Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTGMB1)

• Drug Name: Metanephrine Drug Info
• Synonyms: Metanephrine; Metadrenaline; 5001-33-2; DL-Metanephrine; 3-Methoxyadrenaline; m-O-Methyladrenaline; (+/-)-Metanephrine; 4-[1-Hydroxy-2-(methylamino)ethyl]-2-methoxyphenol; CHEBI:89633; JWJCTZKFYGDABJ-UHFFFAOYSA-N; 3-methoxy-adrenaline; epinephrine metabolite; 3-O-Methylepinephrine; 3-O-methyl-Adrenaline; Adrenaline, 3-methoxy-; AC1L2HML; Prestwick2_000122; Prestwick0_000122; DL-3-O-Methyladrenaline; Prestwick3_000122; Prestwick1_000122; Adrenaline, 3-O-methyl-; DL-METANEPHRINE HCI; CHEMBL775; Vanillyl alcohol, .alpha.-[(methylamin

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 21100
  ChEBI ID: CHEBI:89633
  CAS Number: CAS 5001-33-2
  TTD Drug ID: DMTGMB1

Molecule-Related Drug Atlas

Drug(s) Affected By Amine oxidase A (MAOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[5]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[6]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[7]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[8]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Haloperidol	DM96SE0	Delirium		Approved	[16]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Selenium	DM25CGV	N. A.	N. A.	Approved	[18]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[19]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[5]

Drug(s) Affected By Catechol O-methyltransferase (COMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[23]
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[23]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[23]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[24]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[23]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Catecholamine uptake (CA uptake)	TTJ6ESR	NOUNIPROTAC	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Amine oxidase A (MAOA)	OT8NIWMQ	AOFA_HUMAN	Regulation of Drug Effects	[3]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Regulation of Drug Effects	[3]
Catechol O-methyltransferase (COMT)	OTPWKTQG	COMT_HUMAN	Biotransformations	[3]

References

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• [19] Hepatocellular peroxisomes in human alcoholic and drug-induced hepatitis: a quantitative study. Hepatology. 1991 Nov;14(5):811-7.
• [20] Antioxidant enzyme and malondialdehyde values in social phobia before and after citalopram treatment. Eur Arch Psychiatry Clin Neurosci. 2004 Aug;254(4):231-5.
• [21] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [22] The effect of statins on lipids peroxidation and activities of antioxidants enzymes in patients with dyslipidemia. Przegl Lek. 2006;63(9):738-42.
• [23] Molecular mechanisms controlling the rate and specificity of catechol O-methylation by human soluble catechol O-methyltransferase. Mol Pharmacol. 2001 Feb;59(2):393-402. doi: 10.1124/mol.59.2.393.
• [24] Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT. Sleep. 2010 Aug;33(8):1027-35. doi: 10.1093/sleep/33.8.1027.
• [25] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [26] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
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