Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVIMQX)

Drug Name

ZSTK474 Drug Info

Synonyms

ZSTK474; 475110-96-4; ZSTK-474; 4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine; ZSTK 474; TCMDC-137004; UNII-K0068GK39A; CHEMBL586702; CHEBI:90545; K0068GK39A; 2-(2-difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine; 2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-bis(morpholino)-1,3,5-triazine; AK-40326; 2-(Difluoromethyl)-1-(4,6-Dimorpholin-4-Yl-1,3,5-Triazin-2-Yl)-1h-Benzimidazole; C19H21F2N7O2; 2wxl; PubChem22461; SCHEMBL373282; QCR-72; GTPL7965; CTK8B6247; SYN1099

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID: 11647372
ChEBI ID: CHEBI:90545
CAS Number: CAS 475110-96-4
TTD Drug ID: DMVIMQX

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting PI3-kinase gamma (PIK3CG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAY 80-6946	DMLOS5R	Follicular lymphoma	2A80	Approved	[5]
IPI-145	DMWA24P	Follicular lymphoma	2A80	Approved	[6]
Buparlisib	DM1WEHC	Breast cancer	2C60-2C65	Phase 3	[7]
Enzastaurin	DM5H0R9	Diffuse large B-cell lymphoma	2A81	Phase 3	[8]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[9]
GDC-0032	DMT4QHD	Breast cancer	2C60-2C65	Phase 3	[8]
PQR309	DMMCYZ8	Squamous head and neck cell carcinom	2D60.0	Phase 2	[10]
SAR245409	DMQM7IL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[11]
XL147	DMML7BE	Solid tumour/cancer	2A00-2F9Z	Phase 2	[11]
SF1126	DML10K3	Head and neck cancer	2D42	Phase 2	[12]
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Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[13]
Selenium	DM25CGV	N. A.	N. A.	Approved	[14]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[19]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[21]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[22]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[23]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[24]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[25]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[26]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[29]
Selenium	DM25CGV	N. A.	N. A.	Approved	[14]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[30]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[31]
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Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[38]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[39]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
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Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[47]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[16]
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Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[50]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[53]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[55]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PI3-kinase gamma (PIK3CG)	TTHBTOP	PK3CG_HUMAN	Modulator	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)	OTTOMI8J	PK3CA_HUMAN	Gene/Protein Processing	[3]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)	OTO8JQJA	PK3CB_HUMAN	Gene/Protein Processing	[3]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)	OTOMP6TH	PK3CD_HUMAN	Gene/Protein Processing	[3]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Post-Translational Modifications	[3]
Small ribosomal subunit protein eS6 (RPS6)	OTT4D1LN	RS6_HUMAN	Post-Translational Modifications	[4]

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References

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