Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0CVXA)

Drug Name
Mechlorethamine Drug Info
Synonyms
Antimit; Carolysine; Caryolysin; Caryolysine; Chlorethazine; Chlormethine; Cloramin; Clormetina; Dichloren; Embechine; Embichin; MBA; Mebichloramine; Mechlorethanamine; Mechloroethamine; Mecloretamina; Mustargen; Mustine; Mutagen; Nitrogranulogen; Thyldiethylamine; Dichlor amine; Me chloroethamine; Mecloretamina [Italian]; Mustine note; Nitrogen mustard; HN2; T 1024; TL 146; Chloramine (the nitrogen mustard); Chlormethine (INN); Chlormethine [INN:BAN]; Chlormethinum [INN-Latin]; Clormetina [INN-Spanish]; ENT-25294; HN-2; IBS-L0033631; Mustargen (TN); N-Lost; N-Methyl lost; Stickstofflost (ebewe); T-1024; Bis(2-chloroethyl)methylamine; Bis(beta-chloroethyl) methylamine; Bis(beta-chloroethyl)methylamine; Di(2-chloroethyl)methylamine; Methylbis(2-chloroethyl)amine; Methylbis(beta-chloroethyl)amine; Methyldi(2-chloroethyl)amine; N-Methyl-lost; N-Methyl-lost [German]; Nitrogen mustard (HN-2); Mitoxine (*Hydrochloride*); N,N-Di(chloroethyl)methylamine; N-Methyl-bis-chloraethylamin; N-Methyl-bis-chloraethylamin [German]; Nitol (*Hydrochloride*); Stickstofflost (*Hydrochloride*); N,N-Bis(2-chloroethyl)methylamine; N-Methyl-bis(2-chloroethyl)amine; N-Methyl-bis(beta-chloroethyl)amine; Beta,beta'-Dichlorodiethyl-N-methylamine; N-Methyl-2,2'-dichlorodiethylamine; N,N-Bis(2-chloroethyl)-N-methylamine; 1,5-Dichloro-3-methyl-3-azapentane hydrochloride; 2,2'-Dichloro-N-me; 2,2'-Dichloro-N-methyldiethylamine; 2,2'-Dichlorodiethyl-methylamine; 2-Chloro-N-(2-chloroethyl)-N-methylethanamine
Indication
Disease Entry ICD 11 Status REF
Chronic myelogenous leukaemia 2A20.0 Approved [1]
Lung cancer 2C25.0 Approved [1]
Mycosis fungoides 2B01 Approved [1]
Primary cutaneous T-cell lymphoma Approved [1]
Small lymphocytic lymphoma 2A82.0 Approved [1]
T-cell lymphoma 2A90 Approved [2]
Hodgkin lymphoma 2B30 Phase 3 [3]
Classic Hodgkin lymphoma Investigative [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
4033
ChEBI ID
CHEMBL28925
CAS Number
CAS 51-75-2
TTD Drug ID
DM0CVXA

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Human Deoxyribonucleic acid (hDNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [12]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [13]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [14]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [15]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [16]
Carboplatin DMG281S Adenocarcinoma 2D40 Approved [17]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [18]
Procarbazine DMIK367 Hodgkin lymphoma 2B30 Approved [19]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [20]
Dacarbazine DMNPZL4 Adenocarcinoma 2D40 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [22]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [23]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [24]
Gefitinib DM15F0X Colon adenocarcinoma Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Selenium DM25CGV N. A. N. A. Approved [27]
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [31]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [32]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [33]
Fructose DM43AN2 Vomiting MD90 Approved [22]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [34]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [35]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [40]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [41]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [42]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [44]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [46]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [48]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [46]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [49]
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Drug(s) Affected By Transcription factor JunB (JUNB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [56]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [57]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Leflunomide DMR8ONJ Arthritis FA20 Approved [59]
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Drug(s) Affected By Transcription factor JunD (JUND)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [62]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [63]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [64]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [65]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [66]
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Drug(s) Affected By Protein S100-P (S100P)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [71]
Estrone DM5T6US Acne vulgaris ED80 Approved [72]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [73]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [74]
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [75]
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Drug(s) Affected By Laminin subunit gamma-2 (LAMC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [77]
Panobinostat DM58WKG Chronic graft versus host disease Approved [79]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [80]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [82]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [83]
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Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [84]
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [86]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [87]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [88]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [89]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [90]
Venetoclax DM8I94Y Chronic lymphocytic leukaemia 2A82.0 Approved [91]
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Drug(s) Affected By Transient receptor potential cation channel subfamily A member 1 (TRPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [93]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [81]
Capsaicin DMGMF6V Back pain ME84.Z Approved [94]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [95]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [93]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [96]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [97]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [98]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [99]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Intercalator [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Gene/Protein Processing [5]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [6]
Laminin subunit gamma-2 (LAMC2) OTJMTM72 LAMC2_HUMAN Gene/Protein Processing [7]
Protein S100-P (S100P) OTJCXNJG S100P_HUMAN Gene/Protein Processing [8]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Gene/Protein Processing [9]
Thioredoxin OT6XU6VW THIO_HUMAN Gene/Protein Processing [10]
Thioredoxin reductase 2, mitochondrial OTZQQC3T TRXR2_HUMAN Gene/Protein Processing [11]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Gene/Protein Processing [6]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Gene/Protein Processing [6]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Gene/Protein Processing [6]

References

1 Mechlorethamine FDA Label
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6 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
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30 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
31 Aspirin inhibits ErbB2 to induce apoptosis in cervical cancer cells. Med Oncol. 2010 Jun;27(2):379-87. doi: 10.1007/s12032-009-9221-0. Epub 2009 May 8.
32 High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1993 Nov 15;82(10):3133-40.
33 Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
34 Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
35 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
36 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
37 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
38 Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
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40 Simvastatin suppresses tissue factor expression and increases fibrinolytic activity in tumor necrosis factor-alpha-activated human peritoneal mesothelial cells. Kidney Int. 2003 Jun;63(6):2065-74. doi: 10.1046/j.1523-1755.2003.t01-2-00004.x.
41 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
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43 Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
44 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
45 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
46 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
47 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
48 Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
49 Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
50 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
51 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
52 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
53 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
54 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
55 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
56 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
57 Endoplasmic reticulum stress-mediated apoptosis in imatinib-resistant leukemic K562-r cells triggered by AMN107 combined with arsenic trioxide. Exp Biol Med (Maywood). 2013 Aug 1;238(8):932-42. doi: 10.1177/1535370213492689. Epub 2013 Jul 24.
58 DNA microarray analysis of vitamin D-induced gene expression in a human colon carcinoma cell line. Physiol Genomics. 2004 Apr 13;17(2):122-9. doi: 10.1152/physiolgenomics.00002.2003.
59 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
60 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
61 Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
62 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
63 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
64 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
65 DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
66 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
67 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
68 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
69 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
70 Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
71 Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
72 Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals. Environ Health Perspect. 2004 May;112(7):773-81. doi: 10.1289/ehp.6753.
73 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
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