General Information of Drug (ID: DMSVOCZ)

Drug Name
Pantoprazole
Synonyms
Astropan; Pantoprazol; Pantoprazolum; Pantoprozole; Pantor; Pantozol; Protium; Protonix; Somac; Pantoprazole Na; Pantoprazole Sodium; Protonix IV; BY 1023; Astropan (TN); BY-1023; Controloc (TN); Inipomp (TN); Pantecta (TN); Pantoloc (TN); Pantopan (TN); Pantoprazol [INN-Spanish]; Pantoprazolum [INN-Latin]; Pantor (TN); Pantotab (TN); Pantozol (TN); Protium (TN); Protonix (TN); SK&F 96022; SK-96022; SKF-96022; Somac (TN); Ulcepraz (TN); Pantoprazole (USAN/INN); Pantoprazole [USAN:BAN:INN]; SK&F-96022; 5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridyl)methyl)sulfinyl)benzimidazole; 5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole; 6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzimidazole
Indication
Disease Entry ICD 11 Status REF
Gastroesophageal reflux disease DA22.Z Approved [1], [2]
Therapeutic Class
Antiulcer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 383.4
Topological Polar Surface Area (xlogp) 2.4
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 9
ADMET Property
Absorption AUC
The area under the plot of plasma concentration (AUC) of drug is 5 mgh/L [3]
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 2.5 mg/L [3]
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 2-3 h [3]
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [4]
Bioavailability
The bioavailability of drug is 77% [3]
Clearance
The total clearance of drug is 7.6-14.0 L/h [5]
Elimination
After a single oral or intravenous (IV) dose of 14C-labeled pantoprazole to healthy, normal metabolizing subjects, about 71% of the dose was excreted in the urine, with 18% excreted in the feces by biliary excretion [5]
Half-life
The concentration or amount of drug in body reduced by one-half in 1 hours [6]
Metabolism
The drug is metabolized via the liver [6]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 1.7398 micromolar/kg/day [7]
Unbound Fraction
The unbound fraction of drug in plasma is 0.02% [8]
Vd
The volume of distribution (Vd) of drug is 11.0-23.6 L [5]
Chemical Identifiers
Formula
C16H15F2N3O4S
IUPAC Name
6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzimidazole
Canonical SMILES
COC1=C(C(=NC=C1)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC(F)F)OC
InChI
InChI=1S/C16H15F2N3O4S/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21)
InChIKey
IQPSEEYGBUAQFF-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
4679
ChEBI ID
CHEBI:7915
CAS Number
102625-70-7
DrugBank ID
DB00213
TTD ID
D0T6XX
VARIDT ID
DR00458
INTEDE ID
DR1236
ACDINA ID
D00508

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Gastric H(+)/K(+) ATPase (Proton pump) TTLOKXP ATP4A_HUMAN; ATP4B_HUMAN Modulator [9]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [10]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [11]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME
DE4LYSA CP3A4_HUMAN Substrate [12]
Mephenytoin 4-hydroxylase (CYP2C19)
Main DME
DEGTFWK CP2CJ_HUMAN Substrate [13]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [14]
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Substrate [12]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Pantoprazole (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Cefuroxime DMSIMD8 Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Cefuroxime. Acute bronchitis [CA42] [75]
Framycetin DMF8DNE Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Framycetin. Alcoholic liver disease [DB94] [76]
Paromomycin DM1AGXN Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Paromomycin. Amoebiasis [1A36] [76]
Voriconazole DMAOL2S Moderate Decreased metabolism of Pantoprazole caused by Voriconazole mediated inhibition of CYP450 enzyme. Aspergillosis [1F20] [77]
Posaconazole DMUL5EW Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Posaconazole. Aspergillosis [1F20] [78]
Kanamycin DM2DMPO Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Kanamycin. Bacterial infection [1A00-1C4Z] [76]
Amikacin DM5PDRB Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Amikacin. Bacterial infection [1A00-1C4Z] [76]
Streptomycin DME1LQN Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Streptomycin. Bacterial infection [1A00-1C4Z] [76]
Cefpodoxime DMJUNY5 Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Cefpodoxime. Bacterial infection [1A00-1C4Z] [75]
Gentamicin DMKINJO Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Gentamicin. Bacterial infection [1A00-1C4Z] [76]
Capreomycin DMNZBRY Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Capreomycin. Bacterial infection [1A00-1C4Z] [76]
Bacampicillin DMP54C7 Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Bacampicillin. Bacterial infection [1A00-1C4Z] [75]
Netilmicin DMRD1QK Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Netilmicin. Bacterial infection [1A00-1C4Z] [76]
Cefditoren DMSUVM1 Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Cefditoren. Bacterial infection [1A00-1C4Z] [79]
Tobramycin DMUI0CH Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Tobramycin. Bacterial infection [1A00-1C4Z] [76]
Vismodegib DM5IXKQ Minor Decreased absorption of Pantoprazole due to altered gastric pH caused by Vismodegib. Basal cell carcinoma [2C32] [80]
Pexidartinib DMS2J0Z Major Decreased absorption of Pantoprazole due to altered gastric pH caused by Pexidartinib. Bone/articular cartilage neoplasm [2F7B] [81]
HKI-272 DM6QOVN Major Decreased absorption of Pantoprazole due to altered gastric pH caused by HKI-272. Breast cancer [2C60-2C6Y] [80]
Alpelisib DMEXMYK Moderate Increased metabolism of Pantoprazole caused by Alpelisib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [82]
Bosutinib DMTI8YE Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Bosutinib. Breast cancer [2C60-2C6Y] [83]
Atorvastatin DMF28YC Moderate Increased plasma concentrations of Pantoprazole and Atorvastatin due to competitive inhibition of the same metabolic pathway. Cardiovascular disease [BA00-BE2Z] [84]
Anisindione DM2C48U Moderate Decreased metabolism of Pantoprazole caused by Anisindione mediated inhibition of CYP450 enzyme. Coagulation defect [3B10] [85]
Panitumumab DMQPD1F Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Panitumumab. Colorectal cancer [2B91] [76]
Osilodrostat DMIJC9X Moderate Decreased metabolism of Pantoprazole caused by Osilodrostat mediated inhibition of CYP450 enzyme. Cushing syndrome [5A70] [86]
Lumacaftor DMCLWDJ Moderate Increased metabolism of Pantoprazole caused by Lumacaftor mediated induction of CYP450 enzyme. Cystic fibrosis [CA25] [87]
MK-8228 DMOB58Q Moderate Increased metabolism of Pantoprazole caused by MK-8228 mediated induction of CYP450 enzyme. Cytomegaloviral disease [1D82] [88]
Duloxetine DM9BI7M Minor Decreased absorption of Pantoprazole due to altered gastric pH caused by Duloxetine. Depression [6A70-6A7Z] [89]
Oxcarbazepine DM5PU6O Moderate Decreased metabolism of Pantoprazole caused by Oxcarbazepine mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [80]
Cenobamate DMGOVHA Moderate Decreased metabolism of Pantoprazole caused by Cenobamate mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [90]
Brivaracetam DMSEPK8 Minor Decreased metabolism of Pantoprazole caused by Brivaracetam mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [91]
Ethacrynic acid DM60QMR Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Ethacrynic acid. Essential hypertension [BA00] [92]
Bendroflumethiazide DM7EVLC Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Bendroflumethiazide. Essential hypertension [BA00] [76]
Benzthiazide DMQWZ0H Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Benzthiazide. Essential hypertension [BA00] [76]
Itraconazole DMCR1MV Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Itraconazole. Fungal infection [1F29-1F2F] [93]
Pentamidine DMHZJCG Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Pentamidine. Fungal infection [1F29-1F2F] [76]
Ketoconazole DMPZI3Q Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Ketoconazole. Fungal infection [1F29-1F2F] [93]
Amphotericin B DMTAJQE Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Amphotericin B. Fungal infection [1F29-1F2F] [76]
Chlorothiazide DMLHESP Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Chlorothiazide. Heart failure [BD10-BD1Z] [76]
Furosemide DMMQ8ZG Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Furosemide. Heart failure [BD10-BD1Z] [76]
Digoxin DMQCTIH Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Digoxin. Heart failure [BD10-BD1Z] [94]
Bumetanide DMRV7H0 Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Bumetanide. Heart failure [BD10-BD1Z] [76]
Hydroflumethiazide DMVPUQI Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Hydroflumethiazide. Heart failure [BD10-BD1Z] [76]
Torasemide DMXKJ6C Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Torasemide. Heart failure [BD10-BD1Z] [92]
GS-5885 DMSL3DX Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by GS-5885. Hepatitis virus infection [1E50-1E51] [80]
Rifampin DMA8J1G Moderate Increased metabolism of Pantoprazole caused by Rifampin mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [91]
Indinavir DM0T3YH Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Indinavir. Human immunodeficiency virus disease [1C60-1C62] [95]
Delavirdine DM3NF5G Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Delavirdine. Human immunodeficiency virus disease [1C60-1C62] [96]
Fosamprenavir DM4W9B3 Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Fosamprenavir. Human immunodeficiency virus disease [1C60-1C62] [97]
Etravirine DMGV8QU Moderate Decreased metabolism of Pantoprazole caused by Etravirine mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [98]
Rilpivirine DMJ0QOW Major Decreased absorption of Pantoprazole due to altered gastric pH caused by Rilpivirine. Human immunodeficiency virus disease [1C60-1C62] [99]
Atazanavir DMSYRBX Major Decreased absorption of Pantoprazole due to altered gastric pH caused by Atazanavir. Human immunodeficiency virus disease [1C60-1C62] [100]
Raltegravir DMYURI6 Minor Decreased absorption of Pantoprazole due to altered gastric pH caused by Raltegravir. Human immunodeficiency virus disease [1C60-1C62] [101]
Simvastatin DM30SGU Moderate Decreased clearance of Pantoprazole and Simvastatin due to competitive inhibition of the same transporter. Hyper-lipoproteinaemia [5C80] [84]
Lovastatin DM9OZWQ Moderate Increased plasma concentrations of Pantoprazole and Lovastatin due to competitive inhibition of the same metabolic pathway. Hyper-lipoproteinaemia [5C80] [84]
Fenofibrate DMFKXDY Moderate Decreased metabolism of Pantoprazole caused by Fenofibrate mediated inhibition of CYP450 enzyme. Hyper-lipoproteinaemia [5C80] [80]
Indapamide DMGN1PW Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Indapamide. Hypertension [BA00-BA04] [76]
Trichlormethiazide DMHAQCO Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Trichlormethiazide. Hypertension [BA00-BA04] [76]
Hydrochlorothiazide DMUSZHD Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Hydrochlorothiazide. Hypertension [BA00-BA04] [76]
Liothyronine DM6IR3P Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Liothyronine. Hypo-thyroidism [5A00] [80]
Levothyroxine DMHN027 Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Levothyroxine. Hypo-thyroidism [5A00] [80]
Iron DMAP8MV Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Iron. Iron deficiency anaemia [3A00] [102]
Glycerol phenylbutyrate DMDGRQO Moderate Decreased metabolism of Pantoprazole caused by Glycerol phenylbutyrate mediated inhibition of CYP450 enzyme. Liver disease [DB90-DB9Z] [91]
Porfimer Sodium DM7ZWNY Moderate Increased risk of photosensitivity reactions by the combination of Pantoprazole and Porfimer Sodium. Lung cancer [2C25] [103]
Ceritinib DMB920Z Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Ceritinib. Lung cancer [2C25] [104]
Erlotinib DMCMBHA Major Decreased absorption of Pantoprazole due to altered gastric pH caused by Erlotinib. Lung cancer [2C25] [80]
PF-06463922 DMKM7EW Moderate Increased metabolism of Pantoprazole caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [80]
Dacomitinib DMOH8VY Major Decreased absorption of Pantoprazole due to altered gastric pH caused by Dacomitinib. Lung cancer [2C25] [91]
Selpercatinib DMZR15V Major Decreased absorption of Pantoprazole due to altered gastric pH caused by Selpercatinib. Lung cancer [2C25] [91]
IPI-145 DMWA24P Moderate Decreased metabolism of Pantoprazole caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [105]
Acalabrutinib DM7GCVW Major Decreased absorption of Pantoprazole due to altered gastric pH caused by Acalabrutinib. Mature B-cell lymphoma [2A85] [106]
Ponatinib DMYGJQO Minor Decreased absorption of Pantoprazole due to altered gastric pH caused by Ponatinib. Mature B-cell lymphoma [2A85] [80]
Flibanserin DM70DTN Moderate Decreased metabolism of Pantoprazole caused by Flibanserin mediated inhibition of CYP450 enzyme. Mood disorder [6A60-6E23] [107]
Fedratinib DM4ZBK6 Moderate Decreased metabolism of Pantoprazole caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [91]
Nilotinib DM7HXWT Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Nilotinib. Myeloproliferative neoplasm [2A20] [108]
Dasatinib DMJV2EK Major Decreased absorption of Pantoprazole due to altered gastric pH caused by Dasatinib. Myeloproliferative neoplasm [2A20] [109]
Prasugrel DM7MT6E Minor Decreased absorption of Pantoprazole due to altered gastric pH caused by Prasugrel. Myocardial infarction [BA41-BA43] [110]
Modafinil DMYILBE Moderate Decreased metabolism of Pantoprazole caused by Modafinil mediated inhibition of CYP450 enzyme. Narcolepsy [7A20] [80]
Chlorthalidone DM4DMBT Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Chlorthalidone. Oedema [MG29] [76]
Metolazone DMB39LO Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Metolazone. Oedema [MG29] [76]
Polythiazide DMCH80F Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Polythiazide. Oedema [MG29] [76]
Naproxen DMZ5RGV Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Naproxen. Osteoarthritis [FA00-FA05] [111]
Carboplatin DMG281S Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Carboplatin. Ovarian cancer [2C73] [76]
Aspirin DM672AH Minor Decreased absorption of Pantoprazole due to altered gastric pH caused by Aspirin. Pain [MG30-MG3Z] [112]
Abametapir DM2RX0I Moderate Decreased metabolism of Pantoprazole caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [113]
Choline salicylate DM8P137 Minor Decreased absorption of Pantoprazole due to altered gastric pH caused by Choline salicylate. Postoperative inflammation [1A00-CA43] [112]
Lonafarnib DMGM2Z6 Moderate Decreased metabolism of Pantoprazole caused by Lonafarnib mediated inhibition of CYP450 enzyme. Premature ageing appearance [LD2B] [114]
Enzalutamide DMGL19D Moderate Accelerated clearance of Pantoprazole due to the transporter induction by Enzalutamide. Prostate cancer [2C82] [115]
Riociguat DMXBLMP Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Riociguat. Pulmonary hypertension [BB01] [116]
Axitinib DMGVH6N Minor Decreased absorption of Pantoprazole due to altered gastric pH caused by Axitinib. Renal cell carcinoma [2C90] [117]
Salsalate DM13P4C Minor Decreased absorption of Pantoprazole due to altered gastric pH caused by Salsalate. Rheumatoid arthritis [FA20] [112]
Salicyclic acid DM2F8XZ Minor Decreased absorption of Pantoprazole due to altered gastric pH caused by Salicyclic acid. Seborrhoeic dermatitis [EA81] [112]
Gefitinib DM15F0X Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Gefitinib. Solid tumour/cancer [2A00-2F9Z] [118]
Larotrectinib DM26CQR Moderate Decreased metabolism of Pantoprazole caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [80]
Armodafinil DMGB035 Moderate Decreased metabolism of Pantoprazole caused by Armodafinil mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [80]
Cisplatin DMRHGI9 Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Cisplatin. Solid tumour/cancer [2A00-2F9Z] [76]
Vandetanib DMRICNP Minor Decreased absorption of Pantoprazole due to altered gastric pH caused by Vandetanib. Solid tumour/cancer [2A00-2F9Z] [80]
Warfarin DMJYCVW Moderate Decreased metabolism of Pantoprazole caused by Warfarin mediated inhibition of CYP450 enzyme. Supraventricular tachyarrhythmia [BC81] [85]
Fostamatinib DM6AUHV Moderate Decreased clearance of Pantoprazole due to the transporter inhibition by Fostamatinib. Thrombocytopenia [3B64] [119]
Dicumarol DMFQCB1 Moderate Decreased metabolism of Pantoprazole caused by Dicumarol mediated inhibition of CYP450 enzyme. Thrombosis [DB61-GB90] [120]
Clopidogrel DMOL54H Moderate Decreased metabolism of Pantoprazole caused by Clopidogrel mediated inhibition of CYP450 enzyme. Thrombosis [DB61-GB90] [121]
Mycophenolate mofetil DMPQAGE Moderate Decreased absorption of Pantoprazole due to altered gastric pH caused by Mycophenolate mofetil. Transplant rejection [NE84] [122]
Tacrolimus DMZ7XNQ Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Tacrolimus. Transplant rejection [NE84] [80]
Plazomicin DMKMBES Moderate Increased risk of hypomagnesemia by the combination of Pantoprazole and Plazomicin. Urinary tract infection [GC08] [76]
⏷ Show the Full List of 103 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Calcium carbonate E00198 10112 Binding agent; Buffering agent; Diluent; Opacifying agent
FD&C blue no. 2 E00446 2723854 Colorant
Isopropyl alcohol E00070 3776 Antimicrobial preservative; Solvent
Mannitol E00103 6251 Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
Quinoline yellow WS E00309 24671 Colorant
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Sodium stearyl fumarate E00545 23665634 lubricant
Stearic acid E00079 5281 Emulsifying agent; Solubilizing agent; Viscosity-controlling agent; lubricant
Sunset yellow FCF E00255 17730 Colorant
Ammonia E00007 222 Alkalizing agent
Beta-D-lactose E00099 6134 Diluent; Dry powder inhaler carrier; Lyophilization aid
Butyl alcohol E00011 263 Flavoring agent; Solvent
Calcium stearate E00244 15324 lubricant
Carbonic acid disodium salt E00199 10340 Alkalizing agent; Buffering agent; Diluent; Dispersing agent
Crospovidone E00626 Not Available Disintegrant
Eisenoxyd E00585 56841934 Colorant
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Ferrosoferric oxide E00231 14789 Colorant
Glyceryl behenate E00481 5362585 Binding agent; Coating agent; Flavoring agent; Modified-release agent; Viscosity-controlling agent; lubricant
Glyceryl dibehenate E00537 22477175 Binding agent; Coating agent; Flavoring agent; Modified-release agent; Viscosity-controlling agent; lubricant
Hydroxypropyl cellulose E00632 Not Available Binding agent; Coating agent; Emulsifying agent; Film/Membrane-forming agent; Modified-release agent; Suspending agent; Viscosity-controlling agent
Hypromellose E00634 Not Available Coating agent
Isobutyl alcohol E00130 6560 Flavoring agent; Solvent
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Polyethylene glycol 400 E00653 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyethylene glycol 4000 E00654 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyethylene glycol 6000 E00655 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polysorbate 80 E00665 Not Available Dispersing agent; Emollient; Emulsifying agent; Plasticizing agent; Solubilizing agent; Surfactant; Suspending agent
Povidone E00667 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Propylene glycol E00040 1030 Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Propylene glycol distearate E00395 110800 Emollient; Opacifying agent; Surfactant
Saccharose E00091 5988 Binding agent; Coating agent; Cryoprotectant; Diluent; Flavoring agent; Suspending agent; Viscosity-controlling agent
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Sodium carbonate decahydrate E00405 151402 Alkalizing agent; Buffering agent; Diluent; Dispersing agent
Sodium hydroxide E00234 14798 Alkalizing agent
Soybean lecithin E00637 Not Available Other agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Triethyl citrate E00128 6506 Plasticizing agent; Solvent
⏷ Show the Full List of 39 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Pantoprazole 20 mg tablet 20 mg Delayed Release Oral Tablet Oral
Pantoprazole 40 mg tablet 40 mg Delayed Release Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7260).
2 An overview of proton pump inhibitors. Gastroenterol Nurs. 2003 Sep-Oct;26(5):182-90.
3 Bardou M, Martin J: Pantoprazole: from drug metabolism to clinical relevance. Expert Opin Drug Metab Toxicol. 2008 Apr;4(4):471-83. doi: 10.1517/17425255.4.4.471 .
4 BDDCS applied to over 900 drugs
5 An FDA phase I clinical trial of quinacrine sterilization (QS). Int J Gynaecol Obstet. 2003 Oct;83 Suppl 2:S45-9.
6 FDA approval: ado-trastuzumab emtansine for the treatment of patients with HER2-positive metastatic breast cancer. Clin Cancer Res. 2014 Sep 1;20(17):4436-41.
7 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
8 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
9 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
10 Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions. Cancer Res. 2004 Aug 15;64(16):5804-11.
11 A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26.
12 Interaction of proton pump inhibitors with cytochromes P450: consequences for drug interactions. Yale J Biol Med. 1996 May-Jun;69(3):203-9.
13 Proton pump inhibitors: from CYP2C19 pharmacogenetics to precision medicine. Expert Opin Drug Metab Toxicol. 2018 Apr;14(4):447-460.
14 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
15 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
16 Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
17 Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
18 Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
19 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
20 Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98.
21 Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
22 The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. Biochem Pharmacol. 1994 Jul 19;48(2):267-76.
23 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
24 Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
25 Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells. Mol Carcinog. 2004 Jul;40(3):180-8.
26 Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1). Drug Metab Dispos. 2014 Nov;42(11):1843-50.
27 Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65.
28 PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26.
29 The effect of apigenin on pharmacokinetics of imatinib and its metabolite N-desmethyl imatinib in rats. Biomed Res Int. 2013;2013:789184.
30 The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ. 2007 Aug 1;381(1-3):38-46.
31 Identification of P450 enzymes involved in metabolism of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1993 Sep;348(3):332-7.
32 Metabolism and metabolic inhibition of xanthotoxol in human liver microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509.
33 Progestagenic effects of tibolone are target gene-specific in human endometrial cells. J Soc Gynecol Investig. 2006 Sep;13(6):459-65.
34 Tamoxifen-induced adduct formation and cell stress in human endometrial glands. Drug Metab Dispos. 2010 Jan;38(1):200-7.
35 Proposed role of the sulfotransferase/sulfatase pathway in modulating yolk steroid effects. Integr Comp Biol. 2008 Sep;48(3):419-27.
36 Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects. Birth Defects Res A Clin Mol Teratol. 2008 Mar;82(3):155-65.
37 Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Curr Drug Metab. 2006 Oct;7(7):745-53.
38 Natural products isolated from Mexican medicinal plants: novel inhibitors of sulfotransferases, SULT1A1 and SULT2A1. Phytomedicine. 2001 Nov;8(6):481-8.
39 Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1). Xenobiotica. 2010 Mar;40(3):184-94.
40 Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32.
41 Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate. Biochem Biophys Res Commun. 2005 Sep 23;335(2):417-23.
42 Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. J Appl Toxicol. 2016 Sep;36(9):1090-4.
43 High-dose rabeprazole/amoxicillin therapy as the second-line regimen after failure to eradicate H. pylori by triple therapy with the usual doses of a proton pump inhibitor, clarithromycin and amoxicillin. Hepatogastroenterology. 2003 Nov-Dec;50(54):2274-8.
44 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
45 Cytochrome P450 pharmacogenetics and cancer. Oncogene. 2006 Mar 13;25(11):1679-91.
46 CYP2C19*17 is associated with decreased breast cancer risk. Breast Cancer Res Treat. 2009 May;115(2):391-6.
47 Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1995 Dec;353(1):116-21.
48 Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70.
49 A mechanistic approach to antiepileptic drug interactions. Ann Pharmacother. 1998 May;32(5):554-63.
50 Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33.
51 Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol. Br J Anaesth. 1998 Jun;80(6):788-95.
52 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
53 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
54 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
55 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
56 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
57 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
58 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
59 Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
60 Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
61 The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
62 Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
63 Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
64 Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
65 The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
66 Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7.
67 Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004 Nov 1;104(9):2940-2.
68 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2008
69 N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease. J Pharmacol Exp Ther. 2009 Feb;328(2):671-9.
70 Poor effectiveness of proton pump inhibitors in non-erosive reflux disease: the truth in the end! Neurogastroenterol Motil.2012 Aug;24(8):697-704.
71 Tenatoprazole, a novel proton pump inhibitor with a prolonged plasma half-life: effects on intragastric pH and comparison with esomeprazole in heal... Aliment Pharmacol Ther. 2004 Mar 15;19(6):655-62.
72 Mechanism of action of AZD0865, a K+-competitive inhibitor of gastric H+,K+-ATPase. Biochem Pharmacol. 2007 Jan 15;73(2):198-205.
73 Vasoinhibitory effect of leminoprazole, a H+,K(+)-ATPase inhibitor, on rat aortic rings. Gen Pharmacol. 1996 Jan;27(1):117-21.
74 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
75 Honig PK, Gillespie BK "Clinical significance of pharmacokinetic drug interactions with over-the-counter (OTC) drugs." Clin Pharmacokinet 35 (1998): 167-71. [PMID: 9784931]
76 FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Low magnesium levels can be associated with long-term use of proton pump inhibitor drugs (PPIs).".
77 Eiden C, Peyriere H, Tichit R, et al. "Inherited long QT syndrome revealed by antifungals drug-drug interaction." J Clin Pharm Ther 32 (2007): 321-4. [PMID: 17489884]
78 Alffenaar JW, van Assen S, van der Werf TS, Kosterink JG, Uges DR "Omeprazole significantly reduces posaconazole serum trough level." Clin Infect Dis 48 (2009): 839. [PMID: 19220151]
79 Product Information. Spectracef (cefditoren). TAP Pharmaceuticals Inc, Deerfield, IL.
80 Cerner Multum, Inc. "Australian Product Information.".
81 Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
82 Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
83 Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
84 Bogman K, Peyer AK, Torok M, Kusters E, Drewe J "HMG-CoA reductase inhibitors and P-glycoprotein modulation." Br J Pharmacol 132 (2001): 1183-92. [PMID: 11250868]
85 Ahmad S "Omeprazole-warfarin interaction." South Med J 84 (1991): 674-5. [PMID: 2035104]
86 Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
87 Cerner Multum, Inc. "Canadian Product Information.".
88 Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
89 Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
90 Product Information. Xcopri (cenobamate). SK Life Science, Inc., Paramus, NJ.
91 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
92 Product Information. Nexium (esomeprazole) Astra-Zeneca Pharmaceuticals, Wilmington, DE.
93 Bottiger Y, Tybring G, Gotharson E, Bertilsson L "Inhibition of the sulfoxidation of omeprazole by ketoconazole in poor and extensive metabolizers of S-mephenytoin." Clin Pharmacol Ther 62 (1997): 384-91. [PMID: 9357389]
94 Andersson T "Omeprazole drug interaction studies." Clin Pharmacokinet 21 (1991): 195-212. [PMID: 1764870]
95 Burger DM, Hugen PWH, Kroon FP, Groeneveld P, Brinkman K, Foudraine NA, Sprenger H, Koopmans PP, Hekster YA "Pharmacokinetic interaction between the proton pump inhibitor omeprazole and the HIV protease inhibitor indinavir." AIDS 12 (1998): 2080-2. [PMID: 9814882]
96 Product Information. Rescriptor (delavirdine). Pharmacia and Upjohn, Kalamazoo, MI.
97 Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
98 Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
99 Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
100 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
101 Product Information. Isentress (raltegravir). Merck & Company Inc, West Point, PA.
102 Hutchison C, Geissler CA, Powell JJ, Bomford A "Proton pump inhibitors suppress absorption of dietary non-haem iron in hereditary haemochromatosis." Gut 56 (2007): 1291-5. [PMID: 17344278]
103 Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
104 Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
105 Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
106 Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
107 Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
108 Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
109 Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
110 Product Information. Effient (prasugrel). Lilly, Eli and Company, Indianapolis, IN.
111 Product Information. Naprosyn (naproxen). Syntex Laboratories Inc, Palo Alto, CA.
112 Miner PB Jr, Fort JG, Zhang Y. Intragastric acidity and omeprazole exposure during dosing with either PA32540 (enteric-coated aspirin 325?mg + immediate-release omeprazole 40?mg) or enteric-coated aspirin 325?mg + enteric-coated omeprazole 40?mg - a randomised, phase 1, crossover study.?Aliment Pharmacol Ther. 2013;38(1):62-71. [PMID: 23692061]
113 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
114 Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
115 Benoist G, van Oort I, et al "Drug-drug interaction potential in men treated with enzalutamide: Mind the gap." Br J Clin Pharmacol 0 (2017): epub. [PMID: 28881501]
116 Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
117 Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
118 Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
119 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
120 Product Information. Omeprazole (omeprazole). Mylan Pharmaceuticals Inc, Morgantown, WV.
121 Collet JP, Hulot JS, Pena A, et al. "Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study." Lancet 373 (2009): 309-17. [PMID: 19108880]
122 Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.