Details of the Drug-Related molecule(s) Interaction Atlas

Hydroxyqunoline analog 4 Drug Info

PMID25468267-Compound-44

Cross-matching ID

PubChem CID

44143209

TTD Drug ID

DMGQMCZ

General Information of Drug (ID: DMGQMCZ)

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Patented Agent(s)

Approved Drug(s)

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Drug(s) Targeting Lysine-specific demethylase 4E (KDM4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID25468267-Compound-46	DMSKCEH	N. A.	N. A.	Patented	[1]
Hydroxyqunoline analog 1	DMAJFDT	N. A.	N. A.	Patented	[1]
N-oxalyl-D-tyrosine derivative 2	DMWSZMC	N. A.	N. A.	Patented	[1]
Hydroxyqunoline analog 2	DMX3TZ7	N. A.	N. A.	Patented	[1]
N-oxalyl-D-tyrosine derivative 7	DM13K8R	N. A.	N. A.	Patented	[1]
Pyridine-2,4-dicarboxylic acid analog 4	DMGPCSR	N. A.	N. A.	Patented	[1]
Hydroxyqunoline analog 5	DM5QAKR	N. A.	N. A.	Patented	[1]
N-oxalyl-D-tyrosine derivative 9	DMTMYJ6	N. A.	N. A.	Patented	[1]
Pyridine-2,4-dicarboxylic acid analog 2	DMCNWPI	N. A.	N. A.	Patented	[1]
N-oxalyl-D-tyrosine derivative 5	DM673GR	N. A.	N. A.	Patented	[1]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[4]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[5]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Selenium	DM25CGV	N. A.	N. A.	Approved	[8]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[3]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[9]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[9]
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Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[11]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[12]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[13]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[15]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[16]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[19]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[20]
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Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[21]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[22]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[25]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[28]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[29]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[30]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[31]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[35]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[38]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[21]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Selenium	DM25CGV	N. A.	N. A.	Approved	[40]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[33]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[28]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[41]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[42]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[31]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[45]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[21]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[6]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[47]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
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Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[52]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[53]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[54]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[56]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[58]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[59]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lysine-specific demethylase 4E (KDM4E)	TTWAQBO	KDM4E_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Gene/Protein Processing	[2]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[2]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Gene/Protein Processing	[2]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Gene/Protein Processing	[2]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Gene/Protein Processing	[2]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)	OTM0GDTP	IF2A_HUMAN	Post-Translational Modifications	[2]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Gene/Protein Processing	[2]

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