Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRV5YE)

Drug Name
KURARINOL Drug Info
Synonyms Kurarinol; CHEBI:81093; 855746-98-4; CHEMBL455667; MolPort-039-338-650; ZINC13817026; BDBM50366788; C17444
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44563198
ChEBI ID
CHEBI:81093
CAS Number
CAS 855746-98-4
TTD Drug ID
DMRV5YE

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Phosphodiesterase 5A (PDE5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tadalafil DMJZHT1 Benign prostatic hyperplasia GA90 Approved [3]
Udenafil DM1IQRP Erectile dysfunction HA01.1 Approved [4]
Vardenafil DMTBGW8 Cystic fibrosis CA25 Approved [5]
Dipyridamole DMXY30O Atrial fibrillation BC81.3 Approved [6]
Papaverine DMCA9QP Brain ischaemia 8B1Z Approved [7]
Avanafil DM75CXN Erectile dysfunction HA01.1 Approved [8]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [9]
ICARIIN DMOJQGT N. A. N. A. Phase 3 [10]
EXISULIND DMBY56U Colorectal cancer 2B91.Z Phase 3 [11]
PF-489791 DM3C8GQ Chronic obstructive pulmonary disease CA22 Phase 2 [12]
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Drug(s) Targeting Phosphodiesterase 4B (PDE4B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DENBUFYLLINE DM2R15Q Cognitive impairment 6D71 Phase 3 [13]
SOTB07 DMIG4OX Asthma CA23 Phase 3 [14]
BI 1015550 DM6DO2P Idiopathic pulmonary fibrosis CB03.4 Phase 3 [15]
AN-2898 DMDK7CL Atopic dermatitis EA80 Phase 2 [16]
GPD-1116 DMOQ7YI Asthma CA23 Phase 2 [17]
TA-7906 DMZTAJL Atopic dermatitis EA80 Phase 2 [18]
HT-0712 DM2WP8F Cognitive impairment 6D71 Phase 2 [14]
TOFIMILAST DMLCUAS Chronic obstructive pulmonary disease CA22 Phase 2 [19]
AWD-12-281 DMVADGZ Rhinitis FA20 Phase 2 [20]
LIRIMILAST DMD4KAU Chronic obstructive pulmonary disease CA22 Phase 2 [19]
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Drug(s) Targeting Phosphodiesterase 4A (PDE4A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dyphylline DM8DZC1 Acute bronchial asthma CA23 Approved [21]
Enprofylline DMFYZKN Asthma CA23 Approved [22]
DENBUFYLLINE DM2R15Q Cognitive impairment 6D71 Phase 3 [13]
SOTB07 DMIG4OX Asthma CA23 Phase 3 [23]
Tofisopam DMTGNWU Hyperuricaemia 5C55.Y Phase 2 [24]
AN-2898 DMDK7CL Atopic dermatitis EA80 Phase 2 [16]
GPD-1116 DMOQ7YI Asthma CA23 Phase 2 [17]
TA-7906 DMZTAJL Atopic dermatitis EA80 Phase 2 [18]
HT-0712 DM2WP8F Cognitive impairment 6D71 Phase 2 [23]
TOFIMILAST DMLCUAS Chronic obstructive pulmonary disease CA22 Phase 2 [25]
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Drug(s) Targeting Phosphodiesterase 3A (PDE3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cilostazol DMZMSCT Intermittent claudication BD40.00 Approved [26]
Aminophylline DML2NIB Bronchial asthma CA23 Approved [27]
Anagrelide DMSQ8MD Thrombocythemia 3B63 Approved [28]
Enoximone DMQVZJD Congestive heart failure BD10 Approved [29]
VESNARINONE DMBKX3C Cardiac failure BD10-BD13 Approved [30]
BEMORADAN DMUL6GY Heart failure BD10-BD13 Phase 2 [8]
CI-930 DMADPQX N. A. N. A. Discontinued in Phase 2 [31]
EMD-53998 DMVS8IE Cardiovascular disease BA00-BE2Z Discontinued in Phase 1 [8]
IMAZODAN DMWTFO3 N. A. N. A. Terminated [32]
LAS-31180 DMW2K1L Heart failure BD10-BD13 Terminated [33]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [34]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [36]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [37]
Gefitinib DM15F0X Colon adenocarcinoma Approved [38]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [39]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [40]
Selenium DM25CGV N. A. N. A. Approved [41]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [42]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [43]
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Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [46]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [48]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [51]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [56]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [57]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [58]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [59]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [60]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [61]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [62]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [63]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [66]
Selenium DM25CGV N. A. N. A. Approved [41]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [67]
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [69]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [70]
Quercetin DM3NC4M Obesity 5B81 Approved [71]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [72]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [73]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [74]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [75]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [80]
Ethacrynic acid DM60QMR Edema MG29 Approved [81]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Phosphodiesterase 3A (PDE3A) TT06AWU PDE3A_HUMAN Inhibitor [1]
Phosphodiesterase 4A (PDE4A) TTZ97H5 PDE4A_HUMAN Inhibitor [1]
Phosphodiesterase 4B (PDE4B) TTVIAT9 PDE4B_HUMAN Inhibitor [1]
Phosphodiesterase 5A (PDE5A) TTJ0IQB PDE5A_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [2]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [2]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [2]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Gene/Protein Processing [2]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Post-Translational Modifications [2]

References

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79 D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
80 Anti-cancer properties of glucosamine-hydrochloride in YD-8 human oral cancer cells: Induction of the caspase-dependent apoptosis and down-regulation of HIF-1. Toxicol In Vitro. 2012 Feb;26(1):42-50. doi: 10.1016/j.tiv.2011.10.005. Epub 2011 Oct 13.
81 Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1. Clin Cancer Res. 2012 Dec 15;18(24):6690-701. doi: 10.1158/1078-0432.CCR-12-0770. Epub 2012 Oct 18.