Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWSI0H)

• Drug Name: Tiapamil Drug Info
• Synonyms: ORE-5002; Tiapamil (CNS disease); Tiapamil (CNS disease), Ore Pharmaceuticals

Indication

Disease Entry	ICD 11	Status	REF
Cardiovascular disease	BA00-BE2Z	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 42107
  ChEBI ID: CHEBI:35016
  CAS Number: CAS 57010-31-8
  TTD Drug ID: DMWSI0H
  VARIDT Drug ID: DR01283

Molecule-Related Drug Atlas

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[4]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[5]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[2]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[6]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[2]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[2]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[7]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[2]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[8]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[9]

Drug(s) Affected By Cholinesterase (BCHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[10]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[11]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[12]
Rivastigmine	DMG629M	Alzheimer disease	8A20	Approved	[13]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[14]
Succinylcholine	DM2ET1M	Plasma cell myeloma	2A83.1	Approved	[15]
Ethopropazine	DM0N3L7	Parkinson disease	8A00.0	Approved	[11]
Dimenhydrinate	DM264B3	Meniere disease	AB31.0	Approved	[16]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[17]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[16]

Drug(s) Affected By Acetylcholinesterase (ACHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[18]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[19]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[20]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[23]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[24]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[25]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[26]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acetylcholinesterase (ACHE)	OT2H8HG6	ACES_HUMAN	Protein Interaction/Cellular Processes	[3]
Cholinesterase (BCHE)	OTOH3WQ9	CHLE_HUMAN	Protein Interaction/Cellular Processes	[3]

References

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• [18] Monitoring the reaction of carbachol with acetylcholinesterase by thioflavin T fluorescence and acetylthiocholine hydrolysis. Chem Biol Interact. 2008 Sep 25;175(1-3):235-41. doi: 10.1016/j.cbi.2008.06.002. Epub 2008 Jun 17.
• [19] Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase. Toxicol Lett. 2015 Feb 3;232(3):557-65.
• [20] Dihydroactinidiolide regulates Nrf2/HO-1 expression and inhibits caspase-3/Bax pathway to protect SH-SY5Y human neuroblastoma cells from oxidative stress induced neuronal apoptosis. Neurotoxicology. 2021 May;84:53-63. doi: 10.1016/j.neuro.2021.02.006. Epub 2021 Feb 20.
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• [22] Tribromophenol induces the differentiation of SH-SY5Y human neuroblastoma cells in vitro. Toxicol In Vitro. 2003 Oct-Dec;17(5-6):635-41. doi: 10.1016/s0887-2333(03)00110-3.
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