Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU2H4K)

• Drug Name: STAUROSPORINONE Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID: TTD Drug ID: DMU2H4K

Molecule-Related Drug Atlas

Drug(s) Targeting LCK tyrosine protein kinase (LCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Chronic myelogenous leukaemia	2A20.0	Approved	[3]
VX-680	DM93YKJ	Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
JNJ-26483327	DMSQ3AZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
ISIS-CRP	DMQDUG4	Cardiovascular disease	BA00-BE2Z	Phase 1	[5]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[1]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[1]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[6]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[1]
AMP-PNP	DMTOK1D	Discovery agent	N.A.	Investigative	[7]
BMS-536924	DMXJB4N	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting Protein kinase C alpha (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[9]
Sotrastaurin acetate	DME53YS	Renal transplantation	NE84	Phase 2	[10]
PMID28460551-Compound-3	DMA1FRM	N. A.	N. A.	Patented	[11]
ISIS 3521	DMZFS69	N. A.	N. A.	Discontinued in Phase 2	[12]
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[13]
RO-320432	DMFZ1YW	N. A.	N. A.	Terminated	[14]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[15]
Acteoside	DM0YHKB	Nephritis	GB40	Terminated	[16]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[17]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[6]

Drug(s) Targeting Stress-activated protein kinase JNK1 (JNK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NKP-1339	DM5AWK1	Solid tumour/cancer	2A00-2F9Z	Phase 1	[18]
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[19]
PMID25991433-Compound-F2	DM37VIQ	N. A.	N. A.	Patented	[19]
7-azaindole derivative 1	DMQL5B7	N. A.	N. A.	Patented	[19]
7-azaindole derivative 5	DMV3H98	N. A.	N. A.	Patented	[19]
PMID25991433-Compound-P6	DMNDVC9	N. A.	N. A.	Patented	[19]
PMID25991433-Compound-J3	DM17P3F	N. A.	N. A.	Patented	[19]
PMID25991433-Compound-P1	DMD8AX6	N. A.	N. A.	Patented	[19]
PMID25991433-Compound-O3	DMVOWS5	N. A.	N. A.	Patented	[19]
PMID25991433-Compound-L1	DM2135Y	N. A.	N. A.	Patented	[19]

Drug(s) Targeting Stress-activated protein kinase 2b (p38 beta)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VX-745	DMJAEG6	Alzheimer disease	8A20	Phase 2	[20]
SB 235699	DMNH8XU	Psoriasis vulgaris	EA90	Discontinued in Phase 1	[20]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[1]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[1]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[6]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[1]
KN-62	DMLZ89P	Discovery agent	N.A.	Investigative	[1]
Ro31-8220	DMDJLF0	Discovery agent	N.A.	Investigative	[1]
KT-5720	DM9J50F	Discovery agent	N.A.	Investigative	[1]
L-779450	DM51B74	Discovery agent	N.A.	Investigative	[21]

Drug(s) Targeting cGMP-dependent protein kinase (cGK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TENELLONE A	DM1S209	Discovery agent	N.A.	Investigative	[22]
TENELLONE B	DM9ZVJ7	Discovery agent	N.A.	Investigative	[22]
ARC-1028	DM0KDTG	Discovery agent	N.A.	Investigative	[23]

Drug(s) Targeting Stress-activated protein kinase 2a (p38 alpha)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ozagrel	DMIGKA1	Xerophthalmia	5B55.Y	Phase 4	[24]
Losmapimod	DMIL37Z	Acute coronary syndrome	BA41	Phase 3	[24]
VX-702	DMKJDR6	Coronary artery disease	BA80	Phase 2a	[25]
VX-745	DMJAEG6	Alzheimer disease	8A20	Phase 2	[20]
Dilmapimod	DMBYJ92	Acute lung injury	NB32.3	Phase 2	[24]
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[19]
PMID25991433-Compound-F2	DM37VIQ	N. A.	N. A.	Patented	[19]
PMID25991433-Compound-L2	DM58UO9	N. A.	N. A.	Patented	[19]
PMID25991433-Compound-L3	DM3LWUR	N. A.	N. A.	Patented	[19]
PMID25991433-Compound-L1	DM2135Y	N. A.	N. A.	Patented	[19]

Drug(s) Targeting RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enzastaurin	DM5H0R9	Diffuse large B-cell lymphoma	2A81	Phase 3	[26]
AZD5363	DM9SKW8	Triple negative breast cancer	2C60-2C65	Phase 3	[26]
GDC-0068	DMWBZJD	Breast cancer	2C60-2C65	Phase 3	[26]
CI-1033	DMSI8N3	Lymphoma	2A80-2A86	Phase 2	[3]
CMX-2043	DMPSCVY	Cardiac disease	BA00-BE2Z	Phase 2	[27]
ARQ 092	DM5WK0J	Proteus syndrome	LD2C	Phase 2	[28]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[29]
RX-0201	DMTBAV3	Pancreatic cancer	2C10	Phase 2	[30]
Trametinib + 2141795	DMYP7TO	Solid tumour/cancer	2A00-2F9Z	Phase 2	[29]
PTX-200	DM0ZIT2	Breast cancer	2C60-2C65	Phase 2	[26]

Drug(s) Targeting Glycogen synthase kinase-3 beta (GSK-3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMO-02	DMJRU3A	Myotonic dystrophy	8C71.0	Phase 2/3	[31]
LY2090314	DMTBFE4	Acute myeloid leukaemia	2A60	Phase 2	[32]
Lithium	DMZ3OU6	Fragile X syndrome	LD55	Phase 2	[33]
Tideglusib	DME4LA1	Osteosarcoma	2B51	Phase 2	[34]
9-ING-41	DM57TY3	Myelofibrosis	2A20.2	Phase 2	[35]
Neu-120	DMXKOUC	Parkinson disease	8A00.0	Phase 1/2	[36]
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[37]
CHIR-99021	DMB8MNU	Allergic inflammation	4A80-4A85	Patented	[38]
TDZD-8	DMG6Q45	Malignant glioma	2A00.0	Patented	[39]
AR-A014418	DMUPN01	Ovarian cancer	2C73	Patented	[40]

Drug(s) Targeting MAP kinase p38 (MAPK12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SM-101	DMFX9O6	Idiopathic thrombocytopenic purpura	3B64.10	Approved (orphan drug)	[41]
VX-745	DMJAEG6	Alzheimer disease	8A20	Phase 2	[42]
ARRY-797	DMJ48AB	Dilated cardiomyopathy	BC43.0	Phase 2	[43]
KC706	DMBX6C7	Cardiovascular disease	BA00-BE2Z	Discontinued in Phase 2	[44]
SB 235699	DMNH8XU	Psoriasis vulgaris	EA90	Discontinued in Phase 1	[45]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[1]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[1]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[6]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[1]
AMP-PNP	DMTOK1D	Discovery agent	N.A.	Investigative	[7]

Drug(s) Targeting Ribosomal protein S6 kinase beta-1 (S6K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
M2698	DM3PVBJ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[26]
PF-4708671	DMO0892	Ulcerative colitis	DD71	Clinical trial	[46]
PMID27410995-Compound-Figure3c	DMDQMZT	N. A.	N. A.	Patented	[47]
Pyrimido[4,5-d] pyrimidines and pyrido[4,3-d] pyrimidine derivative 1	DM6O2Q9	N. A.	N. A.	Patented	[47]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[1]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol	DMSKJ1X	Discovery agent	N.A.	Investigative	[48]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[6]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[1]
KN-62	DMLZ89P	Discovery agent	N.A.	Investigative	[1]
Ro31-8220	DMDJLF0	Discovery agent	N.A.	Investigative	[1]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
cGMP-dependent protein kinase (cGK)	TTZC6DR	KGP1_HUMAN; KGP2_HUMAN	Inhibitor	[2]
Glycogen synthase kinase-3 beta (GSK-3B)	TTRSMW9	GSK3B_HUMAN	Inhibitor	[1]
LCK tyrosine protein kinase (LCK)	TT860QF	LCK_HUMAN	Inhibitor	[1]
MAP kinase p38 (MAPK12)	TTYT93M	MK12_HUMAN	Inhibitor	[1]
Protein kinase C alpha (PRKCA)	TTFJ8Q1	KPCA_HUMAN	Inhibitor	[1]
RAC-alpha serine/threonine-protein kinase (AKT1)	TTWTSCV	AKT1_HUMAN	Inhibitor	[1]
Ribosomal protein S6 kinase beta-1 (S6K1)	TTG0U4H	KS6B1_HUMAN	Inhibitor	[1]
Stress-activated protein kinase 2a (p38 alpha)	TTQBR95	MK14_HUMAN	Inhibitor	[1]
Stress-activated protein kinase 2b (p38 beta)	TT73U6C	MK11_HUMAN	Inhibitor	[1]
Stress-activated protein kinase JNK1 (JNK1)	TT0K6EO	MK08_HUMAN	Inhibitor	[1]

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