Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJFH97)

• Drug Name: (R)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide Drug Info
• Synonyms: CHEMBL577283; (R)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide; SCHEMBL6416013

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 11323940
  TTD Drug ID: DMJFH97

Molecule-Related Drug Atlas

Drug(s) Targeting Voltage-gated potassium channel Kv11.1 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VESNARINONE	DMBKX3C	Cardiac failure	BD10-BD13	Approved	[2]
M100907	DM7ZFBA	Sleep-wake disorder	7A00-7B2Z	Phase 3	[3]
HP-184	DMNOMV2	Multiple sclerosis	8A40	Phase 2	[4]
NITD609	DMQHBSX	Malaria	1F40-1F45	Phase 2	[5]
ABT-229	DMN3S1B	Pain	MG30-MG3Z	Phase 2	[6]
ISOQUINE	DMR17YI	Malaria	1F40-1F45	Phase 1	[7]
Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 1	DMC8935	N. A.	N. A.	Patented	[8]
Isoindoline derivative 5	DMIUTQW	N. A.	N. A.	Patented	[9]
Isoindoline derivative 3	DM2MYL9	N. A.	N. A.	Patented	[9]
Isoindoline derivative 4	DMP1NKI	N. A.	N. A.	Patented	[9]

Drug(s) Targeting Norepinephrine transporter (NET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[10]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[11]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[10]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[13]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[14]
Tapentadol hydrochloride	DMXLSH3	Acute pain	MG31	Approved	[15]
Venlafaxine	DMR6QH0	Anxiety disorder	6B00-6B0Z	Approved	[14]
Trimipramine	DM1SC8M	Major depressive disorder	6A70.3	Approved	[16]
Duloxetine	DM9BI7M	Depression	6A70-6A7Z	Approved	[17]

Drug(s) Targeting Serotonin transporter (SERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[10]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[11]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[18]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[19]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[20]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[13]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[14]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[18]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[18]
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[18]

Drug(s) Targeting Dopamine transporter (DAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[13]
Dasotraline	DMLDQFV	Attention deficit hyperactivity disorder	6A05.Z	Approved	[21]
Methylphenidate	DM7SJD6	Attention deficit hyperactivity disorder	6A05.Z	Approved	[22]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[18]
Phenmetrazine	DMXYTN9	Obesity	5B81	Approved	[23]
Ioflupane i-123	DMNARJT	Parkinson disease	8A00.0	Approved	[24]
DEXMETHYLPHENIDATE HYDROCHLORIDE	DM8WBAH	Attention deficit hyperactivity disorder	6A05.Z	Approved	[25]
Altropane	DMO9WDS	Attention deficit hyperactivity disorder	6A05.Z	Approved	[26]
Amitifadine	DMS1X67	Obesity	5B81	Phase 3	[27]
NAV5001	DMRSI1M	Dementia	6D80-6D86	Phase 3	[26]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine transporter (DAT)	TTVBI8W	SC6A3_HUMAN	Inhibitor	[1]
Norepinephrine transporter (NET)	TTAWNKZ	SC6A2_HUMAN	Inhibitor	[1]
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[1]
Voltage-gated potassium channel Kv11.1 (KCNH2)	TTQ6VDM	KCNH2_HUMAN	Inhibitor	[1]

References

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• [15] 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
• [16] Antidepressants suppress production of the Th1 cytokine interferon-gamma, independent of monoamine transporter blockade. Eur Neuropsychopharmacol. 2006 Oct;16(7):481-90.
• [17] Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today. 2007 Jan;12(1-2):34-42.
• [18] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [19] Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
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• [21] Dasotraline for the Treatment of Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Trial in Adults. Neuropsychopharmacology. 2015 Nov;40(12):2745-52.
• [22] Imaging the effects of methylphenidate on brain dopamine: new model on its therapeutic actions for attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005 Jun 1;57(11):1410-5.
• [23] Interaction of the anorectic medication, phendimetrazine, and its metabolites with monoamine transporters in rat brain. Eur J Pharmacol. 2002 Jun 28;447(1):51-7.
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• [25] Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31.
• [26] Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters. Synapse. 1998 Jun;29(2):128-41.
• [27] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 927).