Details of the Drug Combination

General Information of Drug Combination (ID: DC9TWI1)

Drug Combination Name
Ethinyl Estradiol Vinblastine
Indication
Disease Entry Status REF
Chronic myelogenous leukemia Investigative [1]
Component Drugs Ethinyl Estradiol   DMODJ40 Vinblastine   DM5TVS3
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: KBM-7
Zero Interaction Potency (ZIP) Score: 2.12
Bliss Independence Score: 2.12
Loewe Additivity Score: 2.44
LHighest Single Agent (HSA) Score: 2.51

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Ethinyl Estradiol
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [2]
Female hypogonadism GA30.6 Approved [3]
Hot flushes GA30 Approved [2]
Obsolete atrophic vulva N.A. Approved [2]
Ethinyl Estradiol Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Agonist [10]
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Ethinyl Estradiol Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [11]
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Ethinyl Estradiol Interacts with 6 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [12]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [13]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Metabolism [14]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [15]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [14]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [16]
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⏷ Show the Full List of 6 DME(s)
Ethinyl Estradiol Interacts with 280 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Decreases Activity [15]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Expression [17]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Hydroxylation [14]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Increases Hydroxylation [14]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Increases Hydroxylation [14]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [11]
Sulfotransferase 1E1 (SULT1E1) OTGPJ517 ST1E1_HUMAN Decreases Activity [18]
Gamma-aminobutyric acid receptor subunit pi (GABRP) OTGKA8WS GBRP_HUMAN Decreases Expression [7]
Ectoderm-neural cortex protein 1 (ENC1) OTJEUB6U ENC1_HUMAN Decreases Expression [7]
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1) OTFK8KDP NHRF1_HUMAN Increases Expression [7]
Neuropilin-1 (NRP1) OTCGULYV NRP1_HUMAN Increases Expression [7]
Transmembrane protease serine 2 (TMPRSS2) OTN44YQ5 TMPS2_HUMAN Decreases Expression [7]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [7]
Krueppel-like factor 4 (KLF4) OT4O9RQW KLF4_HUMAN Increases Expression [7]
Band 4.1-like protein 2 (EPB41L2) OT6UABPM E41L2_HUMAN Increases Expression [7]
Tetraspanin-1 (TSPAN1) OTZQPIYK TSN1_HUMAN Decreases Expression [7]
Microfibrillar-associated protein 3-like (MFAP3L) OTNMHSAH MFA3L_HUMAN Increases Expression [7]
Short-chain dehydrogenase/reductase 3 (DHRS3) OTSK1DTP DHRS3_HUMAN Increases Expression [7]
Dysferlin (DYSF) OTNSKJU0 DYSF_HUMAN Decreases Expression [7]
Gamma-butyrobetaine dioxygenase (BBOX1) OTKEX4RK BODG_HUMAN Decreases Expression [7]
Nebulette (NEBL) OT2WH1NC NEBL_HUMAN Decreases Expression [7]
ATP-dependent DNA helicase Q5 (RECQL5) OTVZMP1Q RECQ5_HUMAN Decreases Expression [7]
Sorbin and SH3 domain-containing protein 2 (SORBS2) OTJSX44Y SRBS2_HUMAN Decreases Expression [7]
Serine protease 23 (PRSS23) OT6DQAM1 PRS23_HUMAN Decreases Expression [7]
NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6) OTIXNT91 NDUB6_HUMAN Increases Expression [7]
Rap guanine nucleotide exchange factor 3 (RAPGEF3) OTMOW4Z4 RPGF3_HUMAN Decreases Expression [7]
Secretoglobin family 1D member 2 (SCGB1D2) OTSYWZAQ SG1D2_HUMAN Increases Expression [7]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Decreases Expression [7]
Carbonic anhydrase 2 (CA2) OTJRMUAG CAH2_HUMAN Increases Expression [7]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [7]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Increases Expression [7]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Increases Expression [7]
N-myc proto-oncogene protein (MYCN) OTWD33K1 MYCN_HUMAN Decreases Expression [7]
Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCA) OTWJTCRK PCCA_HUMAN Increases Expression [7]
Alkaline phosphatase, placental type (ALPP) OTZU4G9W PPB1_HUMAN Increases Expression [7]
Collagen alpha-2(V) chain (COL5A2) OT5VOSQE CO5A2_HUMAN Decreases Expression [7]
Progesterone receptor (PGR) OT0FZ3QE PRGR_HUMAN Increases Expression [7]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Increases Expression [7]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [7]
Interleukin-6 receptor subunit alpha (IL6R) OTCQL07Z IL6RA_HUMAN Increases Expression [7]
Matrilysin (MMP7) OTVT3SEJ MMP7_HUMAN Increases Expression [7]
Stromelysin-2 (MMP10) OTJDWW8Q MMP10_HUMAN Decreases Expression [7]
Retinol-binding protein 1 (RBP1) OTRP1MFC RET1_HUMAN Decreases Expression [7]
Tropomyosin alpha-1 chain (TPM1) OTD73X6R TPM1_HUMAN Decreases Expression [7]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Decreases Expression [7]
Alkaline phosphatase, germ cell type (ALPG) OTCIM29R PPBN_HUMAN Increases Expression [7]
Creatine kinase B-type (CKB) OTUCKOTT KCRB_HUMAN Increases Expression [7]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Decreases Expression [7]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [7]
Endothelin-2 (EDN2) OTQ7RCPI EDN2_HUMAN Decreases Expression [7]
Collagen alpha-1(V) chain (COL5A1) OT24078H CO5A1_HUMAN Increases Expression [7]
Fibroblast growth factor receptor 2 (FGFR2) OTLOPACK FGFR2_HUMAN Decreases Expression [7]
Galanin peptides (GAL) OTB3VPTO GALA_HUMAN Increases Expression [7]
Fibroblast growth factor receptor 3 (FGFR3) OTSAXDIL FGFR3_HUMAN Decreases Expression [7]
cAMP-dependent protein kinase catalytic subunit beta (PRKACB) OT6RMDCE KAPCB_HUMAN Affects Expression [7]
Prostaglandin G/H synthase 1 (PTGS1) OTHCRLEC PGH1_HUMAN Decreases Expression [7]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Decreases Expression [7]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Decreases Expression [7]
Transcription factor HIVEP2 (HIVEP2) OTVOMCW4 ZEP2_HUMAN Decreases Expression [7]
Sodium- and chloride-dependent taurine transporter (SLC6A6) OT67U7G3 SC6A6_HUMAN Decreases Expression [7]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Expression [7]
Activin receptor type-1B (ACVR1B) OT778HIQ ACV1B_HUMAN Decreases Expression [7]
Collagen alpha-1(XV) chain (COL15A1) OTTFKK18 COFA1_HUMAN Increases Expression [7]
Replication factor C subunit 3 (RFC3) OT1MS7AO RFC3_HUMAN Increases Expression [7]
Exosome RNA helicase MTR4 (MTREX) OTSQY30V MTREX_HUMAN Increases Expression [7]
G protein-activated inward rectifier potassium channel 1 (KCNJ3) OTHQG16J KCNJ3_HUMAN Decreases Expression [7]
Retinol-binding protein 2 (RBP2) OTR8QG5V RET2_HUMAN Decreases Expression [7]
LIM domain kinase 2 (LIMK2) OTRJD7VZ LIMK2_HUMAN Decreases Expression [7]
ADP-ribosylation factor 3 (ARF3) OTYYQX85 ARF3_HUMAN Decreases Expression [7]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Decreases Expression [7]
Phosphoserine phosphatase (PSPH) OTV1PVAX SERB_HUMAN Decreases Expression [7]
Protein jagged-1 (JAG1) OT3LGT6K JAG1_HUMAN Decreases Expression [7]
4-aminobutyrate aminotransferase, mitochondrial (ABAT) OTXAGR7J GABT_HUMAN Decreases Expression [7]
Low-density lipoprotein receptor-related protein 2 (LRP2) OTZ6W681 LRP2_HUMAN Decreases Expression [7]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Increases Expression [7]
Cyclic AMP-responsive element-binding protein 5 (CREB5) OTJDUJPI CREB5_HUMAN Increases Expression [7]
Transcription factor SOX-4 (SOX4) OTSS40SS SOX4_HUMAN Decreases Expression [7]
Amino acid transporter heavy chain SLC3A1 (SLC3A1) OT56V01A SLC31_HUMAN Decreases Expression [7]
Cadherin-18 (CDH18) OTC06P9H CAD18_HUMAN Decreases Expression [7]
Calcyphosin (CAPS) OTC9GZ2M CAYP1_HUMAN Increases Expression [7]
Transcription factor Dp-2 (TFDP2) OTKQFX5H TFDP2_HUMAN Decreases Expression [7]
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A) OTKUW1WT PDE3A_HUMAN Decreases Expression [7]
Next to BRCA1 gene 1 protein (NBR1) OTVRL7J9 NBR1_HUMAN Decreases Expression [7]
Pericentriolar material 1 protein (PCM1) OTFM133C PCM1_HUMAN Decreases Expression [7]
Neutral amino acid transporter B(0) (SLC1A5) OTE2H26Q AAAT_HUMAN Increases Expression [7]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Decreases Expression [7]
Dual specificity protein phosphatase 5 (DUSP5) OTH96RA7 DUS5_HUMAN Increases Expression [7]
Protein Dok-7 (DOK7) OTR2V7HO DOK7_HUMAN Increases Expression [7]
Protein GREB1 (GREB1) OTU6ZA26 GREB1_HUMAN Increases Expression [7]
Piercer of microtubule wall 1 protein (PIERCE1) OTONT0CN PIRC1_HUMAN Decreases Expression [7]
Retrotransposon Gag-like protein 5 (RTL5) OT9ZJR3N RTL5_HUMAN Decreases Expression [7]
Protein phosphatase 1J (PPM1J) OTM6GDJJ PPM1J_HUMAN Increases Expression [7]
Immediate early response gene 5-like protein (IER5L) OT6IG629 IER5L_HUMAN Increases Expression [7]
Disabled homolog 2-interacting protein (DAB2IP) OTF456VC DAB2P_HUMAN Affects Expression [7]
Muscleblind-like protein 2 (MBNL2) OTF7CF1F MBNL2_HUMAN Decreases Expression [7]
Anoctamin-1 (ANO1) OTSREUNI ANO1_HUMAN Increases Expression [7]
Proline-rich membrane anchor 1 (PRIMA1) OT9ITT3P PRIMA_HUMAN Decreases Expression [7]
Prolyl 3-hydroxylase 2 (P3H2) OTY84H6U P3H2_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase TRIM22 (TRIM22) OTJBLG5R TRI22_HUMAN Decreases Expression [7]
Solute carrier family 25 member 45 (SLC25A45) OTP7EAUM S2545_HUMAN Decreases Expression [7]
PACRG-like protein (PACRGL) OT5DEP0X PACRL_HUMAN Increases Expression [7]
N-acetylaspartate synthetase (NAT8L) OTA96AVN NAT8L_HUMAN Decreases Expression [7]
Retinoic acid-induced protein 3 (GPRC5A) OTPOCWR7 RAI3_HUMAN Decreases Expression [7]
Two pore channel protein 2 (TPCN2) OTLAF3ED TPC2_HUMAN Decreases Expression [7]
LIM domain only protein 3 (LMO3) OTR7AJHN LMO3_HUMAN Decreases Expression [7]
DEP domain-containing mTOR-interacting protein (DEPTOR) OTCBP1BT DPTOR_HUMAN Increases Expression [7]
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) OT83O8WI ES8L1_HUMAN Decreases Expression [7]
Complexin-3 (CPLX3) OT0YTMN2 CPLX3_HUMAN Decreases Expression [7]
Histone acetyltransferase KAT2B (KAT2B) OTWQITWK KAT2B_HUMAN Decreases Expression [7]
Protein kinase C-binding protein NELL1 (NELL1) OTF3TX3N NELL1_HUMAN Decreases Expression [7]
LIM/homeobox protein Lhx4 (LHX4) OTVX3J6S LHX4_HUMAN Increases Expression [7]
E3 ubiquitin-protein ligase MIB2 (MIB2) OTJCC3HS MIB2_HUMAN Decreases Expression [7]
Dedicator of cytokinesis protein 10 (DOCK10) OTI3MBLV DOC10_HUMAN Decreases Expression [7]
Galactose mutarotase (GALM) OT7UPL4D GALM_HUMAN Decreases Expression [7]
Endoplasmic reticulum resident protein 27 (ERP27) OTVMGE2H ERP27_HUMAN Decreases Expression [7]
Hedgehog-interacting protein (HHIP) OT77RQYS HHIP_HUMAN Decreases Expression [7]
TSC22 domain family protein 3 (TSC22D3) OT03UM03 T22D3_HUMAN Decreases Expression [7]
Neurturin (NRTN) OT4PAKUY NRTN_HUMAN Increases Expression [7]
Ras-like protein family member 11B (RASL11B) OTHEVZS6 RSLBB_HUMAN Decreases Expression [7]
Mitochondrial ribosome-associated GTPase 1 (MTG1) OTC9U1LI MTG1_HUMAN Decreases Expression [7]
Melanophilin (MLPH) OT7ADCXL MELPH_HUMAN Increases Expression [7]
RNA-binding protein 24 (RBM24) OTQI1AR1 RBM24_HUMAN Increases Expression [7]
Keratin-associated protein 2-1 (KRTAP2-1) OTV1SGF2 KRA21_HUMAN Decreases Expression [7]
Keratin, type I cytoskeletal 23 (KRT23) OTQW6UAG K1C23_HUMAN Decreases Expression [7]
Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1) OT38HXJP CRLD1_HUMAN Increases Expression [7]
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) OTAQD3YV ARNT2_HUMAN Decreases Expression [7]
Plexin-A4 (PLXNA4) OT5XKB3Q PLXA4_HUMAN Decreases Expression [7]
Palmdelphin (PALMD) OTRLOZ4Y PALMD_HUMAN Decreases Expression [7]
Transcription and mRNA export factor ENY2 (ENY2) OTTNU8RK ENY2_HUMAN Decreases Expression [7]
Signal peptide, CUB and EGF-like domain-containing protein 2 (SCUBE2) OT661S7D SCUB2_HUMAN Decreases Expression [7]
Cytochrome P450 26B1 (CYP26B1) OT92XA92 CP26B_HUMAN Decreases Expression [7]
Olfactomedin-like protein 3 (OLFML3) OTDN45FN OLFL3_HUMAN Increases Expression [7]
Cytokine-inducible SH2-containing protein (CISH) OT8T5NYL CISH_HUMAN Increases Expression [7]
ATPase family AAA domain-containing protein 3A (ATAD3A) OTWF6HBP ATD3A_HUMAN Decreases Expression [7]
Kv channel-interacting protein 1 (KCNIP1) OTGLGK1R KCIP1_HUMAN Decreases Expression [7]
Denticleless protein homolog (DTL) OTC29RYE DTL_HUMAN Increases Expression [7]
Peroxisomal sarcosine oxidase (PIPOX) OTWTCOTN SOX_HUMAN Increases Expression [7]
A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) OTV3Q0DS ATS9_HUMAN Increases Expression [7]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) OTHCDQ22 PRGC1_HUMAN Decreases Expression [7]
Dickkopf-related protein 3 (DKK3) OTDU94EY DKK3_HUMAN Decreases Expression [7]
Protein NDRG2 (NDRG2) OT5L6KD7 NDRG2_HUMAN Decreases Expression [7]
Rho family-interacting cell polarization regulator 2 (RIPOR2) OTXB6LIR RIPR2_HUMAN Decreases Expression [7]
Transcription factor HES-2 (HES2) OTMWY2KV HES2_HUMAN Increases Expression [7]
Tolloid-like protein 2 (TLL2) OTHZ4TBL TLL2_HUMAN Increases Expression [7]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Increases Expression [17]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Affects Activity [17]
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) OTX8L3M5 SAHH2_HUMAN Affects Expression [8]
Putative hydrolase DDAH2 (DDAH2) OT8Q40G2 DDAH2_HUMAN Affects Expression [8]
Integrin beta-3 (ITGB3) OTWCK1K6 ITB3_HUMAN Affects Expression [8]
Small integral membrane protein 6 (SMIM6) OTRGL3O1 SMIM6_HUMAN Affects Expression [8]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Affects Expression [8]
Integrin beta-6 (ITGB6) OTI3DJ7U ITB6_HUMAN Affects Expression [8]
Deoxyribonuclease-1 (DNASE1) OTM4KWB3 DNAS1_HUMAN Affects Expression [8]
G0/G1 switch protein 2 (G0S2) OT8FL49L G0S2_HUMAN Affects Expression [8]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Affects Expression [8]
Homeobox protein MOX-1 (MEOX1) OTJEMT2D MEOX1_HUMAN Affects Expression [8]
Diacylglycerol kinase epsilon (DGKE) OTWS86AS DGKE_HUMAN Affects Expression [8]
Cadherin-6 (CDH6) OT81Y80S CADH6_HUMAN Affects Expression [8]
Phospholipid-transporting ATPase ID (ATP8B2) OTH5WJ09 AT8B2_HUMAN Affects Expression [8]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Affects Expression [8]
Programmed cell death protein 4 (PDCD4) OTZ6NXUX PDCD4_HUMAN Affects Expression [8]
Sclerostin domain-containing protein 1 (SOSTDC1) OTAKDNSM SOSD1_HUMAN Affects Expression [8]
Transmembrane protein 64 (TMEM64) OTO9IDFD TMM64_HUMAN Affects Expression [8]
Echinoderm microtubule-associated protein-like 6 (EML6) OTE1MUQS EMAL6_HUMAN Affects Expression [8]
PX domain-containing protein kinase-like protein (PXK) OTSP1WLK PXK_HUMAN Affects Expression [8]
Protein limb expression 1 homolog (LIX1) OT1CPNCC LIX1_HUMAN Affects Expression [8]
Uncharacterized protein FAM241A (FAM241A) OTC12ETA F241A_HUMAN Affects Expression [8]
RalBP1-associated Eps domain-containing protein 2 (REPS2) OTSE3TRP REPS2_HUMAN Affects Expression [8]
Syntaxin-binding protein 6 (STXBP6) OTUEKTIP STXB6_HUMAN Affects Expression [8]
POC1 centriolar protein homolog B (POC1B) OTDIMIRZ POC1B_HUMAN Affects Expression [8]
Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12) OT0EDNV9 GTR12_HUMAN Affects Expression [8]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Affects Expression [8]
Peroxidasin homolog (PXDN) OTFGGM9R PXDN_HUMAN Affects Expression [8]
Secreted frizzled-related protein 3 (FRZB) OTTO3DPY SFRP3_HUMAN Affects Expression [8]
DNA endonuclease RBBP8 (RBBP8) OTRHJ3GI CTIP_HUMAN Affects Expression [8]
Transmembrane protease serine 4 (TMPRSS4) OTCCGY2K TMPS4_HUMAN Affects Expression [8]
Cdc42 effector protein 3 (CDC42EP3) OTUZ3U9Z BORG2_HUMAN Affects Expression [8]
Teneurin-1 (TENM1) OTSKSU4V TEN1_HUMAN Affects Expression [8]
RNA polymerase II elongation factor ELL2 (ELL2) OTZJRTFM ELL2_HUMAN Affects Expression [9]
Mothers against decapentaplegic homolog 6 (SMAD6) OTUZZWUD SMAD6_HUMAN Affects Expression [9]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [19]
RAS guanyl-releasing protein 1 (RASGRP1) OTX9WN2E GRP1_HUMAN Affects Expression [9]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Expression [20]
Cytochrome c oxidase subunit 3 (COX3) OTNNGBYJ COX3_HUMAN Increases Expression [21]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Increases Expression [22]
Plasminogen (PLG) OTWWIPPY PLMN_HUMAN Increases Expression [23]
Renin (REN) OT52GZR2 RENI_HUMAN Increases Activity [24]
ATP synthase subunit a (ATP6) OTPHOGLX ATP6_HUMAN Increases Expression [21]
Antithrombin-III (SERPINC1) OTDFATG0 ANT3_HUMAN Decreases Activity [23]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Increases Expression [24]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Increases Expression [25]
Follitropin subunit beta (FSHB) OTGLS283 FSHB_HUMAN Decreases Expression [26]
Lutropin subunit beta (LHB) OT5GBOVJ LSHB_HUMAN Decreases Activity [27]
Somatotropin (GH1) OT92RTRD SOMA_HUMAN Increases Expression [26]
Insulin-like growth factor II (IGF2) OTJ4O6MW IGF2_HUMAN Increases Expression [28]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Increases Expression [29]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Increases Expression [30]
Trefoil factor 1 (TFF1) OTCYQH4F TFF1_HUMAN Increases Expression [31]
Histidine-rich glycoprotein (HRG) OTPLUFOG HRG_HUMAN Decreases Expression [32]
Sex hormone-binding globulin (SHBG) OTPWU5IW SHBG_HUMAN Increases Expression [33]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Affects Activity [34]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Decreases Expression [26]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Affects Expression [9]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Affects Expression [35]
Thrombomodulin (THBD) OT8VHLKY TRBM_HUMAN Decreases Expression [22]
Vitamin K-dependent protein S (PROS1) OTXQWNOI PROS_HUMAN Decreases Expression [23]
Transcription factor Sp1 (SP1) OTISPT4X SP1_HUMAN Increases Activity [36]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Affects Expression [9]
Coagulation factor VII (F7) OTGNJ97M FA7_HUMAN Increases Expression [22]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Affects Expression [9]
Chromogranin-A (CHGA) OTXYX5JH CMGA_HUMAN Affects Expression [9]
Serine/threonine-protein kinase pim-1 (PIM1) OTWEKXTU PIM1_HUMAN Affects Expression [9]
Keratin, type II cytoskeletal 5 (KRT5) OTVGI9HT K2C5_HUMAN Affects Expression [9]
Beta-1,4-galactosyltransferase 1 (B4GALT1) OTBCXEK7 B4GT1_HUMAN Increases Expression [37]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Affects Expression [9]
Gap junction alpha-1 protein (GJA1) OTT94MKL CXA1_HUMAN Increases Expression [38]
Insulin-like growth factor-binding protein 2 (IGFBP2) OTG1P60E IBP2_HUMAN Decreases Expression [28]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [39]
Myelin and lymphocyte protein (MAL) OTBM30SW MAL_HUMAN Affects Expression [9]
Insulin-like growth factor-binding protein 4 (IGFBP4) OT2HZRBD IBP4_HUMAN Increases Expression [28]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Activity [40]
Insulin-like growth factor-binding protein complex acid labile subunit (IGFALS) OTTWCZYM ALS_HUMAN Decreases Expression [26]
ETS translocation variant 5 (ETV5) OTE2OBM4 ETV5_HUMAN Affects Expression [9]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Affects Expression [9]
Solute carrier organic anion transporter family member 1A2 (SLCO1A2) OTO70C5O SO1A2_HUMAN Decreases Expression [20]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Increases Expression [41]
NADP-dependent malic enzyme (ME1) OTSVEUQE MAOX_HUMAN Affects Expression [9]
Glutamate--cysteine ligase catalytic subunit (GCLC) OTESDI4D GSH1_HUMAN Affects Expression [9]
Cysteine--tRNA ligase, cytoplasmic (CARS1) OTOUZF6O SYCC_HUMAN Affects Expression [9]
Serine--tRNA ligase, cytoplasmic (SARS1) OTFKXQ1O SYSC_HUMAN Affects Expression [9]
CCAAT/enhancer-binding protein delta (CEBPD) OTNBIPMY CEBPD_HUMAN Affects Expression [9]
Inhibin beta E chain (INHBE) OTOI2NYG INHBE_HUMAN Affects Expression [9]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Affects Expression [9]
Transformer-2 protein homolog beta (TRA2B) OTZYQW52 TRA2B_HUMAN Increases Expression [42]
Small ribosomal subunit protein RACK1 (RACK1) OTZBCQ1U RACK1_HUMAN Increases Expression [43]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [44]
Schlafen family member 5 (SLFN5) OTT1AESL SLFN5_HUMAN Affects Expression [9]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Affects Expression [9]
Four and a half LIM domains protein 2 (FHL2) OT0OAYWT FHL2_HUMAN Affects Expression [9]
Hepatic sodium/bile acid cotransporter (SLC10A1) OTUJVMCL NTCP_HUMAN Decreases Expression [20]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Increases Activity [45]
Advanced glycosylation end product-specific receptor (AGER) OTPY0IH7 RAGE_HUMAN Increases Expression [36]
Erythroferrone (ERFE) OTSES1HA ERFE_HUMAN Affects Expression [9]
FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) OTIH6283 FGD3_HUMAN Affects Expression [9]
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1) OTGFK4MH NHRF3_HUMAN Increases Expression [37]
Early estrogen-induced gene 1 protein (EEIG1) OT2BMEAE EEIG1_HUMAN Increases Expression [37]
Very-long-chain (HACD2) OTAZO9F6 HACD2_HUMAN Affects Expression [9]
Retrotransposon-derived protein PEG10 (PEG10) OTWD2278 PEG10_HUMAN Affects Expression [9]
Ly6/PLAUR domain-containing protein 1 (LYPD1) OT0HSGML LYPD1_HUMAN Affects Expression [9]
Scavenger receptor class B member 1 (SCARB1) OTAE1UA1 SCRB1_HUMAN Affects Splicing [42]
Stonin-2 (STON2) OT01JHHE STON2_HUMAN Affects Expression [9]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Affects Expression [9]
Estrogen receptor beta (ESR2) OTXNR2WQ ESR2_HUMAN Increases Activity [46]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Decreases Expression [20]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Affects Expression [9]
Mediator of RNA polymerase II transcription subunit 8 (MED8) OTSIZ1I7 MED8_HUMAN Affects Expression [9]
Bile acid receptor (NR1H4) OTWZLPTB NR1H4_HUMAN Decreases Expression [20]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Affects Expression [9]
G-protein coupled estrogen receptor 1 (GPER1) OTUK0TDC GPER1_HUMAN Increases Expression [30]
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Decreases Expression [47]
Protein associated with UVRAG as autophagy enhancer (RUBCNL) OTMQIDOI PACER_HUMAN Affects Expression [9]
Tetratricopeptide repeat protein 12 (TTC12) OTDB24YV TTC12_HUMAN Affects Expression [9]
Solute carrier family 40 member 1 (SLC40A1) OT8RV2VY S40A1_HUMAN Affects Expression [9]
Matrix-remodeling-associated protein 5 (MXRA5) OTXZBWCU MXRA5_HUMAN Affects Expression [9]
Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2) OT8NJE5D SI1L2_HUMAN Affects Expression [9]
Kelch-like protein 14 (KLHL14) OTYOS55H KLH14_HUMAN Affects Expression [9]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Affects Expression [9]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Affects Expression [9]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1) OTY8J0S4 ZNT1_HUMAN Affects Expression [9]
SET-binding protein (SETBP1) OTKGCOSR SETBP_HUMAN Affects Expression [9]
Sulfotransferase 2A1 (SULT2A1) OT0ISKQ4 ST2A1_HUMAN Increases Metabolism [48]
Sulfotransferase 1A1 (SULT1A1) OT0K7JIE ST1A1_HUMAN Increases Metabolism [48]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Uptake [49]
Cytochrome P450 (CYP2B) OTDDG81I Q14097_HUMAN Increases ADR [50]
Sulfotransferase 1B1 (SULT1B1) OTH0RQYA ST1B1_HUMAN Increases Metabolism [48]
Sulfotransferase 1A3 (SULT1A4) OTHJ8WWV ST1A3_HUMAN Increases Sulfation [51]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Increases Hydroxylation [14]
Fibroblast growth factor 4 (FGF4) OTNVV3ZG FGF4_HUMAN Increases ADR [50]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Affects Metabolism [52]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Increases Hydroxylation [14]
------------------------------------------------------------------------------------
⏷ Show the Full List of 280 DOT(s)
Indication(s) of Vinblastine
Disease Entry ICD 11 Status REF
Advanced cancer 2A00-2F9Z Approved [4]
Anterior urethra cancer N.A. Approved [4]
Extragonadal germ cell tumor N.A. Approved [4]
Gestational trophoblastic neoplasia 2F33-2F76 Approved [4]
Kaposi sarcoma 2B57 Approved [4]
Mycosis fungoides 2B01 Approved [4]
Posterior urethra cancer N.A. Approved [4]
Solid tumour/cancer 2A00-2F9Z Approved [5]
Testicular cancer 2C80 Approved [4]
Testicular germ cell tumor N.A. Approved [4]
Classic Hodgkin lymphoma N.A. Investigative [4]
Vinblastine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Tubulin beta-2 chain (TUBB2) TTJ2PTI TBB2A_HUMAN Inhibitor [54]
------------------------------------------------------------------------------------
Vinblastine Interacts with 5 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [55]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [56]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [57]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [58]
Multidrug resistance protein 3 (ABCB4) DTZRMK5 MDR3_HUMAN Substrate [59]
------------------------------------------------------------------------------------
Vinblastine Interacts with 3 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [60]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [61]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [62]
------------------------------------------------------------------------------------
Vinblastine Interacts with 201 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Response To Substance [63]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Response To Substance [64]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Affects Transport [65]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [66]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Increases Phosphorylation [67]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [68]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Increases Expression [69]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Stability [70]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Decreases Expression [71]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Phosphorylation [72]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Stability [70]
Integrin alpha-L (ITGAL) OTCUQAIS ITAL_HUMAN Decreases Expression [71]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Phosphorylation [67]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Increases Phosphorylation [72]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Increases Phosphorylation [72]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Expression [73]
Protein kinase C delta type (PRKCD) OTSEH90E KPCD_HUMAN Affects Localization [69]
Nuclear factor of activated T-cells, cytoplasmic 4 (NFATC4) OTTDCUAO NFAC4_HUMAN Decreases Localization [74]
Transcriptional regulator QRICH1 (QRICH1) OTPVAX04 QRIC1_HUMAN Increases Phosphorylation [75]
Sorting nexin-10 (SNX10) OT05B7BT SNX10_HUMAN Affects Response To Substance [53]
Histone H1.2 (H1-2) OT0AVI4M H12_HUMAN Affects Response To Substance [53]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Affects Response To Substance [53]
Friend leukemia integration 1 transcription factor (FLI1) OT0EV3LX FLI1_HUMAN Affects Response To Substance [53]
Sulfotransferase 1A1 (SULT1A1) OT0K7JIE ST1A1_HUMAN Affects Response To Substance [53]
Histone H3-like centromeric protein A (CENPA) OT0NEJ4X CENPA_HUMAN Affects Response To Substance [53]
DNA polymerase zeta catalytic subunit (REV3L) OT0OP8EJ REV3L_HUMAN Affects Response To Substance [53]
Rab11 family-interacting protein 1 (RAB11FIP1) OT0T71OW RFIP1_HUMAN Affects Response To Substance [53]
Oxysterol-binding protein-related protein 10 (OSBPL10) OT0TFMBE OSB10_HUMAN Affects Response To Substance [53]
DNA-binding protein inhibitor ID-2 (ID2) OT0U1D53 ID2_HUMAN Affects Response To Substance [53]
NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) OT0UOKIT NDUAD_HUMAN Affects Response To Substance [53]
Tripartite motif-containing protein 2 (TRIM2) OT0V1YVC TRIM2_HUMAN Affects Response To Substance [53]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Affects Response To Substance [53]
Borealin (CDCA8) OT17D55D BOREA_HUMAN Affects Response To Substance [53]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Increases Response To Substance [76]
Condensin complex subunit 3 (NCAPG) OT1AI9EO CND3_HUMAN Affects Response To Substance [53]
m7GpppX diphosphatase (DCPS) OT1FZVC9 DCPS_HUMAN Affects Response To Substance [53]
KN motif and ankyrin repeat domain-containing protein 1 (KANK1) OT2E7A6W KANK1_HUMAN Affects Response To Substance [53]
Aldehyde oxidase (AOX1) OT2FZP6H AOXA_HUMAN Affects Response To Substance [53]
U11/U12 small nuclear ribonucleoprotein 25 kDa protein (SNRNP25) OT2MR6O2 SNR25_HUMAN Affects Response To Substance [53]
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHB) OT2NHE5E ODPB_HUMAN Affects Response To Substance [53]
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB) OT2Z03OB GNPTA_HUMAN Affects Response To Substance [53]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Affects Response To Substance [53]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Affects Response To Substance [53]
Chromosome-associated kinesin KIF4A (KIF4A) OT3UWL7D KIF4A_HUMAN Affects Response To Substance [53]
NADH dehydrogenase 1 beta subcomplex subunit 2, mitochondrial (NDUFB2) OT4717TF NDUB2_HUMAN Affects Response To Substance [53]
High mobility group protein B1 (HMGB1) OT4B7CPF HMGB1_HUMAN Affects Response To Substance [53]
c-Myc-binding protein (MYCBP) OT4IZR4R MYCBP_HUMAN Affects Response To Substance [53]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Affects Response To Substance [53]
Transcription termination factor 2 (TTF2) OT5LJOWM TTF2_HUMAN Affects Response To Substance [53]
Neprilysin (MME) OT5Q39P8 NEP_HUMAN Affects Response To Substance [53]
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) OT6285L4 FKB1A_HUMAN Affects Response To Substance [53]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Affects Response To Substance [53]
Electron transfer flavoprotein subunit beta (ETFB) OT6Q6FBD ETFB_HUMAN Affects Response To Substance [53]
Flap endonuclease 1 (FEN1) OT6QGG7O FEN1_HUMAN Affects Response To Substance [53]
G-protein-signaling modulator 2 (GPSM2) OT6RPMRM GPSM2_HUMAN Affects Response To Substance [53]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Affects Response To Substance [53]
CD40 ligand (CD40LG) OT75Z6A6 CD40L_HUMAN Decreases Response To Substance [77]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Affects Response To Substance [53]
Nucleolar and spindle-associated protein 1 (NUSAP1) OT85HIJ5 NUSAP_HUMAN Affects Response To Substance [53]
Stanniocalcin-2 (STC2) OT86YP8G STC2_HUMAN Affects Response To Substance [53]
Pirin (PIR) OT8ALXHU PIR_HUMAN Affects Response To Substance [53]
NADH dehydrogenase 1 alpha subcomplex subunit 7 (NDUFA7) OT8CV3H5 NDUA7_HUMAN Affects Response To Substance [53]
G0/G1 switch protein 2 (G0S2) OT8FL49L G0S2_HUMAN Affects Response To Substance [53]
Replication protein A 14 kDa subunit (RPA3) OT8JAQGL RFA3_HUMAN Affects Response To Substance [53]
Deoxyribose-phosphate aldolase (DERA) OT8SMO3N DEOC_HUMAN Affects Response To Substance [53]
NADH dehydrogenase iron-sulfur protein 6, mitochondrial (NDUFS6) OT9IOONQ NDUS6_HUMAN Affects Response To Substance [53]
NADH dehydrogenase 1 subunit C2 (NDUFC2) OT9M119L NDUC2_HUMAN Affects Response To Substance [53]
Beta-glucuronidase (GUSB) OT9N1DK3 BGLR_HUMAN Affects Response To Substance [53]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Affects Response To Substance [53]
High mobility group nucleosome-binding domain-containing protein 3 (HMGN3) OTA2TBWS HMGN3_HUMAN Affects Response To Substance [53]
Diphosphoinositol polyphosphate phosphohydrolase NUDT4B (NUDT4) OTA6ICI2 NUD4B_HUMAN Affects Response To Substance [53]
Cysteine-rich PDZ-binding protein (CRIPT) OTA6M8M4 CRIPT_HUMAN Affects Response To Substance [53]
Replication factor C subunit 5 (RFC5) OTAD79RT RFC5_HUMAN Affects Response To Substance [53]
ATP synthase subunit e, mitochondrial (ATP5ME) OTADVEE2 ATP5I_HUMAN Affects Response To Substance [53]
Transmembrane protein 14A (TMEM14A) OTANQA6G TM14A_HUMAN Affects Response To Substance [53]
MAP kinase-activated protein kinase 5 (MAPKAPK5) OTAZHPVK MAPK5_HUMAN Affects Response To Substance [53]
Shootin-1 (SHTN1) OTB07MOG SHOT1_HUMAN Affects Response To Substance [53]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Affects Response To Substance [53]
Fibronectin (FN1) OTB5ZN4Q FINC_HUMAN Affects Response To Substance [53]
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) OTB97VIK IF2B3_HUMAN Affects Response To Substance [53]
Membrane-associated progesterone receptor component 1 (PGRMC1) OTBE6WAC PGRC1_HUMAN Affects Response To Substance [53]
Probable ATP-dependent RNA helicase DDX23 (DDX23) OTBJHS8C DDX23_HUMAN Affects Response To Substance [53]
Protein FAM3C (FAM3C) OTBR6U9G FAM3C_HUMAN Affects Response To Substance [53]
Transmembrane protein 134 (TMEM134) OTBX9H9D TM134_HUMAN Affects Response To Substance [53]
Dual specificity protein kinase TTK (TTK) OTBY1Z5H TTK_HUMAN Affects Response To Substance [53]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Affects Response To Substance [53]
Cyclin-dependent kinase 4 inhibitor C (CDKN2C) OTCLOV90 CDN2C_HUMAN Affects Response To Substance [53]
Cytoskeleton-associated protein 2 (CKAP2) OTCLTC0J CKAP2_HUMAN Affects Response To Substance [53]
Cytochrome c oxidase copper chaperone (COX17) OTCP4LH2 COX17_HUMAN Affects Response To Substance [53]
Tetraspanin-13 (TSPAN13) OTCS9BZY TSN13_HUMAN Affects Response To Substance [53]
S-phase kinase-associated protein 2 (SKP2) OTD5B41X SKP2_HUMAN Affects Response To Substance [53]
Succinate--CoA ligase subunit alpha, mitochondrial (SUCLG1) OTDCSPXH SUCA_HUMAN Affects Response To Substance [53]
Proteasome activator complex subunit 4 (PSME4) OTDGF53O PSME4_HUMAN Affects Response To Substance [53]
Gamma-adducin (ADD3) OTDRSHAZ ADDG_HUMAN Affects Response To Substance [53]
Superkiller complex protein 8 (SKIC8) OTDSQYDN SKI8_HUMAN Affects Response To Substance [53]
Dickkopf-related protein 3 (DKK3) OTDU94EY DKK3_HUMAN Affects Response To Substance [53]
Geminin (GMNN) OTDYKNIY GEMI_HUMAN Affects Response To Substance [53]
EF-hand calcium-binding domain-containing protein 7 (EFCAB7) OTE0EG10 EFCB7_HUMAN Affects Response To Substance [53]
Vitamin K-dependent gamma-carboxylase (GGCX) OTE0FNAP VKGC_HUMAN Affects Response To Substance [53]
ATP synthase subunit f, mitochondrial (ATP5MF) OTE4TBG9 ATPK_HUMAN Affects Response To Substance [53]
Maternal embryonic leucine zipper kinase (MELK) OTEY2UQA MELK_HUMAN Affects Response To Substance [53]
Protein pelota homolog (PELO) OTF3WLIM PELO_HUMAN Affects Response To Substance [53]
Serglycin (SRGN) OTFAVSX0 SRGN_HUMAN Affects Response To Substance [53]
Sortilin (SORT1) OTFCQ4B1 SORT_HUMAN Affects Response To Substance [53]
Exosome complex component RRP45 (EXOSC9) OTFKB37F EXOS9_HUMAN Affects Response To Substance [53]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Affects Response To Substance [53]
High mobility group protein B2 (HMGB2) OTGEGAOK HMGB2_HUMAN Affects Response To Substance [53]
Phospholipid-transporting ATPase ABCA3 (ABCA3) OTH6MSKQ ABCA3_HUMAN Decreases Response To Substance [78]
Sigma intracellular receptor 2 (TMEM97) OTH76ZWK SGMR2_HUMAN Affects Response To Substance [53]
Transmembrane protein 156 (TMEM156) OTH7YJID TM156_HUMAN Affects Response To Substance [53]
Epithelial cell adhesion molecule (EPCAM) OTHBZK5X EPCAM_HUMAN Affects Response To Substance [53]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Affects Response To Substance [53]
Catalase (CAT) OTHEBX9R CATA_HUMAN Affects Response To Substance [53]
Kinesin-like protein KIF11 (KIF11) OTHRGLCQ KIF11_HUMAN Affects Response To Substance [53]
Actin-binding LIM protein 1 (ABLIM1) OTHXEK3E ABLM1_HUMAN Affects Response To Substance [53]
U6 snRNA-associated Sm-like protein LSm7 (LSM7) OTHZ2XPX LSM7_HUMAN Affects Response To Substance [53]
Kinesin-like protein KIF1B (KIF1B) OTI1XQTO KIF1B_HUMAN Affects Response To Substance [53]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Affects Response To Substance [53]
Protein Mis18-beta (OIP5) OTI5C2DE MS18B_HUMAN Affects Response To Substance [53]
G2/mitotic-specific cyclin-B2 (CCNB2) OTIEXTDK CCNB2_HUMAN Affects Response To Substance [53]
Securin (PTTG1) OTIMYS4W PTTG1_HUMAN Affects Response To Substance [53]
Baculoviral IAP repeat-containing protein 7 (BIRC7) OTITCGHB BIRC7_HUMAN Decreases Response To Substance [79]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Affects Response To Substance [53]
NADH dehydrogenase 1 subunit C1, mitochondrial (NDUFC1) OTJ5TNHB NDUC1_HUMAN Affects Response To Substance [53]
Low molecular weight phosphotyrosine protein phosphatase (ACP1) OTJ9CKLU PPAC_HUMAN Affects Response To Substance [53]
G/T mismatch-specific thymine DNA glycosylase (TDG) OTJB0YIH TDG_HUMAN Affects Response To Substance [53]
E3 ubiquitin-protein ligase FANCL (FANCL) OTJC7QPQ FANCL_HUMAN Affects Response To Substance [53]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) OTJDOL20 HCDH_HUMAN Affects Response To Substance [53]
Lysophosphatidic acid receptor 1 (LPAR1) OTJNJQPF LPAR1_HUMAN Affects Response To Substance [53]
Kinesin-like protein KIF15 (KIF15) OTJRJEXL KIF15_HUMAN Affects Response To Substance [53]
TBC1 domain family member 4 (TBC1D4) OTK66C40 TBCD4_HUMAN Affects Response To Substance [53]
Tyrosine-protein kinase receptor UFO (AXL) OTKA2SUX UFO_HUMAN Affects Response To Substance [53]
Gamma-glutamylcyclotransferase (GGCT) OTKAICP5 GGCT_HUMAN Affects Response To Substance [53]
NADH dehydrogenase 1 alpha subcomplex subunit 1 (NDUFA1) OTKBUQXP NDUA1_HUMAN Affects Response To Substance [53]
Origin recognition complex subunit 6 (ORC6) OTKQN3KP ORC6_HUMAN Affects Response To Substance [53]
Sideroflexin-1 (SFXN1) OTL66767 SFXN1_HUMAN Affects Response To Substance [53]
Lamina-associated polypeptide 2, isoform alpha (TMPO) OTL68EL4 LAP2A_HUMAN Affects Response To Substance [53]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Increases Response To Substance [76]
Striatin (STRN) OTLOZL5I STRN_HUMAN Affects Response To Substance [53]
Succinate--CoA ligase subunit beta, mitochondrial (SUCLA2) OTMZD4PW SUCB1_HUMAN Affects Response To Substance [53]
Protein downstream neighbor of Son (DONSON) OTN5HE0W DONS_HUMAN Affects Response To Substance [53]
Cytochrome c oxidase subunit 6B1 (COX6B1) OTNKXYQI CX6B1_HUMAN Affects Response To Substance [53]
Keratinocyte-associated transmembrane protein 2 (C5ORF15) OTO126A1 KCT2_HUMAN Affects Response To Substance [53]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Affects Response To Substance [80]
tRNA (TRMT5) OTOAZBPD TRM5_HUMAN Affects Response To Substance [53]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Affects Response To Substance [53]
Cytochrome c oxidase subunit 5A, mitochondrial (COX5A) OTP0961M COX5A_HUMAN Affects Response To Substance [53]
DNA fragmentation factor subunit beta (DFFB) OTPBW5N5 DFFB_HUMAN Affects Response To Substance [53]
Interleukin-13 receptor subunit alpha-2 (IL13RA2) OTPC2G0X I13R2_HUMAN Affects Response To Substance [53]
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) OTPL0AI1 ABC3C_HUMAN Affects Response To Substance [53]
Kazrin (KAZN) OTPM7BYM KAZRN_HUMAN Affects Response To Substance [53]
G2 and S phase-expressed protein 1 (GTSE1) OTPP742Z GTSE1_HUMAN Affects Response To Substance [53]
Prostaglandin E synthase 3 (PTGES3) OTPPQWI0 TEBP_HUMAN Affects Response To Substance [53]
Epithelial membrane protein 2 (EMP2) OTPS2H0L EMP2_HUMAN Affects Response To Substance [53]
Ornithine decarboxylase antizyme 1 (OAZ1) OTPT0PKZ OAZ1_HUMAN Affects Response To Substance [53]
Sister chromatid cohesion protein DCC1 (DSCC1) OTPUVLZT DCC1_HUMAN Affects Response To Substance [53]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Affects Response To Substance [81]
Pentraxin-related protein PTX3 (PTX3) OTPXHRKU PTX3_HUMAN Affects Response To Substance [53]
Ran-specific GTPase-activating protein (RANBP1) OTQE226K RANG_HUMAN Affects Response To Substance [53]
Rac GTPase-activating protein 1 (RACGAP1) OTQE8IEH RGAP1_HUMAN Affects Response To Substance [53]
MAPK/MAK/MRK overlapping kinase (MOK) OTQK7M9V MOK_HUMAN Affects Response To Substance [53]
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1) OTQRET2B S5A1_HUMAN Affects Response To Substance [53]
Solute carrier family 22 member 3 (SLC22A3) OTQYGVXX S22A3_HUMAN Affects Response To Substance [53]
Large ribosomal subunit protein mL63 (MRPL57) OTRB659E RT63_HUMAN Affects Response To Substance [53]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Affects Response To Substance [53]
Olfactory receptor 1I1 (OR1I1) OTRFD8BH OR1I1_HUMAN Affects Response To Substance [53]
Protein CREG1 (CREG1) OTRHJ8HK CREG1_HUMAN Affects Response To Substance [53]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Affects Response To Substance [53]
Kinetochore protein NDC80 homolog (NDC80) OTS7D306 NDC80_HUMAN Affects Response To Substance [53]
Latent-transforming growth factor beta-binding protein 2 (LTBP2) OTS88GSD LTBP2_HUMAN Affects Response To Substance [53]
Tumor protein D53 (TPD52L1) OTSA6U0I TPD53_HUMAN Affects Response To Substance [53]
Inhibin beta A chain (INHBA) OTSP64PQ INHBA_HUMAN Affects Response To Substance [53]
Leucine-rich repeat-containing protein 1 (LRRC1) OTSVD30Q LRRC1_HUMAN Affects Response To Substance [53]
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) OTSZF7D6 NDUV2_HUMAN Affects Response To Substance [53]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Affects Response To Substance [53]
Rho GTPase-activating protein SYDE1 (SYDE1) OTTIAF4D SYDE1_HUMAN Affects Response To Substance [53]
Isocitrate dehydrogenase , mitochondrial (IDH2) OTTQA4PB IDHP_HUMAN Affects Response To Substance [53]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Affects Response To Substance [53]
General transcription factor II-I (GTF2I) OTUYL1TQ GTF2I_HUMAN Affects Response To Substance [53]
Integrin beta-1-binding protein 1 (ITGB1BP1) OTVQFNGS ITBP1_HUMAN Affects Response To Substance [53]
Transcription factor IIIA (GTF3A) OTVROUVQ TF3A_HUMAN Affects Response To Substance [53]
ATP-binding cassette sub-family A member 2 (ABCA2) OTVSYK0X ABCA2_HUMAN Decreases Response To Substance [78]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Affects Response To Substance [53]
Serine/threonine-protein kinase 26 (STK26) OTW4QE0D STK26_HUMAN Affects Response To Substance [53]
Homer protein homolog 1 (HOMER1) OTWFD3SI HOME1_HUMAN Affects Response To Substance [53]
Acyl-coenzyme A thioesterase 13 (ACOT13) OTWRUST1 ACO13_HUMAN Affects Response To Substance [53]
Divergent protein kinase domain 1A (DIPK1A) OTWS5V2I DIK1A_HUMAN Affects Response To Substance [53]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Affects Response To Substance [53]
Hematopoietic lineage cell-specific protein (HCLS1) OTX7WGYN HCLS1_HUMAN Affects Response To Substance [53]
Nucleotide triphosphate diphosphatase NUDT15 (NUDT15) OTX8SZOT NUD15_HUMAN Affects Response To Substance [53]
NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3) OTXL10N9 NDUA3_HUMAN Affects Response To Substance [53]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Affects Response To Substance [53]
Kinesin-like protein KIF20A (KIF20A) OTXOQHE0 KI20A_HUMAN Affects Response To Substance [53]
Condensin complex subunit 2 (NCAPH) OTXOS97C CND2_HUMAN Affects Response To Substance [53]
Kinesin-like protein KIF23 (KIF23) OTY850JC KIF23_HUMAN Affects Response To Substance [53]
Protein FAN (NSMAF) OTYNVZ23 FAN_HUMAN Affects Response To Substance [53]
Proteasome subunit beta type-1 (PSMB1) OTYRFBAH PSB1_HUMAN Affects Response To Substance [53]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) OTZ092ZJ THIC_HUMAN Affects Response To Substance [53]
G-protein coupled receptor 176 (GPR176) OTZ8PL9B GP176_HUMAN Affects Response To Substance [53]
Tissue factor pathway inhibitor 2 (TFPI2) OTZCRWOR TFPI2_HUMAN Affects Response To Substance [53]
C-X-C motif chemokine 5 (CXCL5) OTZOUPCA CXCL5_HUMAN Affects Response To Substance [53]
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⏷ Show the Full List of 201 DOT(s)

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