Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTQP0K)

Drug Name

Ro 5-4864 Drug Info

Synonyms

4'-Chlorodiazepam; 14439-61-3; 4-Chlorodiazepam; RO5-4864; UNII-2QW0IK1742; HSDB 6958; BRN 0685202; Ro-05-4864; MLS000069627; CHEMBL286346; 2QW0IK1742; Ro-5-4864; SMR000058205; 4 inverted exclamation marka-Chlorodiazepam; 7-Chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Chloro-1,3-dihydro-1-methyl-5-(p-chlorophenyl)-2H-1,4-benzodiazepin-2-one; 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-; 7-chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one; NB-3040

Indication

Disease Entry	ICD 11	Status	REF
Gram-positive bacterial infection	1B74-1G40	Investigative	[1]

Cross-matching ID

PubChem CID: 1688
CAS Number: CAS 14439-61-3
TTD Drug ID: DMTQP0K

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Translocator protein (TSPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[3]
Flunitrazepam	DMGR5Z3	Insomnia	7A00-7A0Z	Approved	[4]
Oxazepam	DMXNZM4	Alcohol withdrawal delirium		Approved	[5]
Midazolam	DMXOELT	Agitation	6A70.3	Approved	[6]
Temazepam	DM02A65	Insomnia	7A00-7A0Z	Approved	[6]
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[7]
Alprazolam	DMC7XDN	Anxiety		Approved	[4]
Clotiazepam	DM59AZT	Anxiety disorder	6B00-6B0Z	Approved	[8]
Quazepam	DMY4D87	Insomnia	7A00-7A0Z	Approved	[6]
Eszopiclone	DM8RZ9H	Insomnia	7A00-7A0Z	Approved	[9]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting Polypeptide deformylase (PDF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[10]
Meprobamate	DMHM93Y	Anxiety		Approved	[11]
Pralatrexate	DMAO80I	Breast cancer	2C60-2C65	Approved	[12]
Ustekinumab	DMHTYK3	Plaque psoriasis	EA90.0	Approved	[13]
Trimetrexate	DMDEA85	Toxoplasmosis	1F57	Approved	[14]
MCB-3837	DM0R4Z5	Malaria	1F40-1F45	Approved	[11]
Chlorproguanil	DM1IFGT	Malaria	1F40-1F45	Approved	[11]
LY333531	DMGMC8H	Solid tumour/cancer	2A00-2F9Z	Phase 2	[15]
Metoprine	DM5GQD7	Advanced cancer	2A00-2F9Z	Phase 2	[16]
Aminopterin	DMQ9RBV	leukaemia	2A60-2B33	Withdrawn from market	[17]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Polypeptide deformylase (PDF)	TT9SL3Q	DEFM_HUMAN	Inhibitor	[1]
Translocator protein (TSPO)	TTPTXIN	TSPO_HUMAN	Binder	[2]

------------------------------------------------------------------------------------

References

1	Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
2	Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. Br J Cancer. 2001 Nov 30;85(11):1771-80.
3	Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo. Eur J Pharmacol. 2010 Jan 25;626(2-3):131-8.
4	Comparison of five benzodiazepine-receptor agonists on buprenorphine-induced mu-opioid receptor regulation. J Pharmacol Sci. 2009 May;110(1):36-46.
5	Effects of the combination of metyrapone and oxazepam on cocaine and food self-administration in rats. Pharmacol Biochem Behav. 2008 Nov;91(1):181-9.
6	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
7	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2879).
8	Effects of benzodiazepines and non-benzodiazepine compounds on the GABA-induced response in frog isolated sensory neurones. Br J Pharmacol. 1989 Nov;98(3):735-40.
9	New hypnotics: perspectives from sleep physiology. Vertex. 2007 Jul-Aug;18(74):294-9.
10	Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10931-6.
11	The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
12	Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
13	Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase. Antimicrob Agents Chemother. 2002 Nov;46(11):3362-9.
14	Expression and characterization of recombinant human-derived Pneumocystis carinii dihydrofolate reductase. Antimicrob Agents Chemother. 2000 Nov;44(11):3092-6.
15	Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs. J Mol Biol. 2000 Jan 14;295(2):307-23.
16	Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34.
17	Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines. Int J Cancer. 2003 Feb 20;103(5):587-99.