Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIYHAW)

Drug Name
PU-H71 Drug Info
Synonyms
PU-H71; 873436-91-0; PU H71; PU-H 71; UNII-06IVK87M04; CHEMBL200102; 06IVK87M04; 6-amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-n-(1-methylethyl)-9h-purine-9-propanamine; NSC 750424; 8-[(6-Iodo-1,3-Benzodioxol-5-Yl)thio]-9-[3-(Isopropylamino)propyl]-9h-Purin-6-Amine; 8-(6-Iodobenzo[d][1,3]dioxol-5-ylthio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine; 8-((6-Iodobenzo[d][1,3]dioxol-5-yl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine; H71; PUH-71; 2fwz; PU-H-71
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 1 [1]
Myelofibrosis 2A20.2 Phase 1 [1]
Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
Cross-matching ID
PubChem CID
9549213
CAS Number
CAS 873436-91-0
TTD Drug ID
DMIYHAW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Heat shock protein 90 beta (HSP90B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SNX-5422 DMIU0VP Haematological malignancy 2B33.Y Phase 1/2 [1]
TAS-116 DMRX530 Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [5]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [6]
Quercetin DM3NC4M Obesity 5B81 Approved [7]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [8]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [9]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [10]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [11]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [12]
Testosterone DM7HUNW Hot flushes GA30 Approved [13]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [15]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [17]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [18]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [19]
Paclitaxel DMLB81S Breast carcinoma Approved [20]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [21]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [22]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [23]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [24]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [25]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [26]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [27]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [28]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [29]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Verapamil DMA7PEW Angina pectoris BA40 Approved [31]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [32]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [33]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [34]
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Drug(s) Affected By Receptor-type tyrosine-protein kinase FLT3 (FLT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quizartinib DM8Y4JS Acute myeloid leukaemia 2A60 Approved [35]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [36]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [37]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [38]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [39]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [40]
Venetoclax DM8I94Y Chronic lymphocytic leukaemia 2A82.0 Approved [3]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [41]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [42]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [43]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [46]
Gefitinib DM15F0X Colon adenocarcinoma Approved [47]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Etretinate DM2CZFA Keratosis ED56 Approved [50]
Prednisone DM2HG4X Acute asthma CA23 Approved [51]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [52]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [53]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [33]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [55]
Methotrexate DM2TEOL Anterior urethra cancer Approved [56]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [60]
Ethacrynic acid DM60QMR Edema MG29 Approved [61]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Heat shock protein 90 beta (HSP90B) TTH5YN2 HS90B_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [3]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [3]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Gene/Protein Processing [3]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Protein Interaction/Cellular Processes [4]
Receptor-type tyrosine-protein kinase FLT3 (FLT3) OTMSRYMK FLT3_HUMAN Gene/Protein Processing [3]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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4 Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2476-85. doi: 10.1073/pnas.1205459109. Epub 2012 Aug 15.
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20 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
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25 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
26 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
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33 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
34 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
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