Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DEYWLRK)

• DME Name: Sulfotransferase 1A1 (SULT1A1) DME Info
• Gene Name: SULT1A1

Molecule-Related Drug & Molecule List

24 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[1]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[2]
Apomorphine	DMX38HQ	Parkinson disease	8A00.0	Approved	[3]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[4]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[5]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[6]
Celecoxib	DM6LOQU	Dysmenorrhea	GA34.3	Approved	[7]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[8]
Digitoxin	DMWVIGP	Arrhythmia	BC9Z	Approved	[9]
Ephedrine	DMMV0KW	Allergic rhinitis	CA08.0	Approved	[10]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[11]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[12]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[13]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[14]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[15]
Pantoprazole	DMSVOCZ	Gastrinoma	2C10.1	Approved	[16]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[17]
Pseudoephedrine	DMIVJ0D	Allergic rhinitis	CA08.0	Approved	[10]
Ritodrine	DM4V6RL	Premature labour	JB00	Approved	[18]
Rotigotine	DMP7X6Q	N. A.	N. A.	Approved	[19]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[20]
Teicoplanin	DMAQ2LK	Bacterial infection	1A00-1C4Z	Approved	[21]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[22]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[23]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CERC-801	DM3SZ7P	N. A.	N. A.	Phase 2	[24]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CLIOQUINOL	DM746BZ	N. A.	N. A.	Withdrawn from market	[25]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aminobenzoic acid	DMNGW2M	N. A.	N. A.	Investigative	[26]
Diiodo-l-thyronine	DM917FE	N. A.	N. A.	Investigative	[13]
L-thyroxine	DM83HWL	N. A.	N. A.	Investigative	[13]
Triiodo-l-thyronine	DMVJD1A	N. A.	N. A.	Investigative	[13]

References

• [1] Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects. Birth Defects Res A Clin Mol Teratol. 2008 Mar;82(3):155-65.
• [2] Regulation of sulfate assimilation in plants: 7. Cysteine inactivation of adenosine 5'-phosphosulfate sulfotransferase in Lemna minor L. Plant Physiol. 1978 Mar;61(3):342-7.
• [3] Sulfation of apomorphine by human sulfotransferases: evidence of a major role for the polymorphic phenol sulfotransferase, SULT1A1. Xenobiotica. 2003 Nov;33(11):1139-48.
• [4] Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Curr Drug Metab. 2006 Oct;7(7):745-53.
• [5] Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. J Appl Toxicol. 2016 Sep;36(9):1090-4.
• [6] Sulfation of budesonide by human cytosolic sulfotransferase, dehydroepiandrosterone-sulfotransferase (DHEA-ST). Drug Metab Dispos. 2002 May;30(5):582-5.
• [7] Sulfonation of 17beta-estradiol and inhibition of sulfotransferase activity by polychlorobiphenylols and celecoxib in channel catfish, Ictalurus punctatus. Aquat Toxicol. 2007 Mar 10;81(3):286-92.
• [8] Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1). Xenobiotica. 2010 Mar;40(3):184-94.
• [9] Hydroxysteroid sulfotransferase and a specific UDP-glucuronosyltransferase are involved in the metabolism of digitoxin in man. Naunyn Schmiedebergs Arch Pharmacol. 1992 Aug;346(2):226-33.
• [10] Benzylic alcohols as stereospecific substrates and inhibitors for aryl sulfotransferase. Chirality. 1991;3(2):104-11.
• [11] Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate. Biochem Biophys Res Commun. 2005 Sep 23;335(2):417-23.
• [12] Proposed role of the sulfotransferase/sulfatase pathway in modulating yolk steroid effects. Integr Comp Biol. 2008 Sep;48(3):419-27.
• [13] Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32.
• [14] Platelet phenol sulfotransferase and erythrocyte catechol-O-methyltransferase activities: correlation with methyldopa metabolism. Clin Pharmacol Ther. 1984 Jan;35(1):55-63.
• [15] Sulfation of minoxidil by multiple human cytosolic sulfotransferases. Chem Biol Interact. 1998 Feb 20;109(1-3):53-67.
• [16] Interaction of proton pump inhibitors with cytochromes P450: consequences for drug interactions. Yale J Biol Med. 1996 May-Jun;69(3):203-9.
• [17] Progestagenic effects of tibolone are target gene-specific in human endometrial cells. J Soc Gynecol Investig. 2006 Sep;13(6):459-65.
• [18] Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3. Pharm Res. 2005 Aug;22(8):1406-10.
• [19] Identification of the human SULT enzymes involved in the metabolism of rotigotine. J Clin Pharmacol. 2016 Jun;56(6):754-60.
• [20] Tamoxifen-induced adduct formation and cell stress in human endometrial glands. Drug Metab Dispos. 2010 Jan;38(1):200-7.
• [21] The 2.7 A resolution structure of the glycopeptide sulfotransferase Teg14. Acta Crystallogr D Biol Crystallogr. 2010 Dec;66(Pt 12):1278-86.
• [22] Sulfation of tibolone metabolites by human postmenopausal liver and small intestinal sulfotransferases (SULTs). Steroids. 2006 May;71(5):343-51.
• [23] Natural products isolated from Mexican medicinal plants: novel inhibitors of sulfotransferases, SULT1A1 and SULT2A1. Phytomedicine. 2001 Nov;8(6):481-8.
• [24] Sulfation of the galactose residues in the glycosaminoglycan-protein linkage region by recombinant human chondroitin 6-O-sulfotransferase-1. J Biol Chem. 2008 Oct 10;283(41):27438-43.
• [25] Clioquinol is sulfated by human jejunum cytosol and SULT1A3, a human-specific dopamine sulfotransferase. Toxicol Lett. 2011 Oct 10;206(2):229-33.
• [26] Activities of drug metabolizing enzymes in bovine colon epithelial cell cultures. Arch Toxicol. 2003 Nov;77(11):621-9.