Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DEZMWRE)

• DME Name: Cytochrome P450 2C18 (CYP2C18) DME Info
• Gene Name: CYP2C18

Molecule-Related Drug & Molecule List

26 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[1]
Clobazam - Lundbeck	DMW1OQ0	Anxiety disorder	6B00-6B0Z	Approved	[2]
Clotiazepam	DM59AZT	Anxiety disorder	6B00-6B0Z	Approved	[3]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[4]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[5]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[6]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[7]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[8]
Istradefylline	DM20VSK	Parkinson disease	8A00.0	Approved	[9]
Lansoprazole	DMXYLQ3	Gastric ulcer	DA60	Approved	[10]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[11]
Mephenytoin	DM5UGDK	Epilepsy	8A60-8A68	Approved	[12]
Methadone	DMTW6IU	Advanced cancer	2A00-2F9Z	Approved	[13]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[14]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[15]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[16]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[11]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[17]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[18]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[11]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[11]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[20]
Aminophenazone	DMY2AH1	N. A.	N. A.	Phase 4	[21]
Etizolam	DM8TNX3	Anxiety disorder	6B00-6B0Z	Phase 4	[22]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SALVINORIN A	DMJ3HQY	Cerebral vasospasm	BA85.Z	Phase 1	[23]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenazone	DMCE985	Discovery agent	N.A.	Investigative	[24]

References

• [1] In vitro metabolism study of buprenorphine: evidence for new metabolic pathways. Drug Metab Dispos. 2005 May;33(5):689-95.
• [2] In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2C19. Drug Metab Dispos. 2004 Nov;32(11):1279-86.
• [3] Contribution of human hepatic cytochrome p450 isoforms to the metabolism of psychotropic drugs. Biol Pharm Bull. 2005 Sep;28(9):1711-6.
• [4] Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. Drug Metab Dispos. 1999 Jun;27(6):655-66.
• [5] CYP2C8/9 mediate dapsone N-hydroxylation at clinical concentrations of dapsone. Drug Metab Dispos. 2000 Aug;28(8):865-8.
• [6] Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51. Arch Biochem Biophys. 1997 Feb 15;338(2):157-64.
• [7] Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70.
• [8] Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs. J Pharmacol Exp Ther. 1997 Jun;281(3):1199-210.
• [9] Effects of rifampin on the pharmacokinetics of a single dose of istradefylline in healthy subjects. J Clin Pharmacol. 2018 Feb;58(2):193-201.
• [10] Oxidative metabolism of lansoprazole by human liver cytochromes P450. Mol Pharmacol. 1995 Feb;47(2):410-8.
• [11] Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
• [12] Cytochrome P450 metabolic dealkylation of nine N-nitrosodialkylamines by human liver microsomes. Carcinogenesis. 1996 Sep;17(9):2029-34.
• [13] Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes. Chem Res Toxicol. 1996 Mar;9(2):365-73.
• [14] Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes. Drug Metab Dispos. 1996 Oct;24(10):1081-7.
• [15] Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine. Br J Clin Pharmacol. 2000 Dec;50(6):563-71.
• [16] Induction of CYP2C genes in human hepatocytes in primary culture. Drug Metab Dispos. 2001 Mar;29(3):242-51.
• [17] Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol. Br J Anaesth. 1998 Jun;80(6):788-95.
• [18] Thalidomide metabolism by the CYP2C subfamily. Clin Cancer Res. 2002 Jun;8(6):1964-73.
• [19] Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8.
• [20] Human P450 metabolism of warfarin. Pharmacol Ther. 1997;73(1):67-74.
• [21] Contribution of human hepatic cytochrome P450s and steroidogenic CYP17 to the N-demethylation of aminopyrine. Xenobiotica. 1999 Feb;29(2):187-93.
• [22] Etizolam (INN) Pre-Review Report.
• [23] Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen. Eur J Pharm Biopharm. 2009 Jun;72(2):471-7.
• [24] Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.