General Information of Drug (ID: DMMD9QE)

Drug Name
Colistin Drug Info
Synonyms Colistin sulphate; Polymyxin E; Colistin sulfate, nonsterile; Polymyxin E. Sulfate; Coly-Mycin M Parenteral (TN)
Indication
Disease Entry ICD 11 Status REF
Pseudomonas infection 1B92 Approved [1]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
5311054
CAS Number
CAS 1066-17-7
TTD Drug ID
DMMD9QE
INTEDE Drug ID
DR2644

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [5]
Sulfadiazine DMTW3R8 Rheumatic fever 1B40-1B42 Approved [6]
Doripenem DM9UCJK Cholecystitis Approved [7]
Sulphadoxine DMZI2UF Malaria 1F40-1F45 Approved [8]
Sulfisoxazole DMXLT8C Acute otitis media AB00 Approved [9]
Sulfapyridine DMIUYFH Dermatitis herpetiformis EB44 Approved [10]
Gramicidin D DMPT74U Bacterial infection 1A00-1C4Z Approved [11]
Oritavancin DM28D05 Bacterial infection 1A00-1C4Z Approved [7]
Faropenem DMX7A5V Gram-positive bacterial infection 1B74-1G40 Approved [7]
Daptomycin DMFDQ3I Bacterial infection 1A00-1C4Z Approved [12]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Endoglucanase Y (EGY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gentamicin DMKINJO Bacteremia 1A73 Approved [3]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [3]
Streptomycin DME1LQN Bacterial infection 1A00-1C4Z Approved [3]
Bacitracin DM5OHYE Blepharoconjunctivitis Approved [3]
Gentamicin DMKINJO Bacteremia 1A73 Approved [3]
Amikacin DM5PDRB Bacteremia 1A73 Approved [3]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [3]
Streptomycin DME1LQN Bacterial infection 1A00-1C4Z Approved [3]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By DNA polymerase beta (POLB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [14]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [15]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [16]
Arsenic DMTL2Y1 N. A. N. A. Approved [17]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [18]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [19]
4-hydroxy-2-nonenal DM2LJFZ Discovery agent N.A. Investigative [20]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [21]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [22]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Dihydropteroate synthetase (Bact folP) TT4ILYC DHPS_ECOLI Binder [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Endoglucanase Y (EGY) DE2M583 A0A256VAC0_LACRE Substrate [3]
Endoglucanase Y (EGY) DE2AZTG A0A256VAC0_LACRE Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
DNA polymerase beta (POLB) OTPJIL05 DPOLB_HUMAN Drug Response [4]

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria. Ann Pharmacother. 1999 Sep;33(9):960-7.
3 Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63.
4 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
5 In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrob Agents Chemother. 1995 Apr;39(4):948-52.
6 Sulfadiazine/hydroxypropyl-beta-cyclodextrin host-guest system: Characterization, phase-solubility and molecular modeling. Bioorg Med Chem. 2008 May 15;16(10):5788-94.
7 Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
8 The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
9 Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995 Aug;39(8):1756-63.
10 A confirmatory method for the simultaneous extraction, separation, identification and quantification of Tetracycline, Sulphonamide, Trimethoprim an... J Chromatogr A. 2009 Nov 13;1216(46):8110-6.
11 Structures of gramicidins A, B, and C incorporated into sodium dodecyl sulfate micelles. Biochemistry. 2001 Oct 2;40(39):11676-86.
12 Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin. Chem Biol. 2004 Jul;11(7):949-57.
13 Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
14 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
15 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
16 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
17 Curcumin prevents DNA damage and enhances the repair potential in a chronically arsenic-exposed human population in West Bengal, India. Eur J Cancer Prev. 2011 Mar;20(2):123-31. doi: 10.1097/cej.0b013e328341017a.
18 The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death. Cancer Res. 2005 Jul 15;65(14):6394-400. doi: 10.1158/0008-5472.CAN-05-0715.
19 Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells. Br J Cancer. 2009 May 5;100(9):1425-33. doi: 10.1038/sj.bjc.6605039.
20 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
21 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
22 A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.