Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRV5YE)

• Drug Name: KURARINOL Drug Info
• Synonyms: Kurarinol; CHEBI:81093; 855746-98-4; CHEMBL455667; MolPort-039-338-650; ZINC13817026; BDBM50366788; C17444

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 44563198
  ChEBI ID: CHEMBL81093
  CAS Number: CAS 855746-98-4
  TTD Drug ID: DMRV5YE

Molecule-Related Drug Atlas

Drug(s) Targeting Phosphodiesterase 5A (PDE5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tadalafil	DMJZHT1	Benign prostatic hyperplasia	GA90	Approved	[3]
Udenafil	DM1IQRP	Erectile dysfunction	HA01.1	Approved	[4]
Vardenafil	DMTBGW8	Cystic fibrosis	CA25	Approved	[5]
Dipyridamole	DMXY30O	Atrial fibrillation	BC81.3	Approved	[6]
Papaverine	DMCA9QP	Brain ischaemia	8B1Z	Approved	[7]
Avanafil	DM75CXN	Erectile dysfunction	HA01.1	Approved	[8]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[9]
ICARIIN	DMOJQGT	N. A.	N. A.	Phase 3	[10]
EXISULIND	DMBY56U	Colorectal cancer	2B91.Z	Phase 3	[11]
PF-489791	DM3C8GQ	Chronic obstructive pulmonary disease	CA22	Phase 2	[12]

Drug(s) Targeting Phosphodiesterase 4B (PDE4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DENBUFYLLINE	DM2R15Q	Cognitive impairment	6D71	Phase 3	[13]
SOTB07	DMIG4OX	Asthma	CA23	Phase 3	[14]
BI 1015550	DM6DO2P	Idiopathic pulmonary fibrosis	CB03.4	Phase 3	[15]
AN-2898	DMDK7CL	Atopic dermatitis	EA80	Phase 2	[16]
GPD-1116	DMOQ7YI	Asthma	CA23	Phase 2	[17]
TA-7906	DMZTAJL	Atopic dermatitis	EA80	Phase 2	[18]
HT-0712	DM2WP8F	Cognitive impairment	6D71	Phase 2	[14]
TOFIMILAST	DMLCUAS	Chronic obstructive pulmonary disease	CA22	Phase 2	[19]
AWD-12-281	DMVADGZ	Rhinitis	FA20	Phase 2	[20]
LIRIMILAST	DMD4KAU	Chronic obstructive pulmonary disease	CA22	Phase 2	[19]

Drug(s) Targeting Phosphodiesterase 4A (PDE4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dyphylline	DM8DZC1	Acute bronchial asthma	CA23	Approved	[21]
Enprofylline	DMFYZKN	Asthma	CA23	Approved	[22]
DENBUFYLLINE	DM2R15Q	Cognitive impairment	6D71	Phase 3	[13]
SOTB07	DMIG4OX	Asthma	CA23	Phase 3	[23]
Tofisopam	DMTGNWU	Hyperuricaemia	5C55.Y	Phase 2	[24]
AN-2898	DMDK7CL	Atopic dermatitis	EA80	Phase 2	[16]
GPD-1116	DMOQ7YI	Asthma	CA23	Phase 2	[17]
TA-7906	DMZTAJL	Atopic dermatitis	EA80	Phase 2	[18]
HT-0712	DM2WP8F	Cognitive impairment	6D71	Phase 2	[23]
TOFIMILAST	DMLCUAS	Chronic obstructive pulmonary disease	CA22	Phase 2	[25]

Drug(s) Targeting Phosphodiesterase 3A (PDE3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cilostazol	DMZMSCT	Intermittent claudication	BD40.00	Approved	[26]
Aminophylline	DML2NIB	Bronchial asthma	CA23	Approved	[27]
Anagrelide	DMSQ8MD	Thrombocythemia	3B63	Approved	[28]
Enoximone	DMQVZJD	Congestive heart failure	BD10	Approved	[29]
VESNARINONE	DMBKX3C	Cardiac failure	BD10-BD13	Approved	[30]
BEMORADAN	DMUL6GY	Heart failure	BD10-BD13	Phase 2	[8]
CI-930	DMADPQX	N. A.	N. A.	Discontinued in Phase 2	[31]
EMD-53998	DMVS8IE	Cardiovascular disease	BA00-BE2Z	Discontinued in Phase 1	[8]
IMAZODAN	DMWTFO3	N. A.	N. A.	Terminated	[32]
LAS-31180	DMW2K1L	Heart failure	BD10-BD13	Terminated	[33]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[36]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[43]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 3A (PDE3A)	TT06AWU	PDE3A_HUMAN	Inhibitor	[1]
Phosphodiesterase 4A (PDE4A)	TTZ97H5	PDE4A_HUMAN	Inhibitor	[1]
Phosphodiesterase 4B (PDE4B)	TTVIAT9	PDE4B_HUMAN	Inhibitor	[1]
Phosphodiesterase 5A (PDE5A)	TTJ0IQB	PDE5A_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[2]

References

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