Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRLXAI)

• Drug Name: ED-71 Drug Info
• Synonyms: Edirol; Eldecalcitol; (5Z,7E)-(1R,2R,3R)-2-(3-hydroxypropoxy)-9,10-seco-5,7,10(19)-cholestatriene-1,3,25-triol; 104121-92-8; 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)cholecalciferol; 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3; 2-(3-Hydroxypropoxy)-1,25-dihydroxyvitamin D3; ED 71; ED-71; I2JP8UE90H; UNII-I2JP8UE90H
• Cross-matching ID:
  PubChem CID: 6918141
  ChEBI ID: CHEBI:73927
  CAS Number: CAS 104121-92-8
  TTD Drug ID: DMRLXAI
  INTEDE Drug ID: DR0562

Molecule-Related Drug Atlas

Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[3]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[5]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[6]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[7]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[9]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[10]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[11]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[12]

Drug(s) Affected By 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[13]
Calcidiol	DMN4CV5	Hypophosphatemia		Approved	[14]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[21]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[22]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[23]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[26]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[28]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[29]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[30]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[31]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Methylsterol monooxygenase 1 (MSMO1) Main DME	DE5FUD0	MSMO1_HUMAN	Substrate	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)	OTG2T749	CP24A_HUMAN	Regulation of Drug Effects	[1]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Regulation of Drug Effects	[1]
Retinoic acid receptor RXR-alpha (RXRA)	OTP1TBDM	RXRA_HUMAN	Protein Interaction/Cellular Processes	[2]
Vitamin D3 receptor	OTFC7K35	VDR_HUMAN	Protein Interaction/Cellular Processes	[1]

References

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