Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM51FY6)

Drug Name
Tacrine Drug Info
Synonyms
Cognex; Romotal; Tacrina; Tacrinal; Tacrinum; Tenakrin; Tetrahydroaminacrine; Tetrahydroaminoacridine; Tetrahydroaminocrin; Tetrahydroaminocrine; Tha; Tacrine hydrochloride; BBL001044; CS 12602; Cognex (TN); Tacrina [INN-Spanish]; Tacrinal (TN); Tacrine (INN); Tacrine [INN:BAN]; Tacrinum [INN-Latin]; 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE; 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE (SEE ALSO 1684-40-8); 1,2,3,4-Tetrahydro-9-acridineamine; 1,2,3,4-Tetrahydro-acridin-9-ylamine; 1,2,3,4-Tetrahydroaminoacridine; 1,2,3,4-tetrahydroacridin-9-amine; 5-Amino-6,7,8,9-tetrahydroacridine (European); 9-AMINOTETRAHYDROACRIDINE; 9-Acridinamine, 1,2,3,4-tetrahydro-(9CI); 9-Amino-1,2,3,4-Tetrahydroacridine Hydrate Hydrochloride Hydrate; 9-amino-1,2,3,4-tetrahydroacridine
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Approved [1]
Therapeutic Class
Parasympathomimetics
Cross-matching ID
PubChem CID
1935
ChEBI ID
CHEBI:45980
CAS Number
CAS 321-64-2
TTD Drug ID
DM51FY6
VARIDT Drug ID
DR00183
INTEDE Drug ID
DR1523

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Acetylcholinesterase (AChE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Donepezil DMIYG7Z Advanced cancer 2A00-2F9Z Approved [15]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [16]
Galantamine DMEO794 Alzheimer disease 8A20 Approved [17]
Huperzine A DMMAWLU Alzheimer disease 8A20 Approved [18]
Neostigmine DM6T2J3 Myasthenia gravis 8C6Y Approved [19]
YM443 DMNZCI1 Functional dyspepsia DD90.3 Approved [20]
Ambenonium DMOP0BL Myasthenia gravis 8C6Y Approved [21]
Demecarium bromide DMAYEU1 Open-angle glaucoma 9C61 Approved [22]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [23]
Pyridostigmine DM8HO1L Myasthenia gravis 8C6Y Approved [24]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [25]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Folic Acid DMEMBJC Colorectal carcinoma Approved [28]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [27]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [27]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [29]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [27]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [31]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [32]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [33]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [34]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [36]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [37]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [38]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [39]
Verapamil DMA7PEW Angina pectoris BA40 Approved [40]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [41]
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Drug(s) Metabolized By Glutathione S-transferase alpha-1 (GSTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [42]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [43]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [44]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [45]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [46]
Trabectedin DMG3Y89 Leiomyosarcoma 2B58 Approved [47]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [48]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [49]
Ethacrynic acid DM60QMR Edema MG29 Approved [50]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [51]
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Drug(s) Affected By Cholinesterase (BCHE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [52]
Galantamine DMEO794 Alzheimer disease 8A20 Approved [53]
Rivastigmine DMG629M Alzheimer disease 8A20 Approved [54]
Donepezil DMIYG7Z Advanced cancer 2A00-2F9Z Approved [7]
Succinylcholine DM2ET1M Plasma cell myeloma 2A83.1 Approved [55]
Ethopropazine DM0N3L7 Parkinson disease 8A00.0 Approved [8]
Dimenhydrinate DM264B3 Meniere disease AB31.0 Approved [56]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [57]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [56]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [58]
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Drug(s) Affected By Cocaine esterase (CES2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [59]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [60]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [61]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [64]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [65]
Testosterone enanthate DMB6871 N. A. N. A. Approved [66]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
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Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [69]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [73]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [74]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [75]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [77]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [78]
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Drug(s) Affected By Ribosyldihydronicotinamide dehydrogenase (NQO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [80]
Panobinostat DM58WKG Chronic graft versus host disease Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [82]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [84]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [85]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [86]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [87]
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Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [88]
Verapamil DMA7PEW Angina pectoris BA40 Approved [89]
Methysergide DM1EF73 Migraine 8A80 Approved [14]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [90]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [14]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [91]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [92]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [93]
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Drug(s) Affected By Acetylcholinesterase (ACHE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetylcholine DMDF79Z Cataract 9B10 Approved [94]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [95]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [96]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [96]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [98]
Neostigmine DM6T2J3 Myasthenia gravis 8C6Y Approved [99]
Testosterone DM7HUNW Hot flushes GA30 Approved [100]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [65]
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Drug(s) Affected By Liver carboxylesterase 1 (CES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [101]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [102]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [61]
Selenium DM25CGV N. A. N. A. Approved [103]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [104]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [59]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [105]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [67]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [107]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [108]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [109]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [110]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [111]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [112]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [10]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [113]
Methotrexate DM2TEOL Anterior urethra cancer Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [115]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [102]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [116]
Gefitinib DM15F0X Colon adenocarcinoma Approved [117]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [118]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [112]
Etretinate DM2CZFA Keratosis ED56 Approved [119]
Prednisone DM2HG4X Acute asthma CA23 Approved [120]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [121]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [122]
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Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoclopramide DMFA5MY Nausea MD90 Approved [123]
Quinidine DMLPICK N. A. N. A. Approved [124]
Verapamil DMA7PEW Angina pectoris BA40 Approved [125]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [126]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [126]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [127]
Propranolol DM79NTF Angina pectoris BA40 Approved [128]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [129]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [130]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [126]
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Drug(s) Affected By Apolipoprotein E (APOE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [131]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [132]
Selenium DM25CGV N. A. N. A. Approved [103]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [91]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [133]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [134]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [135]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [136]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [65]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [137]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [138]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [139]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [140]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [141]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [141]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [142]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [143]
Capsaicin DMGMF6V Back pain ME84.Z Approved [144]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [145]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acetylcholinesterase (AChE) TT1RS9F ACES_HUMAN Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Substrate [4]
Cytochrome P450 1A2 (CYP1A2) Main DME DEJGDUW CP1A2_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Acetylcholinesterase (ACHE) OT2H8HG6 ACES_HUMAN Gene/Protein Processing [6]
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Drug Response [7]
Cholinesterase (BCHE) OTOH3WQ9 CHLE_HUMAN Gene/Protein Processing [8]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Gene/Protein Processing [9]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [10]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Drug Response [11]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [10]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Gene/Protein Processing [12]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Gene/Protein Processing [13]
Phosphatidylcholine translocator ABCB4 (ABCB4) OTE6PY83 MDR3_HUMAN Gene/Protein Processing [14]

References

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