Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYGHX5)

• Drug Name: Moxidectin Drug Info
• Synonyms: Moxidectin; ProHeart 6; UNII-NGU5H31YO9; Cydectin; NGU5H31YO9; Moxidectine [INN-French]; Moxidectinum [INN-Latin]; Moxidectina [INN-Spanish]; C37H53NO8; Moxidectina; Moxidectine; Moxidectinum; Moxidectin [USAN:INN:BAN]

Indication

Disease Entry	ICD 11	Status	REF
Onchocerciasis	1F6A	Approved	[1]
River blindness	1F6A.0	Approved	[2]

• Cross-matching ID:
  PubChem CID: 9832912
  CAS Number: CAS 113507-06-5
  TTD Drug ID: DMYGHX5

Molecule-Related Drug Atlas

Drug(s) Targeting Onchocerca Glutamate-gated chloride channel (Onchoc GluCl)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[5]

Drug(s) Targeting Gamma-aminobutyric acid receptor (GAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[6]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[7]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[8]
Clonazepam	DMTO13J	Absence epilepsy		Approved	[9]
Piperazine	DMTY9LU	Ascariasis	1F62	Approved	[10]
Alpidem	DMN7Y9K	Anxiety disorder	6B00-6B0Z	Approved	[11]
DP-VPA	DMGOXPQ	Bipolar disorder	6A60	Approved	[12]
ANDROSTERONE	DMITJAK	N. A.	N. A.	Phase 3	[7]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[13]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[8]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[14]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[16]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[17]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[18]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[19]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[20]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[21]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[22]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[20]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[23]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[24]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[25]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[26]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[27]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[30]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[31]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gamma-aminobutyric acid receptor (GAR)	TTNJYV2	NOUNIPROTAC	Modulator	[2]
Onchocerca Glutamate-gated chloride channel (Onchoc GluCl)	TTSNVHO	Q25634_ONCVO	Modulator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[3]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Regulation of Drug Effects	[4]

References

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