Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIVY0Q)

Drug Name
Eckol Drug Info
Synonyms
Eckol; 88798-74-7; 4-(3,5-dihydroxyphenoxy)dibenzo-p-dioxin-1,3,6,8-tetrol; 1-(3,5-Dihydroxyphenoxy)-2,4,7,9-tetrahydroxydibenzo-1,4-dioxin; UNII-4A5E8354UB; CHEMBL471187; CHEBI:65819; 4A5E8354UB; 4-(3,5-dihydroxyphenoxy)oxanthrene-1,3,6,8-tetrol; 4-(3,5-dihydroxyphenoxy)-dibenzo(b,e)(1,4)dioxin-1,3,6,8-tetrol; AC1L3S7Z; SCHEMBL2562621; DTXSID40237333; ZINC6091359; BDBM50259982; Dibenzo[b,e][1,4]dioxin-1,3,6,8-tetrol, 4-(3,5-dihydroxyphenoxy)-; Dibenzo(b,e)(1,4)-dioxin-1,3,6,8-tetrol, 4-(3,5-dihydroxyphenoxy)-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
145937
ChEBI ID
CHEBI:65819
CAS Number
CAS 88798-74-7
TTD Drug ID
DMIVY0Q

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Beta-secretase (BACE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
(S)-FLURBIPROFEN DMF2O4T Myalgia FB56.2 Preregistration [4]
E-2609 DMTNUJ8 Alzheimer disease 8A20 Phase 3 [5]
verubecestat DM4CGH5 Alzheimer disease 8A20 Phase 3 [6]
Lanabecestat DMFJLB6 Alzheimer disease 8A20 Phase 3 [7]
AZD3293 DMJQHXD Alzheimer disease 8A20 Phase 2/3 [8]
JNJ-54861911 DMGPJ5U Alzheimer disease 8A20 Phase 2/3 [7]
R-flurbiprofen DMFIVSR N. A. N. A. Phase 2 [4]
LY2886721 DMV14LM Alzheimer disease 8A20 Phase 2 [9]
LY3202626 DM7IFNB Alzheimer disease 8A20 Phase 2 [7]
AZD-3839 DM72FOD Alzheimer disease 8A20 Phase 1 [10]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RNA-binding protein Musashi homolog 1 (MSI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [11]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [12]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [13]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [14]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [15]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [16]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [11]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [17]
Mivebresib DMCPF90 Acute myeloid leukaemia 2A60 Phase 1 [18]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [19]
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Drug(s) Affected By Prominin-1 (PROM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [20]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [21]
Quercetin DM3NC4M Obesity 5B81 Approved [22]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [23]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [24]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [27]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [28]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [29]
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Drug(s) Affected By Forkhead box protein O3 (FOXO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [30]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [34]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [35]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
Leflunomide DMR8ONJ Arthritis FA20 Approved [38]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [39]
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Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [44]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [45]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [46]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [47]
Testosterone DM7HUNW Hot flushes GA30 Approved [48]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [49]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Selenium DM25CGV N. A. N. A. Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [53]
Epinephrine DM3KJBC Acute asthma CA23 Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [56]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [57]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
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Drug(s) Affected By Cytochrome b-245 heavy chain (CYBB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [11]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [44]
Ethanol DMDRQZU Chronic pain MG30 Approved [61]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [62]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [63]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [11]
Dalcetrapib DMKNCVM Acute coronary syndrome BA41 Phase 3 [64]
Anacetrapib DMP2BFG Arteriosclerosis BD40 Phase 3 [64]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [65]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [71]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [72]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [73]
Testosterone DM7HUNW Hot flushes GA30 Approved [74]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [75]
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Drug(s) Affected By Transcription factor SOX-2 (SOX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [76]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [20]
Quercetin DM3NC4M Obesity 5B81 Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Panobinostat DM58WKG Chronic graft versus host disease Approved [79]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [13]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [83]
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Drug(s) Affected By Nestin (NES)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [84]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [86]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [87]
Testosterone enanthate DMB6871 N. A. N. A. Approved [88]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [13]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [89]
Clozapine DMFC71L Schizophrenia 6A20 Approved [90]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [91]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Beta-secretase (BACE) TT8JRS7 NOUNIPROTAC Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [2]
Cytochrome b-245 heavy chain (CYBB) OTGSG868 CY24B_HUMAN Gene/Protein Processing [2]
Forkhead box protein O3 (FOXO3) OTHXQG4P FOXO3_HUMAN Post-Translational Modifications [3]
Nestin (NES) OTZ9PZ14 NEST_HUMAN Gene/Protein Processing [2]
Prominin-1 (PROM1) OTBHV8NX PROM1_HUMAN Gene/Protein Processing [2]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Gene/Protein Processing [2]
RNA-binding protein Musashi homolog 1 (MSI1) OTAN4FSC MSI1H_HUMAN Gene/Protein Processing [2]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Gene/Protein Processing [3]
Transcription factor SOX-2 (SOX2) OTFAWCAU SOX2_HUMAN Gene/Protein Processing [2]

References

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67 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
68 Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol. 2008 Mar 31;583(1):26-31. doi: 10.1016/j.ejphar.2007.12.034. Epub 2008 Feb 5.
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74 Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
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77 Apigenin Inhibits Cancer Stem Cell-Like Phenotypes in Human Glioblastoma Cells via Suppression of c-Met Signaling. Phytother Res. 2016 Nov;30(11):1833-1840. doi: 10.1002/ptr.5689. Epub 2016 Jul 29.
78 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
79 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
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