Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIVY0Q)

Drug Name

Eckol Drug Info

Synonyms

Eckol; 88798-74-7; 4-(3,5-dihydroxyphenoxy)dibenzo-p-dioxin-1,3,6,8-tetrol; 1-(3,5-Dihydroxyphenoxy)-2,4,7,9-tetrahydroxydibenzo-1,4-dioxin; UNII-4A5E8354UB; CHEMBL471187; CHEBI:65819; 4A5E8354UB; 4-(3,5-dihydroxyphenoxy)oxanthrene-1,3,6,8-tetrol; 4-(3,5-dihydroxyphenoxy)-dibenzo(b,e)(1,4)dioxin-1,3,6,8-tetrol; AC1L3S7Z; SCHEMBL2562621; DTXSID40237333; ZINC6091359; BDBM50259982; Dibenzo[b,e][1,4]dioxin-1,3,6,8-tetrol, 4-(3,5-dihydroxyphenoxy)-; Dibenzo(b,e)(1,4)-dioxin-1,3,6,8-tetrol, 4-(3,5-dihydroxyphenoxy)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 145937
ChEBI ID: CHEMBL471187
CAS Number: CAS 88798-74-7
TTD Drug ID: DMIVY0Q

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Beta-secretase (BACE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(S)-FLURBIPROFEN	DMF2O4T	Myalgia	FB56.2	Preregistration	[4]
E-2609	DMTNUJ8	Alzheimer disease	8A20	Phase 3	[5]
verubecestat	DM4CGH5	Alzheimer disease	8A20	Phase 3	[6]
Lanabecestat	DMFJLB6	Alzheimer disease	8A20	Phase 3	[7]
AZD3293	DMJQHXD	Alzheimer disease	8A20	Phase 2/3	[8]
JNJ-54861911	DMGPJ5U	Alzheimer disease	8A20	Phase 2/3	[7]
R-flurbiprofen	DMFIVSR	N. A.	N. A.	Phase 2	[4]
LY2886721	DMV14LM	Alzheimer disease	8A20	Phase 2	[9]
LY3202626	DM7IFNB	Alzheimer disease	8A20	Phase 2	[7]
AZD-3839	DM72FOD	Alzheimer disease	8A20	Phase 1	[10]
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Drug(s) Affected By RNA-binding protein Musashi homolog 1 (MSI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[16]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[11]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[17]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
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Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[20]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[25]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
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Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[30]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[35]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[37]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[38]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[39]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Selenium	DM25CGV	N. A.	N. A.	Approved	[41]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[42]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[43]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[46]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[47]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
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Drug(s) Affected By Cytochrome b-245 heavy chain (CYBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[51]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[53]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[11]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[54]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[54]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[55]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[62]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[64]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[65]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Beta-secretase (BACE)	TT8JRS7	NOUNIPROTAC	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Gene/Protein Processing	[2]
Cytochrome b-245 heavy chain (CYBB)	OTGSG868	CY24B_HUMAN	Gene/Protein Processing	[2]
Forkhead box protein O3 (FOXO3)	OTHXQG4P	FOXO3_HUMAN	Post-Translational Modifications	[3]
RAF proto-oncogene serine/threonine-protein kinase (RAF1)	OT51LSFO	RAF1_HUMAN	Gene/Protein Processing	[2]
RNA-binding protein Musashi homolog 1 (MSI1)	OTAN4FSC	MSI1H_HUMAN	Gene/Protein Processing	[2]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Gene/Protein Processing	[3]

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