Details of Disease

General Information of Disease (ID: DISHF0H3)

• Disease Name: Allergic asthma
• Synonyms: atopic asthma; extrinsic asthma with acute exacerbation; extrinsic asthma with status asthmaticus; allergic form of asthma
• Disease Class: CA23: Asthma
• Definition: A asthma with a basis in a pathological type I hypersensitivity reaction.
• Disease Hierarchy:
  DISW9QNS: Asthma
  DISAAZU9: Respiratory allergy
  DISHF0H3: Allergic asthma
• ICD Code:
  ICD-11: ICD-11: CA23.0
  ICD-10: ICD-10: J45.0
  Expand ICD-11: 'CA23.0
  Expand ICD-10: 'J45.0
  Expand ICD-9: 493995.3
• Disease Identifiers:
  MONDO ID: MONDO_0004784
  UMLS CUI: C0155877
  MedGen ID: 102343
  SNOMED CT ID: 389145006

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 6 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Fluticasone propionate	DMRWLB2	Approved	NA	[1]
Formoterol	DMSOURV	Approved	Small molecular drug	[2]
Mometasone	DM45OJN	Approved	Small molecular drug	[3]
Montelukast	DMD157S	Approved	Small molecular drug	[4]
Salmeterol	DMIEU69	Approved	Small molecular drug	[5]
Zileuton	DMVRIC2	Approved	Small molecular drug	[6]

This Disease is Treated as An Indication in 5 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
MK-8237	DM0IRFU	Phase 3	NA	[7]
ARRY-502	DM17469	Phase 2	NA	[8]
ASM8	DMTHR4U	Phase 2	Antisense drug	[9]
CNT0-5825	DMSO62Q	Phase 1	NA	[10]
CNTO-5825	DMF8WAT	Phase 1	Antibody	[11]

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Seratrodast	DMPNTDL	Discontinued in Phase 3	Small molecular drug	[12]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 67 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ADAM33	TTQICM2	Limited	Biomarker	[13]
CSF2RA	TT6MP2Z	Limited	Altered Expression	[14]
FOXP3	TT1X3QF	Limited	Biomarker	[15]
IL25	TTVMO5W	Limited	Biomarker	[16]
IL33	TT5MD4P	Limited	Biomarker	[17]
IL5	TTPREZD	Limited	Biomarker	[18]
STAT6	TTWOE1T	Limited	Genetic Variation	[19]
IL9	TT0JTFD	moderate	Biomarker	[20]
AGXT	TTF5NVW	Strong	Biomarker	[21]
AOAH	TT2EJXQ	Strong	Biomarker	[22]
ARG1	TT7ZQEV	Strong	Altered Expression	[23]
BDKRB2	TTGY8IW	Strong	Biomarker	[24]
C5AR1	TTHXFA1	Strong	Altered Expression	[25]
CCL11	TTCF05Y	Strong	Biomarker	[26]
CCR4	TT7HQD0	Strong	Biomarker	[27]
CCR8	TTE836A	Strong	Biomarker	[28]
CCR9	TTIPS8B	Strong	Biomarker	[29]
CD4	TTN2JFW	Strong	Biomarker	[30]
CHIA	TTJB1O0	Strong	Biomarker	[31]
CHIT1	TTDYX6T	Strong	Biomarker	[32]
CHRM2	TTYEG6Q	Strong	Biomarker	[33]
CMA1	TT8VUE0	Strong	Biomarker	[34]
CRLF2	TTRMZ0N	Strong	Genetic Variation	[35]
CTH	TTLQUZS	Strong	Altered Expression	[36]
CYSLTR2	TT0PZR5	Strong	Genetic Variation	[37]
DCLK3	TTMYK4Z	Strong	Biomarker	[38]
EGLN2	TTMHFRY	Strong	Biomarker	[39]
EPX	TTCIO0M	Strong	Biomarker	[40]
FCAR	TTGUJAO	Strong	Genetic Variation	[41]
GNAO1	TTAXD8Z	Strong	Genetic Variation	[42]
HLA-DQB2	TTL7VOU	Strong	Genetic Variation	[42]
HNMT	TT2B6EV	Strong	Genetic Variation	[43]
HRH1	TTTIBOJ	Strong	Genetic Variation	[43]
IFNL1	TTM624L	Strong	Biomarker	[44]
IL12B	TTGW72V	Strong	Genetic Variation	[45]
IL13RA1	TTNEAMG	Strong	Genetic Variation	[46]
IL16	TTW4R0B	Strong	Genetic Variation	[47]
IL17F	TT2B6PS	Strong	Altered Expression	[48]
IL3RA	TTENHJ0	Strong	Altered Expression	[18]
IL5RA	TTXH9AD	Strong	Altered Expression	[18]
IRF1	TT4TU3L	Strong	Genetic Variation	[49]
LIPG	TTHSZXO	Strong	Biomarker	[50]
LTA	TTP73TM	Strong	Biomarker	[51]
LTB4R2	TTVJX54	Strong	Biomarker	[52]
LTC4S	TTW7OTG	Strong	Genetic Variation	[53]
NOD1	TTYSRXM	Strong	Biomarker	[54]
NPR1	TTM9IYA	Strong	Biomarker	[55]
NPSR1	TTV1C0Z	Strong	Biomarker	[56]
P2RX4	TT1NLOA	Strong	Biomarker	[57]
PDE4A	TTZ97H5	Strong	Biomarker	[58]
PDE4B	TTVIAT9	Strong	Biomarker	[58]
PIM2	TT69J2Z	Strong	Biomarker	[59]
PLA2G4C	TTBYG4O	Strong	Genetic Variation	[60]
PLA2R1	TTHKW7D	Strong	Altered Expression	[61]
PTAFR	TTQL5VC	Strong	Altered Expression	[62]
PTGDR	TTNVEIR	Strong	Biomarker	[63]
PTGDR2	TTQDMX5	Strong	Biomarker	[64]
RIPK2	TTCQ2E5	Strong	Genetic Variation	[65]
S100A12	TTQ4ESF	Strong	Biomarker	[38]
S1PR2	TTVSMOH	Strong	Biomarker	[66]
SCGB1A1	TTONPVW	Strong	Altered Expression	[67]
SFTPD	TTGLMU7	Strong	Biomarker	[68]
TBX21	TTNF9PH	Strong	Genetic Variation	[69]
TBXA2R	TT2O84V	Strong	Biomarker	[70]
TSLP	TTHMW3T	Strong	Biomarker	[71]
VSIR	TT51SK8	Strong	Biomarker	[72]
IL31	TT1RJXK	Definitive	Altered Expression	[73]

This Disease Is Related to 3 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC25A25	DTN7X5J	Strong	Biomarker	[74]
SLC27A5	DT0TQS3	Strong	Biomarker	[75]
SLC5A8	DTE3TAW	Strong	Biomarker	[76]

This Disease Is Related to 4 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
DDO	DE8PQ7T	Strong	Genetic Variation	[77]
EGLN3	DEMQTKH	Strong	Biomarker	[39]
INPP4A	DEBJ2NL	Strong	Genetic Variation	[78]
PTGDS	DER3H9C	Strong	Biomarker	[79]

This Disease Is Related to 63 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CPLANE1	OTXGGNNB	Limited	Genetic Variation	[80]
HLA-DPA1	OT7OG7Y2	Limited	Genetic Variation	[81]
MYDGF	OT9HRPL6	Limited	Biomarker	[16]
ACAA1	OTVKRET0	Strong	Genetic Variation	[82]
ARHGEF28	OT3F32IU	Strong	Genetic Variation	[65]
ARHGEF5	OTUVGFT9	Strong	Genetic Variation	[83]
ATP5F1A	OT3FZDLX	Strong	Altered Expression	[84]
BATF	OT9VSD2D	Strong	Altered Expression	[85]
BCL11B	OT8KKCVJ	Strong	Biomarker	[86]
CAMK2N2	OT1NDPEL	Strong	Biomarker	[87]
CCL18	OT7JYSK9	Strong	Biomarker	[88]
CCL25	OTLWJ8CJ	Strong	Biomarker	[29]
CDHR3	OTZZ0CA8	Strong	Genetic Variation	[89]
CETN1	OTGQ8JOZ	Strong	Biomarker	[90]
CHML	OTW3VW8D	Strong	Genetic Variation	[91]
CTNNBL1	OT6KLHPA	Strong	Biomarker	[92]
DAD1	OTUUNQBT	Strong	Genetic Variation	[93]
DOCK8	OTNQLL21	Strong	Biomarker	[94]
EDIL3	OTDVVNS0	Strong	Biomarker	[95]
ELP1	OTYEWBF7	Strong	Genetic Variation	[96]
FLG	OTE9QDV6	Strong	Genetic Variation	[97]
GAB1	OTQKE6V4	Strong	Biomarker	[98]
GSDMB	OTWA7P10	Strong	Genetic Variation	[89]
HAVCR1	OT184CRZ	Strong	Genetic Variation	[83]
IL1F10	OTJAASGC	Strong	Biomarker	[99]
IL3	OT0CQ35N	Strong	Biomarker	[100]
IL9R	OTILCLXA	Strong	Biomarker	[101]
IRF7	OTC1A2PQ	Strong	Biomarker	[102]
ISG20	OTCWRJJW	Strong	Altered Expression	[103]
KLF10	OT4F4UGS	Strong	Biomarker	[55]
LAT	OTZC1XZ1	Strong	Biomarker	[104]
MARCHF1	OTI2EYO6	Strong	Biomarker	[105]
METTL24	OTU5MRWG	Strong	Genetic Variation	[77]
MEX3B	OTPUZ8CW	Strong	Biomarker	[106]
MS4A2	OTMCAS2D	Strong	Genetic Variation	[107]
NUFIP2	OTZBZ224	Strong	Biomarker	[108]
OPN3	OTON6BFU	Strong	Genetic Variation	[91]
ORM1	OTZKSBRE	Strong	Genetic Variation	[109]
OXA1L	OTS0BFRD	Strong	Genetic Variation	[93]
PARP9	OT7K4494	Strong	Biomarker	[75]
PCDH1	OT7KDEL3	Strong	Genetic Variation	[110]
PDCD5	OT6T2DDL	Strong	Biomarker	[111]
PHC1	OT1JMX8U	Strong	Biomarker	[39]
PHF11	OT5F6LUP	Strong	Genetic Variation	[112]
PRRC2A	OTBX6FM5	Strong	Genetic Variation	[113]
PTPRE	OTOD5NID	Strong	Biomarker	[114]
RAD50	OTYMU9G1	Strong	Genetic Variation	[89]
RHEB	OTFLTSEC	Strong	Biomarker	[115]
RIOX2	OT2YFPI2	Strong	Genetic Variation	[116]
RNASE2	OT8Z4FNE	Strong	Biomarker	[117]
SAA2	OTYAVJWG	Strong	Biomarker	[118]
SCGB3A2	OTB63PHR	Strong	Genetic Variation	[119]
SDF4	OTQ7WFYW	Strong	Biomarker	[90]
SEC14L3	OTGQ8GWM	Strong	Biomarker	[120]
SEMA3E	OTD4S36H	Strong	Biomarker	[121]
SEMA4A	OT8901H3	Strong	Biomarker	[122]
SIGLEC8	OTQ5TRRV	Strong	Biomarker	[123]
SIT1	OT7MDF09	Strong	Biomarker	[124]
SMC3	OTWGFRHD	Strong	Biomarker	[125]
TES	OTL8PP6V	Strong	Biomarker	[126]
TFF2	OTRXB19X	Strong	Biomarker	[127]
TFIP11	OT7NVSWU	Strong	Biomarker	[128]
TIMELESS	OTD8DCBJ	Strong	Genetic Variation	[83]

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