Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLRBN1)

• Drug Name: L-698544 Drug Info
• Synonyms: 7-Chloro-3-nitro-3,4-dihydroquinolin-2(1H)-one; 147778-05-0; 7-chloro-3-nitro-3,4-dihydro-1H-quinolin-2-one; 7-CHLORO-3-NITRO-3,4-DIHYDROQUINOLIN-2(1H)-ONE; CHEMBL102574; 2(1H)-Quinolinone,7-chloro-3,4-dihydro-3-nitro-; ACMC-1C9KO; SCHEMBL8271408; CTK4C5567; DTXSID50436916; BDBM50038176; 3697AJ; AKOS024260378; AB06846; AK153524; DB-063735; AX8026622; FT-0703007; Z-7553; CNDQ; 7-Chloro-3-nitro-3,4-dihydro-1H-quinolin-2-one

Indication

Disease Entry	ICD 11	Status	REF
Alzheimer disease	8A20	Terminated	[1]

• Cross-matching ID:
  PubChem CID: 10220180
  CAS Number: CAS 147778-05-0
  TTD Drug ID: DMLRBN1

Molecule-Related Drug Atlas

Drug(s) Targeting Glutamate receptor ionotropic NMDA 2A (NMDAR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glycine	DMIOZ29	Malnutrition	5B50-5B71	Approved	[4]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[5]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[6]
Spermine	DMD4BFY	N. A.	N. A.	Terminated	[7]
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[8]
Dizocilpine	DMMGYXR	Cerebrovascular ischaemia	8B1Z	Terminated	[9]
RPR-104632	DM9L50N	N. A.	N. A.	Terminated	[10]
L-698532	DMO9HM7	Neurological disorder	6B60	Terminated	[11]
L-695902	DMT1DNS	N. A.	N. A.	Terminated	[3]
L-701324	DMAIJSX	Cerebrovascular ischaemia	8B1Z	Terminated	[11]

Drug(s) Targeting Glutamate receptor AMPA (GRIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[12]
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[13]
Zopiclone	DMPI6Z0	Insomnia	7A00-7A0Z	Approved	[14]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[15]
Enflurane	DM0YJSB	Anaesthesia	9A78.6	Approved	[16]
Isoflurane	DMY6T31	Anaesthesia	9A78.6	Approved	[17]
Bromazepam	DMY9TCW	Anxiety disorder	6B00-6B0Z	Approved	[18]
Artemisinin SP	DMFETDK	Malaria	1F40-1F45	Approved	[19]
Dihydroergotoxine	DM5D6WZ	Alzheimer disease	8A20	Approved	[20]
Barbiturate	DMJIA6T	Anaesthesia	9A78.6	Approved	[21]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 1 (NMDAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cycloserine	DMT1I52	Bacterial infection	1A00-1C4Z	Approved	[22]
D-Serine	DM3YH4I	N. A.	N. A.	Phase 4	[23]
ELIPRODIL	DMIOGZM	Multiple sclerosis	8A40	Phase 2	[24]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[5]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[6]
Spermine	DMD4BFY	N. A.	N. A.	Terminated	[7]
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[25]
Dizocilpine	DMMGYXR	Cerebrovascular ischaemia	8B1Z	Terminated	[9]
RPR-104632	DM9L50N	N. A.	N. A.	Terminated	[10]
L-698532	DMO9HM7	Neurological disorder	6B60	Terminated	[11]

Drug(s) Targeting N-methyl-D-aspartate receptor (NMDAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-glutamic acid	DM4PUDW	Schizophrenia	6A20	Approved	[26]
Cycloserine	DMT1I52	Bacterial infection	1A00-1C4Z	Approved	[27]
Benzphetamine	DMIJATC	Obesity	5B81	Approved	[28]
Ketamine	DMT5HA4	Anaesthesia	9A78.6	Approved	[29]
Felbamate	DM1V5ZS	Epilepsy	8A60-8A68	Approved	[30]
Memantine	DMD9WSC	Alzheimer disease	8A20	Approved	[31]
Huperzine A	DMMAWLU	Alzheimer disease	8A20	Approved	[32]
Levorphanol	DMGS80V	Pain	MG30-MG3Z	Approved	[33]
Magnesium Sulfate	DMVEK07	Acute pain	MG31	Approved	[34]
Magnesium	DMU4ORS	Ischemic stroke	8B11.5Z	Approved	[35]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 2B (NMDAR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha 1-PI	DMXC1K9	Alpha-1 antitrypsin deficiency	5C5A	Approved	[36]
ELIPRODIL	DMIOGZM	Multiple sclerosis	8A40	Phase 2	[24]
CP-101,606	DMIU19E	Parkinson disease	8A00.0	Phase 2	[37]
CERC-301	DMSABRI	Major depressive disorder	6A70.3	Phase 2	[38]
RGH-896	DMCHZAN	Peripheral neuropathy	8C0Z	Phase 2	[39]
MIJ821	DMN45RI	Major depressive disorder	6A70.3	Phase 2	[40]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[5]
Neu-2000	DMNJTLC	Cardiac arrest	MC82	Phase 1	[41]
EVT100	DMAKWQD	Major depressive disorder	6A70.3	Phase 1	[42]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[6]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor AMPA (GRIA)	TTAN6JD	NOUNIPROTAC	Antagonist	[2]
Glutamate receptor ionotropic NMDA 1 (NMDAR1)	TTLD29N	NMDZ1_HUMAN	Inhibitor	[3]
Glutamate receptor ionotropic NMDA 2A (NMDAR2A)	TTKJEMQ	NMDE1_HUMAN	Inhibitor	[3]
Glutamate receptor ionotropic NMDA 2B (NMDAR2B)	TTN9D8E	NMDE2_HUMAN	Inhibitor	[3]
N-methyl-D-aspartate receptor (NMDAR)	TT9IK2Z	NOUNIPROTAC	Modulator	[2]

References

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