Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMO1ZHE)

• Drug Name: isonipecotic acid Drug Info
• Synonyms: Isonipecotic acid; Piperidine-4-carboxylic acid; 498-94-2; 4-Piperidinecarboxylic acid; 4-Carboxypiperidine; Hexahydroisonicotinic acid; h-inp-oh; dl-isopipecolinic acid; Isonicotinic acid, hexahydro-; Acide isonipecotique; 4-Hexahydroisonicotinic acid; NSC 61049; UNII-M5TZP1RWIE; iso-nipecotic acid; Acide isonipecotique [French]; Acide piperidine-carboxylique-4; M5TZP1RWIE; EINECS 207-872-3; BRN 0112553; 4-Piperidine carboxylic acid; Acide piperidine-carboxylique-4 [French]; CHEMBL279998; SRJOCJYGOFTFLH-UHFFFAOYSA-N

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 3773
  CAS Number: CAS 498-94-2
  TTD Drug ID: DMO1ZHE
  VARIDT Drug ID: DR00940

Molecule-Related Drug Atlas

Drug(s) Targeting GABA(A) receptor rho3 (GABRR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[8]
piperidine-4-sulphonic acid	DMMIZWE	Discovery agent	N.A.	Investigative	[8]
trans-3-ACPBPA	DM6HI8W	Discovery agent	N.A.	Investigative	[8]
cis-3-ACPBPA	DMQ0EA7	Discovery agent	N.A.	Investigative	[8]
5-Me-IAA	DMFZN7J	Discovery agent	N.A.	Investigative	[8]
aza-THIP	DML70NC	Discovery agent	N.A.	Investigative	[8]
TPMPA	DMBF6KS	Discovery agent	N.A.	Investigative	[8]
(+/-)-cis-2-CAMP	DMY3J0B	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting GABA(A) receptor alpha-5 (GABRA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[4]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[10]
Basmisanil	DMQ8J0U	Alzheimer disease	8A20	Phase 2	[11]
RG-7816	DMD16JK	Autism spectrum disorder	6A02	Phase 1	[12]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[4]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[13]
Ro-15-3505	DM4NW3U	Discovery agent	N.A.	Investigative	[14]
[3H]Ro154513	DMMBWKL	Discovery agent	N.A.	Investigative	[15]
[3H]CGS8216	DMLP68J	Inflammation	1A00-CA43.1	Investigative	[4]
CI-218872	DM0RH3S	Discovery agent	N.A.	Investigative	[16]

Drug(s) Targeting GABA(A) receptor gamma-3 (GABRG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolpidem	DMWOSKJ	Insomnia	7A00-7A0Z	Approved	[5]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[11]
Clobazam - Lundbeck	DMW1OQ0	Anxiety disorder	6B00-6B0Z	Approved	[17]
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[5]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[18]
Thiamylal	DMHDF7B	Anaesthesia	9A78.6	Approved	[17]
Ganaxolone	DMXJMKF	Epileptic seizures	8A61-8A6Z	Approved	[11]
Mebutamate	DM0KYI4	Anxiety disorder	6B00-6B0Z	Approved	[17]
Metharbital	DM5A38V	Epilepsy	8A60-8A68	Approved	[17]
Etomidate	DMZI3WO	Anaesthesia	9A78.6	Approved	[17]

Drug(s) Targeting GABA(A) receptor alpha-2 (GABRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[2]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[10]
PF-4480682	DMWYJHC	Neuropathic pain	8E43.0	Discontinued in Phase 2	[19]
CGS-17867A	DMMZJY3	Alcohol dependence	6C40.2	Terminated	[20]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[2]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[13]
Ro-15-3505	DM4NW3U	Discovery agent	N.A.	Investigative	[14]
[3H]Ro154513	DMMBWKL	Discovery agent	N.A.	Investigative	[15]
[3H]CGS8216	DMLP68J	Inflammation	1A00-CA43.1	Investigative	[2]
CI-218872	DM0RH3S	Discovery agent	N.A.	Investigative	[16]

Drug(s) Targeting GABA(A) receptor alpha-3 (GABRA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[3]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[10]
Adipiplon	DM821BS	Sleep-wake disorder	7A00-7B2Z	Phase 2	[21]
NS-2710	DMMUR6V	Anxiety disorder	6B00-6B0Z	Phase 2	[22]
AZD6280	DMFAZLU	Anxiety disorder	6B00-6B0Z	Discontinued in Phase 1	[23]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[3]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[13]
Ro-15-3505	DM4NW3U	Discovery agent	N.A.	Investigative	[14]
[3H]Ro154513	DMMBWKL	Discovery agent	N.A.	Investigative	[15]
[3H]CGS8216	DMLP68J	Inflammation	1A00-CA43.1	Investigative	[3]

Drug(s) Targeting Gamma-aminobutyric acid receptor (GAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[24]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[25]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[26]
Clonazepam	DMTO13J	Absence epilepsy		Approved	[27]
Piperazine	DMTY9LU	Ascariasis	1F62	Approved	[28]
Alpidem	DMN7Y9K	Anxiety disorder	6B00-6B0Z	Approved	[29]
Moxidectin	DMYGHX5	Onchocerciasis	1F6A	Approved	[30]
DP-VPA	DMGOXPQ	Bipolar disorder	6A60	Approved	[31]
ANDROSTERONE	DMITJAK	N. A.	N. A.	Phase 3	[25]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[32]

Drug(s) Targeting GABA(A) receptor rho2 (GABRR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[7]
piperidine-4-sulphonic acid	DMMIZWE	Discovery agent	N.A.	Investigative	[7]
trans-3-ACPBPA	DM6HI8W	Discovery agent	N.A.	Investigative	[7]
cis-3-ACPBPA	DMQ0EA7	Discovery agent	N.A.	Investigative	[7]
5-Me-IAA	DMFZN7J	Discovery agent	N.A.	Investigative	[7]
aza-THIP	DML70NC	Discovery agent	N.A.	Investigative	[7]
TPMPA	DMBF6KS	Discovery agent	N.A.	Investigative	[7]
(+/-)-cis-2-CAMP	DMY3J0B	Discovery agent	N.A.	Investigative	[7]

Drug(s) Targeting GABA(A) receptor rho1 (GABRR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[6]
piperidine-4-sulphonic acid	DMMIZWE	Discovery agent	N.A.	Investigative	[6]
trans-3-ACPBPA	DM6HI8W	Discovery agent	N.A.	Investigative	[6]
cis-3-ACPBPA	DMQ0EA7	Discovery agent	N.A.	Investigative	[6]
5-Me-IAA	DMFZN7J	Discovery agent	N.A.	Investigative	[6]
aza-THIP	DML70NC	Discovery agent	N.A.	Investigative	[6]
TPMPA	DMBF6KS	Discovery agent	N.A.	Investigative	[6]
(+/-)-cis-2-CAMP	DMY3J0B	Discovery agent	N.A.	Investigative	[6]
CACA	DMPKFYZ	Discovery agent	N.A.	Investigative	[33]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA(A) receptor alpha-2 (GABRA2)	TTBMV1G	GBRA2_HUMAN	Agonist	[2]
GABA(A) receptor alpha-3 (GABRA3)	TT37EDJ	GBRA3_HUMAN	Agonist	[3]
GABA(A) receptor alpha-5 (GABRA5)	TTNZPQ1	GBRA5_HUMAN	Agonist	[4]
GABA(A) receptor gamma-3 (GABRG3)	TTEX6LM	GBRG3_HUMAN	Agonist	[5]
GABA(A) receptor rho1 (GABRR1)	TT6XFEU	GBRR1_HUMAN	Antagonist	[6]
GABA(A) receptor rho2 (GABRR2)	TTQMXLS	GBRR2_HUMAN	Antagonist	[7]
GABA(A) receptor rho3 (GABRR3)	TT4N6D8	GBRR3_HUMAN	Antagonist	[8]
Gamma-aminobutyric acid receptor (GAR)	TTNJYV2	NOUNIPROTAC	Inhibitor	[9]

References

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• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 405).
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• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408).
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• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 420).
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 421).
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