Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZLQ5W)

• Drug Name: S-34324 Drug Info
• Synonyms: CHEMBL90997; S-34324; SCHEMBL6949357; BDBM50131357; 4-(5-Fluoro-2-indanylmethyl)-2-imidazoline; L001645

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 10220053
  TTD Drug ID: DMZLQ5W

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic receptor alpha-2C (ADRA2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MOXONIDINE	DMGFB0E	Alcohol dependence	6C40.2	Approved	[2]
Dihydroergocristine	DM5SQ1G	Alcohol dependence	6C40.2	Approved	[3]
Brimonidine	DMQLT4N	Ocular hypertension	9C61.01	Approved	[4]
Amosulalol	DML8QSZ	Hypertension	BA00-BA04	Approved	[5]
Amezinium	DM6I2WQ	Hypotension	BA20-BA21	Approved	[6]
Propylhexedrine	DMTBW2O	Obesity	5B81	Approved	[7]
Tetrahydrozoline	DMT57WC	Ocular disease	1F00.1Z	Approved	[8]
Rilmenidine	DM13PQW	Hypertension	BA00-BA04	Approved	[9]
Xylometazoline	DMKV32D	Allergic rhinitis	CA08.0	Phase 4	[10]
TNX-102	DMO1234	Fibromyalgia	MG30.01	Phase 3	[11]

Drug(s) Targeting Adrenergic receptor alpha-2A (ADRA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lofexidine	DM1WXA6	Heroin and opiate withdrawal	6C43	Approved	[12]
MOXONIDINE	DMGFB0E	Alcohol dependence	6C40.2	Approved	[2]
Connexyn	DMF29Q5	Attention deficit hyperactivity disorder	6A05.Z	Approved	[13]
Guanfacine	DMPN5IH	Attention deficit hyperactivity disorder	6A05.Z	Phase 4	[14]
A295	DM55GO2	Aggressive cancer	2A00-2F9Z	IND submitted	[15]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[16]
DSP-1200	DM4WSHG	Depression	6A70-6A7Z	Phase 1	[17]
MAZAPERTINE	DMRHYAU	N. A.	N. A.	Discontinued in Phase 2	[18]
NMI-870	DMU596F	Sexual dysfunction	HA00-HA01	Discontinued in Phase 2	[19]
SNAP-5089	DMROJEN	Heart arrhythmia	BC65	Terminated	[20]

Drug(s) Targeting Norepinephrine transporter (NET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[22]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[23]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[21]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[24]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[25]
Tapentadol hydrochloride	DMXLSH3	Acute pain	MG31	Approved	[26]
Venlafaxine	DMR6QH0	Anxiety disorder	6B00-6B0Z	Approved	[25]
Trimipramine	DM1SC8M	Major depressive disorder	6A70.3	Approved	[27]
Duloxetine	DM9BI7M	Depression	6A70-6A7Z	Approved	[28]

Drug(s) Targeting Serotonin transporter (SERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[22]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[29]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[30]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[31]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[24]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[25]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[29]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[29]
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[29]

Drug(s) Targeting Adrenergic receptor alpha-2B (ADRA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MOXONIDINE	DMGFB0E	Alcohol dependence	6C40.2	Approved	[2]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[16]
AGN-199981	DMP5Y1A	Neuropathic pain	8E43.0	Phase 2	[32]
INDORAMIN	DMNSJFD	Hypertension	BA00-BA04	Withdrawn from market	[33]
MAZAPERTINE	DMRHYAU	N. A.	N. A.	Discontinued in Phase 2	[18]
SNAP-5089	DMROJEN	Heart arrhythmia	BC65	Terminated	[20]
A-80426	DMBC3DG	N. A.	N. A.	Terminated	[1]
WB-4101	DMQU8B1	N. A.	N. A.	Terminated	[34]
SK&F-104078	DMRADBU	N. A.	N. A.	Terminated	[33]
(+/-)-nantenine	DM0L3GE	Discovery agent	N.A.	Investigative	[35]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-2A (ADRA2A)	TTWG9A4	ADA2A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2B (ADRA2B)	TTWM4TY	ADA2B_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Inhibitor	[1]
Norepinephrine transporter (NET)	TTAWNKZ	SC6A2_HUMAN	Inhibitor	[1]
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[1]

References

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