General Information of DTT (ID: TT1RS9F)

DTT Name Acetylcholinesterase (AChE) DTT Info
Gene Name ACHE

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Patented Agent(s)
15 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ambenonium DMOP0BL Myasthenia gravis 8C6Y Approved [1]
Demecarium bromide DMAYEU1 Open-angle glaucoma 9C61 Approved [2]
Donepezil DMIYG7Z Advanced cancer 2A00-2F9Z Approved [3]
Echothiophate Iodide DMSNVGB Chronic glaucoma 9C61.0Z Approved [4]
Edrophonium DMCRQHB Myasthenia gravis 8C6Y Approved [5]
Galantamine DMEO794 Alzheimer disease 8A20 Approved [6]
Huperzine A DMMAWLU Alzheimer disease 8A20 Approved [7]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [8]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [9]
Neostigmine DM6T2J3 Myasthenia gravis 8C6Y Approved [5]
Pralidoxime Chloride DMGQ0ZI Poisoning due to pesticides and chemicals NE6Z Approved [4]
Pyridostigmine DM8HO1L Myasthenia gravis 8C6Y Approved [10]
Rivastigmine DMG629M Alzheimer disease 8A20 Approved [3]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [11]
YM443 DMNZCI1 Functional dyspepsia DD90.3 Approved [12]
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⏷ Show the Full List of 15 Approved Drug(s)
17 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(-)-Phenserine DMNCY1I Alzheimer disease 8A20 Phase 3 [13]
Amocarzine DMB9587 Helminth infection 1F90.0 Phase 3 [14]
Eptastigmine DMTV7ZM Cognitive impairment 6D71 Phase 3 [15]
INM-176 DMLG96Z Alzheimer disease 8A20 Phase 3 [16]
Suronacrine maleate DMH2FN1 Cognitive impairment 6D71 Phase 3 [17]
AD-35 DMVDQO6 Alzheimer disease 8A20 Phase 2 [18]
Ladostigil DMJSY3Q Alzheimer disease 8A20 Phase 2 [19]
Methanesulfonyl fluoride DMS7FRI Alzheimer disease 8A20 Phase 2 [20]
R-phenserine DM4L5VJ Alzheimer disease 8A20 Phase 2 [21]
T-82 DM4JFMZ Cognitive impairment 6D71 Phase 2 [22]
CPC-212 DM3J1T9 Alzheimer disease 8A20 Phase 1 [23]
CPC-250 DMDQG4Y Alzheimer disease 8A20 Phase 1 [23]
Desoxypeganine DMTR7EH Alcohol dependence 6C40.2 Phase 1 [24]
GTP-004 DM20HS7 Myasthenia gravis 8C6Y Phase 1 [23]
KW-5092 DMALK7F Pain MG30-MG3Z Phase 1 [25]
PRX-105 DMWT8RI Poison intoxication NE6Z Phase 1 [26]
ZT-1 DMO2WYX Parkinson disease 8A00.0 Phase 1 [27]
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⏷ Show the Full List of 17 Clinical Trial Drug(s)
54 Patented Agent(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-PAM derivative 1 DMI4KBC N. A. N. A. Patented [28]
4-PAM derivative 1 DMN37BI N. A. N. A. Patented [28]
Amidine oxime derivative 1 DM8STUQ N. A. N. A. Patented [28]
Decyle nelycorine dibromo salt derivative 1 DMXKUMJ N. A. N. A. Patented [29]
Di-substituted piperidine derivative 2 DM23XQL N. A. N. A. Patented [29]
Egonol compound 1 DMQF1UM N. A. N. A. Patented [28]
Fluorinated donepezil derivative 1 DMQOGHN N. A. N. A. Patented [28]
Fluorinated donepezil derivative 2 DMV1SCA N. A. N. A. Patented [28]
Galantamine analog 1 DM5BVCS N. A. N. A. Patented [28]
Indoline derivative 1 DMJ41UI N. A. N. A. Patented [29]
Isochroman-4-ketone derivative 1 DMDBK6O N. A. N. A. Patented [29]
Lycorine dimer salt derivative 1 DMGKQXP N. A. N. A. Patented [28]
PMID27967267-Compound-12 DMBNHI7 N. A. N. A. Patented [28]
PMID27967267-Compound-13 DMY5UB8 N. A. N. A. Patented [28]
PMID27967267-Compound-14 DMGI5Z8 N. A. N. A. Patented [28]
PMID27967267-Compound-15 DMEW46T N. A. N. A. Patented [28]
PMID27967267-Compound-27 DMO0QME N. A. N. A. Patented [28]
PMID27967267-Compound-28 DMVM31E N. A. N. A. Patented [28]
PMID27967267-Compound-3 DM7JIF0 N. A. N. A. Patented [28]
PMID27967267-Compound-36 DM7CWZ4 N. A. N. A. Patented [28]
PMID27967267-Compound-39 DMQOAJP N. A. N. A. Patented [28]
PMID27967267-Compound-42 DM68KPS N. A. N. A. Patented [28]
PMID27967267-Compound-43 DM12X0P N. A. N. A. Patented [28]
PMID27967267-Compound-47 DMEXATH N. A. N. A. Patented [28]
PMID27967267-Compound-48 DM81A50 N. A. N. A. Patented [28]
PMID27967267-Compound-49 DMQTRFX N. A. N. A. Patented [28]
PMID27967267-Compound-51 DMNH891 N. A. N. A. Patented [28]
PMID27967267-Compound-52 DMRH7ZY N. A. N. A. Patented [28]
PMID27967267-Compound-7 DMAN71J N. A. N. A. Patented [28]
PMID27967267-Compound-neostenine DM7TLDW N. A. N. A. Patented [28]
PMID27967267-Compound-neotuberostemonine DM3CPJQ N. A. N. A. Patented [28]
PMID27967267-Compound-stenine DM2K54D N. A. N. A. Patented [28]
PMID29757691-Compound-10 DMZBHR9 N. A. N. A. Patented [29]
PMID29757691-Compound-2a DMEUC04 N. A. N. A. Patented [29]
PMID29757691-Compound-2a-i DMBRQP1 N. A. N. A. Patented [29]
PMID29757691-Compound-4 DMFD9UZ N. A. N. A. Patented [29]
PMID29757691-Compound-7 DM7TPBF N. A. N. A. Patented [29]
PMID29757691-Compound-8a DM5IFBV N. A. N. A. Patented [29]
PMID29757691-Compound-8b DMEOZKF N. A. N. A. Patented [29]
PMID29757691-Compound-8c DMHL7SW N. A. N. A. Patented [29]
PMID29757691-Compound-8d DM6PDEH N. A. N. A. Patented [29]
Quinazoline alkaloid derivative 1 DMH86F2 N. A. N. A. Patented [29]
Tacrine heterodimer derivative 1 DMFOKRW N. A. N. A. Patented [29]
Tacrine-caffeic acid hybrid derivative 1 DMJ04RQ N. A. N. A. Patented [28]
Tacrine-caffeic acid hybrid derivative 2 DMMVPSY N. A. N. A. Patented [28]
Tacrine-dihydropyridine hybrid derivative 1 DMK0S4I N. A. N. A. Patented [28]
Tacrine-indole hybrid derivative 1 DMQ3K5B N. A. N. A. Patented [28]
Tacrine-indole hybrid derivative 2 DMH9N2T N. A. N. A. Patented [28]
Tacrine-indole hybrid derivative 3 DMUTKNW N. A. N. A. Patented [28]
Tacrine-phenothiazine hybrid derivative 1 DMNGY8R N. A. N. A. Patented [28]
Tetra-hydro-isoquinoline derivative 1 DML86IO N. A. N. A. Patented [29]
Tetra-hydro-isoquinoline derivative 2 DM5CKVF N. A. N. A. Patented [29]
Tetra-hydro-isoquinoline derivative 3 DMCZA45 N. A. N. A. Patented [29]
Tetra-hydro-isoquinoline derivative 4 DMDV0MP N. A. N. A. Patented [29]
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⏷ Show the Full List of 54 Patented Agent(s)
20 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
VELNACRINE DMUB0EC Cognitive impairment 6D71 Discontinued in Phase 3 [30]
Zanapezil DMTCP8H Alzheimer disease 8A20 Discontinued in Phase 3 [31]
Caracemide DMNOLHT Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 2 [32]
HP-290 DMUMGCY Parkinson disease 8A00.0 Discontinued in Phase 2 [33]
Icopezil maleate DM5WUK9 Cognitive impairment 6D71 Discontinued in Phase 2 [34]
Physostigmine DM2N0TO Xerostomia DA02.1 Discontinued in Phase 2 [35]
S-9977 DMEO6A5 Cognitive impairment 6D71 Discontinued in Phase 2 [36]
SM-10888 DMBUH7E Cognitive impairment 6D71 Discontinued in Phase 2 [37]
TAK-802 DMHNZ31 Urinary dysfunction GC2Z Discontinued in Phase 2 [38]
ZIFROSILONE DMC6H4Y Cognitive impairment 6D71 Discontinued in Phase 2 [39]
NP-61 DMXI5YW Alzheimer disease 8A20 Discontinued in Phase 1 [40]
7-methoxytacrine DMX5K4C N. A. N. A. Terminated [42]
ABS-301 DMCW5DJ Alzheimer disease 8A20 Terminated [43]
CI-1002 DMJ2P1Q Alzheimer disease 8A20 Terminated [44]
F-3796 DMXB8SE Alzheimer disease 8A20 Terminated [45]
FR-152558 DMOEYX2 Alzheimer disease 8A20 Terminated [46]
MF-8615 DM47WS2 Alzheimer disease 8A20 Terminated [47]
MF268 DMHV5OD Alzheimer disease 8A20 Terminated [48]
NP-7557 DM4B1VF Alzheimer disease 8A20 Terminated [49]
Ro-46-5934 DMU9JAH Alzheimer disease 8A20 Terminated [50]
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⏷ Show the Full List of 20 Discontinued Drug(s)
2 Preclinical Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
PHENSERINE TARTRATE DMIGH6W Parkinson disease 8A00.0 Preclinical [21]
SPH-1285 DMMA2ZW Alzheimer disease 8A20 Preclinical [41]
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220 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(-)-huperzine B DMBO9J3 Discovery agent N.A. Investigative [51]
(-)-Tolserine DMAT58Z Discovery agent N.A. Investigative [13]
(1R)-1,2,2-TRIMETHYLPROPYL (S)-METHYLPHOSPHINATE DMCVKTB Discovery agent N.A. Investigative [48]
(2-Butyryloxy-ethyl)-trimethyl-ammonium iodide DMLTMPC Discovery agent N.A. Investigative [52]
(2-Chloro-ethyl)-trimethyl-ammonium chloride DM6DH15 Discovery agent N.A. Investigative [52]
(2-Ethoxy-ethyl)-trimethyl-ammonium iodide DMN7XT9 Discovery agent N.A. Investigative [52]
(2-Mercapto-ethyl)-trimethyl-ammonium iodide DMCJKOQ Discovery agent N.A. Investigative [52]
(24S)-ethylcholesta-7,9(11),22(E)-triene-3b-ol DMPL80G Discovery agent N.A. Investigative [53]
(3-Bromo-propyl)-trimethyl-ammonium DMUJ18K Discovery agent N.A. Investigative [52]
(3-Hydroxy-2-methyl-phenyl)-trimethyl-ammonium DM08UQF Discovery agent N.A. Investigative [52]
(3R)-9-amino-3-methyl-1,2,3,4-tetrahydroacridine DMEUBGY Discovery agent N.A. Investigative [54]
(4-Bromo-butyl)-trimethyl-ammonium DMU1HFM Discovery agent N.A. Investigative [52]
(4-Iodo-butyl)-trimethyl-ammonium iodide DMOWFE5 Discovery agent N.A. Investigative [52]
(5-Bromo-pentyl)-trimethyl-ammonium DM4EH2J Discovery agent N.A. Investigative [52]
(R)-tacrine(10)-hupyridone DMSFA2D Discovery agent N.A. Investigative [48]
(RS)-tacrine(10)-hupyridone DMCN6WR Discovery agent N.A. Investigative [51]
(S)-tacrine(10)-hupyridone DMH7QZ2 Discovery agent N.A. Investigative [48]
(S,S)-(-)-bis(10)-hupyridone DMBR1JS Discovery agent N.A. Investigative [51]
(S,S)-(-)-bis(12)-hupyridone DM6PQ8D Discovery agent N.A. Investigative [51]
1,10-bis(pyridinium)-decane dibromide DM6VCI3 Discovery agent N.A. Investigative [55]
1,11-bis(pyridinium)-undecane dibromide DMVXYZL Discovery agent N.A. Investigative [55]
1,2-Di(berberine-9-O-yl)ethane dibromide DM7S1D5 Discovery agent N.A. Investigative [56]
1,2-NAPHTHOQUINONE DMYXELH Discovery agent N.A. Investigative [57]
1,3-Bis-(3-imidazolidin-2-yl-phenyl)-urea DM78UPQ Discovery agent N.A. Investigative [58]
1,3-Di(berberine-9-O-yl)ethane dibromide DMZKUOX Discovery agent N.A. Investigative [56]
1,4-Di(berberine-9-O-yl)ethane dibromide DM87MWN Discovery agent N.A. Investigative [56]
1,9-bis(pyridinium)-nonane dibromide DMWC7QE Discovery agent N.A. Investigative [55]
1-(3-Bromomethyl-phenyl)-2,2,2-trifluoro-ethanone DM58S47 Discovery agent N.A. Investigative [59]
1-benzene sulfonyl-cis-2,6-dimethyl piperidine DMQ1EVT Discovery agent N.A. Investigative [60]
1-Deoxy-1-Thio-Heptaethylene Glycol DMAEWHB Discovery agent N.A. Investigative [48]
1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE DMJBFN0 Discovery agent N.A. Investigative [48]
10-Hydroxy-infractopicrin DM5H73W Discovery agent N.A. Investigative [61]
2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-imine DMYHFUO Discovery agent N.A. Investigative [62]
2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose DMOUG6Y Discovery agent N.A. Investigative [63]
2-(N-Morpholino)-Ethanesulfonic Acid DMZVHSB Discovery agent N.A. Investigative [63]
2-Hex-5-enyl-5-non-8-enyl-3,4-dihydro-2H-pyrrole DMRXW3U Discovery agent N.A. Investigative [64]
2-Hex-5-enyl-5-non-8-enyl-pyrrolidine DM7KDQV Discovery agent N.A. Investigative [64]
2-Hex-5-enyl-5-nonyl-pyrrolidine DMIBRYM Discovery agent N.A. Investigative [64]
2-morpholino-N-phenethylpyrimidin-4-amine DMIQYWM Discovery agent N.A. Investigative [65]
2-Propyl-beta-carboline-2-ium iodide DMBW6GA Discovery agent N.A. Investigative [66]
24-ethyl-cholest-7-ene-3,5,6-triol DMQSTYZ Discovery agent N.A. Investigative [53]
24-ethylcholest-6-ene-3,5-diol DMZIQ56 Discovery agent N.A. Investigative [53]
3,4,5,6-Tetrachloro-[1,2]benzoquinone DMSV6K5 Discovery agent N.A. Investigative [67]
3,6,9,12,15-Pentaoxaheptadecane DMY8IOP Discovery agent N.A. Investigative [48]
3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM DMBIRC6 Discovery agent N.A. Investigative [48]
3-(2,5-Dioxo-pyrrolidin-1-yl)-benzoic acid DM6JTNW Discovery agent N.A. Investigative [68]
3-(2-Diethylamino-acetamino)-rutaecarpine DM08GRF Discovery agent N.A. Investigative [69]
3-(2-Diethylamino-propionamino)-rutaecarpine DM1FOIZ Discovery agent N.A. Investigative [69]
3-(2-N-Piperidyl-acetamino)-rutaecarpine DM3BQO0 Discovery agent N.A. Investigative [69]
3-(2-N-Piperidyl-propionamino)-rutaecarpine DMFEHDY Discovery agent N.A. Investigative [69]
3-(2-N-Pyrrolyl-acetamino)-rutaecarpine DMQ0A8W Discovery agent N.A. Investigative [69]
3-(2-N-Pyrrolyl-propionamino)-rutaecarpine DM9MRTW Discovery agent N.A. Investigative [69]
3-(3-Carboxy-propionylamino)-benzoic acid DMSJGQE Discovery agent N.A. Investigative [68]
3-(4-Benzoylpiperazine-1-carbonyl)coumarin DMAT7VN Discovery agent N.A. Investigative [70]
3-(4-o-Tolylpiperazine-1-carbonyl)coumarin DMIBAM2 Discovery agent N.A. Investigative [70]
3-(4-Phenylpiperazin-1-carbonyl)coumarin DMH27E0 Discovery agent N.A. Investigative [70]
3-(dimethylamino)phenyl phenylcarbamate DMM05G2 Discovery agent N.A. Investigative [13]
3-hydroxy-N,N,N-trimethylbenzenaminium iodide DMXO98C Discovery agent N.A. Investigative [71]
3-[(1s)-1-(Dimethylamino)Ethyl]Phenol DM2KXFS Discovery agent N.A. Investigative [48]
3-[2-(1-Benzyl-piperidin-4-yl)-ethyl]-1H-indazole DME1UNY Discovery agent N.A. Investigative [34]
3-[3-(benzylmethylamino)propoxy]xanthen-9-one DMPVXTB Discovery agent N.A. Investigative [72]
3-[4-(benzylmethylamino)butoxy]xanthen-9-one DMZPULH Discovery agent N.A. Investigative [72]
3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one DMQZ0A7 Discovery agent N.A. Investigative [72]
3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one DM89RN3 Discovery agent N.A. Investigative [72]
3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one DMMD3G6 Discovery agent N.A. Investigative [72]
3-[8-(benzylmethylamino)octyloxy]xanthen-9-one DM31WYF Discovery agent N.A. Investigative [72]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G Discovery agent N.A. Investigative [73]
4-formylphenyl-O-beta-D-ribopyranoside DM7DW0G Discovery agent N.A. Investigative [74]
4-formylphenyl-O-beta-Dglucopyranoside DM1VNEF Discovery agent N.A. Investigative [74]
4-ISOPROPYLPHENSERINE DMMDGR2 Discovery agent N.A. Investigative [75]
4-[4-(benzhydryloxy)piperidino]butyl benzoate DM5Z64L Discovery agent N.A. Investigative [76]
4ALPHA-(HYDROXYMETHYL)-4ALPHA-DEMETHYLTERRITREM B DMGYK25 Discovery agent N.A. Investigative [77]
5,6-dinitroacenaphthoquinone DM07HYA Discovery agent N.A. Investigative [57]
5-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine DMTJNY0 Discovery agent N.A. Investigative [78]
5-Hex-5-enyl-2-nonyl-3,4-dihydro-2H-pyrrole DMHGQRF Discovery agent N.A. Investigative [64]
6,8-Dichloro-1,2,3,4-tetrahydro-acridin-9-ylamine DMUEFDM Discovery agent N.A. Investigative [79]
6-chlorotacrine hydrochloride DMV0C69 Discovery agent N.A. Investigative [80]
6-hydroxy-1,2,9-trimethyl-9H-beta-carbolin-2-ium DMWLN2Y Discovery agent N.A. Investigative [81]
6-hydroxy-1,2-dimethyl-9H-beta-carbolin-2-ium DM20DAG Discovery agent N.A. Investigative [81]
6-hydroxy-2,9-dimethyl-9H-beta-carbolin-2-ium DMNA2M6 Discovery agent N.A. Investigative [81]
6-hydroxy-2-methyl-9H-beta-carbolin-2-ium DMAK35M Discovery agent N.A. Investigative [81]
6-methoxy-1,2-dimethyl-9H-beta-carbolin-2-ium DMJUT70 Discovery agent N.A. Investigative [81]
6-methoxy-1,9-dimethyl-9H-pyrido[3,4-b]indole DMOHWPD Discovery agent N.A. Investigative [81]
6-methoxy-2,9-dimethyl-9H-beta-carbolin-2-ium DMG3F7D Discovery agent N.A. Investigative [81]
6-methoxy-2-methyl-9H-beta-carbolin-2-ium DMHITF8 Discovery agent N.A. Investigative [81]
6-Methyl-4-(4-benzoylpiperazin-1-yl)coumarin DMOVUP2 Discovery agent N.A. Investigative [70]
6-Methyl-4-(4-o-tolylpiperazin-1-yl)coumarin DMN0SYW Discovery agent N.A. Investigative [70]
6-Methyl-4-(4-phenylpiperazin-1-yl)coumarin DMU7E3O Discovery agent N.A. Investigative [70]
7-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine DM1SEXA Discovery agent N.A. Investigative [78]
7-Oxo-7H-dibenzo[de,g]quinoline DMJZR0A Discovery agent N.A. Investigative [82]
8-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine DMS7DA3 Discovery agent N.A. Investigative [78]
9-Amino-1,2,3,4-tetrahydro-acridine-1,7-diol DMNHZFG Discovery agent N.A. Investigative [30]
9-amino-7H-dibenzo[de,h]quinolin-7-one DMNMVCZ Discovery agent N.A. Investigative [82]
9-Ethyl-2-methyl-beta-carboline-2-ium iodide DM70MPJ Discovery agent N.A. Investigative [66]
9-Ethyl-beta-carboline DMHKUO9 Discovery agent N.A. Investigative [66]
9-hydrazino-1,2,3,4-tetrahydroacridine DMOX21P Discovery agent N.A. Investigative [83]
9-O-[2-(Phenylol-1-yloxy)ethyl]berberine bromide DMYXEJ8 Discovery agent N.A. Investigative [84]
9-O-[2-(Phenylol-1-yloxy)hexyl]berberine bromide DM081G2 Discovery agent N.A. Investigative [84]
9-O-[3-(2-Pyridinoxyl)butyl]-berberine bromide DMHRV2A Discovery agent N.A. Investigative [56]
9-O-[3-(4-Bromo-phenoxyl)butyl]-berberine bromide DM4JG9S Discovery agent N.A. Investigative [56]
9-O-[3-(4-Nitro-phenoxyl)butyl]-berberine bromide DMWVSPH Discovery agent N.A. Investigative [56]
9-O-[3-(Phenylamino)propyl]-berberine bromide DMKPUWX Discovery agent N.A. Investigative [56]
9-O-[3-(Phenylol-1-yloxy)propyl]berberine bromide DM0FNUX Discovery agent N.A. Investigative [84]
9-O-[4-(Phenylol-1-yloxy)butyl]berberine bromide DM58XF6 Discovery agent N.A. Investigative [84]
9-O-[5-(Phenylol-1-yloxy)pentyl]berberine bromide DMPZTG9 Discovery agent N.A. Investigative [84]
Allyl-trimethyl-ammonium DM1VHCL Discovery agent N.A. Investigative [52]
AP-2238 DMQWIEL Discovery agent N.A. Investigative [85]
AP-2243 DMRYL9X Discovery agent N.A. Investigative [86]
BENZOQUINONE DMNBA0G Discovery agent N.A. Investigative [67]
Beta-L-fucose DM3BOQA Discovery agent N.A. Investigative [87]
BIS(12)-HUPERZINE B DMWAS4Q Discovery agent N.A. Investigative [88]
Bis(14)-Huperzine B DM58YDV Discovery agent N.A. Investigative [88]
BIS(16)-HUPERZINE B DMYQM3B Discovery agent N.A. Investigative [88]
BIS(18)-HUPERZINE B DM3W1T4 Discovery agent N.A. Investigative [88]
BIS(20)-HUPERZINE B DMHQKCJ Discovery agent N.A. Investigative [88]
BIS(8)-HUPERZINE B DMER5GT Discovery agent N.A. Investigative [88]
BIS(9)-HUPERZINE B DM5WFQM Discovery agent N.A. Investigative [88]
Bis-7-tacrine DMVNC1R Discovery agent N.A. Investigative [65]
But-3-enyl-trimethyl-ammonium bromide DMMHGIN Discovery agent N.A. Investigative [52]
BW284C51 DMQ3AC0 Discovery agent N.A. Investigative [89]
BZYX DMA0GSY Neurodegenerative disorder 8A20-8A23 Investigative [3]
CAPROCTAMINE DMDZE8N Discovery agent N.A. Investigative [90]
Carinatumins B (2) DMUSGYQ Discovery agent N.A. Investigative [91]
CHF-2819 DMLJGVX Discovery agent N.A. Investigative [92]
CHLORANIL DMCHGF1 Discovery agent N.A. Investigative [67]
Chlorphrifos oxon DMGBT68 Discovery agent N.A. Investigative [93]
CHLORPYRIFOS DMKPUI6 Discovery agent N.A. Investigative [94]
CHOLINE IODIDE DMW6U7K Discovery agent N.A. Investigative [52]
Cis-2,6-dimethyl-1-methyl sulfonyl piperidine DMJ3HG9 Discovery agent N.A. Investigative [60]
CLEBOPRIDE DMTLOU6 Discovery agent N.A. Investigative [58]
CORONARIDINE DMZBUE7 Discovery agent N.A. Investigative [95]
CP-126998 DM3ZIDT Discovery agent N.A. Investigative [96]
CRYPTADINE B DM92IK8 Discovery agent N.A. Investigative [97]
DECIDIUM DM4SWYX Discovery agent N.A. Investigative [51]
Dimethyl-pent-4-enyl-ammonium bromide DMO0UI8 Discovery agent N.A. Investigative [52]
Ethyl octylfluorophosphonate DMXMRK7 Discovery agent N.A. Investigative [93]
ETHYLPHENSERINE DMT51QD Discovery agent N.A. Investigative [98]
Fucose DMAHMSV N. A. N. A. Investigative [63]
Galanthamine derivative DMAFE24 Discovery agent N.A. Investigative [51]
GANSTIGMINE DMFT4GU Discovery agent N.A. Investigative [51]
GENESERINE DMAUFLQ Discovery agent N.A. Investigative [92]
HALOXYSTEROL A DM4AEGQ Discovery agent N.A. Investigative [53]
HALOXYSTEROL B DMD8O7S Discovery agent N.A. Investigative [53]
Haloxysterol C DMU1DHM Discovery agent N.A. Investigative [53]
Haloxysterol D DMWCZLT Discovery agent N.A. Investigative [53]
Hexyl-trimethyl-ammonium DM9EW7V Discovery agent N.A. Investigative [52]
Huprine X DMTPXB6 Discovery agent N.A. Investigative [51]
Huprine Y DMYH0XQ N. A. N. A. Investigative [99]
Huprine-Tacrine Heterodimer DMJ4ME7 Discovery agent N.A. Investigative [100]
Infractopicrin DMV6UJ5 Discovery agent N.A. Investigative [61]
Iso-OMPA DMFX16H Discovery agent N.A. Investigative [101]
Isopropyl dodecylfluorophosphonate DML54EA Discovery agent N.A. Investigative [93]
Isosorbide-2-(methylcarbamate)-5-benzoate DMC7MLN Discovery agent N.A. Investigative [101]
Isosorbide-2-(methylcarbamate)-5-mononitrate DMEKMOF Discovery agent N.A. Investigative [101]
Isosorbide-2-benzylcarbamate-5-cyclopentanoate DMWDQ90 Discovery agent N.A. Investigative [101]
Isosorbide-2-benzylcarbamate-5-cyclopropanoate DM8E2L6 Discovery agent N.A. Investigative [101]
Isosorbide-2-benzylcarbamate-5-tosylate DMCHSWQ Discovery agent N.A. Investigative [101]
Isosorbide-di-(4-nitrophenyl carbamate) DMPA2ON Discovery agent N.A. Investigative [102]
Isosorbide-di-(benzylcarbamate) DMFVN71 Discovery agent N.A. Investigative [102]
Isosorbide-di-(ethylcarbamate) DMTHWXO Discovery agent N.A. Investigative [102]
Isosorbide-di-phenylcarbamate DMT1ZGM Discovery agent N.A. Investigative [102]
LAWSARITOL DM5GNFO Discovery agent N.A. Investigative [53]
LIPOCRINE DMUIVCX Discovery agent N.A. Investigative [103]
LYSICAMINE DMIZQW6 Discovery agent N.A. Investigative [104]
MEMOQUIN DM9S30P Discovery agent N.A. Investigative [103]
MESUAGENIN A DMZ12GE Discovery agent N.A. Investigative [105]
MESUAGENIN B DMKXG3V Discovery agent N.A. Investigative [105]
Mesuagenin D DMLZGO7 Discovery agent N.A. Investigative [105]
Methyl Phosphinic Acid DM096SI Discovery agent N.A. Investigative [63]
MMB-4 DMUL4PE Poison intoxication NE6Z Investigative [3]
Monoisopropylphosphorylserine DM0OFT6 Discovery agent N.A. Investigative [63]
N,N'-(1',10'-decylene)-bis-(-)-nor-MEP DMIX0CT Discovery agent N.A. Investigative [106]
N,N'-(1',11'-undecydene)-bis-(-)-nor-MEP DM5NVIO Discovery agent N.A. Investigative [106]
N,N'-(1',12'-dodecydene)-bis-(-)-nor-MEP DMWI06H Discovery agent N.A. Investigative [106]
N,N'-(1',5'-pentylene)-bis-(-)-nor-MEP DMBPC0K Discovery agent N.A. Investigative [106]
N,N'-(1',6-hexylene)-bis-(-)-nor-MEP DMU4BIW Discovery agent N.A. Investigative [106]
N,N'-(1',7'-heptylene)-bis-(-)-nor-MEP DMSORHA Discovery agent N.A. Investigative [106]
N,N'-(1',8'-octylene)-bis-(-)-nor-MEP DMHFYK2 Discovery agent N.A. Investigative [106]
N,N'-(1',9'-nonylene)-bis-(-)-nor-MEP DMIWF7U Discovery agent N.A. Investigative [106]
N-(14-methylallyl)norgalanthamine DMW460V Discovery agent N.A. Investigative [107]
N-ALLYLNORGALANTHAMINE DMRXA8N Discovery agent N.A. Investigative [107]
N-allylnorlitebamine DM5W2VK Discovery agent N.A. Investigative [108]
N-benzyl-2-(pyrrolidin-1-yl)pyrimidin-4-amine DM0ZXBQ Discovery agent N.A. Investigative [65]
N-benzyl-2-morpholinopyrimidin-4-amine DMQCGFL Discovery agent N.A. Investigative [65]
N-benzyl-2-thiomorpholinopyrimidin-4-amine DMRJMGK Discovery agent N.A. Investigative [65]
N-benzylnorlitebamine DMVEZH1 Discovery agent N.A. Investigative [108]
N-butylnorlitebamine DMNFTO6 Discovery agent N.A. Investigative [108]
N-isobutylnorlitebamine DM9Z6VP Discovery agent N.A. Investigative [108]
N-isopropylnorlitebamine DMG8NB0 Discovery agent N.A. Investigative [108]
N-isopropylnorlitebamineN-methoiodide DMDVO9T Discovery agent N.A. Investigative [108]
N-Methyl-1'H-phenothiazine-1'-carboxamide DMK8VZM Discovery agent N.A. Investigative [109]
N-n-dodecyl-7-methoxytacrine hydrochloride DM8FOSR Discovery agent N.A. Investigative [42]
N-n-heptyl-7-methoxytacrine hydrochloride DMA8R47 Discovery agent N.A. Investigative [42]
N-n-hexyl-7-methoxytacrine hydrochloride DM4ZMG6 Discovery agent N.A. Investigative [42]
N-n-nonyl-7-methoxytacrine hydrochloride DMLH23M Discovery agent N.A. Investigative [42]
N-n-octyl-7-methoxytacrine hydrochloride DMLC257 Discovery agent N.A. Investigative [42]
N-n-pentyl-7-methoxytacrine hydrochloride DMWAK5V Discovery agent N.A. Investigative [42]
N-n-propyl-7-methoxytacrine hydrochloride DMCN78A Discovery agent N.A. Investigative [42]
N-phenethyl-2-(pyrrolidin-1-yl)pyrimidin-4-amine DMJQZMH Discovery agent N.A. Investigative [65]
N-propylnorlitebamine DM3JQYD Discovery agent N.A. Investigative [108]
NPRx-30 DMYB2EZ Neurodegenerative disorder 8A20-8A23 Investigative [3]
NSC-23180 DMJ91Y7 Discovery agent N.A. Investigative [57]
OBIDOXIME DMM98BC Discovery agent N.A. Investigative [94]
PARAOXON DMN4ZKC Discovery agent N.A. Investigative [93]
Petrosamine DMYIEOJ Discovery agent N.A. Investigative [110]
Propidium DMZ1FRS Discovery agent N.A. Investigative [63]
Pseudocolumbamine trifluoroacetate DM0E5G9 Discovery agent N.A. Investigative [104]
Pseudopalmatine trifluoroacetate DM4HE1V Discovery agent N.A. Investigative [104]
TACRINE(8)-4-AMINOQUINOLINE DMOWHER Discovery agent N.A. Investigative [48]
TASPINE DM9S5DV Discovery agent N.A. Investigative [111]
TERRITREM B DMPX7QS Discovery agent N.A. Investigative [112]
Tetraethylene Glycol DMH4AGL Discovery agent N.A. Investigative [63]
THIOCTIC ACID DMNFCXW Discovery agent N.A. Investigative [113]
TOLSERINE DMPTM6V Discovery agent N.A. Investigative [98]
TRIMEDOXIME DMPXHTY Discovery agent N.A. Investigative [94]
Trimethyl-(3-nitro-phenyl)-ammonium iodide DMQXPMB Discovery agent N.A. Investigative [52]
Trimethyl-(4-oxo-pentyl)-ammonium iodide DMJ4I98 Discovery agent N.A. Investigative [52]
TURBINATINE DMLDYVB Discovery agent N.A. Investigative [114]
Voacangine DMA106W Discovery agent N.A. Investigative [95]
XANTHOSTIGMINE DM38TLN Discovery agent N.A. Investigative [115]
------------------------------------------------------------------------------------
⏷ Show the Full List of 220 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens. Neuropsychopharmacology. 2008 Aug;33(9):2158-66.
2 The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs. Vet Ophthalmol. 2003 Mar;6(1):23-5.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2465).
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5 Screening of acetylcholinesterase inhibitors by CE after enzymatic reaction at capillary inlet. J Sep Sci. 2009 May;32(10):1748-56.
6 [From symptomatic to disease modifying therapy Recent developments in the pharmacotherapy of Alzheimer's disease]. Fortschr Neurol Psychiatr. 2009 Jun;77(6):326-33.
7 Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia. Brain Res. 2002 Sep 13;949(1-2):162-70.
8 Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators. Chem Biol. 2003 Jun;10(6):491-502.
9 Acetylcholinesterase activity in Corbicula fluminea Mull., as a biomarker of organophosphate pesticide pollution in Pinacanauan River, Philippines. Environ Monit Assess. 2010 Jun;165(1-4):331-40.
10 Neuromuscular blockade, reversal agent use, and operating room time: retrospective analysis of US inpatient surgeries. Curr Med Res Opin. 2009 Apr;25(4):943-50.
11 Evidence that the clinical effects of cholinesterase inhibitors are related to potency and targeting of action. Int J Clin Pract Suppl. 2002 Jun;(127):6-19.
12 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
13 Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine. Bioorg Med Chem. 2010 Jul 1;18(13):4687-93.
14 Activity, mechanism of action and pharmacokinetics of 2-tert-butylbenzothiazole and CGP 6140 (amocarzine) antifilarial drugs. Acta Trop. 1992 Aug;51(3-4):195-211.
15 Eptastigmine: ten years of pharmacology, toxicology, pharmacokinetic, and clinical studies. CNS Drug Rev. 2001 Winter;7(4):369-86.
16 The memory ameliorating effects of INM-176, an ethanolic extract of Angelica gigas, against scopolamine- or Abeta(1-42)-induced cognitive dysfunction in mice. J Ethnopharmacol. 2012 Sep 28;143(2):611-20.
17 Potential clinical use of an adrenergic/cholinergic agent (HP 128) in the treatment of Alzheimer's disease. Ann N Y Acad Sci. 1991;640:263-7.
18 Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-alpha and IL-1beta in an Abeta25-35-induced Rat Model of Alzheimer's Disease. J Alzheimers Dis. 2017;56(4):1403-1417.
19 Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94.
20 A randomized phase I study of methanesulfonyl fluoride, an irreversible cholinesterase inhibitor, for the treatment of Alzheimer's disease. Br J Clin Pharmacol. 2013 May;75(5):1231-9.
21 An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Curr Alzheimer Res. 2005 Jul;2(3):281-90.
22 Effects of T-82, a novel acetylcholinesterase inhibitor, on impaired learning and memory in passive avoidance task in rats. Eur J Pharmacol. 2003 Mar 28;465(1-2):97-103.
23 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
24 Phase I clinical trial with desoxypeganine, a new cholinesterase and selective MAO-A inhibitor: tolerance and pharmacokinetics study of escalating single oral doses. Methods Find Exp Clin Pharmacol. 2008 Mar;30(2):141-7.
25 Oral administration of KW-5092, a novel gastroprokinetic agent with acetylcholinesterase inhibitory and acetylcholine release enhancing activities, causes a dose-dependent increase in the blood acetylcholine content of beagle dogs. Neurosci Lett. 1997 Mar 28;225(1):25-8.
26 Preclinical and first-in-human evaluation of PRX-105, a PEGylated, plant-derived, recombinant human acetylcholinesterase-R. Toxicol Appl Pharmacol. 2015 Sep 15;287(3):202-9.
27 A sensitive method for the determination of the novel cholinesterase inhibitor ZT-1 and its active metabolite huperzine A in rat blood using liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2004;18(6):651-6.
28 Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476.
29 A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465.
30 Synthesis and biological activity of putative mono-hydroxylated metabolites of velnacrine, Bioorg. Med. Chem. Lett. 2(8):865-870 (1992).
31 Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats. Br J Pharmacol. 2005 Aug;145(8):1035-44.
32 Biochemical pharmacology of N-acetyl-N-(methylcarbamoyloxy)-N'-methylurea (caracemide; NSC-253272). Biochem Pharmacol. 1986 Aug 15;35(16):2781-7.
33 NXX-066 in patients with Alzheimer's disease: a bridging study. Life Sci. 1999;64(14):1215-21.
34 A docking score function for estimating ligand-protein interactions: application to acetylcholinesterase inhibition. J Med Chem. 2004 Oct 21;47(22):5492-500.
35 The effects of physostigmine on acetylcholinesterase activity of CSF plasma and brain. A comparison of intravenous and intraventricular administration in beagle dogs. Neuropharmacology. 1986 Oct;25(10):1167-77.
36 Xanthine derivatives IBMX and S-9977-2 potentiate transmission at an Aplysia central cholinergic synapse. Brain Res. 1992 Jul 17;586(1):78-85.
37 Pharmacological and biochemical assessment of SM-10888, a novel cholinesterase inhibitor. Jpn J Pharmacol. 1990 Jun;53(2):145-55.
38 Effects of TAK-802, a novel acetylcholinesterase inhibitor, on distension-induced rhythmic bladder contractions in rats and guinea pigs. Eur J Pharmacol. 2004 Feb 6;485(1-3):299-305.
39 Acetylcholinesterase inhibition by zifrosilone: pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther. 1995 Jul;58(1):54-61.
40 Potent beta-amyloid modulators. Neurodegener Dis. 2008;5(3-4):153-6.
41 Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: effects on the course of Alzheimer's disease. Biol Psychiatry. 2001 Feb 1;49(3):289-99.
42 Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5.
43 Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors. J Med Chem. 1997 Oct 24;40(22):3516-23.
44 PD 142676 (CI 1002), a novel anticholinesterase and muscarinic antagonist. Mol Neurobiol. 1994 Aug-Dec;9(1-3):93-106.
45 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004498)
46 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006757)
47 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006922)
48 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
49 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017551)
50 A novel acetylcholinesterase inhibitor, Ro 46-5934, which interacts with muscarinic M2 receptors. Biochem Soc Trans. 1994 Aug;22(3):755-8.
51 Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely... J Med Chem. 2008 Jun 12;51(11):3154-70.
52 Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors. J Med Chem. 1996 Dec 20;39(26):5064-71.
53 Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg Med Chem Lett. 2006 Feb;16(3):573-80.
54 Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones. Eur J Med Chem. 2010 Feb;45(2):526-35.
55 Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for My... Bioorg Med Chem Lett. 2010 Mar 1;20(5):1763-6.
56 Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem. 2010 Jun 15;18(12):4475-84.
57 Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34.
58 Efficient method for high-throughput virtual screening based on flexible docking: discovery of novel acetylcholinesterase inhibitors. J Med Chem. 2004 Sep 23;47(20):4818-28.
59 A structure-based design approach to the development of novel, reversible AChE inhibitors. J Med Chem. 2001 Sep 27;44(20):3203-15.
60 Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylc... Eur J Med Chem. 2009 Oct;44(10):4057-62.
61 Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus. Bioorg Med Chem. 2010 Mar 15;18(6):2173-2177.
62 Homobivalent quinazolinimines as novel nanomolar inhibitors of cholinesterases with dirigible selectivity toward butyrylcholinesterase. J Med Chem. 2006 Sep 7;49(18):5411-3.
63 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
64 Acetylcholinesterase inhibition by alkaloids of the ant's venom Monomorium minutum, Bioorg. Med. Chem. Lett. 5(11):1131-1132 (1995).
65 Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3606-9.
66 Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem. 2010 May 13;53(9):3611-7.
67 Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15.
68 Synthesis, anticholinesterase activity and structure-activity relationships of m-Aminobenzoic acid derivatives. Bioorg Med Chem Lett. 2003 May 19;13(10):1825-7.
69 Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors. Eur J Med Chem. 2010 Apr;45(4):1415-23.
70 Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues. Bioorg Med Chem. 2008 Sep 1;16(17):8011-21.
71 Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors. Bioorg Med Chem. 2008 Aug 1;16(15):7450-6.
72 Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones. Bioorg Med Chem. 2007 Jan 1;15(1):575-85.
73 Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97.
74 Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors. Eur J Med Chem. 2008 Jan;43(1):166-73.
75 Design, synthesis, evaluation and QSAR analysis of N(1)-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1718-20.
76 Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abe... Bioorg Med Chem. 2007 Oct 15;15(20):6596-607.
77 Structure and anti-acetylcholinesterase activity of 4 alpha-(hydroxymethyl)-4 alpha-demethylterritrem B. J Nat Prod. 1997 Aug;60(8):842-3.
78 The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex ) derivaties, Bioorg. Med. Chem. Lett. 2(8):861-864 (1992).
79 Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1779-82.
80 Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. J Med Chem. 2009 Sep 10;52(17):5365-79.
81 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5840-3.
82 Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinester... Eur J Med Chem. 2009 Jun;44(6):2523-32.
83 Novel heterobivalent tacrine derivatives as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase. J Med Chem. 2006 Dec 14;49(25):7540-4.
84 Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1244-51.
85 Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238. Bioorg Med Chem. 2010 Mar 1;18(5):1749-60.
86 Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds. Bioorg Med Chem Lett. 2008 Jan 1;18(1):423-6.
87 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
88 Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors. J Med Chem. 2005 Feb 10;48(3):655-7.
89 Cholinesterases: new roles in brain function and in Alzheimer's disease. Neurochem Res. 2003 Apr;28(3-4):515-22.
90 Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inne... J Med Chem. 2008 Nov 27;51(22):7308-12.
91 Carinatumins A-C, new alkaloids from Lycopodium carinatum inhibiting acetylcholinesterase. Bioorg Med Chem. 2007 Feb 15;15(4):1703-7.
92 Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug g... J Med Chem. 2006 Aug 24;49(17):5051-8.
93 Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol. 2008 Jun;4(6):373-8.
94 Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpy... Bioorg Med Chem Lett. 2006 Feb;16(3):622-7.
95 Indole alkaloids from Ervatamia hainanensis with potent acetylcholinesterase inhibition activities. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6185-7.
96 PET imaging of brain acetylcholinesterase using [11C]CP-126,998, a brain selective enzyme inhibitor. Synapse. 2002 Jul;45(1):1-9.
97 Cryptadines A and B, novel C27N3-type pentacyclic alkaloids from Lycopodium cryptomerinum. Bioorg Med Chem. 2007 Dec 15;15(24):7803-8.
98 Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based vi... J Med Chem. 2010 Sep 9;53(17):6490-505.
99 Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors. Bioorg Med Chem. 2009 Jul 1;17(13):4523-36.
100 Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors. J Med Chem. 2005 Mar 24;48(6):1701-4.
101 Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9.
102 Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability. Bioorg Med Chem. 2010 Feb;18(3):1045-53.
103 Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks. J Med Chem. 2009 Dec 10;52(23):7883-6.
104 Characterization of Acetylcholinesterase Inhibitory Constituents from Annona glabra Assisted by HPLC Microfractionation. J Nat Prod. 2010 Oct 22;73(10):1632-5.
105 4-Phenylcoumarins from Mesua elegans with acetylcholinesterase inhibitory activity. Bioorg Med Chem. 2010 Nov 15;18(22):7873-7.
106 Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36.
107 N-Alkylated galanthamine derivatives: Potent acetylcholinesterase inhibitors from Leucojum aestivum. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2263-6.
108 Litebamine N-homologues: preparation and anti-acetylcholinesterase activity. J Nat Prod. 1998 Jan;61(1):46-50.
109 Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244.
110 Petrosamine, a potent anticholinesterase pyridoacridine alkaloid from a Thai marine sponge Petrosia n. sp. Bioorg Med Chem. 2008 Jul 1;16(13):6560-7.
111 Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana. J Nat Prod. 2006 Sep;69(9):1341-6.
112 Acetylcholinesterase inhibition by territrem B derivatives. J Nat Prod. 1995 Jun;58(6):857-62.
113 Multi-target-directed ligands to combat neurodegenerative diseases. J Med Chem. 2008 Feb 14;51(3):347-72.
114 Indole glucoalkaloids from Chimarrhis turbinata and their evaluation as antioxidant agents and acetylcholinesterase inhibitors. J Nat Prod. 2004 Nov;67(11):1882-5.
115 Acetylcholinesterase inhibitors: synthesis and structure-activity relationships of omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)- methyl]aminoalkox... J Med Chem. 1998 Oct 8;41(21):3976-86.