Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGESUH)

• Drug Name: ETHIONINE Drug Info
• Synonyms: L-Ethionine; Ethionine; 13073-35-3; S-Ethyl-L-homocysteine; (S)-2-amino-4-(ethylthio)butanoic acid; L-S-Ethylhomocysteine; Homocysteine, S-ethyl-; L-Homocysteine, S-ethyl-; Ethionine (VAN); L-2-Amino-4-(ethylthio)butyric acid; UNII-WX1BN24WZT; (L)-Ethionine; (+)-ethionine; NSC 82393; CCRIS 289; C6H13NO2S; HSDB 5080; Butyric acid, 2-amino-4-(ethylthio)-, L-; EINECS 235-966-4; WX1BN24WZT; Butanoic acid, 2-amino-4-(ethylthio)-, (S)-; BRN 1722528; (+)-S-ethyl-L-homocysteine; CHEMBL203187; CHEBI:4886; Butyric acid, 2-amino-4-(ethylene)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 25674
  ChEBI ID: CHEBI:4886
  CAS Number: CAS 13073-35-3
  TTD Drug ID: DMGESUH

Molecule-Related Drug Atlas

Drug(s) Targeting Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diltiazem	DMAI7ZV	Angina pectoris	BA40	Approved	[3]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[4]
Lercanidipine	DMPWSEM	Hypertension	BA00-BA04	Approved	[5]
Pregabalin	DMDVP3B	Chronic obstructive pulmonary disease	CA22	Approved	[6]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[7]
Mirogabalin	DM5GIWZ	Peripheral neuropathy	8C0Z	Registered	[8]
Imagabalin	DMRLVUD	Generalized anxiety disorder	6B00	Phase 3	[9]
NP-118809	DM8A64W	Pain	MG30-MG3Z	Discontinued in Phase 2	[10]
PD-144550	DM03526	Discovery agent	N.A.	Investigative	[11]
3-Aminomethyl-5-methyl-hexanoic acid	DMTYXH1	Discovery agent	N.A.	Investigative	[11]

Drug(s) Affected By Methionine aminopeptidase 2 (METAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[17]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[18]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[19]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[12]
PMID27998201-Compound-22	DMS9QA7	Alzheimer disease	8A20	Patented	[20]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	TTFK1JQ	CA2D1_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Methionine aminopeptidase 2 (METAP2)	OTNDI7YK	MAP2_HUMAN	Gene/Protein Processing	[2]

References

• [1] Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41.
• [2] Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese. Biochemistry. 2003 May 6;42(17):5035-42. doi: 10.1021/bi020670c.
• [3] Egr-1, the potential target of calcium channel blockers in cardioprotection with ischemia/reperfusion injury in rats. Cell Physiol Biochem. 2009;24(1-2):17-24.
• [4] Sulfobutyl ether-alkyl ether mixed cyclodextrin derivatives with enhanced inclusion ability. J Pharm Sci. 2009 Dec;98(12):4769-80.
• [5] Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine Expert Opin Drug Metab Toxicol. 2009 Aug;5(8):981-7.
• [6] Pregabalin reduces the release of synaptic vesicles from cultured hippocampal neurons. Mol Pharmacol. 2006 Aug;70(2):467-76.
• [7] A first drug combination for the treatment of arterial hypertension with a calcium channel antagonist (amlodipine besylate) and an angiotensin receptor blocker (valsartan): Exforge. Rev Med Liege. 2007 Nov;62(11):688-94.
• [8] Efficacy and safety of mirogabalin (DS-5565) for the treatment of diabetic peripheral neuropathic pain: a randomized, double-blind, placebo- and active comparator-controlled, adaptive proof-of-concept phase 2 study. Diabetes Care. 2014 Dec;37(12):3253-61.
• [9] Methodology for rapid measures of glutamate release in rat brain slices using ceramic-based microelectrode arrays: basic characterization and drug pharmacology. Brain Res. 2011 Jul 15;1401:1-9.
• [10] Scaffold-based design and synthesis of potent N-type calcium channel blockers. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6467-72.
• [11] Enantioselective synthesis of PD144723: a potent stereospecific anticonvulsant, Bioorg. Med. Chem. Lett. 4(6):823-826 (1994).
• [12] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [13] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [14] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [15] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [16] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [17] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [18] Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
• [19] Gamma-irradiation and doxorubicin treatment of normal human cells cause cell cycle arrest via different pathways. Mol Cells. 2005 Dec 31;20(3):331-8.
• [20] Effect of nitroxoline on angiogenesis and growth of human bladder cancer. J Natl Cancer Inst. 2010 Dec 15;102(24):1855-73. doi: 10.1093/jnci/djq457. Epub 2010 Nov 18.