)	DEZNP5G	B2HH81_MYCMM	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[4]
Lanosterol 14-alpha demethylase (CYP51A1)	OTAYHG9C	CP51A_HUMAN	Regulation of Drug Effects	[5]

References

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• [8] Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin. Circulation. 2008 Jul 22;118(4):355-62. doi: 10.1161/CIRCULATIONAHA.108.773267. Epub 2008 Jun 16.
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• [10] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [11] Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
• [12] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [13] Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
• [14] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [15] PPAR gamma ligands, troglitazone and pioglitazone, up-regulate expression of HMG-CoA synthase and HMG-CoA reductase gene in THP-1 macrophages. FEBS Lett. 2002 Jun 5;520(1-3):177-81.
• [16] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [17] Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles. Toxicology. 2006 Nov 10;228(1):24-32. doi: 10.1016/j.tox.2006.08.007. Epub 2006 Aug 12.
• [18] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [19] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [20] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [21] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [22] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.